--CURRICULUM VITAE--

　　　Experience:

　1975-1977 Intern in Osaka University Hospital
　1977-1978 Staff member in Ikeda Municipal Hospital
　1978-1984 Clinical and Research Fellow in Osaka University Medical School
　1984-1989 Clinical Assistant in Osaka University Medical School
　1989-1995 Assistant Professor in Osaka University Medical School
　1995-1997 Associate Professor in Osaka University Medical School
　1998- Professor in School of Medicine Ehime University


　1986-1987 Visiting scientist in St. Mary's Hospital of London University and in Yale University

1)　
　Miki T, Nakura J, Ye L, Mitsuda N, Morishima A, Sato N, Kamino K. and Ogihara T.
　 Molecular and Epidemiological studies of Werner syndrome in the Japanese popolutaion.
　Mech. Ageing Dev. 98:255-265,1997.

2)
　Kamino K, Sato S, Sakaki Y, Yoshiiwa A, Nishiwaki Y, Takeda M, Tanabe T, Nishimura T, Ii K, St George-Hyslop P, Miki T, Ogihara T.:
　Three different mutations of presenilin1 gene in early-onset Alzheimer's disease families.
　Neuroscience Lett. 208:195-198,1996.

3)
　Yamagata H., Miki T., Nakagawa M., Johnson K., Deka R. and Ogihara T.
　Association of CTG repeats and 1 kb Alu insertion/deletion polymorphism at the myotonin protein kinase gene in the Japanese population suggests a common Eurasian origin of the myotonic dystrophy mutation.
　Hum. Genet.97:145-147,1996.

4)
　Sato S., Kamino K., Miki T., Doi, K., Ii K., St George-Hyslop PH.,Ogihara T. and Sakaki Y. (1998)
　Splicing mutation of presenilin 1 gene for early-onset familial Alzheimer's disease
　Hum.Mutation. Suppl 1:S91-S94

5)
　Nakano K., Ohta S., Nishimaki K., Miki T. and Matuda S. (1997)
　Alzheimer's disease and DLST genotype
　Lancet 350:1367-1368.

6)
　Kamino K., Nishiwaki Y., Yoshiiwa A., Takeda M., Sato S., Sakaki Y., Ii K., Miki T. and Ogihara T.(1997)
　A variety of presenilin1 mutations in Japanese familial early-onset Alzheimer's disease."Alzheimer's Disease:Neuobiology, Diagnosis, and Therapeutics" (eds.Iqbal K, Winblad B, Nishimura T, Takeda M and Wisniewski HM,), John Wiley & Sons Ltd, New York, p79-84.

7)
　Ye L., Miki T., Nakura J., Oshima J., Kamino K., Rakugi H., Ikegami H., Higaki J., Edland SD., Martin G. and Ogihara T.(1997)
　Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population
　Am. J. Med. Genet. 68:494-498.

8)
　Sato N., Kamino K., Tateishi K., Satoh T., Nishiwaki Y., Yoshiiwa A., Miki T. and Ogihara T. (1997)
　Elevated amyloid b protein (1-40) induces CREB phophorylation at serine-133 via p44/42 MAP kinase (Erkl/2) - dependent pathway in rat pheochromocytroma PC12 cells.
　Biochem. Biophys. Res. Commun. 232:637-642.

9)
　Mitsuda N., Nakura J., Ye L., Zhao Y., Fujioka Y., Takahashi-Fujii A., Ishino Y., Kato I., Hashimoto K., Ogihara T. and Miki T. (1997)
　A high density STS map based on a single contig of YAC and P1 clones in the chromosome 8p12-p21 region
　Genomics 41:49-55.

10)
　Nishiwaki Y., Kamino K., Yoshiiwa A., Sato N., Tateishi K., Takeda M., Kobayashi T., Nonomura Y., Yoneda H., Sakai T., Imagawa M., Miki T.and Ogihara T.
　T/G polymorphism at intron 9 of presenilin 1 gene is associated with, but not responsible for sporadic late-onset Alzheimer's disease in Japanese population (1997)
　Neuroscience Lett. 227:1-4.

11)
　Yoshiiwa A, Kamino K., Yamamoto H., Kobayashi T,. Imagawa M.,Nonomura Y., Yoneda H., Sakai T., Nishiwaki Y., Sato N., Rakugi H., Miki T. and Ogihara T. (1997)
　a1-Antichmotrypsin as a risk modifier for late - onset Alzheimer's disease in Japanese APOE4 carriers
　Ann Neurology 42:115-117.

12)
　Sato N., Katsuya T., Rakugi H., Takami S., Nakata Y., Miki T.,Higaki J. and Ogihara T.(1997)
　Association of variants in critical core promoter element of angiotensinogen gene with increased risk essential hypertension in Japanese
　Hypertension 30: 321-325.

13)
　Yu C-E., Oshima J., Fu Y-H., Wijsman EM., Hisima F., Nakura J., Miki T., Ouais S., Martin GM., Mulligan J. and Schellenbrg GD.(1996)
　Positional cloning of the Werner's syndrome gene
　Science 272:258-262.

14)
　Nishiwaki, Y., Kamino,K., Yoshiiwa, A., Nagano, K., Takeda M.,Tanabe H.,Nishimura T., KobayashiT., Yamamoto H., Nonomura Y., Yoneda H., Sakai T.,Imagawa M., Miki T. and Ogihara T. (1996)
　Mutational screening of APP gene in patients with early-onset Alzheimer's disease utilizing mismatched PCR-RFLP
　Clin. Genet. 49:119-123.

15)
　Kamino K., Yoshiiwa A., Nishiwaki Y., Nagano K., Yamamoto H.,Kobayashi T., Nonomura Y., Yoneda H., Sakai T.,Imagawa M., Miki T. and Ogihara T. (1996)
　Genetic association study between senile dementia of Alzheimer's type and APOE/C1/C2 gene cluster.
　Gerontology 42 (suppl1):12-19.

16)
　Nakata Y., Katusya T., Rakugi H., Takami S., Ohishi M., Kamino K.,Higaki J.,Tabuchi Y., Kumahara Y., Miki T. and Ogihara T. (1996)
　Polymorphism of the apolipoprotein E and angiotensin-converting enzyme genes in Japanese subjects with silent myocardial ischemia.
　Hypertension 27: 1205-1209.

17)
　Nakura J., Miki T., Ye L., Mitsuda N., Zhao Y., Kihara K., Yu C-E., Oshima J., Fukuchi K., Wijsman EM., Schellenberg GD., Martin GM., Murano S., Hashimoto K.,Fujiwara Y. and Ogihara T. (1996)
　Narrowing the position of the Werner syndrome locus by homozygosity analysis - Extension of homozygosity analysis
　Genomics 36:130-141

18)
　Yoshiiwa A., Kamino K., Nagano K., Nonomura Y., Yoneda H., Sakai T., Miki T. and Ogihara T. (1995)
　Association study of apolipoprotein E and sporadic Alzheimer's disease in the Japanese population. Research Advances in Alzheimer's Disease and Related Disorders
　ed. Iqbal K, Mortimer JA, Winbald B, Wisniewski HM. John Wiley & Sons Ltd. p113-120

19)
　Ye L., Nakura J., Mitsuda N., Fujioka Y., Kamino K., Ohta T., Jinno Y., Niikawa N., Miki T. and Ogihara T. (1995)
　Genetic association between chromosome 8 microsatellite (MS8-134) and Werner syndrome (WRN): Chromosome microdissection and homozygosity mapping.
　Genomics 28:566-569.

20)
　Deka R., Miki T., Yin S-J., McGarvey ST., Shriver MD., Ferrell RE. and Chakrabory R.(1995)
　Normal CAG repeat variation at the DRPLA locus in the world populations.
　Am. J. Hum. Genet. 57:508-511.

21)
　Kamino K., Nagano K., Katsuya T., Nishiwaki Y., Takeda M., Tanabe H., Nishimura T., Ii K., Fujimoto K., Tsujimoto R., Nonomura Y., Yoneda H., Sakai T., Nakajima T., Imagawa M., Martin GM.,Bird TD., Schellenberg GD., Miki T. and Ogihara T. (1995)
　Linkage and haplotype analysis of familial Alzheimer's disease in Japanese population.
　Jpn. J. Hum. Genet. 40:229-241.

22)
　Nakagawa M., Yamada H., Higuchi I., Kaminishi Y., Miki T., Johnson K. and Osame M.(1994)
　A case of paternally inherited congenital myotonic dystrophy
　J. Medical Genetics 31:397-400.

23)
　Yamagata H, Miki T, Sakoda S, Yamanaka N, Davies J, Shelbourne P,Kubota R, Takenaga S, Nakagawa M, Ogihara T and Johnson K. (1994)
　Detection of a premutation in Japanese myotonic dystrophy
　Hum. Mol. Genet. 3:819-820.

24)
　Yu C-E, Oshima J, Goddard K AB, Miki T, Nakura J, Ogihara T, Poot M, Hoehn H, Fraccaro M, Piussan C, Martin G, Schellenberg GD and Wijsman EM. (1994)
　Linkage disequilibrium and haplotype studies of chromosome 8p 11.1-21.1 markers and Werner's syndrome
　Am. J. Hum. Genet. 55:356-364.

　

---