Department of Molecular Parasitology
 愛媛大学 大学院・医学系研究科  寄生病原体学分野   業績   2001-present 
【部門業績：教授　鳥居　本美 （2001-present）】
[1975-1994] [1995-2000] 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
2011

原著


Ito D, Han ET, Takeo S, Thongkukiatkul A, Otsuki H, Torii M, Tsuboi T. Plasmodial ortholog of Toxoplasma gondii rhoptry neck protein 3 is localized to the rhoptry body. Parasitol Int. 2011 Jan 13. [Abstract]


 その他　

　

2010

原著

Gueirard P, Tavares J, Thiberge S, Bernex F, Ishino T, Milon G, Franke-Fayard B, Janse CJ, Me´nard R, Amino R. Development of the malaria parasite in the skin of the mammalian host. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18640-5.[Abstract]

Miyata T, Harakuni T, Tsuboi T, Sattabongkot J, Kohama H, Tachibana M, Matsuzaki G, Torii M, Arakawa T. Plasmodium vivax ookinete surface protein Pvs25 linked to cholera toxin B subunit induces potent transmission-blocking immunity by intranasal as well as subcutaneous immunization. Infect Immun. 2010 Sep;78(9):3773-82. [Abstract]

Tsuboi T, Takeo S, Sawasaki T, Torii M, Endo Y. An efficient approach to the production of vaccines against the malaria parasite. Methods Mol Biol. 2010;607:73-83. [Abstract]

Tsuboi T, Takeo S, Arumugam TU, Otsuki H, Torii M. The wheat germ cell-free protein synthesis system: A key tool for novel malaria vaccine candidate discovery. Acta Trop. 2010 Jun;114(3):171-6. [Abstract]


 その他　

　

2009 原著

Arakawa T, Tachibana M, Miyata T, Harakuni T, Kohama H, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Torii M, Tsuboi T. Malaria ookinete surface protein-based vaccination via the intranasal route completely blocks parasite transmission in both passive and active vaccination regimens in a rodent model of malaria infection. Infect Immun. 2009 Dec;77(12):5496-500. [Abstract]

Tetsutani K, Ishiwata K, Ishida H, Tu L, Torii M, Hamano S, Himeno K, Hisaeda H. Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice. Eur J Immunol. 2009 Oct;39(10):2822-30. [Abstract]

Otsuki H, Kaneko O, Thongkukiatkul A, Tachibana M, Iriko H, Takeo S, Tsuboi T, Torii M. Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence. Proc Natl Acad Sci U S A.  106(17):7167-72, 2009. [Abstract]

Iriko H, Jin L, Kaneko O, Takeo S, Han ET, Tachibana M, Otsuki H, Torii M, Tsuboi T. A small-scale systematic analysis of alternative splicing in Plasmodium falciparum.Parasitol Int.  58(2):196-199, 2009. [Abstract]

Cao J, Kaneko O, Thongkukiatkul A, Tachibana M, Otsuki H, Gao Q, Tsuboi T, Torii M. Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites.Parasitol Int.  58(1):29-35, 2009 . [Abstract]

 その他　
鳥居本美　糸状虫症　今日の治療指針 2009年版:190-191, 医学書院, 2009
　
2008 原著

Tetsutani K, Ishiwata K, Torii M, Hamano S, Hisaeda H, Himeno K. Concurrent infection with Heligmosomoides polygyrus modulates murine host response against Plasmodium berghei ANKA infection. Am J Trop Med Hyg.  79(6):819-22, 2008. [Abstract]

Yano K, Otsuki H, Arai M, Komaki-Yasuda K, Tsuboi T, Torii M, Kano S, Kawazu S. Disruption of the Plasmodium berghei 2-Cys peroxiredoxin TPx-1 gene hinders the sporozoite development in the vector mosquito. Mol Biochem Parasitol.  159(2):142-5, 2008. [Abstract]

Tsuboi T, Takeo S, Iriko H, Jin L, Tsuchimochi M, Matsuda S, Han ET, Otsuki H, Kaneko O, Sattabongkot J, Udomsangpetch R, Sawasaki T, Torii M, Endo Y. Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates. Infect Immun.  76(4):1702-8, 2008. [Abstract]

Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K. Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J Immunol  180(4):2496-503, 2008. [Abstract]

Iriko H, Kaneko O, Otsuki H, Tsuboi T, Su XZ, Tanabe K, Torii M. Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum. Mol Biochem Parasitol  158(1):11-21, 2008 . [Abstract]
その他　
鳥居本美　蟯虫症　今日の治療指針 2008年版:188, 医学書院, 2008
　

2007 原著

金子明生, 児玉俊夫, 石川明邦, 島村一郎, 西谷元宏, 鄭暁東, 大槻均, 鳥居本美, 首藤政親 ヒト結膜嚢に寄生した東洋眼虫の形態的特徴 臨床眼科 61(4):531-536,2007

Katsube T, Matsumoto S, Takatsuka M, Okuyama M, Ozeki Y, Naito M, Nishiuchi Y, Fujiwara N, Yoshimura M, Tsuboi T, Torii M, Oshitani N, Arakawa T, Kobayashi K Control of cell wall assembly bu a histone-like protein in mycobacteria. J Bacteriol 189(22): 8241-8249 2007 [Abstract]

Tetsutani K, To H, Torii M, Hisaeda H, Himeno K. Malaria parasite induces tryptophan-related immune suppression in mice. Parasitology. 134 (7): 923-930, 2007[Abstract]

Kobayashi F, Waki S, Niikura M, Tachibana M, Tsuboi T, Torii M, Kamiya S. Plasmodium berghei XAT: Protective 155/160 kDa antigens are located in parasitophorous vacuoles of schizont-stage parasite. Exp Parasitol 116(4):450-457,2007 [Abstract]

Cortes A, Carret C, Kaneko O, Yim-Lim BYS, Ivens A, Holder AA. Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. PLoS Pathogen [Abstract]

Moll K, Chene A, Ribacke U, Kaneko O, Nilsson S, Winter G, Haeggstrom M, Pan W, Berzins K, Wahlgren M, Chen Q. A novel DBL-domain of the P. falciparum 332 molecule involved in erythrocyte adhesion. PLoS ONE [Abstract]

Ghoneim A, Kaneko O, Tsuboi T, Torii M.  The Plasmodium falciparum RhopH2 promoter and first 24 amino acids are sufficient to target proteins to the rhoptries. Parasitol Int. 56(1):31-43 (2007/03) [Abstract]

総説
Kaneko O. Erythrocyte invasion: vocabulary and grammar of the Plasmodium rhoptry. Parasitol Int. [Abstract]

坪井敬文、竹尾暁、入子英幸、金子修、鳥居本美、遠藤弥重太　「コムギ胚芽無細胞タンパク質合成法：マラリアワクチン研究への応用」　愛媛医学　26(1): 8-11　(2007).
その他　
鳥居本美　有鉤脳虫症, マンソン孤虫症　今日の治療指針 2007年版:189, 医学書院 2007
　
2006 原著

Palacpac NM, Leung BW, Arisue N, Tanabe K, Sattabongkot J, Tsuboi T, Torii M, Udomsangpetch R, Horii T. Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections. Mol Biochem Parasitol. 150(2):353-358 (2006/12) [No Abstract]

Kaneko O, Templeton TJ, Iriko H, Tachibana M, Otsuki H, Takeo S, Sattabongkot J, Torii M, Tsuboi T.  The Plasmodium vivax homolog of the ookinete adhesive micronemal protein, CTRP Parasitol Int 55:227-231 (2006). [Abstract]

Yano K, Komaki-Yasuda K, Tsuboi T, Torii M, Kano S, Kawazu S.  2-Cys Peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei.  Mol Biochem Parasitol 148(1):44-51 (2006/07). [Abstract]

　
2005 原著

KArakawa T, Komesu Ai, Otsuki H, Sattabongkot J, Udomsangpetch R, Matsumoto Y, Tsuji N, Wu Y, Torii M, Tsuboi T.  Nasal immunization with a malaria transmission-blocking vaccine candidate Pfs25 induces complete protective immunity in mice against field-isolated Plasmodium falciparum.  Infect Immun 73(11):7375-80 (2005/11).
[Abstract] [Full Text]

Kaneko O, Yim-Lim BYS, Iriko H, Ling IT, Otsuki H, Grainger M, Tsuboi T, Adams JH, Mattei D, Holder AA, Torii M.  Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex. Mol Biochem Parasitol 143(1):20-28 (2005)
[Abstract]

Winter G, Kawai S, Haeggstrom M, Kaneko O, von Euler A, Kawazu S, Palm D, Fernandez V, Wahlgren M.  SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytes. J Exp Med 201(11):1853-63 (2005/06).
[Abstract]

 Rungruang T, Kaneko O, Murakami Y, Tsuboi T, Hamamoto H, Akimitsu N, Sekimizu K, Kinoshita T, Torii M.  Erythrocyte surface glycosylphosphatidyl inositol anchored receptor for the malaria parasite. Mol Biochem Parasitol 140(1):13-21 (2005). [Abstract]

その他（Proceedings等）

 Rungruang T, Kaneko O, Tsuboi T, Torii M. "Review: the erythrocyte surface binding of the Plasmodium yoelii RhopH complex." Proceedings of the 11th Korea-Japan Parasitologists' Seminar 2005.Jun.3-5 (Seoul, Korea): p13-23 (2005). [PDF file, 455KB]

 Tsuboi T, Takeo S, Iriko H, Jin L, Han ET, Kaneko O, Torii M, Endo Y. "Malaria Vaccine Research: Post-genome Approach." Proceedings of the 11th Korea-Japan Parasitologists' Seminar 2005.Jun.3-5 (Seoul, Korea): p79-87 (2005).

大槻均　「Fraction Collector：マラリア原虫の赤血球侵入経路切り換えの分子機構」　蛋白質核酸酵素 　50/12, 2010-2011 (2005)

金子修　「Fraction Collector：原虫のオシリで働く切断酵素―細胞侵入期にはたらく膜プロテアーゼ」　蛋白質核酸酵素 　50/8, 992-993 (2005)

金子修　「Fraction Collector：媒介昆虫に発現する病原体レセプター−リーシュマニア原虫とガレクチン−」　蛋白質核酸酵素 　50/2, 176-177 (2005)

　
2004 原著

K Kongkasuriyachai D, Bartels-Andrews L, Stowers A, Collins WE, Sullivan J, Sattabongkot J, Torii M, Tsuboi T, Kumar N. Potent immunogenicity of DNA vaccines encoding Plasmodium vivax transmission-blocking vaccine candidates Pvs25 and Pvs28-evaluation of homologous and heterologous antigen-delivery prime-boost strategy. Vaccine. 22(23-24):3205-13 (2004). [Abstract]

Akimitsu N, Kim HS, Hamamoto H, Kamura K, Fukuma N, Arimitsu N, Ono K, Wataya Y, Torii M, Sekimizu K. Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL. Parasitol Res 93(6):499-503  (2004).  [Abstract]

Preiser P, Renia L, Singh N, Balu B, Jarra W, Voza T, Kaneko O, Blair P, Torii M, Landau I, Adams JH.  Antibodies against MAEBL ligand domains M1 and M2 inhibit sporozoite development in vitro.  Infect Immun 72(6):3604–8 (2004). [Abstract] [Full Text]

Katakura K, Fujise H, Takeda K, Kaneko O, Torii M, Suzuki M, Chang KP, Hashiguchi Y.  Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensis.  FEBS Let 561(1-3):207-12 (2004). [Abstract]

Tsuboi T, Kaneko O, Cao YM, Tachibana M, Yakushijin Y, Nagao T, Kanbara H, Torii M.  A rapid genotyping method for the vivax malaria transmission-blocking vaccine candidates, Pvs25 and Pvs28.  Parasitol Int 53:211–6 (2004). [Abstract]

Li F, Templeton TJ, Popov VL, Comer JE, Tsuboi T, Torii M, Vinetz JM. Plasmodium ookinete-secreted proteins secreted through a common micronemal pathway are targets of blocking malaria transmission. J Biol Chem 279(25):26635-44 (2004). [Abstract] [Full Text]

Palacpac NMQ, Hiramine Y, Mi-ichi F, Torii M, Kita K, Hiramatsu R, Horii T, Mitamura T. Developmental stage-specific triacylglycerol biosynthesis, degradation and trafficking as lipid bodies in Plasmodium falciparum-infected erythrocyte.  J Cell Sci 117:1469-80 (2004). [Abstract]

Ling IT, Florens L, Dluzewski AR, Kaneko O, Grainger M, Yim- Lim BYS, Tsuboi T, Hopkins JM, Johnson JR, Torii M, Bannister LH, Yates JR 3rd, Holder AA and Mattei D.  The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion.  Mol Microbiol 52(1):107-18 (2004). [Abstract]

 Mayer DC, Mu JB, Kaneko O, Duan J, Su XZ, Miller LH.  "Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity."  Proc Natl Acad Sci USA. 101: 2518-23 (2004). [Abstract] [Full Text]

症例報告

岡宏保、高田清式、金子修、坪井敬文、白川洋一、藤田繁　「愛媛県で発症した最近のマラリア症例について」　愛媛医学　23(4): 338-341　(2004).[PDF file, 5MB]

その他

金子修　「Fraction Collector：なぜヒトはマラリアで死ぬのか−脳の血管に発現するマラリアレセプター−」　蛋白質核酸酵素　49/5, 657-658  (2004)

　
2003 原著

KSattabongkot J, Tsuboi T, Hisaeda H, Tachibana M, Suwanabun N, Rungruang T, Cao YM, Stowers AW, Sirichaisinthop J, Coleman RE, Torii M. Blocking of transmission to mosquitoes by antibody to Plasmodium vivax malaria vaccine candidates Pvs25 and Pvs28 despite antigenic polymorphism in field isolates.  Am J Trop Med Hyg 69(5):536-541 (2003). [Abstract]

Kawazu S, Nozaki T, Tsuboi T, Nakano Y, Komaki-Yasuda K, Ikenoue N, Torii M, Kano S.  Expression profile of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoelii.  Int J Parasitol 33(13):1455-61 (2003). [Abstract]
Tsuboi T, Kaneko O, Eitoku C, Suwanabun N, Sattabongkot J, Vinetz JM, Torii M.  Gene structure and ookinete expression of the chitinase genes of Plasmodium vivax and Plasmodium yoelii.  Mol Biochem Parasitol 130(1):51-4 (2003). [No Abstract]

Arakawa T, Tsuboi T, Kishimoto A, Sattabongkot J, Suwanabun N, Rungruang T, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Shimabukuro I, Sato Y, Torii M.  2003.  Serum antibodies induced by intranasal immunization of mice with Plasmodium vivax Pvs25 co-administered with cholera toxin completely block parasite transmission to mosquitoes.  Vaccine 21(23):3143-8. [Abstract]

Ling IT, Kaneko O, Narum D, Tsuboi T, Howell S , Taylor HM, Scott-Finnigan TJ, Torii M, Holder AA.  2003.  Characterisation of the rhoph2 gene of Plasmodium falciparum and Plasmodium yoelii.  Mol Biochem Parasitol 127(1):47-57. [Abstract]

総説

Tsuboi T, Tachibana M, Kaneko O, Torii M,  2003. Transmission-blocking vaccine of vivax malaria. Parasitol Int 52(1):1-11. [Abstract]

Mi-Ichi F, Takeo S, Takashima E, Kobayashi T, Kim HS, Wataya Y, Matsuda A, Torii M, Tsuboi T, Kita K.  2003.  Unique properties of respiratory chain in Plasmodium falciparum mitochondria.  Adv Exp Med Biol. 531:117-33. [Abstract]

金子修、大槻均、入子英幸、坪井敬文、鳥居本美　「マラリア原虫の赤血球侵入に関わる多重遺伝子族」　愛媛医学　22(2): 102-9　(2003).[PDF file, 6MB]

その他（Proceedings等）

 Kaneko O, Rungruang T, Tsuboi T, Torii M. "Review: Identification of Plasmodium yoelii rhoph2 gene." Proceedings of the 9th Korea-Japan Parasitologists' Seminar 2003.Oct.28-30 (Seoul, Korea): p20-26 (2003). [PDF file, 469KB]

金子修　「Fraction Collector：マラリアがアフリカから世界に広まった時期」　蛋白質核酸酵素　48/13, 1839-1840 (2003).

金子修　「学会見聞録：第１回感染症若手研究者沖縄フォーラム」　蛋白質核酸酵素　48/5, 774-776 (2003).

　
2002 原著

Tachibana M, Tsuboi T, Kaneko O, Khuntirat B, Torii M. 2002.  Two types of Plasmodium ovale defined by SSU rRNA have distinct sequences for ookinete surface proteins.  Mol Biochem Parasitol 122:223-6. [No Abstract]

Michon P, Stevens JR, Kaneko O, Adams JH, 2002. Evolutionary relationships of conserved cysteine-rich motifs in adhesive molecules of malaria parasites. Mol Biol Evol 19(7):1128-42 (2002). [Abstract] [Full Text]

Kaneko O, Mu J, Tsuboi T, Su X, Torii M, 2002, Gene structure and expression of a Plasmodium falciparum 220-kilodalton protein homologous to the Plasmodium vivax reticulocyte binding proteins. Mol Biochem Parasitol 121:275-8. [No Abstract]

総説

坪井敬文、堀井俊宏　「マラリアワクチン開発の現状」　臨床と微生物　29(2): 119-25, 近代出版　(2002)

Kaneko O, Tsuboi T, Rungruang T, Torii M, 2002, Characterization of the high molecular mass rhoptry protein, RhopH, complex, in Plasmodium yoelii. Proceed. 7th Korea - Japan Parasitologists' Seminar (Forum Cheju-7) Oct 23-25, 2001: 76-85.

Mi-ichi F, Takeo S, Takashima E, Kobayashi T, Kim H-S, Wataya Y, Matsuda A, Torii M, Tsuboi T, Kita K. 2002.  "Unique properties of respiratory chain in Plasmodium falciparum mitochondria." In Marzuki S, Verhoef J, Snippe H (ed), "Tropical Disease: From Molecule to Bedside", Kluwer Academic/Plenum Publishers, New York, USA, 2002.
22: 45-50, 2002.

症例報告

「熱帯熱マラリア感染の一症例」　関谷希実子、新家敏之、半田智子、坂東史郎、村瀬光春、高田清式、日並淳介、金子修、坪井敬文、鳥居本美　愛媛県臨技会誌 22: 45-50, 2002.

その他（Proceedings等）

 Tsuboi T, Cao YM, Rungruang T, Otsuki H, Iriko H, Kaneko O, Sattabongkot J, Torii M. "Recent progress on transmission-blocking vaccine development of vivax malaria." Proceedings of the 8th Korea-Japan Parasitologists' Seminar 2002.Oct.5-7 (Maebashi, Japan): p66-73 (2002). [PDF file, 350KB]

　
2001 原著

Shirano M, Tsuboi T, Kaneko O, Tachibana M, Adams JH, Torii M. 2001. Conserved Regions of the Plasmodium yoelii Rhoptry Protein RhopH3 Revealed by Comparison with the P. falciparum Homologue. Mol Biochem Parasitol 112:297-9. [No Abstract]

Tachibana M, Tsuboi T, Templeton TJ, Kaneko O, Torii M. 2001. Presence of three distinct ookinete surface protein genes, Pos25, Pos28-1, and Pos28-2 in Plasmodium ovale. Mol Biochem Parasitol 113:341-4. [No Abstract]

Mayer DCG, Kaneko O, Hudson-Taylor D, Reid ME, Miller LH.  2001.  Characterization of a Plasmodium falciparum erythrocyte binding protein paralogous to EBA-175.  Proc Natl Acad Sci USA. 98(9): 5222-7. [Abstract] [Full Text]

Suwanabun N, Sattabongkot J, Tsuboi T, Torii M, Maneechai N, Rachapaew N, Yim-Amnuaychok N, Punkitchar V, Coleman RE. 2001. Development of a method for the in vitro production of Plasmodium vivax ookinetes. J Parasitol: 87(4):928-0. [Abstract]

  Yuda M, Yano K, Tsuboi T, Torii M, Chinzei Y. 2001. von Willebrand Factor A Domain-related Protein, a novel microneme protein of the malaria ookinete highly conserved throughout Plasmodium parasites. Mol Biochem Parasitol 116:65–72. [Abstract]

Kaneko O, Tsuboi T, Ling IT, Howell S, Shirano M, Tachibana M, Cao YM, Holder AA, Torii M.  2001.   The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii.  Mol Biochem Parasitol 118(2):223-31. [Abstract]

総説

Adams JH, Kaneko O, Blair PL, Peterson DS.  2001.  An Expanding ebl Family of Plasmodium falciparum. Trends Parasitol 17(6): 297-9. [No Abstract]

鳥居本美　「感染性髄膜炎：　アメーバ性髄膜脳炎」　化学療法の領域　17(7): 1312-5, 医薬ジャーナル社　(2001)

鳥居本美　「病原寄生虫の治療と薬剤：線虫症（１）」　医薬ジャーナル　37(10): 2976-80, 医薬ジャーナル社　(2001)

鳥居本美、坪井敬文、金子修、橘真由美　「マラリア感染の生物学」 Progr Med 21(2):325-9, ライフサイエンス・メディカ　（2001).

著書

鳥居本美　（分担執筆）　「医療禁忌マニュアル 」　第二版　総編集　富野康日己 (2001).

その他（Proceedings等）

鳥居本美　「鉤虫症（十二指腸虫症）」　今日の治療指針 42: 200-201 (2001)

Kaneko O, Tsuboi T, Rungruang T, Torii M. "Characterization of the high molecular mass rhoptry protein, RhopH, complex, in Plasmodium yoelii." Proceedings of the 7th Korea-Japan Parasitologists' Seminar 2001.Oct.23-25 (Seoul, Korea): p76-85 (2001). [PDF file, 828KB]

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