主な業績

主な原著論文

Miyata T, Harakuni T, Tsuboi T, Sattabongkot J, Ikehara A, Tachibana M, Torii M, Matsuzaki G, Arakawa T. Tricomponent immunopotentiating system as a novel molecular design strategy for malaria vaccine development. Infect Immun. 2011 Oct;79(10):4260-75. [Abstract]

Tachibana M, Wu Y, Iriko H, Muratova O, MacDonald NJ, Sattabongkot J, Takeo S, Otsuki H, Torii M, Tsuboi T. N-terminal prodomain of Pfs230 synthesized using a cell-free system is sufficient to induce complement-dependent malaria transmission-blocking activity. Clin Vaccine Immunol. 2011 Aug;18(8):1343-50. [Abstract]

Doi M, Tanabe K, Tachibana S, Hamai M, Tachibana M, Mita T, Yagi M, Zeyrek FY, Ferreira MU, Ohmae H, Kaneko A, Randrianarivelojosia M, Sattabongkot J, Cao YM, Horii T, Torii M, Tsuboi T. Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax. Vaccine. 2011 Jun 10;29(26):4308-15. [Abstract]

Miyata T, Harakuni T, Sugawa H, Sattabongkot J, Kato A, Tachibana M, Torii M, Tsuboi T, Arakawa T. Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine. Vaccine. 2011 Mar 24;29(15):2720-6. [Abstract]

Miyata T, Harakuni T, Tsuboi T, Sattabongkot J, Kohama H, Tachibana M, Matsuzaki G, Torii M, Arakawa T. Plasmodium vivax ookinete surface protein Pvs25 linked to cholera toxin B subunit induces potent transmission-blocking immunity by intranasal as well as subcutaneous immunization. Infect Immun. 2010 Sep;78(9):3773-82. [Abstract]

Tsuboi T, Takeo S, Sawasaki T, Torii M, Endo Y. An efficient approach to the production of vaccines against the malaria parasite. Methods Mol Biol. 2010;607:73-83. [Abstract]

Tsuboi T, Takeo S, Arumugam TU, Otsuki H, Torii M. The wheat germ cell-free protein synthesis system: A key tool for novel malaria vaccine candidate discovery. Acta Trop. 2010 Jun;114(3):171-6. [Abstract]

Arakawa T, Tachibana M, Miyata T, Harakuni T, Kohama H, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Torii M, Tsuboi T. Malaria ookinete surface protein-based vaccination via the intranasal route completely blocks parasite transmission in both passive and active vaccination regimens in a rodent model of malaria infection. Infect Immun. 2009 Dec;77(12):5496-500. [Abstract]

Tetsutani K, Ishiwata K, Ishida H, Tu L, Torii M, Hamano S, Himeno K, Hisaeda H. Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice. Eur J Immunol. 2009 Oct;39(10):2822-30. [Abstract]

Otsuki H, Kaneko O, Thongkukiatkul A, Tachibana M, Iriko H, Takeo S, Tsuboi T, Torii M. Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence.Proc Natl Acad Sci U S A.  106(17):7167-72, 2009. [Abstract]

Iriko H, Jin L, Kaneko O, Takeo S, Han ET, Tachibana M, Otsuki H, Torii M, Tsuboi T. A small-scale systematic analysis of alternative splicing in Plasmodium falciparum.Parasitol Int.  58(2):196-199, 2009. [Abstract]

Cao J, Kaneko O, Thongkukiatkul A, Tachibana M, Otsuki H, Gao Q, Tsuboi T, Torii M. Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites.Parasitol Int.  58(1):29-35, 2009 . [Abstract]

Tetsutani K, Ishiwata K, Torii M, Hamano S, Hisaeda H, Himeno K. Concurrent infection with Heligmosomoides polygyrus modulates murine host response against Plasmodium berghei ANKA infection.Am J Trop Med Hyg.  79(6):819-22, 2008. [Abstract]

Yano K, Otsuki H, Arai M, Komaki-Yasuda K, Tsuboi T, Torii M, Kano S, Kawazu S. Disruption of the Plasmodium berghei 2-Cys peroxiredoxin TPx-1 gene hinders the sporozoite development in the vector mosquito.Mol Biochem Parasitol.  159(2):142-5, 2008. [Abstract]

Tsuboi T, Takeo S, Iriko H, Jin L, Tsuchimochi M, Matsuda S, Han ET, Otsuki H, Kaneko O, Sattabongkot J, Udomsangpetch R, Sawasaki T, Torii M, Endo Y. Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates.Infect Immun.  76(4):1702-8, 2008. [Abstract]

Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K. Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J Immunol  180(4):2496-503, 2008. [Abstract]

Iriko H, Kaneko O, Otsuki H, Tsuboi T, Su XZ, Tanabe K, Torii M. Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum. Mol Biochem Parasitol  158(1):11-21, 2008 . [Abstract]

Katsube T, Matsumoto S, Takatsuka M, Okuyama M, Ozeki Y, Naito M, Nishiuchi Y, Fujiwara N, Yoshimura M, Tsuboi T, Torii M, Oshitani N, Arakawa T, Kobayashi K Control of cell wall assembly bu a histone-like protein in mycobacteria. J Bacteriol 189(22): 8241-8249 2007 [Abstract]

Tetsutani K, To H, Torii M, Hisaeda H, Himeno K. Malaria parasite induces tryptophan-related immune suppression in mice. Parasitology. 134 (7): 923-930, 2007[Abstract]

Kobayashi F, Waki S, Niikura M, Tachibana M, Tsuboi T, Torii M, Kamiya S. Plasmodium berghei XAT: Protective 155/160 kDa antigens are located in parasitophorous vacuoles of schizont-stage parasite. Exp Parasitol116(4):450-457,2007 [Abstract]

Ghoneim A, Kaneko O, Tsuboi T, Torii M.  The Plasmodium falciparum RhopH2 promoter and first 24 amino acids are sufficient to target proteins to the rhoptries. Parasitol Int. 56(1):31-43 (2007/03). [Abstract]

Kaneko O, Templeton TJ, Iriko H, Tachibana M, Otsuki H, Takeo S, Sattabongkot J, Torii M, Tsuboi T.  The Plasmodium vivax homolog of the ookinete adhesive micronemal protein, CTRP Parasitol Int 55:227-231 (2006). [Abstract]

Arakawa T, Komesu Ai, Otsuki H, Sattabongkot J, Udomsangpetch R, Matsumoto Y, Tsuji N, Wu Y, Torii M, Tsuboi T. Nasal immunization with a malaria transmission-blocking vaccine candidate Pfs25 induces complete protective immunity in mice against field-isolated Plasmodium falciparum.  Infect Immun 73(11):7375-80 (2005/11). [Abstract] [Full Text]

Kaneko O, Yim-Lim BYS, Iriko H, Ling IT, Otsuki H, Grainger M, Tsuboi T, Adams JH, Mattei D, Holder AA, Torii M. Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex. Mol Biochem Parasitol 143(1):20-28 (2005/09) [Abstract]

Rungruang T, Kaneko O, Murakami Y, Tsuboi T, Hamamoto H, Akimitsu N, Sekimizu K, Kinoshita T, Torii M.  "Erythrocyte surface glycosylphosphatidyl inositol anchored receptor for the malaria parasite." Mol Biochem Parasitol 140(1):13-21 (2005). [Abstract]

Kongkasuriyachai D, Bartels-Andrews L, Stowers A, Collins WE, Sullivan J, Sattabongkot J, Torii M, Tsuboi T, Kumar N. "Potent immunogenicity of DNA vaccines encoding Plasmodium vivax transmission-blocking vaccine candidates Pvs25 and Pvs28-evaluation of homologous and heterologous antigen-delivery prime-boost strategy." Vaccine. 22(23-24):3205-13 (2004). [Abstract]

Akimitsu N, Kim HS, Hamamoto H, Kamura K, Fukuma N, Arimitsu N, Ono K, Wataya Y, Torii M, Sekimizu K. "Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL." Parasitol Res 93:499-503 (2004). [Abstract]

Preiser P, Renia L, Singh N, Balu B, Jarra W, Voza T, Kaneko O, Blair P, Torii M, Landau I, Adams JH.  "Antibodies against MAEBL ligand domains M1 and M2 inhibit sporozoite development in vitro." Infect Immun72(6):3604–8 (2004) [Abstract] [Full Text]

Tsuboi T, Kaneko O, Cao YM, Tachibana M, Yakushijin Y, Nagao T, Kanbara H, Torii M.  A rapid genotyping method for the vivax malaria transmission-blocking vaccine candidates, Pvs25 and Pvs28.  Parasitol Int 53:211–6 (2004) [Abstract]

Li F, Templeton TJ, Popov VL, Comer JE, Tsuboi T, Torii M, Vinetz JM. Plasmodium ookinete-secreted proteins secreted through a common micronemal pathway are targets of blocking malaria transmission. J Biol Chem. 279(25):26635-44 (2004) [Abstract] [Full Text]

Ling IT, Florens L, Dluzewski AR, Kaneko O, Grainger M, Yim- Lim BYS, Tsuboi T, Hopkins JM, Johnson JR, Torii M, Bannister LH, Yates JR 3rd, Holder AA and Mattei D.  The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion.  Mol Microbiol 52(1):107-18 (2004) [Abstract]

Sattabongkot J, Tsuboi T, Hisaeda H, Tachibana M, Suwanabun N, Rungruang T, Cao YM, Stowers AW, Sirichaisinthop J, Coleman RE, Torii M. Blocking of transmission to mosquitoes by antibody to Plasmodium vivax malaria vaccine candidates Pvs25 and Pvs28 despite antigenic polymorphism in field isolates.  Am J Trop Med Hyg 69(5):536-541 (2003)  [Abstract]

Tsuboi T, Kaneko O, Eitoku C, Suwanabun N, Sattabongkot J, Vinetz JM, Torii M.  Gene structure and ookinete expression of the chitinase genes of Plasmodium vivax and Plasmodium yoelii.  Mol Biochem Parasitol 130(1):51-4 (2003). [No Abstract]

Arakawa T, Tsuboi T, Kishimoto A, Sattabongkot J, Suwanabun N, Rungruang T, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Shimabukuro I, Sato Y, Torii M.  2003.  Serum antibodies induced by intranasal immunization of mice with Plasmodium vivax Pvs25 co-administered with cholera toxin completely block parasite transmission to mosquitoes. Vaccine 21(23):3143-8. [Abstract]

Tachibana M, Tsuboi T, Kaneko O, Khuntirat B, Torii M. "Two types of Plasmodium ovale defined by SSU rRNA have distinct sequences for ookinete surface proteins. " Mol Biochem Parasitol 122:223-6 (2002) [No Abstract]

Kaneko O, Mu J, Tsuboi T, Su X, Torii M, "Gene structure and expression of a Plasmodium falciparum 220-kilodalton protein homologous to the Plasmodium vivax reticulocyte binding proteins." Mol Biochem Parasitol 121:275-8 (2002). [No Abstract]

Kaneko O, Tsuboi T, Ling IT, Howell S, Shirano M, Tachibana M, Cao YM, Holder AA, Torii M, 2001. "The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii" Mol Biochem Parasitol 118(2):223-31. [Abstract]

Tachibana M, Tsuboi T, Templeton TJ, Kaneko O, Torii M. 2001. "Presence of three distinct ookinete surface protein genes, Pos25, Pos28-1, and Pos28-2 in Plasmodium ovale." Mol Biochem Parasitol 113:341-4. [No Abstract]

Shirano M, Tsuboi T, Kaneko O, Tachibana M, Adams JH, Torii M. 2001. "Conserved Regions of the Plasmodium yoelii Rhoptry Protein RhopH3 Revealed by Comparison with the P. falciparum Homologue." Mol Biochem Parasitol 112:297-9. No [Abstract]

Langer RC, Hayward RE, Tsuboi T, Tachibana M, Torii M, Vinetz JM. 2000. "Micronemal Transport of Plasmodium Ookinete Chitinases to the Electron-Dense Area of the Apical Complex for Extracellular Secretion." Infect Immun 68(11):6461-5. [Abstract] [Full Text]

Adams JH, Hudson DE, Torii M, Ward GE, Wellems TE, Aikawa M, Miller LH. 1990. The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites. Cell 63(1):141-53. [Abstract]

Torii M, Adams JH, Miller LH, Aikawa M. 1989. Release of merozoite dense granules during erythrocyte invasion by Plasmodium knowlesi. Infect Immun 57(10):3230-3. [Abstract] [Full Text]


 総説

Tsuboi T, Tachibana M, Kaneko O, Torii M. 2003.  Transmission-blocking vaccine of vivax malaria.   Parasitol Int 52(1):1-11. [Abstract]

Mi-Ichi F, Takeo S, Takashima E, Kobayashi T, Kim HS, Wataya Y, Matsuda A, Torii M, Tsuboi T, Kita K.  2003.  Unique properties of respiratory chain in Plasmodium falciparum mitochondria.  Adv Exp Med Biol. 531:117-33. [Abstract]


著書（和文）

鳥居本美. マラリア原虫の免疫電顕法. マラリア学ラボマニュアル. 田辺・脇・小島・北編: 157-164 菜根出版, 東京 (2000)


  著書（英文）

Torii M, Aikawa M. 1998. Ultrastructure of Asexual Stages. Malaria: parasite biology, pathogenesis, and protection. Sherman IW (ed.): 123-134. ASM press.

その他の業績