Department of Molecular Parasitology
Ehime Univ Graduate School of Medicine Mol Parasitol Torii

Motomi Torii, MD, PhD
Professor
Ehime University School of Medicine, 1979
Ehime University Graduate School, Medical Science, 1983
Post Doc, Case Western Reserve University, USA, 1988-90
Address Department of Molecular Parasitology
Ehime University, Graduate School of Medicine
Shitsukawa, Toon, Ehime 791-0925
Phone (+81)-89-960-5285
Fax (+81)-89-960-5287
E-mail
Scientific Interest Malaria Vaccine Development, Invasion Mechanism of the erythrocytes
Technique Immunoelectron Microscopy, Molecular Biology
Theme :: Publications



Immuno-EM

P. gallinaceum ookinete

Microneme & Surface 
Localization of Chitinase


Microneme & Surface 
Localization of Chitinase

EM

P. knowlesi merozoite

Erythrocyte invasion

  P. falciparum schizont

Lipid Body
Theme

Invasion of the erythrocytes by merozoites
Focusing on the rhoptry/microneme proteins

Publications

Recent Research Articles

Ghoneim A, Kaneko O, Tsuboi T, Torii M.  The Plasmodium falciparum RhopH2 promoter and first 24 amino acids are sufficient to target proteins to the rhoptries. Parasitol Int 56(1):31-43 (2007/03) [Abstract]

 Kaneko O, Templeton TJ, Iriko H, Tachibana M, Otsuki H, Takeo S, Sattabongkot J, Torii M, Tsuboi T.  The Plasmodium vivax homolog of the ookinete adhesive micronemal protein, CTRP Parasitol Int 55:227-231 (2006). [Abstract]

Arakawa T, Komesu Ai, Otsuki H, Sattabongkot J, Udomsangpetch R, Matsumoto Y, Tsuji N, Wu Y, Torii M, Tsuboi T. Nasal immunization with a malaria transmission-blocking vaccine candidate Pfs25 induces complete protective immunity in mice against field-isolated Plasmodium falciparumInfect Immun 73(11):7375-80 (2005/11). [Abstract]

Kaneko O, Yim-Lim BYS, Iriko H, Ling IT, Otsuki H, Grainger M, Tsuboi T, Adams JH, Mattei D, Holder AA, Torii M.  Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex. Mol Biochem Parasitol 143(1):20-28 (2005/09). [Abstract]

Rungruang T, Kaneko O, Murakami Y, Tsuboi T, Hamamoto H, Akimitsu N, Sekimizu K, Kinoshita T, Torii M
Erythrocyte surface glycosylphosphatidyl inositol anchored receptor for the malaria parasite. 
Mol Biochem Parasitol 140(1):13-21 (2005). [Abstract]

Kongkasuriyachai D, Bartels-Andrews L, Stowers A, Collins WE, Sullivan J, Sattabongkot J, Torii M, Tsuboi T, Kumar N. Potent immunogenicity of DNA vaccines encoding Plasmodium vivax transmission-blocking vaccine candidates Pvs25 and Pvs28-evaluation of homologous and heterologous antigen-delivery prime-boost strategy. Vaccine 22(23-24):3205-13 (2004). [Abstract]

Akimitsu N, Kim HS, Hamamoto H, Kamura K, Fukuma N, Arimitsu N, Ono K, Wataya Y, Torii M, Sekimizu K. Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL. Parasitol Res 93:499-503 (2004). [Abstract]

Preiser P, Renia L, Singh N, Balu B, Jarra W, Voza T, Kaneko O, Blair P, Torii M, Landau I, Adams JH.  Antibodies against MAEBL ligand domains M1 and M2 inhibit sporozoite development in vitro.  Infect Immun
72(6):3604–8 (2004) [Abstract]

 
Tsuboi T, Kaneko O, Cao YM, Tachibana M, Yakushijin Y, Nagao T, Kanbara H, Torii M.  A rapid genotyping method for the vivax malaria transmission-blocking vaccine candidates, Pvs25 and Pvs28.  Parasitol Int 53:211–6 (2004) [Abstract]

 Li F, Templeton TJ, Popov VL, Comer JE, Tsuboi T, Torii M, Vinetz JM. Plasmodium ookinete-secreted proteins secreted through a common micronemal pathway are targets of blocking malaria transmission. J Biol Chem 279(25):26635-44 (2004)
[Abstract] [Full Text]

 
Ling IT, Florens L, Dluzewski AR, Kaneko O, Grainger M, Yim-Lim BYS, Tsuboi T, Hopkins JM, Johnson JR, Torii M, Bannister LH, Yates JR
3rd, Holder AA and Mattei D.
  The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion.   Mol Microbiol 52(1):107-18 (2004) [Abstract]

Sattabongkot J, Tsuboi T, Hisaeda H, Tachibana M, Suwanabun N, Rungruang T, Cao YM, Stowers AW, Sirichaisinthop J, Coleman RE, Torii M. Blocking of transmission to mosquitoes by antibody to Plasmodium vivax malaria vaccine candidates Pvs25 and Pvs28 despite antigenic polymorphism in field isolates.  Am J Trop Med Hyg 69(5):536-541 (2003)
[Abstract]

Kawazu S, Nozaki T, Tsuboi T, Nakano Y, Komaki-Yasuda K, Ikenoue N, Torii M, Kano S.  Expression profile of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoeliiInt J Parasitol 33(13):1455-61 (2003) [Abstract]

Tsuboi T, Kaneko O, Eitoku C, Suwanabun N, Sattabongkot J, Vinetz JM, Torii M.  Gene structure and ookinete expression of the chitinase genes of Plasmodium vivax and Plasmodium yoelii.  Mol Biochem Parasitol 130(1):51-4 (2003). [No Abstract]

Arakawa T, Tsuboi T, Kishimoto A, Sattabongkot J, Suwanabun N, Rungruang T, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Shimabukuro I, Sato Y, Torii M.  Serum antibodies induced by intranasal immunization of mice with Plasmodium vivax Pvs25 co-administered with cholera toxin completely block parasite transmission to mosquitoes.  Vaccine 21(23):3143-8. (2003) [Abstract]

Ling IT, Kaneko O, Narum D, Tsuboi T, Howell S , Taylor HM, Scott-Finnigan TJ, Torii M, Holder AA.   Characterisation of the rhoph2 gene of Plasmodium falciparum and Plasmodium yoelii.  Mol Biochem Parasitol 127(1):47-57 (2003). [Abstract]

Tachibana M, Tsuboi T, Kaneko O, Khuntirat B, Torii M. "Two types of Plasmodium ovale defined by SSU rRNA have distinct sequences for ookinete surface proteins." Mol Biochem Parasitol 122:223-6 (2002) [No Abstract]

Kaneko O, Mu J, Tsuboi T, Su X, Torii M  Gene structure and expression of a Plasmodium falciparum 220-kilodalton protein homologous to the Plasmodium vivax reticulocyte binding proteins.  Mol Biochem Parasitol 121:275-8 (2002). [No Abstract]

Kaneko O, Tsuboi T, Ling IT, Howell S, Shirano M, Tachibana M, Cao YM, Holder AA, Torii M, 2001. The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii Mol Biochem Parasitol 118(2):223-31. [Abstract]

Yuda M, Yano K, Tsuboi T, Torii M, Chinzei Y. 2001. "von Willebrand Factor A Domain-related Protein, a novel microneme protein of the malaria ookinete highly conserved throughout Plasmodium parasites." Mol Biochem Parasitol 116:65–72 [Abstract]

Suwanabun N, Sattabongkot J, Tsuboi T, Torii M, Maneechai N, Rachapaew N, Yim-Amnuaychok N, Punkitchar V, Coleman RE. 2001. "Development of a method for the in vitro production of Plasmodium vivax ookinetes." J Parasitol: 87(4):928-930 [Abstract]

Tachibana M, Tsuboi T, Templeton TJ, Kaneko O, Torii M. 2001. "Presence of three distinct ookinete surface protein genes, Pos25, Pos28-1, and Pos28-2 in Plasmodium ovale." Mol Biochem Parasitol 113:341-4. [No Abstract]

Shirano M, Tsuboi T, Kaneko O, Tachibana M, Adams JH, Torii M. 2001. "Conserved Regions of the Plasmodium yoelii Rhoptry Protein RhopH3 Revealed by Comparison with the P. falciparum Homologue." Mol Biochem Parasitol 112:297-9. [No Abstract]

More

Review Airticle

Tsuboi T, Tachibana M, Kaneko O, Torii M. 2003.
   Transmission-blocking vaccine of vivax malaria.  Parasitol Int 52(1):1-11. [Abstract]

Mi-Ichi F, Takeo S, Takashima E, Kobayashi T, Kim HS, Wataya Y, Matsuda A, Torii M, Tsuboi T, Kita K.  2003.  Unique properties of respiratory chain in Plasmodium falciparum mitochondria.  Adv Exp Med Biol. 531:117-33. [Abstract]

Book


Torii M, Aikawa M. 1998. Ultrastructure of Asexual Stages. Malaria: parasite biology, pathogenesis, and protection. Sherman IW (ed.): 123-134. ASM press.


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