{"id":223,"date":"2021-07-15T21:35:09","date_gmt":"2021-07-15T12:35:09","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/anatomy1\/wordpress\/?page_id=223"},"modified":"2026-03-27T19:26:36","modified_gmt":"2026-03-27T10:26:36","slug":"%e6%ad%a6%e5%86%85-%e7%ab%a0%e8%8b%b1-akihide-takeuchi-md-ph-d","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/anatomy1\/?page_id=223","title":{"rendered":"\u6b66\u5185 \u7ae0\u82f1 Akihide TAKEUCHI, MD., Ph.D."},"content":{"rendered":"\n
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\u6559\u5ba4\u54e1\u306e\u65b9\u304c\u66f8\u3044\u3066\u304f\u308c\u305f\u4f3c\u9854\u7d75\u3002\u7740\u4efb\u3057\u305f\u3070\u304b\u308a\u3067\u307e\u3060\u6050\u308d\u3057\u3055\u304c\u4f1d\u308f\u3063\u3066\u3044\u306a\u3044\u3089\u3057\u3044\u2026\u3002\u3042\u3068\uff15\u5e74\u304f\u3089\u3044\u3057\u3066\u3053\u3093\u306a\u6e29\u539a\u306a\u611f\u3058\u306b\u306a\u308c\u305f\u3089\u3088\u3044\u3060\u308d\u3046\u304b\uff1f\u3002<\/figcaption><\/figure>\n\n\n\n

E-mail: takeuchi.akihide.jo[\uff20]ehime-u.ac.jp<\/p>\n\n\n\n

\u8077\u540d<\/td>\u4e3b\u4efb\u6559\u6388<\/td><\/tr>
\u5352\u696d<\/td>\u540d\u53e4\u5c4b\u5927\u5b66\u533b\u5b66\u90e8\/1993\u5e74 \u5352\u696d<\/td><\/tr>
\u5b66\u4f4d<\/td>\u533b\u5b66\u535a\u58eb\/\u540d\u53e4\u5c4b\u5927\u5b66\/1999\u5e743\u6708<\/td><\/tr>
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researchmap<\/td>https:\/\/researchmap.jp\/7000008943<\/a><\/td><\/tr>
\u6240\u5c5e\u5b66\u4f1a<\/td>\u65e5\u672c\u89e3\u5256\u5b66\u4f1a\u3001\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u3001\u65e5\u672c\u795e\u7d4c\u79d1\u5b66\u4f1a\u3001\u65e5\u672cRNA\u5b66\u4f1a\u3001\u65e5\u672c\u7b4b\u5b66\u4f1a\u3001Society for Neuroscience\u3001RNA Society<\/td><\/tr>
\u305d\u306e\u4ed6<\/td>\u5c90\u961c\u770c\u51fa\u8eab
\u5263\u9053\uff1a\u6559\u58eb\uff17\u6bb5\uff08\u6771\u6e29\u5e02\u307e\u305f\u306f\u677e\u5c71\u5e02\u3067\u591c\u306b\u7a3d\u53e4\u306b\u53c2\u52a0\u3055\u305b\u3066\u8cb0\u3048\u308b\u6240\u3092\u63a2\u3057\u3066\u3044\u307e\u3059\uff09
\u30e9\u30f3\u30cb\u30f3\u30b0\uff1a\u30d5\u30eb\u30de\u30e9\u30bd\u30f3 3:54'28\"\uff082026, \u30b0\u30ed\u30b9 3:57'04\"\uff09\u3001\u30cf\u30fc\u30d5\u30de\u30e9\u30bd\u30f3 1:42'39\"\uff082026, \u30cd\u30c3\u30c8\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u8077\u6b74<\/h2>\n\n\n\n
1993-1994<\/td>\u5c90\u961c\u5927\u57a3\u5e02\u6c11\u75c5\u9662\u3000\u7814\u4fee\u533b<\/td><\/tr>
1994-1995<\/td>\u5c90\u961c\u5927\u57a3\u5e02\u6c11\u75c5\u9662\u3000\u8133\u795e\u7d4c\u5916\u79d1<\/td><\/tr>
1999-2003<\/td>\u56fd\u7acb\u9577\u5bff\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3000\u30ea\u30b5\u30fc\u30c1\u30ec\u30b8\u30c7\u30f3\u30c8\u304a\u3088\u3073\u7814\u7a76\u54e1
\u30002001 RINAT Neuroscience Corporation (Palo Alto, CA, U.S.A.)\u3000PostDoctoral Fellow
\u30002002 Stem Cells Inc. (Palo Alto, CA, U.S.A.)\u3000Scientist<\/td><\/tr>
2003-2006<\/td>The Salk Institute for Biological Studies (La Jolla, CA, U.S.A)\u3000Research Associate (Dr. Dennis DM O'Leary)<\/td><\/tr>
2006-2010<\/td> \u6771\u4eac\u533b\u79d1\u6b6f\u79d1\u5927\u5b66\/\u96e3\u6cbb\u75be\u60a3\u7814\u7a76\u6240\u3000\u52a9\u624b\u301c\u52a9\u6559<\/td><\/tr>
2010-2012<\/td>\u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\/\u5f62\u614b\u5f62\u6210\u6a5f\u69cb\u5b66\u3000\u52a9\u6559<\/td><\/tr>
2012-2021<\/td>\u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\/\u5f62\u614b\u5f62\u6210\u6a5f\u69cb\u5b66\u3000\u51c6\u6559\u6388<\/td><\/tr>
2021-<\/td>\u611b\u5a9b\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\/\u751f\u4f53\u69cb\u9020\u533b\u5b66\u8b1b\u5ea7\uff08\u65e7\uff1a\u89e3\u5256\u5b66\u30fb\u7d44\u7e54\u5b66\u8b1b\u5ea7\uff09\u3000\u6559\u6388\uff08\u73fe\u5728\u306b\u81f3\u308b\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u696d\u7e3e<\/h2>\n\n\n\n

1          Takeuchi, A., Takahashi, Y., Iida, K., Hosokawa, M., Irie, K., Ito, M., Brown, J. B., Ohno, K., Nakashima, K. & Hagiwara, M. Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Stem Cell Reports<\/em> 15<\/strong>, 883-897, doi:10.1016\/j.stemcr.2020.08.010 (2020).<\/p>\n\n\n\n

2          Iida, K., Hagiwara, M. & Takeuchi, A. Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ. iScience<\/em> 23<\/strong>, 101325, doi:10.1016\/j.isci.2020.101325 (2020).<\/p>\n\n\n\n

3          Kurokawa, R., Takeuchi, A., Shiina, N., Katahira, M., Yamashita, T., Matsuno, Y., Hitachi, K., Ishigaki, S., Haamad, N., Yoneda, R., Ueda, N., Iida, K., Hosokawa, M., Hagiwara, M., Iida, M., Mashima, T., Yamaoki, Y., So, M., Nagata, T., Sobue, G., Kondo, K., Watanabe, H. & Uchihashi, T. Versatility of RNA-Binding Proteins in Living Cells. Biomedical Sciences<\/em> 5<\/strong>, 7-13, doi:10.11648\/j.bs.20190501.12 (2019).<\/p>\n\n\n\n

4          Hosokawa, M., Takeuchi, A., Tanihata, J., Iida, K., Takeda, S. & Hagiwara, M. Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. iScience<\/em> 13<\/strong>, 229-242, doi:10.1016\/j.isci.2019.02.023 (2019).<\/p>\n\n\n\n

5          Takeuchi, A., Iida, K., Tsubota, T., Hosokawa, M., Denawa, M., Brown, J. B., Ninomiya, K., Ito, M., Kimura, H., Abe, T., Kiyonari, H., Ohno, K. & Hagiwara, M. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Cell Rep<\/em> 23<\/strong>, 1326-1341, doi:10.1016\/j.celrep.2018.03.141 (2018).<\/p>\n\n\n\n

6          Yoshida, M., Kataoka, N., Miyauchi, K., Ohe, K., Iida, K., Yoshida, S., Nojima, T., Okuno, Y., Onogi, H., Usui, T., Takeuchi, A., Hosoya, T., Suzuki, T. & Hagiwara, M. Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proceedings of the National Academy of Sciences, USA<\/em> 112<\/strong>, 2764-2769, doi:10.1073\/pnas.1415525112 (2015).<\/p>\n\n\n\n

7          Ohnishi, T., Yanazawa, M., Sasahara, T., Kitamura, Y., Hiroaki, H., Fukazawa, Y., Kii, I., Nishiyama, T., Kakita, A., Takeda, H., Takeuchi, A., Arai, Y., Ito, A., Komura, H., Hirao, H., Satomura, K., Inoue, M., Muramatsu, S., Matsui, K., Tada, M., Sato, M., Saijo, E., Shigemitsu, Y., Sakai, S., Umetsu, Y., Goda, N., Takino, N., Takahashi, H., Hagiwara, M., Sawasaki, T., Iwasaki, G., Nakamura, Y., Nabeshima, Y., Teplow, D. B. & Hoshi, M. Na, K-ATPase alpha3 is a death target of Alzheimer patient amyloid-beta assembly. Proceedings of the National Academy of Sciences, USA<\/em> 112<\/strong>, E4465-4474, doi:10.1073\/pnas.1421182112 (2015).<\/p>\n\n\n\n

8          Sims-Lucas, S., Cusack, B., Baust, J., Eswarakumar, V. P., Masatoshi, H., Takeuchi, A. & Bates, C. M. Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Developmental Dynamics<\/em> 240<\/strong>, 240-249, doi:10.1002\/dvdy.22501 (2011).<\/p>\n\n\n\n

9          Takeuchi, A., Hosokawa, M., Nojima, T. & Hagiwara, M. Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. PLoS One<\/em> 5<\/strong>, e10946, doi:10.1371\/journal.pone.0010946 (2010).<\/p>\n\n\n\n

10        Takeuchi, A., Hamasaki, T., Litwack, E. D. & O'Leary, D. D. Novel IgCAM, MDGA1, expressed in unique cortical area- and layer-specific patterns and transiently by distinct forebrain populations of Cajal-Retzius neurons. Cerebral Cortex<\/em> 17<\/strong>, 1531-1541, doi:bhl064 [pii]<\/p>\n\n\n\n

10.1093\/cercor\/bhl064 (2007).<\/p>\n\n\n\n

11        O'Leary, D. D., Chou, S. J., Hamasaki, T., Sahara, S., Takeuchi, A., Thuret, S. & Leingartner, A. Regulation of laminar and area patterning of mammalian neocortex and behavioural implications. Novartis Foundation Symposium<\/em> 288<\/strong>, 141-159; discussion 159-164, 276-181 (2007).<\/p>\n\n\n\n

12        Takeuchi, A. & O'Leary, D. D. Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1. Journal of Neuroscience<\/em> 26<\/strong>, 4460-4464, doi:26\/17\/4460 [pii]<\/p>\n\n\n\n

10.1523\/JNEUROSCI.4935-05.2006 (2006).<\/p>\n\n\n\n

13        Takeuchi, A., Mishina, Y., Miyaishi, O., Kojima, E., Hasegawa, T. & Isobe, K. Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nature Genetics<\/em> 33<\/strong>, 172-176, doi:10.1038\/ng1072<\/p>\n\n\n\n

ng1072 [pii] (2003).<\/p>\n\n\n\n

14        Kojima, E., Takeuchi, A., Haneda, M., Yagi, A., Hasegawa, T., Yamaki, K., Takeda, K., Akira, S., Shimokata, K. & Isobe, K. The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB Journal<\/em> 17<\/strong>, 1573-1575, doi:10.1096\/fj.02-1184fje<\/p>\n\n\n\n

02-1184fje [pii] (2003).<\/p>\n\n\n\n

15        Takeuchi, A., Miyaishi, O., Kiuchi, K. & Isobe, K. Macrophage colony-stimulating factor is expressed in neuron and microglia after focal brain injury. Journal of Neuroscience Research<\/em> 65<\/strong>, 38-44 (2001).<\/p>\n\n\n\n

16        Takeuchi, A., Miyaishi, O., Kiuchi, K. & Isobe, K. Cu\/Zn- and Mn-superoxide dismutases are specifically up-regulated in neurons after focal brain injury. Journal of Neurobiology<\/em> 45<\/strong>, 39-46, doi:10.1002\/1097-4695(200010)45:1<39::AID-NEU4>3.0.CO;2-A [pii] (2000).<\/p>\n\n\n\n

17        Hasegawa, T., Takeuchi, A., Miyaishi, O., Xiao, H., Mao, J. & Isobe, K. PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters. Biochemical Journal<\/em> 347 Pt 1<\/strong>, 55-59 (2000).<\/p>\n\n\n\n

18        Maehara, K., Hasegawa, T., Xiao, H., Takeuchi, A., Abe, R. & Isobe, K. Cooperative interaction of NF-kappaB and C\/EBP binding sites is necessary for manganese superoxide dismutase gene transcription mediated by lipopolysaccharide and interferon-gamma. FEBS Letters<\/em> 449<\/strong>, 115-119, doi:S0014579399004081 [pii] (1999).<\/p>\n\n\n\n

19        Takeuchi, A., Isobe, K. I., Miyaishi, O., Sawada, M., Fan, Z. H., Nakashima, I. & Kiuchi, K. Microglial NO induces delayed neuronal death following acute injury in the striatum. European Journal of Neuroscience<\/em> 10<\/strong>, 1613-1620 (1998).<\/p>\n\n\n\n

20        Yamada, E., Ishiguro, N., Miyaishi, O., Takeuchi, A., Nakashima, I., Iwata, H. & Isobe, K. Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA-encoding murine ATPase inhibitor. Immunology<\/em> 92<\/strong>, 571-576 (1997).<\/p>\n\n\n\n

21        Nozaki, Y., Hasegawa, Y., Takeuchi, A., Fan, Z. H., Isobe, K. I., Nakashima, I. & Shimokata, K. Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats. American Journal of Physiology: Lung Cellular and Molecular Physiology<\/em> 272<\/strong>, L651-658 (1997).<\/p>\n\n\n\n

22        Hasegawa, T., Takeuchi, A., Miyaishi, O., Isobe, K. & de Crombrugghe, B. Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. Journal of Biological Chemistry<\/em> 272<\/strong>, 4915-4923 (1997).<\/p>\n\n\n\n

23        Aono, K., Isobe, K., Kiuchi, K., Fan, Z. H., Ito, M., Takeuchi, A., Miyachi, M., Nakashima, I. & Nimura, Y. In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines. Journal of Cellular Biochemistry<\/em> 65<\/strong>, 349-358, doi:10.1002\/(SICI)1097-4644(19970601)65:3<349::AID-JCB5>3.0.CO;2-S [pii] (1997).<\/p>\n\n\n\n

\u7dcf\u8aac<\/h2>\n\n\n\n

1          \u6b66\u5185\u7ae0\u82f1. \u907a\u4f1d\u5b50\u767a\u73fe\u306b\u304a\u3051\u308bRNA \u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u591a\u5f69\u306a\u6a5f\u80fd. \u5b9f\u9a13\u533b\u5b66\u5897\u520a \u30bb\u30f3\u30c8\u30e9\u30eb\u30c9\u30b0\u30de\u306e\u65b0\u5e38\u8b58<\/em>, 141-148 (2022).<\/p>\n\n\n\n

2          \u6b66\u5185\u7ae0\u82f1. <\/em>\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u30b0\u30ea\u30a2\u65b0\u751f\u3078\u306e\u904b\u547d\u6c7a\u5b9a\u3092\u5236\u5fa1\u3059\u308bRNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8ceaQk\u306e\u767a\u898b. \u611b\u5a9b\u533b\u5b66 EHIME MEDICAL JOURNAL<\/em>40<\/strong>, 121-127 (2021).<\/p>\n\n\n\n

\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

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