{"id":668,"date":"2021-08-11T09:34:19","date_gmt":"2021-08-11T00:34:19","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/anatomy1\/?page_id=668"},"modified":"2026-08-06T10:48:40","modified_gmt":"2026-08-06T01:48:40","slug":"%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/anatomy1\/?page_id=668&lang=en","title":{"rendered":"Publications (Prof. Takeuchi)"},"content":{"rendered":"\n

Original Articles<\/strong><\/p>\n\n\n\n

    \n
  1. Hosokawa, M., Kawakami, R., Imami, K., Kurosawa, R., Ishihama, Y., Imamura, T., Hagiwara, M., and\u00a0Takeuchi, A.<\/u><\/strong>\u00a0RNA-dependent SFPQ condensates coordinate multidimensional regulation of extra-long neuronal genes\u00a0Cell Chemical Biology<\/em><\/strong>. 10.1016\/j.chembiol.2026.06.004<\/mark><\/a><\/strong>.(2026<\/mark>)<\/mark><\/a>- \ud83c\udfc6 Lab's Featured Paper<\/mark><\/strong><\/li>\n\n\n\n
  2. Okano, M., Yoshino, Y., Verma, A.K., Kumon, H., Mori, H., Hosokawa, M., Iga, J.I., Dwivedi, Y.,\u00a0Takeuchi, A.<\/u><\/strong>, and Ueno, S.I. Altered IRF1-miR-20a-5p regulatory axis in the hippocampus of patients with major depressive disorder.\u00a0Psychiatry Clin. Neurosci.<\/em><\/strong>10.1111\/pcn.70111.(2026)<\/li>\n\n\n\n
  3. Masaki, S., Nojima, T., Oshiro-Ideue, T., Suenaga, A.,\u00a0Takeuchi, A.<\/u><\/strong>, Kii, I., Suzuki, K., Tanaka, S., Hagiwara, M., and Kataoka, N. PUF60 is a Critical Regulator of PKM Splicing During Myogenesis.\u00a0Mol. Cell. Biol.<\/em><\/strong>, 1-16. 10.1080\/10985549.2026.2699151.(2026)<\/li>\n\n\n\n
  4. Shimazaki, R., Saito, Y., Awaya, T., Minami, N., Kurosawa, R., Hosokawa, M., Ohara, H., Hayashi, S.,\u00a0Takeuchi, A.<\/u><\/strong>, Hagiwara, M., Hayashi, Y.K., Noguchi, S., and Nishino, I. Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy.\u00a0Orphanet J Rare Dis<\/em><\/strong>\u00a020<\/em>, 1. 10.1186\/s13023-024-03521-2.(2025)<\/li>\n\n\n\n
  5. Lee, S.A., Ogawa, M., Saito, Y., Shimazaki, R., Awaya, T., Hosokawa, M., Kurosawa, R., Ohara, H.,\u00a0Takeuchi, A.<\/u><\/strong>, Hayashi, S., Goto, Y.I., Hagiwara, M., Nishino, I., and Noguchi, S. Substitutions of nucleotides at the 3' ends of COL6A1\/2\/3 exons induce exon skipping associated with collagen VI-related muscular dystrophies and therapeutic strategies.\u00a0Genet. Med.<\/em><\/strong>, 101431. 10.1016\/j.gim.2025.101431.(2025)<\/li>\n\n\n\n
  6. Ogi, Y., Egi, H., Ishimaru, K., Koga, S., Yoshida, M., Kikuchi, S., Akita, S., Sugishita, H., Matsumoto, H., Shimokawa, T.,\u00a0Takeuchi, A.<\/u><\/strong>, and Watanabe, Y. Cadaveric and CT angiography study of vessels around the transverse colon mesentery.\u00a0World J Surg Oncol<\/em><\/strong>\u00a021<\/em>, 36. 10.1186\/s12957-023-02919-9.(2023)<\/li>\n\n\n\n
  7. Khan, S.,\u00a0Takeuchi, A.<\/u><\/strong>, Nabeka, H., Khan, F., Shimokawa, T., Takanezawa, S., Saitou, T., Imamura, T., Tachibana, T., Nishizono, A., Hamada, F., and Matsuda, S. Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions.\u00a0iScience<\/em><\/strong>\u00a026<\/em>, 106277. 10.1016\/j.isci.2023.106277.(2023)<\/li>\n\n\n\n
  8. Kanemitsu, E., Zhao, X., Iwaisako, K., Inoue, A.,\u00a0Takeuchi, A.<\/u><\/strong>, Yagi, S., Masumoto, H., Ohara, H., Hosokawa, M., Awaya, T., Aoki, J., Hatano, E., Uemoto, S., and Hagiwara, M. Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation.\u00a0Transl Res<\/em><\/strong>\u00a0255<\/em>, 26-36. 10.1016\/j.trsl.2022.11.003.(2023)<\/li>\n\n\n\n
  9. Takeuchi, A.<\/u><\/strong>, Takahashi, Y., Iida, K., Hosokawa, M., Irie, K., Ito, M., Brown, J.B., Ohno, K., Nakashima, K., and Hagiwara, M. Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage.\u00a0Stem Cell Reports<\/em><\/strong>\u00a015<\/em>, 883-897. 10.1016\/j.stemcr.2020.08.010.(2020)<\/li>\n\n\n\n
  10. Iida, K., Hagiwara, M., and\u00a0Takeuchi, A.<\/u><\/strong>\u00a0Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ.\u00a0iScience<\/em><\/strong>\u00a023<\/em>, 101325. 10.1016\/j.isci.2020.101325.(2020)<\/li>\n\n\n\n
  11. Kurokawa, R.,\u00a0Takeuchi, A.<\/u><\/strong>, Shiina, N., Katahira, M., Yamashita, T., Matsuno, Y., Hitachi, K., Ishigaki, S., Haamad, N., Yoneda, R., Ueda, N., Iida, K., Hosokawa, M., Hagiwara, M., Iida, M., Mashima, T., Yamaoki, Y., So, M., Nagata, T., Sobue, G., Kondo, K., Watanabe, H., and Uchihashi, T. Versatility of RNA-Binding Proteins in Living Cells.\u00a0Biomedical Sciences<\/em><\/strong>\u00a05<\/em>, 7-13. 10.11648\/j.bs.20190501.12.(2019)<\/li>\n\n\n\n
  12. Hosokawa, M.,\u00a0Takeuchi, A.<\/u><\/strong>, Tanihata, J., Iida, K., Takeda, S., and Hagiwara, M. Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy.\u00a0iScience<\/em><\/strong>\u00a013<\/em>, 229-242. 10.1016\/j.isci.2019.02.023.(2019)<\/li>\n\n\n\n
  13. Takeuchi, A.<\/u><\/strong>, Iida, K., Tsubota, T., Hosokawa, M., Denawa, M., Brown, J.B., Ninomiya, K., Ito, M., Kimura, H., Abe, T., Kiyonari, H., Ohno, K., and Hagiwara, M. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain.\u00a0Cell Rep<\/em><\/strong>\u00a023<\/em>, 1326-1341. 10.1016\/j.celrep.2018.03.141.(2018)<\/li>\n\n\n\n
  14. Yoshida, M., Kataoka, N., Miyauchi, K., Ohe, K., Iida, K., Yoshida, S., Nojima, T., Okuno, Y., Onogi, H., Usui, T.,\u00a0Takeuchi, A.<\/u><\/strong>, Hosoya, T., Suzuki, T., and Hagiwara, M. Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia.\u00a0Proc. Natl. Acad. Sci. USA<\/em><\/strong>\u00a0112<\/em>, 2764-2769. 10.1073\/pnas.1415525112.(2015)<\/li>\n\n\n\n
  15. Ohnishi, T., Yanazawa, M., Sasahara, T., Kitamura, Y., Hiroaki, H., Fukazawa, Y., Kii, I., Nishiyama, T., Kakita, A., Takeda, H.,\u00a0Takeuchi, A.<\/u><\/strong>, Arai, Y., Ito, A., Komura, H., Hirao, H., Satomura, K., Inoue, M., Muramatsu, S., Matsui, K., Tada, M., Sato, M., Saijo, E., Shigemitsu, Y., Sakai, S., Umetsu, Y., Goda, N., Takino, N., Takahashi, H., Hagiwara, M., Sawasaki, T., Iwasaki, G., Nakamura, Y., Nabeshima, Y., Teplow, D.B., and Hoshi, M. Na, K-ATPase alpha3 is a death target of Alzheimer patient amyloid-beta assembly.\u00a0Proc. Natl. Acad. Sci. USA<\/em><\/strong>112<\/em>, E4465-4474. 10.1073\/pnas.1421182112.(2015)<\/li>\n\n\n\n
  16. Sims-Lucas, S., Cusack, B., Baust, J., Eswarakumar, V.P., Masatoshi, H.,\u00a0Takeuchi, A.<\/u><\/strong>, and Bates, C.M. Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development.\u00a0Dev. Dyn.<\/em><\/strong>\u00a0240<\/em>, 240-249. 10.1002\/dvdy.22501.(2011)<\/li>\n\n\n\n
  17. Takeuchi, A.<\/u><\/strong>, Hosokawa, M., Nojima, T., and Hagiwara, M. Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection.\u00a0PLoS One<\/em><\/strong>\u00a05<\/em>, e10946. 10.1371\/journal.pone.0010946.(2010)<\/li>\n\n\n\n
  18. Takeuchi, A.<\/u><\/strong>, Hamasaki, T., Litwack, E.D., and O'Leary, D.D. Novel IgCAM, MDGA1, expressed in unique cortical area- and layer-specific patterns and transiently by distinct forebrain populations of Cajal-Retzius neurons.\u00a0Cereb. Cortex<\/em><\/strong>\u00a017<\/em>, 1531-1541. 10.1093\/cercor\/bhl064.(2007)<\/li>\n\n\n\n
  19. O'Leary, D.D., Chou, S.J., Hamasaki, T., Sahara, S.,\u00a0Takeuchi, A.<\/u><\/strong>, Thuret, S., and Leingartner, A. Regulation of laminar and area patterning of mammalian neocortex and behavioural implications.\u00a0Novartis Foundation Symposium<\/em><\/strong>\u00a0288<\/em>, 141-159; discussion 159-164, 276-181.(2007)<\/li>\n\n\n\n
  20. Takeuchi, A.<\/u><\/strong>, and O'Leary, D.D. Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1.\u00a0J. Neurosci.<\/em><\/strong>\u00a026<\/em>, 4460-4464. 10.1523\/JNEUROSCI.4935-05.2006.(2006)<\/li>\n\n\n\n
  21. Takeuchi, A.<\/u><\/strong>, Mishina, Y., Miyaishi, O., Kojima, E., Hasegawa, T., and Isobe, K. Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis.\u00a0Nat. Genet.<\/em><\/strong>\u00a033<\/em>, 172-176. 10.1038\/ng1072.(2003)<\/li>\n\n\n\n
  22. Kojima, E.,\u00a0Takeuchi, A.<\/u><\/strong>, Haneda, M., Yagi, A., Hasegawa, T., Yamaki, K., Takeda, K., Akira, S., Shimokata, K., and Isobe, K. The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice.\u00a0FASEB J.<\/em><\/strong>\u00a017<\/em>, 1573-1575. 10.1096\/fj.02-1184fje.(2003)<\/li>\n\n\n\n
  23. Takeuchi, A.<\/u><\/strong>, Miyaishi, O., Kiuchi, K., and Isobe, K. Macrophage colony-stimulating factor is expressed in neuron and microglia after focal brain injury.\u00a0J. Neurosci. Res.<\/em><\/strong>\u00a065<\/em>, 38-44. doi.org\/10.1002\/jnr.1125.(2001)<\/li>\n\n\n\n
  24. Takeuchi, A.<\/u><\/strong>, Miyaishi, O., Kiuchi, K., and Isobe, K. Cu\/Zn- and Mn-superoxide dismutases are specifically up-regulated in neurons after focal brain injury.\u00a0J. Neurobiol.<\/em><\/strong>\u00a045<\/em>, 39-46. 10.1002\/1097-4695(200010)45:1<39::AID-NEU4>3.0.CO;2-A [pii].(2000)<\/li>\n\n\n\n
  25. Hasegawa, T.,\u00a0Takeuchi, A.<\/u><\/strong>, Miyaishi, O., Xiao, H., Mao, J., and Isobe, K. PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters.\u00a0Biochem. J.<\/em><\/strong>\u00a0347 Pt 1<\/em>, 55-59.(2000)<\/li>\n\n\n\n
  26. Maehara, K., Hasegawa, T., Xiao, H.,\u00a0Takeuchi, A.<\/u><\/strong>, Abe, R., and Isobe, K. Cooperative interaction of NF-kappaB and C\/EBP binding sites is necessary for manganese superoxide dismutase gene transcription mediated by lipopolysaccharide and interferon-gamma.\u00a0FEBS Lett.<\/em><\/strong>\u00a0449<\/em>, 115-119. S0014579399004081 [pii].(1999)<\/li>\n\n\n\n
  27. Takeuchi, A.<\/u><\/strong>, Isobe, K.I., Miyaishi, O., Sawada, M., Fan, Z.H., Nakashima, I., and Kiuchi, K. Microglial NO induces delayed neuronal death following acute injury in the striatum.\u00a0Eur. J. Neurosci.<\/em><\/strong>\u00a010<\/em>, 1613-1620. doi.org\/10.1046\/j.1460-9568.1998.00168.x.(1998)<\/li>\n\n\n\n
  28. Yamada, E., Ishiguro, N., Miyaishi, O.,\u00a0Takeuchi, A.<\/u><\/strong>, Nakashima, I., Iwata, H., and Isobe, K. Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA-encoding murine ATPase inhibitor.\u00a0Immunology<\/em><\/strong>\u00a092<\/em>, 571-576. doi: 10.1046\/j.1365-2567.1997.00370.x.(1997)<\/li>\n\n\n\n
  29. Nozaki, Y., Hasegawa, Y.,\u00a0Takeuchi, A.<\/u><\/strong>, Fan, Z.H., Isobe, K.I., Nakashima, I., and Shimokata, K. Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats.\u00a0American Journal of Physiology: Lung Cellular and Molecular Physiology<\/em><\/strong>\u00a0272<\/em>, L651-658.\u00a0https:\/\/doi.org\/10.1152\/ajplung.1997.272.4.L651.(1997<\/a>)<\/li>\n\n\n\n
  30. Hasegawa, T.,\u00a0Takeuchi, A.<\/u><\/strong>, Miyaishi, O., Isobe, K., and de Crombrugghe, B. Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes.\u00a0J. Biol. Chem.<\/em><\/strong>\u00a0272<\/em>, 4915-4923. doi.org\/10.1002\/jnr.1125.(1997)<\/li>\n\n\n\n
  31. Aono, K., Isobe, K., Kiuchi, K., Fan, Z.H., Ito, M.,\u00a0Takeuchi, A.<\/u><\/strong>, Miyachi, M., Nakashima, I., and Nimura, Y. In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines.\u00a0J. Cell. Biochem.<\/em><\/strong>\u00a065<\/em>, 349-358. 10.1002\/(SICI)1097-4644(19970601)65:3<349::AID-JCB5>3.0.CO;2-S [pii].(1997)<\/li>\n<\/ol>\n\n\n\n

    <\/p>\n\n\n\n

    Books<\/strong><\/p>\n\n\n\n

      \n
    • Kuroyanagi H., Takeuchi A.<\/span><\/strong>, Nojima T. & Hagiwara M. Chapter 28: Single cell detection of splicing events with fluorescent splicing reporters. Alternative pre-mRNA Splicing: Theory and Protocols.(Stamm S., Smith C., L\u00fchrmann R. ed). Wiley-VCH. (2012)<\/li>\n<\/ul>\n\n\n\n

      <\/p>\n\n\n\n

      Review Articles<\/strong><\/p>\n\n\n\n

        \n
      • Takeuchi A.<\/span><\/strong> Diverse functions of RNA-binding proteins in gene expression. Jikken Igaku, Special Issue: New Concepts in the Central Dogma<\/em>, Chapter 3: New Concepts in RNA, 141\u2013148 (2022). ISBN-10: 4758104042; ISBN-13: 978-4758104043.<\/li>\n\n\n\n
      • Takeuchi A.<\/span><\/strong> Discovery of the RNA-binding protein Qk as a regulator of neural stem cell fate during gliogenesis. Ehime Medical Journal<\/em> 40, 121\u2013127 (2021).<\/li>\n\n\n\n
      • Takeuchi A.<\/span><\/strong>, Hagiwara M. Visualizing splicing reporter system explores the world of mRNA regulation in mammals. Cell Technology<\/em> 31, 698\u2013704 (2012).<\/li>\n\n\n\n
      • Takeuchi A.<\/span><\/strong>, Mishina Y, Isobe K-I. Haploinsufficiency of Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Experimental Medicine<\/em> 21, 912\u2013915 (2003).<\/li>\n\n\n\n
      • Isobe K-I, Takeuchi A.<\/span><\/strong>, Hasegawa T, Ohkusu K. Aging and apoptosis. Clinical Immunology<\/em> 29, 1422\u20131426 (1997).<\/li>\n\n\n\n
      • Miyaishi O, Takeuchi A<\/span><\/strong><\/span><\/strong>, Isobe K-I. Understanding aging from a molecular cell biology perspective. Otolaryngology\u2013Head and Neck Surgery<\/em> 15, 971\u2013975 (1997).<\/li>\n<\/ul>\n\n\n\n

        <\/p>\n\n\n\n

        Patents<\/strong><\/p>\n\n\n\n

          \n
        • Hagiwara M, Takeuchi A.<\/span><\/strong> Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms. Japanese Patent No. 5,875,009. Assignee: Kyoto University. Granted January 29, 2016.<\/li>\n\n\n\n
        • Hagiwara M, Takeuchi A.<\/span><\/strong> Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms. U.S. Patent No. 9,273,364 B2. Assignee: Kyoto University (2016).<\/li>\n\n\n\n
        • Hagiwara M, Takeuchi A.<\/span><\/strong> Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in rodents. European Patent No. 2,576,778. Assignee: Kyoto University. Granted April 5, 2017.<\/li>\n<\/ul>\n\n\n\n

          <\/p>\n\n\n\n

          <\/p>\n","protected":false},"excerpt":{"rendered":"

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