{"id":498,"date":"2025-12-01T20:01:46","date_gmt":"2025-12-01T11:01:46","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/biochem2\/?page_id=498"},"modified":"2025-12-25T17:28:18","modified_gmt":"2025-12-25T08:28:18","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/biochem2\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>Junko Murai\u306e\u3053\u308c\u307e\u3067\u306epublication (\u611b\u5a9b\u5927\u5b66\u4ee5\u524d\u3082\u542b\u3080\uff09\u3002<\/p>\n<ul>\n<li>Co-expression of CD30 and SLFN11 serves as a dual biomarker for the treatment of cutaneous T-cell lymphoma.<br \/>\nTakatoshi Shimauchi, Junko Murai, Manami Iwasaki, Pawit Phadungsaksawasdi, Toshiyuki Ojima, Kazuyasu Fujii, Tetsuya Honda<br \/>\nNAR cancer 7(4) zcaf037 2025\u5e7412\u670810.1093\/narcan\/zcaf037,10.1093\/narcan\/zcaf037<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">\u6d5c\u677e\u533b\u79d1\u5927\u5b66\u76ae\u819a\u79d1\u3001\u5cf6\u5185\u5148\u751f\u3001\u672c\u7530\u5148\u751f\u3068\u306e\u30b3\u30e9\u30dc\u8ad6\u6587\u3002\u76ae\u819aT\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3067\u306f\u3001CD30\u3068SLFN11\u304c\u5171\u967d\u6027\u306b\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u306e\u3067\u3001CD30\u3092\u6a19\u7684\u3068\u3059\u308bADC\u306epayload\u306fSLFN11-related drugs (TOP1\/2 inhibitors)\u306e\u65b9\u304c\u7406\u306b\u304b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u304c\u3093\u7d30\u80de\u7279\u7570\u7684\u8868\u9762\u6297\u539f\u304cADC\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u304c\u3001payload\u306b\u5bfe\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3082\u8003\u616e\u306b\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u3055\u3089\u306a\u308b\u7cbe\u5bc6\u533b\u7642\u304c\u5b9f\u73fe\u3059\u308b\u3002ADC\u306b\u5bfe\u3057\u3066\u3001dual biomaker\u3068\u3044\u3046\u6982\u5ff5\u3092\u521d\u3081\u3066\u63d0\u5531\u3057\u305f\u8ad6\u6587\uff08\u305f\u3076\u3093\uff09\u3002<\/p>\n<ul>\n<li>KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death<br \/>\nKyosuke Habu, Yosuke Matsuoka, Hiromi Hiyoshi, Jun Nakayama, Katsuya Watanabe, Sota Tate, Tomohisa Sakaue, Junko Murai, Konomu Uno, Hirotada Nishie, Eiji Kubota, Hiromi Kataoka, Takashi Joh, Yuji Watanabe, Taro Oshikiri, Shigeki Higashiyama<br \/>\nCancer Science 116(9) 2444-2456 2025\u5e747\u670810.1111\/cas.70108,https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.70108,10.1111\/cas.70108<\/li>\n<li>PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer.<br \/>\nYohei Okuda, Taigo Kato, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Koji Hatano, Atsunari Kawashima, Junko Murai, Norio Nonomura<br \/>\nInternational journal of urology : official journal of the Japanese Urological Association 2025\u5e746\u67089\u65e510.1111\/iju.70100,10.1111\/iju.70100<\/li>\n<li>SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis.<br \/>\nAkane Ogawa, Keiichi Izumikawa, Sota Tate, Sho Isoyama, Masaru Mori, Kohei Fujiwara, Soyoka Watanabe, Takayuki Ohga, Ukhyun Jo, Daiki Taniyama, Shojiro Kitajima, Soichiro Tanaka, Hiroshi Onji, Shun-Ichiro Kageyama, Gaku Yamamoto, Hitoshi Saito, Tomoko Yamamori Morita, Masayasu Okada, Manabu Natsumeda, Masami Nagahama, Junya Kobayashi, Akihiro Ohashi, Hiroyuki Sasanuma, Shigeki Higashiyama, Shingo Dan, Yves Pommier, Junko Murai<br \/>\nMolecular cell 85(5) 894-912 2025\u5e741\u670830\u65e510.1016\/j.molcel.2025.01.008,10.1016\/j.molcel.2025.01.008<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">SLFN11\u967d\u6027\u7d30\u80de\u3067\u306f\u3001\u8907\u88fd\u30b9\u30c8\u30ec\u30b9\u3092\u304b\u3051\u305f\u969b\u306b4\u22126\u6642\u9593\u7a0b\u5ea6\u3067TP53\u975e\u4f9d\u5b58\u7684\u306a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u8d77\u3053\u308b\u304c\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u8feb\u3063\u305f\u8ad6\u6587\u3002\u8db3\u639b\u305112\u5e74\uff08\u672c\u6c17\u3092\u51fa\u3057\u3066\u304b\u30894\u5e74\uff09\u304b\u304b\u3063\u305f\u8ad6\u6587\u3002\u5c0f\u5ddd\u3055\u3093\uff08\u5f53\u6642\u6176\u61c9SFC\u5b66\u90e8\u751f\uff09\u6cc9\u5ddd\u5148\u751f\uff08\u660e\u6cbb\u85ac\u79d1\u5927\u5b66\u51c6\u6559\u6388\uff09\u7530\u624b\u3055\u3093\uff08\u5f53\u6559\u5ba4\u52a9\u6559\uff09\u304c\u30b3\u30d5\u30a1\u30fc\u30b9\u30c8\u30aa\u30fc\u30b5\u30fc\u3002\u4e16\u754c\u3068\u6226\u3063\u305f\u9054\u6210\u611f\u3042\u308a\u3001\u3053\u306e\u6642\u306e\u30e2\u30c1\u30d9\u3092\u5fd8\u308c\u305a\u306b\u3001\u6700\u5f8c\u307e\u3067\u7814\u7a76\u4eba\u751f\u3092\u8cab\u304d\u305f\u3044\u3002<\/p>\n<p style=\"padding-left: 40px;\">\u5b9f\u9a13\u533b\u5b66\u306ecurrent topic\u306b\u8981\u7d04\u3092\u5bc4\u7a3f\u3000<a href=\"https:\/\/www.m.ehime-u.ac.jp\/school\/biochem2\/biochem2_wp\/wp-content\/uploads\/2025\/12\/2025\u5b9f\u9a13\u533b\u5b66\u30ab\u30ec\u30f3\u30c8\u30c8\u30d4\u30c3\u30af\u30b9.pdf\">2025\u5b9f\u9a13\u533b\u5b66\u30ab\u30ec\u30f3\u30c8\u30c8\u30d2\u309a\u30c3\u30af\u30b9<\/a><\/p>\n<p style=\"padding-left: 40px;\">\u8aad\u58f2\u65b0\u805e\uff08\u5168\u56fd\u7248\uff09\u3001\u6bce\u65e5\u65b0\u805e\uff08\u56db\u56fd\u7248\uff09\u3001Yahoo!News Japan\u3001NHK\u611b\u5a9b\u306b\u53d6\u308a\u4e0a\u3052\u3089\u308c\u305f\u3002\u304d\u3083\u3063\u307b\u30fc\u3002<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-588 alignleft\" src=\"https:\/\/www.m.ehime-u.ac.jp\/school\/biochem2\/biochem2_wp\/wp-content\/uploads\/2025\/12\/20250210-Yahoo-news.png\" alt=\"\" width=\"299\" height=\"260\" \/><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-589 alignleft\" src=\"https:\/\/www.m.ehime-u.ac.jp\/school\/biochem2\/biochem2_wp\/wp-content\/uploads\/2025\/12\/NHK\u3072\u3081\u307d\u3093.jpg\" alt=\"\" width=\"215\" height=\"289\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\">\u00a0<a href=\"https:\/\/www.m.ehime-u.ac.jp\/school\/biochem2\/biochem2_wp\/wp-content\/uploads\/2025\/12\/\u8aad\u58f2\u65b0\u805e2025.2.6.pdf\">\u8aad\u58f2\u65b0\u805e2025.2.6<\/a><\/p>\n<p style=\"padding-left: 40px;\"><a href=\"https:\/\/www.m.ehime-u.ac.jp\/school\/biochem2\/biochem2_wp\/wp-content\/uploads\/2025\/12\/\u6297\u304c\u3093\u5264\u306e\u52b9\u679c\u9ad8\u3081\u308b\u305f\u3093\u3071\u304f\u8cea\u300cSLFN11\u300d\u611b\u5a9b\u5927\u304c\u4ed5\u7d44\u307f\u89e3\u660e-\u6bce\u65e5\u65b0\u805e.pdf\">\u6297\u304b\u3099\u3093\u5264\u306e\u52b9\u679c\u9ad8\u3081\u308b\u305f\u3093\u306f\u309a\u304f\u8cea\u300cSLFN11\u300d\u611b\u5a9b\u5927\u304b\u3099\u4ed5\u7d44\u307f\u89e3\u660e | \u6bce\u65e5\u65b0\u805e<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of H3F3A K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid.<br \/>\nSatoshi Shibuma, Jotaro On, Manabu Natsumeda, Akihide Koyama, Haruhiko Takahashi, Jun Watanabe, Masaki Mitobe, Satoshi Nakata, Yuki Tanaka, Yoshihiro Tsukamoto, Masayasu Okada, Junichi Yoshimura, Mari Tada, Hiroshi Shimizu, Soichi Oya, Junko Murai, Kouichirou Okamoto, Hiroyuki Kawashima, Akiyoshi Kakita, Makoto Oishi<br \/>\nPediatric blood &amp; cancer e31535 2025\u5e741\u67089\u65e510.1002\/pbc.31535,10.1002\/pbc.31535<\/li>\n<li>Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks.<br \/>\nHiroshi Onji, Sota Tate, Tomohisa Sakaue, Kohei Fujiwara, Shiho Nakano, Miho Kawaida, Nobuyuki Onishi, Takashi Matsumoto, Wataru Yamagami, Takashi Sugiyama, Shigeki Higashiyama, Yves Pommier, Yusuke Kobayashi, Junko Murai<br \/>\nOncogene 43(32) 2475-2489 2024\u5e747\u67083\u65e510.1038\/s41388-024-03094-1,10.1038\/s41388-024-03094-1<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">PARP\u963b\u5bb3\u5264\u306f\u8907\u88fd\u30d5\u30a9\u30fc\u30af\u306e\u5f8c\u65b9\u3067ssDNA gap\u3092\u5f62\u6210\u3059\u308b\u304c\u3001SLFN11\u306f\u305d\u306essDNA\u306b\u7d50\u5408\u3057\u3066\u3001gap\u3092\u62e1\u3052\u308b\u3053\u3068\u3067\u6297\u816b\u760d\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002BRCA\u5909\u7570\u7d30\u80de\u3067\u3082ssDNA gap\u304c\u5897\u3048\u308b\u306e\u3067\u3001\u305d\u3053\u306bSLFN11\u304c\u3042\u308b\u3068\u3055\u3089\u306bgap\u304c\u5897\u3048\u308b\u306e\u3067\u3001BRCAmut\/SLFN11-positive\u816b\u760d\u3067\u306f\u3001\u3055\u3089\u306b\u6297\u816b\u760d\u52b9\u679c\u304c\u9ad8\u307e\u308b\u3002\u7b51\u6ce2\u5927\u5b66\u5c0f\u6797\u5148\u751f\u3068\u306e\u30b3\u30e9\u30dc\u8ad6\u6587\u3002\u611b\u5a9b\u5927\u5b66\u306b\u304a\u3044\u3066\u3001\u521d\u306e\u5927\u5b66\u9662\u306e\u6307\u5c0e\u6559\u54e1\u3092\u62c5\u5f53\u3057\u305f\u6069\u5730\u5148\u751f\u306e\u5b66\u4f4d\u8ad6\u6587\u3068\u3044\u3046\u70b9\u3067\u3082\u611f\u6168\u6df1\u3044\u8ad6\u6587\u3002\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u306b\u3057\u305f\u3068\u3053\u308d150\u4e07\u5186\u304f\u3089\u3044\u304b\u304b\u3063\u3066\u3057\u307e\u3044\u3001\u7523\u5a66\u4eba\u79d1\u6559\u5ba4\u306b\u3054\u8ff7\u60d1\u3092\u304b\u3051\u307e\u3057\u305f\u3002<\/p>\n<ul>\n<li>The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 13.<br \/>\nKohei Fujiwara, Masashi Maekawa, Yuki Iimori, Akane Ogawa, Takeshi Urano, Nobuaki Kono, Hiroyuki Takeda, Shigeki Higashiyama, Makoto Arita, Junko Murai<br \/>\niScience 26(12) 108529-108529 2023\u5e7412\u670815\u65e510.1016\/j.isci.2023.108529,10.1016\/j.isci.2023.108529<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">2022\u5e74\u306bSLFN11\u306essDNA binding site (K652)\u3084\u3001ssDNA bind\u306e\u305f\u3081\u306b\u8131\u30ea\u30f3\u9178\u5316\u3055\u308c\u3066\u304a\u304f\u3079\u304d\u30b5\u30a4\u30c8\uff08S753)\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u30b5\u30a4\u30c8\u304cSLFN11\u306e\u30af\u30ed\u30de\u30c1\u30f3\u30ea\u30af\u30eb\u30fc\u30c8\u3001\u8907\u88fd\u963b\u5bb3\u3001\u85ac\u5264\u611f\u53d7\u6027\u306b\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u3092\u3001\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u793a\u3057\u305f\u3002 \u3055\u3089\u306b\u3001SLFN11\u3068\u76f8\u540c\u6027\u306e\u9ad8\u3044SLFN13\u304c\u3001\u85ac\u5264\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u7406\u7531\u304cSLFN13\u306essDNA binding site\u304c\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306b\u306a\u3063\u3066\u3044\u308b\u304b\u3089\u3060\u3068\u8a3c\u660e\u3057\u3001\u30ea\u30b8\u30f3\u306b\u3059\u308b\u3053\u3068\u3067SLFN11 like\u306a\u6a5f\u80fd\u3092\u6301\u305f\u305b\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u305f\u3002SLFN13\u306e\uff11\u30a2\u30df\u30ce\u9178\u5909\u7570\u3067SLFN11 like\u306b\u306a\u308b\u3068\u306f\u3001\u30af\u30e9\u30e9\u304c\u7acb\u3063\u305f\uff01\u304f\u3089\u3044\u306e\u9a5a\u304d\u3068\u559c\u3073\u3067\u3042\u3063\u305f\u3002\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u85ac\u5b66\u90e8\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b\u306e3\u5e74\u751f\u304b\u3089\u300cSLFN11\u304a\u3082\u308d\u3044\u3063\u3059\u3001\u3084\u308a\u305f\u3044\u3063\u3059\u300d\u3068\u30a6\u30c1\u306e\u30e9\u30dc\u306b\u6765\u3066\u304f\u308c\u305f\u85e4\u539f\u3055\u3093\u306e\u535a\u58eb\u8ad6\u6587\u3067\u3042\u308b\u3002SLFN11\u53f2\u4e0a\u3001\u5f8c\u4e16\u306b\u6b8b\u308b\u3053\u3068\u9593\u9055\u3044\u306a\u3057\u306e\u79c0\u9038\u8ad6\u6587\u3002<\/p>\n<ul>\n<li>SLFN11 is a BRCA independent biomarker for the response to platinum-based chemotherapy in high-grade serous ovarian cancer and clear cell ovarian carcinoma.<br \/>\nHidehiko Akashi, Nozomi Yachida, Haruka Ueda, Manako Yamaguchi, Kaoru Yamawaki, Ryo Tamura, Kazuaki Suda, Tatsuya Ishiguro, Sosuke Adachi, Yoshikazu Nagase, Yutaka Ueda, Masashi Ueda, Kaoru Abiko, Masahiro Kagabu, Tsukasa Baba, Hirofumi Nakaoka, Takayuki Enomoto, Junko Murai, Kosuke Yoshihara\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Molecular cancer therapeutics 23(1) 106-116 2023\u5e749\u670815\u65e510.1158\/1535-7163.MCT-23-0257,10.1158\/1535-7163.MCT-23-0257<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">\u65b0\u6f5f\u5927\u5b66\u7523\u5a66\u4eba\u79d1\u306e\u660e\u77f3\u5148\u751f\u3001\u5409\u539f\u5148\u751f\u3089\u3068\u306e\u30b3\u30e9\u30dc\u8ad6\u6587\u3002\u5375\u5de3\u304c\u3093\u306b\u304a\u3044\u3066\u3001SLFN11\u304c\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u307b\u3046\u304c\u3001\u767d\u91d1\u88fd\u5264\u3092\u542b\u3080\u5316\u5b66\u7642\u6cd5\u65bd\u884c\u5f8c\u306ePFS,OS\u304c\u9577\u3044\u3053\u3068\u3092\u3001\u4e8c\u3064\u306e\u30b3\u30db\u30fc\u30c8\u3067\u5171\u901a\u3057\u3066\u660e\u3089\u304b\u306b\u3057\u305f\u3002BRCA\u5909\u7570\u3068\u306f\u72ec\u7acb\u3057\u305f\u6307\u6a19\u3067\u3042\u308a\u3001BRCA\u5909\u7570\u304b\u3064SLFN11\u967d\u6027\u306e\u5834\u5408\u30015\u5e74\u6642\u70b9\u3067\u306e\u751f\u5b58\u7387\u304c\u4ed6\u306e\u7fa4\u306b\u6bd4\u3079\u6700\u3082\u9ad8\u304b\u3063\u305f\u3002\u660e\u77f3\u5148\u751f\u306e\u5b66\u4f4d\u8ad6\u6587\u3002<\/p>\n<ul>\n<li>Schlafen 11 (SLFN11) kills cancer cells undergoing unscheduled re-replication<br \/>\nJunko Murai, Michele Ceribelli, Haiqing Fu, Christophe E. Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I. Aladjem, Craig J. Thomas, Yves Pommier<br \/>\nMolecular Cancer Therapeutics 22(8) 985-995 2023\u5e745\u670822\u65e510.1158\/1535-7163.MCT-22-0552\/3333375\/mct-22-0552.pdf,10.1158\/1535-7163.mct-22-0552<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">SLFN11\u306f\u8907\u88fd\u30b9\u30c8\u30ec\u30b9\u3092\u7d30\u80de\u306b\u304b\u3051\u305f\u6642\u306b\u751f\u3058\u308bssDNA\u306b\u7d50\u5408\u3057\u3066\u3001\u8907\u88fd\u30d6\u30ed\u30c3\u30af\u3092\u8d77\u3053\u3059\u3002neddylation inhibitor\u3067\u3042\u308bMLN4924\u3092\u6295\u4e0e\u3057\u305f\u6642\u306b\u3001CDT1\u306e\u84c4\u7a4d\u306b\u3088\u3063\u3066\u3001M\u671f\u306e\u7d30\u80de\u304cre-replication\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u3053\u306ere-replication\u306f\u6b63\u5e38\u8907\u88fd\u3067\u306f\u306a\u304fssDNA\u304c\u3042\u3061\u3053\u3061\u306b\u3067\u304d\u308b\u3088\u3046\u306a\u7570\u5e38\u306a\uff08stressed)\u8907\u88fd\u3067\u3042\u308b\u3002\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001SLFN11\u304cre-replication\u6642\u306b\u751f\u3058\u308bssDNA\u306b\u7d50\u5408\u3057\u3066\u3001re-replication\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002re-replication\u306f\u6297\u304c\u3093\u4f5c\u7528\u306b\u3064\u306a\u304c\u308b\u304c\u3001SLFN11\u304cre-replication\u3092\u6b62\u3081\u3066\u3057\u307e\u3046\u3053\u3068\u3067\u3001\u6297\u304c\u3093\u4f5c\u7528\u306f\u3055\u3089\u306b\u5f37\u304f\u306a\u3063\u305f\u3002\u3064\u307e\u308a\u3001SLFN11\u306fMLN4924\u306b\u5bfe\u3057\u3066\u3082\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\uff08\u305f\u3060\u3057\u3001\u5ea6\u5408\u3044\u306fCPT\u3084\u30d7\u30e9\u30c1\u30ca\u306b\u6bd4\u3079\u308b\u3068\u5f31\u3044\uff09\u3002NIH\u6642\u4ee3\u306e\u30c9\u30e9\u30c3\u30af\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u65e5\u672c\u306b\u6301\u3061\u5e30\u3063\u3066\u3001\u6570\u5e74\u304c\u304b\u308a\u3067\u5b8c\u6210\u3055\u305b\u305f\u306e\u3067\u81ea\u5206\u304c\u30d5\u30a1\u30fc\u30b9\u30c8\u3002<\/p>\n<ul>\n<li>Epigenetic upregulation of Schlafen11 renders WNT- and SHH-activated medulloblastomas sensitive to\u00a0cisplatin.<br \/>\nSatoshi Nakata, Junko Murai, Masayasu Okada, Haruhiko Takahashi, Tyler H Findlay, Kristen Malebranche, Akhila Parthasarathy, Satoshi Miyashita, Ramil Gabdulkhaev, Ilan Benkimoun, Sabine Druillennec, Sara Chabi, Eleanor Hawkins, Hiroaki Miyahara, Kensuke Tateishi, Shinji Yamashita, Shiori Yamada, Taiki Saito, Jotaro On, Jun Watanabe, Yoshihiro Tsukamoto, Junichi Yoshimura, Makoto Oishi, Toshimichi Nakano, Masaru Imamura, Chihaya Imai, Tetsuya Yamamoto, Hideo Takeshima, Atsuo T Sasaki, Fausto J Rodriguez, Sumihito Nobusawa, Pascale Varlet, Celio Pouponnot, Satoru Osuka, Yves Pommier, Akiyoshi Kakita, Yukihiko Fujii, Eric H Raabe, Charles G Eberhart, Manabu Natsumeda<br \/>\nNeuro-oncology 25(5) 899-912 2023\u5e745\u67084\u65e510.1093\/neuonc\/noac243,10.1093\/neuonc\/noac243<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">\u7fa4\u99ac\u5927\u5b66\u8133\u5916\u79d1\u306e\u4e2d\u7530\u5148\u751f\u3001\u65b0\u6f5f\u5927\u5b66\u8133\u5916\u79d1\u306e\u68d7\u7530\u5148\u751f\u3001NIH\u3001\u30b8\u30e7\u30f3\u30b9\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u3068\u306e\u30b3\u30e9\u30dc\u8ad6\u6587\u3002\u8133\u816b\u760d\u306e\u4e00\u3064\u3067\u3042\u308b\u9ac4\u82bd\u816b\uff08medulloblastoma\uff09\u306e\u30b5\u30d6\u30bf\u30a4\u30d7 WNT-type\u306f\u3001\u30d7\u30e9\u30c1\u30ca\u88fd\u5264\u304c\u8457\u52b9\u3057\u3084\u3059\u304f\u3001\u751f\u547d\u4e88\u5f8c\u304c\u826f\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u305f\u3002\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001WNT-type\u306e\u591a\u304f\u3068SHH-type\u306e\u4e00\u90e8\u3067\u306fSLFN11\u304c\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u3001\u3055\u3089\u306bSLFN11\u304cmedulloblastoma\u306b\u304a\u3044\u3066\u3082\u85ac\u5264\u611f\u53d7\u6027\u3092\u9ad8\u3081\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u8133\u795e\u7d4c\u9818\u57df\u306e\u6700\u9ad8\u5cf0\u96d1\u8a8cNeuro-oncology\u3092\u4e00\u672c\u72d9\u3044\u3067\u3001requirement\u3092\u6b63\u78ba\u306b\u628a\u63e1\u3057\u3001\u9806\u8abf\u306b\u30a2\u30af\u30bb\u30d7\u30c8\u307e\u3067\u3053\u304e\u3064\u3051\u305f\u68d7\u7530\u5148\u751f\u306ePI\u3068\u3057\u3066\u306e\u624b\u8155\u306b\u611f\u9298\u3092\u53d7\u3051\u305f\u3002<\/p>\n<ul>\n<li>BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality<br \/>\nJunko Murai, Yves Pommier<br \/>\nCancer Research 83(8) 1173-1174 2023\u5e744\u670814\u65e510.1158\/0008-5472.can-23-0628,https:\/\/aacrjournals.org\/cancerres\/article-pdf\/83\/8\/1173\/3320562\/1173.pdf,10.1158\/0008-5472.can-23-0628<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">AACR\u304c\u9078\u3093\u3060\u8ad6\u6587\uff08Dr. Ashworsh\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u304cBRCAness\u3092\u6700\u521d\u306b\u63d0\u5531\u3057\u305f\u8ad6\u6587\uff09\u3078\u306e\u30b3\u30e1\u30f3\u30bf\u30ea\u30fc\u8a18\u4e8b\u3002PARP\u963b\u5bb3\u5264\u304c\u307e\u3060\u307e\u3060\u71b1\u3044\uff01<\/p>\n<ul>\n<li>Schlafen family member 11 indicates favorable prognosis of patients with head and neck cancer following platinum-based chemoradiotherapy<br \/>\nSeijiro Hamada, Satoshi Kano, Junko Murai, Takayoshi Suzuki, Nayuta Tsushima, Takatsugu Mizumachi, Masanobu Suzuki, Tsuyoshi Takashima, Daiki Taniyama, Naoya Sakamoto, Yoichiro Fujioka, Yusuke Ohba, Akihiro Homma<br \/>\nFrontiers in Oncology 12 978875-978875 2023\u5e741\u670819\u65e510.3389\/fonc.2022.978875,https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.978875\/full,10.3389\/fonc.2022.978875<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">\u5317\u6d77\u9053\u5927\u5b66\u8033\u9f3b\u54bd\u5589\u79d1\u306e\u6d5c\u7530\u5148\u751f\u3089\u3068\u306e\u30b3\u30e9\u30dc\u8ad6\u6587\u3002\u982d\u9838\u90e8\u764c\u306b\u304a\u3044\u3066\u3001SLFN11\u304c\u30b1\u30e2\u30e9\u30b8\u611f\u53d7\u6027\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u8ad6\u6587\u3002\u982d\u9838\u90e8\u304c\u3093\u3067\u306f\u3001\u5916\u79d1\u7684\u306b\u54bd\u982d\u5589\u982d\u3092\u6458\u51fa\u3059\u308bvs\u5316\u5b66\u7642\u6cd5\u3067\u6839\u6cbb\u3092\u76ee\u6307\u3059\u3001\u306e\uff12\u629e\u3092\u8feb\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u5f8c\u8005\u3092\u9078\u3076\u6839\u62e0\u3068\u3057\u3066SLFN11\u304c\u6709\u7528\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u307e\u3055\u306bSLFN11\u306e\u6d3b\u7528\u3057\u3069\u3053\u308d\u3067\u3042\u308a\u3001\u5b9f\u81e8\u5e8a\u3078\u306e\u5fdc\u7528\u3092\u9858\u3063\u3066\u3044\u308b\u3002\u6d5c\u7530\u5148\u751f\u306e\u5b66\u4f4d\u8ad6\u6587\u3002<\/p>\n<ul>\n<li>The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells<br \/>\nChristopher Noyes, Shunsuke Kitajima, Fengkai Li, Yusuke Suita, Saradha Miriyala, Shakson Isaac, Nagib Ahsan, Erik Knelson, Amir Vajdi, Tetsuo Tani, Tran C. Thai, Derek Xu, Junko Murai, Nikos Tapinos, Chiaki Takahashi, David A. Barbie, Mamiko Yajima<br \/>\nCommunications Biology 6(1) 2023\u5e741\u670818\u65e510.1038\/s42003-023-04444-7,https:\/\/www.nature.com\/articles\/s42003-023-04444-7.pdf,https:\/\/www.nature.com\/articles\/s42003-023-04444-7,10.1038\/s42003-023-04444-7<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">\u7814\u7a76\u8005\u53cb\u9054\u30d6\u30e9\u30a6\u30f3\u5927\u5b66\u77e2\u5cf6\u307e\u307f\u3053\u3055\u3093\u3068\u306e\u30b3\u30e9\u30dc\u8ad6\u6587\u3002<\/p>\n<ul>\n<li>Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells<br \/>\nHarada, Y., Mizote, Y., Suzuki, T., Hirayama, A., Ikeda, S., Nishida, M., Hiratsuka, T., Ueda, A., Imagawa, Y., Maeda, K., Ohkawa, Y., Murai, J., Freeze, H.H., Miyoshi, E., Higashiyama, S., Udono, H., Dohmae, N., Tahara, H., Taniguchi, N.<br \/>\neLife 12 2023\u5e7410.7554\/eLife.83870,http:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85164999733&amp;partnerID=MN8TOARS,10.7554\/eLife.83870<\/li>\n<li>Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing a Dramatic Response to Methotrexate-Case Report.<br \/>\nYoshihiro Mouri, Manabu Natsumeda, Noritaka Okubo, Taro Sato, Taiki Saito, Kohei Shibuya, Shiori Yamada, Jotaro On, Yoshihiro Tsukamoto, Masayasu Okada, Makoto Oishi, Takeyoshi Eda, Junko Murai, Hiroshi Shimizu, Akiyoshi Kakita, Yukihiko Fujii<br \/>\nJournal of clinical medicine 11(19) 2022\u5e749\u670822\u65e510.3390\/jcm11195548,10.3390\/jcm11195548<\/li>\n<li>Reconsidering the mechanisms of action of PARP inhibitors based on clinical outcomes.<br \/>\nHiroshi Onji, Junko Murai<br \/>\nCancer science 113(9) 2943-2951 2022\u5e749\u670810.1111\/cas.15477,10.1111\/cas.15477<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">PARP\u963b\u5bb3\u5264\u306e\u4f5c\u7528\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u306e\u7dcf\u8aac\u3002\u306a\u305cHRP\u306b\u3082PARP\u963b\u5bb3\u5264\u304c\u4f7f\u308f\u308c\u308b\u306e\u304b\u3001talazoparib, olaparib, niraparib\u306e\u9055\u3044\u306a\u3069\u3002<\/p>\n<ul>\n<li>Prognostic impact of Schlafen 11 in bladder cancer patients treated with platinum-based chemotherapy.<br \/>\nDaiki Taniyama, Naoya Sakamoto, Tsuyoshi Takashima, Masahiko Takeda, Quoc Thang Pham, Shoichi Ukai, Ryota Maruyama, Kenji Harada, Takashi Babasaki, Yohei Sekino, Tetsutaro Hayashi, Kazuhiro Sentani, Yves Pommier, Junko Murai, Wataru Yasui<br \/>\nCancer science 113(2) 784-795 2022\u5e742\u670810.1111\/cas.15207,10.1111\/cas.15207<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">NIH\u306b\u7559\u5b66\u3057\u305f\u8c37\u5c71\u3055\u3093\u3089\u3068\u306e\u30b3\u30e9\u30dc\u8ad6\u6587\u3002\u8180\u80f1\u764c\u306b\u304a\u3044\u3066\u4e16\u754c\u521d\u306eSLFN11\u306e\u7814\u7a76\u3002<\/p>\n<ul>\n<li>Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway<br \/>\nYasuhisa Murai, Ukhyun Jo, Junko Murai, Shinsaku Fukuda, Naoko Takebe, Yves Pommier<br \/>\niScience 24(10) 103173-103173 2021\u5e7410\u670810.1016\/j.isci.2021.103173,10.1016\/j.isci.2021.103173<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">SLFN11\u306e\u767a\u73fe\u5236\u5fa1\u306f\u3081\u3061\u3083\u5927\u4e8b\u3067\u3059\u304c\u3001JAK\u30b7\u30b0\u30ca\u30eb\u3067SLFN11\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u8ad6\u6587\u3002\uff11st\u306e\u6751\u4e95\u3084\u3059\u3055\u3093\u306f\u3001\u5f18\u524d\u5927\u5b66\u5927\u5b66\u9662\u6642\u4ee3\u306bNIH\u306b\u7559\u5b66\u3002\u308f\u305a\u304b2\u5e74\u3067\u51c4\u307e\u3058\u3044\u696d\u7e3e\u3092\u3042\u3052\u305f\u304c\u3001\u3053\u306e\u8ad6\u6587\u306f\u305d\u306e\u4e00\u3064\u3002<\/p>\n<ul>\n<li>Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers.<br \/>\nTsuyoshi Takashima, Daiki Taniyama, Naoya Sakamoto, Maika Yasumoto, Ryuichi Asai, Takuya Hattori, Ririno Honma, Pham Quoc Thang, Shoichi Ukai, Ryota Maruyama, Kenji Harada, Kazuya Kuraoka, Kazuaki Tanabe, Atsuo T Sasaki, Hideki Ohdan, Eiichi Morii, Junko Murai, Wataru Yasui<br \/>\nBritish journal of cancer 125(1) 65-77 2021\u5e747\u670810.1038\/s41416-021-01364-3,10.1038\/s41416-021-01364-3<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">\u80c3\u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308bSLFN11\u306e\u6709\u7528\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u4e16\u754c\u521d\u306e\u8ad6\u6587\u3002\uff08\u5f53\u6642\uff09\u5e83\u5cf6\u5927\u5b66\u5206\u5b50\u75c5\u7406\u5b66\uff11st\u306e\u9ad8\u5cf6\u3055\u3093\u30012nd\u306e\u8c37\u5c71\u3055\u3093\u30013rd\uff08\u30b3\u30ec\u30b9\u30dd\uff09\u306e\u5742\u672c\u3055\u3093\u306e\u898b\u4e8b\u306a\u30c1\u30fc\u30e0\u30ef\u30fc\u30af\u3067\u3001SLFN11\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u7814\u7a76\u306e\u571f\u53f0\u304c\u3053\u306e\u8ad6\u6587\u3067\u3067\u304d\u305f\u3088\u3046\u306b\u601d\u3046\u3002\u3053\u306e\u304a\u4e09\u65b9\u3068\u51fa\u4f1a\u3048\u3066\u672c\u5f53\u306b\u5e78\u904b\u3060\u3063\u305f\u3002\u3053\u306e\u51fa\u4f1a\u3044\u3068\u672c\u8ad6\u6587\u306e\u304a\u304b\u3052\u3067\u3001\u305d\u306e\u5f8c\u306e\u591a\u304f\u306e\u30e9\u30dc\u3068\u306eSLFN11\u30b3\u30e9\u30dc\u306b\u7e4b\u304c\u3063\u305f\u3002\u9ad8\u5cf6\u3055\u3093\u306e\u4fee\u58eb\u8ad6\u6587\u305d\u306e\uff12\u3002<\/p>\n<ul>\n<li>SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243<br \/>\nYasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa M. Jenkins, Shar-Yin N. Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier<br \/>\nCancer Research 81(11) 3067-3078 2021\u5e746\u67081\u65e510.1158\/0008-5472.can-20-2694,https:\/\/syndication.highwire.org\/content\/doi\/10.1158\/0008-5472.CAN-20-2694,10.1158\/0008-5472.can-20-2694<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">SLFN11\u967d\u6027\u7d30\u80de\u306e\u65b9\u304c\u85ac\u5264\u611f\u53d7\u6027\u304c\u304a\u3061\u308b\u3068\u3044\u3046\u3001\u5f53\u521d\u6469\u8a36\u4e0d\u601d\u8b70\u3060\u3063\u305fTAK243\u306e\u8b0e\u3092\u89e3\u3044\u305f\u8ad6\u6587\u3002SLFN11\u306f\u3001proteotoxic stress\u3092\u6291\u5236\u3059\u308b\u65b9\u5411\u306b\u50cd\u304f\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/p>\n<ul>\n<li>SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR\/CHK1 inhibitors.<br \/>\nUkhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M Miller Jenkins, Yves Pommier<br \/>\nProceedings of the National Academy of Sciences of the United States of America 118(6) 2021\u5e742\u67089\u65e510.1073\/pnas.2015654118,10.1073\/pnas.2015654118<\/li>\n<li>De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma<br \/>\nMaruyama, A., Sato, Y., Nakayama, J., Murai, J., Ishikawa, T., Soga, T., Makinoshima, H.<br \/>\nScientific Reports 11(1) 2021\u5e7410.1038\/s41598-021-92948-9,http:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85108953819&amp;partnerID=MN8TOARS,10.1038\/s41598-021-92948-9<\/li>\n<li>Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development.<br \/>\nFumiya Moribe, Momoko Nishikori, Tsuyoshi Takashima, Daiki Taniyama, Nobuyuki Onishi, Hiroshi Arima, Hiroyuki Sasanuma, Remi Akagawa, Fathi Elloumi, Shunichi Takeda, Yves Pommier, Eiichi Morii, Akifumi Takaori-Kondo, Junko Murai<br \/>\nPloS one 16(1) e0237554 2021\u5e7410.1371\/journal.pone.0237554,10.1371\/journal.pone.0237554<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">\u30d2\u30c8\u306e\u6b63\u5e38B\u7d30\u80de\u306e\u5206\u5316\u6bb5\u968e\u306b\u304a\u3051\u308bSLFN11\u306e\u767a\u73fe\u91cf\u3092\u3001\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u89e3\u6790\u3068\u3001\u30d2\u30c8\u7d44\u7e54\u306e\u80da\u4e2d\u5fc3\u306a\u3069\u3092\u7528\u3044\u3066\u660e\u3089\u304b\u306b\u3057\u305f\u8ad6\u6587\u3002\u300cSLFN11\u3063\u3066\u6b63\u5e38\u7d30\u80de\u3067\u306a\u306b\u3057\u3066\u308b\u3093\uff1f\u3069\u3053\u3067\u767a\u73fe\u3059\u308b\u306e\uff1f\u300d\u3068\u3088\u304f\u805e\u304b\u308c\u308b\u304c\u3001\u305d\u306e\u7b54\u3048\u306e\u4e00\u90e8\u306f\u3053\u3053\u306b\u3042\u308a\u3002preB\u7d30\u80de\u3068mature B\u7d30\u80de\uff08\u5f62\u8cea\u7d30\u80de\u542b\u3080\uff09\u306fSLFN11\u3092\u9ad8\u767a\u73fe\u3059\u308b\u304c\u3001\u305d\u306e\u9014\u4e2d\u3067\u306f\u767a\u73fe\u304c\u6025\u6fc0\u306b\u4e0b\u304c\u308b\u3002\u80da\u4e2d\u5fc3\u3067\u306f\u3001somatic recombination, hypermutation\u304c\u8d77\u3053\u308a\u3001\u304b\u3064\u7206\u767a\u6483\u306b\u7d30\u80de\u304c\u5897\u3048\u308b\u306e\u3067\u3001SLFN11\u304c\u967d\u6027\u3060\u3068\u30de\u30ba\u30a4\u306e\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u4e00\u904e\u6027\u306bSLFN11\u306e\u767a\u73fe\u304c\u4e0b\u304c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3084\u751f\u7406\u5b66\u7684\u610f\u7fa9\u3092\u89e3\u660e\u3057\u305f\u3044\u3068\u601d\u3044\u3064\u3064\u3001\u307e\u3060\u3067\u304d\u3066\u3044\u306a\u3044\u3002\uff11st\u306e\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u306e\u68ee\u90e8\u304f\u3093\u306f\u5f53\u6642\u5b66\u90e8\u751f\uff01\uff01\u4eac\u5927\u306e\u30ab\u30ea\u30ad\u30e5\u30e9\u30e0\u3067\u3042\u308b\u30de\u30a4\u30b3\u30fc\u30b9\u3067NIH\u306b\u77ed\u671f\u7559\u5b66\u3057\u305f\u6642\u306b\u3001\u79c1\u3068SLFN11\u306b\u51fa\u4f1a\u3044\u3001\u5e30\u56fd\u5f8c\u3082\u72ec\u81ea\u3067\u7814\u7a76\u3092\u7d9a\u3051\u305f\u30b9\u30fc\u30d1\u30fc\u5b66\u751f\u3055\u3093\u3002<\/p>\n<ul>\n<li>Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer.<br \/>\nJayakumar Nair, Tzu-Ting Huang, Junko Murai, Brittany Haynes, Patricia S Steeg, Yves Pommier, Jung-Min Lee<br \/>\nOncogene 39(33) 5520-5535 2020\u5e748\u670810.1038\/s41388-020-1383-4,10.1038\/s41388-020-1383-4<\/li>\n<li>Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq.<br \/>\nTsuyoshi Takashima, Naoya Sakamoto, Junko Murai, Daiki Taniyama, Ririno Honma, Shoichi Ukai, Ryota Maruyama, Kazuya Kuraoka, Vinodh N Rajapakse, Yves Pommier, Wataru Yasui<br \/>\nVirchows Archiv : an international journal of pathology 478(3) 569-579 2020\u5e745\u670830\u65e510.1007\/s00428-020-02840-6,10.1007\/s00428-020-02840-6<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">\u5e83\u5cf6\u5927\u5b66\u5206\u5b50\u75c5\u7406\u5b66\u6559\u5ba4\u306e\u3001\u5742\u672c\u5148\u751f\u3089\u3068\u306e\u30b3\u30e9\u30dc\u8ad6\u6587\u3002SLFN11\u306eIHC\u309216\u81d3\u5668700\u75c7\u4f8b\u3067\u5b9f\u65bd\u3057\u305f\u7d50\u679c\u3092\u307e\u3068\u3081\u305f\u8ad6\u6587\u3002human genome atlas\u3067\u3048\u3048\u3084\u3093\u3001TCGA\u3067\u3048\u3048\u3084\u3093\u3001\u3068\u601d\u3063\u305f\u65b9\u306f\u305c\u3072\u3054\u4e00\u8aad\u3092\uff01SLFN11\u306e\u8a55\u4fa1\u306b\u306fIHC\u304c\u4e00\u756a\u306a\u306e\u3067\u3059\u3002SLFN11\u7814\u7a76\u306e\u30d0\u30a4\u30d6\u30eb\u7684\u5b58\u5728\u3002\uff11s\u3068\u306e\u9ad8\u5cf6\u3055\u3093\u306f\uff08\u5f53\u6642\uff09\u4fee\u58eb\u5b66\u751f\u3067\u3001\u4fee\u58eb\u8ad6\u6587\u305d\u306e\uff11\u3002<\/p>\n<ul>\n<li>Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.<br \/>\nDaniel Rathkey, Manakamana Khanal, Junko Murai, Jingli Zhang, Manjistha Sengupta, Qun Jiang, Betsy Morrow, Christine N Evans, Raj Chari, Patricia Fetsch, Hye-Jung Chung, Liqiang Xi, Mark Roth, Armando Filie, Mark Raffeld, Anish Thomas, Yves Pommier, Raffit Hassan<br \/>\nJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 15(5) 843-859 2020\u5e745\u670810.1016\/j.jtho.2020.01.012,10.1016\/j.jtho.2020.01.012<\/li>\n<li>BAMscale: quantification of next-generation sequencing peaks and generation of scaled coverage tracks.<br \/>\nLorinc S Pongor, Jacob M Gross, Roberto Vera Alvarez, Junko Murai, Sang-Min Jang, Hongliang Zhang, Christophe Redon, Haiqing Fu, Shar-Yin Huang, Bhushan Thakur, Adrian Baris, Leonardo Marino-Ramirez, David Landsman, Mirit I Aladjem, Yves Pommier<br \/>\nEpigenetics &amp; chromatin 13(1) 21-21 2020\u5e744\u670822\u65e510.1186\/s13072-020-00343-x,10.1186\/s13072-020-00343-x<\/li>\n<li>Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress.<br \/>\nJunko Murai, Hongliang Zhang, Lorinc Pongor, Sai-Wen Tang, Ukhyun Jo, Fumiya Moribe, Yixiao Ma, Masaru Tomita, Yves Pommier<br \/>\nCell reports 30(12) 4137-4151 2020\u5e743\u670824\u65e510.1016\/j.celrep.2020.02.117,10.1016\/j.celrep.2020.02.117<\/li>\n<li>The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib.<br \/>\nLaetitia Marzi, Ludmila Szabova, Melanie Gordon, Zoe Weaver Ohler, Shyam K Sharan, Michael L Beshiri, Moudjib Etemadi, Junko Murai, Kathleen Kelly, Yves Pommier<br \/>\nClinical cancer research : an official journal of the American Association for Cancer Research 25(20) 6206-6216 2019\u5e7410\u670815\u65e510.1158\/1078-0432.CCR-19-0419,10.1158\/1078-0432.CCR-19-0419<\/li>\n<li>Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies.<br \/>\nJunko Murai, Anish Thomas, Markku Miettinen, Yves Pommier<br \/>\nPharmacology &amp; therapeutics 201 94-102 2019\u5e749\u670810.1016\/j.pharmthera.2019.05.009,10.1016\/j.pharmthera.2019.05.009<\/li>\n<li>Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1.<br \/>\nJunko Murai, Yves Pommier<br \/>\nCancer research 79(10) 2460-2461 2019\u5e745\u670815\u65e510.1158\/0008-5472.CAN-19-0798,10.1158\/0008-5472.CAN-19-0798<\/li>\n<li>Restored replication fork stabilization, a mechanism of PARP inhibitor resistance, can be overcome by cell cycle checkpoint inhibition.<br \/>\nBrittany Haynes, Junko Murai, Jung-Min Lee<br \/>\nCancer treatment reviews 71 1-7 2018\u5e7412\u670810.1016\/j.ctrv.2018.09.003,10.1016\/j.ctrv.2018.09.003<\/li>\n<li>Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors.<br \/>\nLaetitia Marzi, Keli Agama, Junko Murai, Simone Difilippantonio, Amy James, Cody J Peer, William D Figg, Daniel Beck, Mohamed S A Elsayed, Mark Cushman, Yves Pommier<br \/>\nMolecular cancer therapeutics 17(8) 1694-1704 2018\u5e748\u670810.1158\/1535-7163.MCT-18-0028,10.1158\/1535-7163.MCT-18-0028<\/li>\n<li>The evolving landscape of predictive biomarkers of response to PARP inhibitors.<br \/>\nAnish Thomas, Junko Murai, Yves Pommier<br \/>\nThe Journal of clinical investigation 128(5) 1727-1730 2018\u5e745\u67081\u65e510.1172\/JCI120388,10.1172\/JCI120388<\/li>\n<li>Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors.<br \/>\nSai-Wen Tang, Anish Thomas, Junko Murai, Jane B Trepel, Susan E Bates, Vinodh N Rajapakse, Yves Pommier<br \/>\nClinical cancer research : an official journal of the American Association for Cancer Research 24(8) 1944-1953 2018\u5e744\u670815\u65e510.1158\/1078-0432.CCR-17-0443,10.1158\/1078-0432.CCR-17-0443<\/li>\n<li>Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform.<br \/>\nShar-Yin N Huang, Ilaria Dalla Rosa, Stephanie A Michaels, David V Tulumello, Keli Agama, Salim Khiati, Sae Rin Jean, Simone A Baechler, Valentina M Factor, Sudhir Varma, Junko Murai, Lisa M Miller Jenkins, Shana O Kelley, Yves Pommier<br \/>\nEMBO reports 19(3) 2018\u5e743\u670810.15252\/embr.201642139,10.15252\/embr.201642139<\/li>\n<li>SLFN11 Blocks Stressed Replication Forks Independently of ATR.<br \/>\nJunko Murai, Sai-Wen Tang, Elisabetta Leo, Simone A Baechler, Christophe E Redon, Hongliang Zhang, Muthana Al Abo, Vinodh N Rajapakse, Eijiro Nakamura, Lisa M Miller Jenkins, Mirit I Aladjem, Yves Pommier<br \/>\nMolecular cell 69(3) 371-384 2018\u5e742\u67081\u65e510.1016\/j.molcel.2018.01.012,10.1016\/j.molcel.2018.01.012<\/li>\n<li>Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer.<br \/>\nAlberto Ballestrero, Davide Bedognetti, Domenico Ferraioli, Paola Franceschelli, Sana Intidhar Labidi-Galy, Elisabetta Leo, Junko Murai, Yves Pommier, Petros Tsantoulis, Valerio Gaetano Vellone, Gabriele Zoppoli<br \/>\nJournal of translational medicine 15(1) 199-199 2017\u5e7410\u67082\u65e510.1186\/s12967-017-1296-3,10.1186\/s12967-017-1296-3<\/li>\n<li>Targeting DNA repair and replication stress in the treatment of ovarian cancer.<br \/>\nJunko Murai<br \/>\nInternational journal of clinical oncology 22(4) 619-628 2017\u5e748\u670810.1007\/s10147-017-1145-7,10.1007\/s10147-017-1145-7<\/li>\n<li>A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress<br \/>\nPeter M. Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E. Koch, Timothy J. Eisen, Justin R. Pritchard, Yves Pommier, Stephen J. Lippard, Michael T. Hemann<br \/>\nNATURE MEDICINE 23(4) 461-+ 2017\u5e744\u670810.1038\/nm.4291,10.1038\/nm.4291<\/li>\n<li>ALC1\/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.<br \/>\nMasataka Tsuda, Kosai Cho, Masato Ooka, Naoto Shimizu, Reiko Watanabe, Akira Yasui, Yuka Nakazawa, Tomoo Ogi, Hiroshi Harada, Keli Agama, Jun Nakamura, Ryuta Asada, Haruna Fujiike, Tetsushi Sakuma, Takashi Yamamoto, Junko Murai, Masahiro Hiraoka, Kaoru Koike, Yves Pommier, Shunichi Takeda, Kouji Hirota<br \/>\nPloS one 12(11) e0188320 2017\u5e7410.1371\/journal.pone.0188320,10.1371\/journal.pone.0188320<\/li>\n<li>Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition.<br \/>\nJunko Murai, Ying Feng, Guoying K Yu, Yuanbin Ru, Sai-Wen Tang, Yuqiao Shen, Yves Pommier<br \/>\nOncotarget 7(47) 76534-76550 2016\u5e7411\u670822\u65e510.18632\/oncotarget.12266,10.18632\/oncotarget.12266<\/li>\n<li>In vivo evidence for translesion synthesis by the replicative DNA polymerase \u03b4<br \/>\nKouji Hirota, Masataka Tsuda, Mohiuddin, Toshiki Tsurimoto, Isadora S. Cohen, Zvi Livneh, Kaori Kobayashi, Takeo Narita, Kana Nishihara, Junko Murai, Shigenori Iwai, Guillaume Guilbaud, Julian E. Sale, Shunichi Takeda<br \/>\nNucleic Acids Research 44(15) 7242-7250 2016\u5e749\u67086\u65e510.1093\/nar\/gkw439,10.1093\/nar\/gkw439<\/li>\n<li>SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma.<br \/>\nSai-Wen Tang, Sven Bilke, Liang Cao, Junko Murai, Fabricio G Sousa, Mihoko Yamade, Vinodh Rajapakse, Sudhir Varma, Lee J Helman, Javed Khan, Paul S Meltzer, Yves Pommier<br \/>\nClinical cancer research : an official journal of the American Association for Cancer Research 21(18) 4184-93 2015\u5e749\u670815\u65e510.1158\/1078-0432.CCR-14-2112,10.1158\/1078-0432.CCR-14-2112<\/li>\n<li>The POLD3 subunit of DNA polymerase \u03b4 can promote translesion synthesis independently of DNA polymerase \u03b6.<br \/>\nHirota K, Yoshikiyo K, Guilbaud G, Tsurimoto T, Murai J, Tsuda M, Phillips LG, Narita T, Nishihara K, Kobayashi K, Yamada K, Nakamura J, Pommier Y, Lehmann A, Sale JE, Takeda S<br \/>\nNucleic acids research 43(3) 1671-83 2015\u5e742\u670818\u65e510.1093\/nar\/gkv023,10.1093\/nar\/gkv023<\/li>\n<li>Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase i inhibitors and alkylating agents<br \/>\nMurai, J., Pommier, Y.<br \/>\nCancer Drug Discovery and Development 83 2015\u5e7410.1007\/978-3-319-14151-0_10,http:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85088854670&amp;partnerID=MN8TOARS,10.1007\/978-3-319-14151-0_10<\/li>\n<li>SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss<br \/>\nKouji Hirota, Masataka Tsuda, Junko Murai, Tokiyo Takagi, Islam Shamima Keka, Takeo Narita, Mari Fujita, Hiroyuki Sasanuma, Junya Kobayashi, Shunichi Takeda<br \/>\nGENES TO CELLS 19(10) 743-754 2014\u5e7410\u670810.1111\/gtc.12173,10.1111\/gtc.12173<\/li>\n<li>Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.<br \/>\nJunko Murai, Christophe Marchand, Sampada A Shahane, Hongmao Sun, Ruili Huang, Yiping Zhang, Adel Chergui, Jiuping Ji, James H Doroshow, Ajit Jadhav, Shunichi Takeda, Menghang Xia, Yves Pommier<br \/>\nDNA repair 21 177-82 2014\u5e749\u670810.1016\/j.dnarep.2014.03.006,10.1016\/j.dnarep.2014.03.006<\/li>\n<li>Biochemical Assays for the Discovery of TDP1 Inhibitors<br \/>\nChristophe Marchand, Shar-yin N. Huang, Thomas S. Dexheimer, Wendy A. Lea, Bryan T. Mott, Adel Chergui, Alena Naumova, Andrew G. Stephen, Andrew S. Rosenthal, Ganesha Rai, Junko Murai, Rui Gao, David J. Maloney, Ajit Jadhav, William L. Jorgensen, Anton Simeonov, Yves Pommier<br \/>\nMOLECULAR CANCER THERAPEUTICS 13(8) 2116-2126 2014\u5e748\u670810.1158\/1535-7163.MCT-13-0952,10.1158\/1535-7163.MCT-13-0952<\/li>\n<li>Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.<br \/>\nMaulik R Patel, Aaditya Bhatt, Jamin D Steffen, Adel Chergui, Junko Murai, Yves Pommier, John M Pascal, Louis D Trombetta, Frank R Fronczek, Tanaji T Talele<br \/>\nJournal of medicinal chemistry 57(13) 5579-601 2014\u5e747\u670810\u65e510.1021\/jm5002502,10.1021\/jm5002502<\/li>\n<li>Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).<br \/>\nYves Pommier, Shar-yin N Huang, Rui Gao, Benu Brata Das, Junko Murai, Christophe Marchand<br \/>\nDNA repair 19 114-29 2014\u5e747\u670810.1016\/j.dnarep.2014.03.020,10.1016\/j.dnarep.2014.03.020<\/li>\n<li>Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.<br \/>\nJunko Murai, Yiping Zhang, Joel Morris, Jiuping Ji, Shunichi Takeda, James H Doroshow, Yves Pommier<br \/>\nThe Journal of pharmacology and experimental therapeutics 349(3) 408-16 2014\u5e746\u670810.1124\/jpet.113.210146,10.1124\/jpet.113.210146<\/li>\n<li>PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.<br \/>\nBenu Brata Das, Shar-yin N Huang, Junko Murai, Ishita Rehman, Jean-Christophe Am\u00e9, Souvik Sengupta, Subhendu K Das, Papiya Majumdar, Hongliang Zhang, Denis Biard, Hemanta K Majumder, Val\u00e9rie Schreiber, Yves Pommier<br \/>\nNucleic acids research 42(7) 4435-49 2014\u5e744\u670810.1093\/nar\/gku088,10.1093\/nar\/gku088<\/li>\n<li>Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib<br \/>\nJ. Murai, S.-Y.N. Huang, A. Renaud, Y. Zhang, J. Ji, S. Takeda, J. Morris, B. Teicher, J.H. Doroshow, Y. Pommier<br \/>\nMolecular Cancer Therapeutics 13(2) 433-43 2014\u5e742\u670810.1158\/1535-7163.MCT-13-0803,10.1158\/1535-7163.MCT-13-0803<\/li>\n<li>Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel<br \/>\nYuko Maede, Hiroyasu Shimizu, Toru Fukushima, Toshiaki Kogame, Terukazu Nakamura, Tsuneharu Miki, Shunichi Takeda, Yves Pommier, Junko Murai<br \/>\nMOLECULAR CANCER THERAPEUTICS 13(1) 214-220 2014\u5e741\u670810.1158\/1535-7163.MCT-13-0551,10.1158\/1535-7163.MCT-13-0551<\/li>\n<li>TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs<br \/>\nShar-yin N. Huang, Junko Murai, Ilaria Dalla Rosa, Thomas S. Dexheimer, Alena Naumova, William H. Gmeiner, Yves Pommier<br \/>\nNUCLEIC ACIDS RESEARCH 41(16) 7793-7803 2013\u5e749\u670810.1093\/nar\/gkt483,10.1093\/nar\/gkt483<\/li>\n<li>Trapping of PARP1 and PARP2 by clinical PARP inhibitors<br \/>\nJ. Murai, S.-Y.N. Huang, B.B. Das, A. Renaud, Y. Zhang, J.H. Doroshow, J. Ji, S. Takeda, Y. Pommier<br \/>\nCancer Research 72(21) 5588-99 2012\u5e7411\u67081\u65e510.1158\/0008-5472.CAN-12-2753,10.1158\/0008-5472.CAN-12-2753<\/li>\n<li>TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1<br \/>\nZhihong Zeng, Abhishek Sharma, Limei Ju, Junko Murai, Lieve Umans, Liesbeth Vermeire, Yves Pommier, Shunichi Takeda, Danny Huylebroeck, Keith W. Caldecott, Sherif F. El-Khamisy<br \/>\nNUCLEIC ACIDS RESEARCH 40(17) 8371-8380 2012\u5e749\u670810.1093\/nar\/gks622,10.1093\/nar\/gks622<\/li>\n<li>Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells<br \/>\nJunko Murai, Shar-yin N. Huang, Benu Brata Das, Thomas S. Dexheimer, Shunichi Takeda, Yves Pommier<br \/>\nJOURNAL OF BIOLOGICAL CHEMISTRY 287(16) 12848-12857 2012\u5e744\u670810.1074\/jbc.M111.333963,10.1074\/jbc.M111.333963<\/li>\n<li>Conditional Deletion of Bmpr1a in Differentiated Osteoclasts Increases Osteoblastic Bone Formation, Increasing Volume of Remodeling Bone in Mice<br \/>\nMina Okamoto, Junko Murai, Yuuki Imai, Daisuke Ikegami, Nobuhiro Kamiya, Shigeaki Kato, Yuji Mishina, Hideki Yoshikawa, Noriyuki Tsumaki<br \/>\nJOURNAL OF BONE AND MINERAL RESEARCH 26(10) 2511-2522 2011\u5e7410\u670810.1002\/jbmr.477,10.1002\/jbmr.477<\/li>\n<li>Regulation of the Fanconi anemia pathway by a SUMO-like delivery network<br \/>\nKailin Yang, George-Lucian Moldovan, Patrizia Vinciguerra, Junko Murai, Shunichi Takeda, Alan D. D&amp;apos;Andrea<br \/>\nGENES &amp; DEVELOPMENT 25(17) 1847-1858 2011\u5e749\u670810.1101\/gad.17020911,10.1101\/gad.17020911<\/li>\n<li>Regulation of the Fanconi anemia pathway by a SUMO-like delivery network<br \/>\nKailin Yang, George -Lucian Moldovan, Patrizia Vinciguerra, Junko Murai, Shunichi Takeda, Alan D. D&#8217;Andrea<br \/>\nCANCER RESEARCH 71(17) 1847-1858 2011\u5e749\u670810.1158\/1538-7445.FBCR11-PR4,10.1158\/1538-7445.FBCR11-PR4<\/li>\n<li>The USP1\/UAF1 complex promotes double-strand break repair through homologous recombination<br \/>\nJ. Murai, K. Yang, D. Dejsuphong, K. Hirota, S. Takeda, A.D. D&#8217;Andrea<br \/>\nMolecular and Cellular Biology 31(12) 2462-9 2011\u5e746\u670810.1128\/MCB.05058-11,10.1128\/MCB.05058-11<\/li>\n<li>Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2<br \/>\nJunko Murai, Daisuke Ikegami, Mina Okamoto, Hideki Yoshikawa, Noriyuki Tsumaki<br \/>\nJOURNAL OF BIOLOGICAL CHEMISTRY 283(41) 27677-27687 2008\u5e7410\u670810.1074\/jbc.M803657200,10.1074\/jbc.M803657200<\/li>\n<li>Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways<br \/>\nTakao Iwai, Junko Murai, Hideki Yoshikawa, Noriyuki Tsumaki<br \/>\nJOURNAL OF BIOLOGICAL CHEMISTRY 283(40) 27154-27164 2008\u5e7410\u670810.1074\/jbc.M801175200,10.1074\/jbc.M801175200<\/li>\n<li>Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic<br \/>\nIwai, Takao, Harada, Yoshifumi, Imura, Koichi, Iwabuchi, Sadahiro, Murai, Junko, Hiramatsu, Kunihiko, Myoui, Akira, Yoshikawa, Hideki, Tsumaki, Noriyuki<br \/>\nJOURNAL OF BONE AND MINERAL METABOLISM 25(6) 392-399 2007\u5e7411\u670810.1007\/s00774-007-0777-5,10.1007\/s00774-007-0777-5<\/li>\n<li>Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development<br \/>\nM Okamoto, J Murai, H Yoshikawa, N Tsumaki<br \/>\nJOURNAL OF BONE AND MINERAL RESEARCH 21(7) 1022-1033 2006\u5e747\u670810.1359\/JBMR.060411,10.1359\/JBMR.060411<\/li>\n<li>Smad6\/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia<br \/>\nM Horiki, T Imamura, M Okamoto, M Hayashi, J Murai, A Myoui, T Ochi, K Miyazono, H Yoshikawa, N Tsumaki<br \/>\nJOURNAL OF CELL BIOLOGY 165(3) 433-445 2004\u5e745\u670810.1083\/jcb.200311015,10.1083\/jcb.200311015<\/li>\n<li>Role of BMPs and Smads during endochondral bone formation<br \/>\nTsumaki, N., Horiki, M., Murai, J., Yoshikawa, H.<br \/>\nClinical calcium 14(7) 52-57 2004\u5e74,http:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-16644372153&amp;partnerID=MN8TOARS<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Junko Murai\u306e\u3053\u308c\u307e\u3067\u306epublication (\u611b\u5a9b\u5927\u5b66\u4ee5\u524d\u3082\u542b\u3080\uff09\u3002 Co-expression of CD30 and SLFN11 serves as a dual biomarker for the  [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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