{"id":4532,"date":"2017-11-04T17:23:51","date_gmt":"2017-11-04T08:23:51","guid":{"rendered":"http:\/\/www.m.ehime-u.ac.jp\/school\/clpharma\/?p=4532"},"modified":"2022-08-08T10:44:43","modified_gmt":"2022-08-08T01:44:43","slug":"%e7%ac%ac11%e5%9b%9e%e3%80%80%e3%83%91%e3%83%bc%e3%82%ad%e3%83%b3%e3%82%bd%e3%83%b3%e7%97%85%e3%83%bb%e9%81%8b%e5%8b%95%e9%96%a2%e9%80%a3%e7%96%be%e6%82%a3%e3%82%b3%e3%83%b3%e3%82%b0%e3%83%ac%e3%82%b9","status":"publish","type":"post","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/clpharma\/blog\/2017\/%e7%ac%ac11%e5%9b%9e%e3%80%80%e3%83%91%e3%83%bc%e3%82%ad%e3%83%b3%e3%82%bd%e3%83%b3%e7%97%85%e3%83%bb%e9%81%8b%e5%8b%95%e9%96%a2%e9%80%a3%e7%96%be%e6%82%a3%e3%82%b3%e3%83%b3%e3%82%b0%e3%83%ac%e3%82%b9\/","title":{"rendered":"\u7b2c11\u56de\u3000\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u30fb\u904b\u52d5\u969c\u5bb3\u75be\u60a3\u30b3\u30f3\u30b0\u30ec\u30b9\uff08MDSJ\uff09"},"content":{"rendered":"

2017\u5e7410\u670826\u65e5-28\u65e5\u306b\u6771\u4eac\u3067\u958b\u50ac\u3055\u308c\u3066\u3044\u305f\u7b2c11\u56de\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u30fb\u904b\u52d5\u969c\u5bb3\u75be\u60a3\u30b3\u30f3\u30b0\u30ec\u30b9\uff08MDSJ\uff09\u306b\u3001
\n\u591a\u7530\u8061\u5148\u751f\u3001\u7814\u4fee\u533b\u306e\u5ee3\u702c\u672a\u512a\u5148\u751f\u3068\u3068\u3082\u306b\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002
\nMDSJ\u306f\u3001\u6771\u4eac\u3068\u4eac\u90fd\u306b\u30661\u5e74\u4ea4\u4ee3\u3067\u6bce\u5e74\u958b\u50ac\u3055\u308c\u3066\u3044\u308b\u5b66\u4f1a\u3067\u3001\u79c1\u306f\u53bb\u5e74\u306e\u4eac\u90fd\u306b\u5f15\u304d\u7d9a\u3044\u3066\u306e\u53c2\u52a0\u3068\u306a\u308a\u307e\u3059\u3002
\n\u51fa\u767a\u306e\u6570\u65e5\u524d\u307e\u3067\u5de8\u5927\u3067\u5927\u578b\u306e\u53f0\u98a821\u53f7\u304c\u65e5\u672c\u5217\u5cf6\u306b\u4e0a\u9678\u3057\u3066\u304a\u308a\u3001\u98db\u884c\u6a5f\u306f\u591a\u304f\u306e\u4fbf\u304c\u6b20\u822a\u3057\u3066\u304a\u308a\u307e\u3057\u305f\u304c\u3001
\n\u7121\u4e8b\u5b66\u4f1a\u524d\u65e5\u306e25\u65e5\u591c\u306b\u6771\u4eac\u3078\u305f\u3069\u308a\u7740\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n

1\u65e5\u76ee\uff0810\u670826\u65e5\uff09\u306f\u3001\u591a\u7530\u5148\u751f\u304c\u3001
\n\u300e\u30c9\u30d1\u30df\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u30b7\u30f3\u30c1\u30b0\u30e9\u30d5\u30a3\uff08DaTSPECT\uff09\u306b\u304a\u3051\u308bDaTQUANT\u306e\u6709\u7528\u6027\u306e\u691c\u8a0e\u300f<\/strong>\u306b\u3064\u3044\u3066\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002
\n\u591a\u7530\u5148\u751f\u306f\u7814\u4fee\u533b\u6642\u4ee3\u304b\u3089DaTSPECT\u3001MIBG\u5fc3\u7b4b\u30b7\u30f3\u30c1\u3068\u3044\u3063\u305f\u795e\u7d4c\u753b\u50cf\u8a3a\u65ad\u306b\u6df1\u304f\u5f93\u4e8b\u3055\u308c\u3066\u304a\u308a\u3001
\n\u4eca\u56de\u306fDaTSPECT\u306b\u304a\u3051\u308b\u89e3\u6790\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3067\u3042\u308bDaTView\u3068DaTQUANT\u306e\u6bd4\u8f03\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u767a\u8868\u3092\u884c\u3044\u307e\u3057\u305f\u3002
\n\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u304a\u3088\u3073\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c7\u5019\u7fa4\u306e\u8a3a\u65ad\u30fb\u8a55\u4fa1\u304a\u3044\u3066\u3001DATView\u306b\u304a\u3051\u308bSBR (Specific Binding ratio) \u304c\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u57fa\u6e96\u7dda\u3092\u76ee\u8996\u306b\u3088\u308a\u8a2d\u5b9a\u3059\u308b\u3053\u3068\u304b\u3089\u8aa4\u5dee\u304c\u751f\u3058\u3084\u3059\u3044\u3068\u3044\u308f\u308c\u3066\u304a\u308a\u3001\u307e\u305f\u8996\u899a\u7684\u306a\u96c6\u7a4d\u4f4e\u4e0b\u3068SBR\u5024\u306b\u4e56\u96e2\u304c\u307f\u3089\u308c\u308b\u5834\u5408\u3092\u5c11\u306a\u304b\u3089\u305a\u8a8d\u3081\u308b\u3068\u3044\u3063\u305f\u554f\u984c\u304c\u53d6\u308a\u4e0a\u3052\u3089\u308c\u3066\u304a\u308a\u307e\u3059\u3002\u305d\u308c\u306b\u5bfe\u3057DaTQUANT\u3067\u306f\u81ea\u52d5\u51e6\u7406\u306b\u3066\u89e3\u6790\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u304b\u3089\u3001SUR (Specific Uptake Ratio) \u5024\u306f\u9ad8\u3044\u518d\u73fe\u6027\u3092\u6709\u3059\u308b\u3068\u3044\u308f\u308c\u3066\u304a\u308a\u3001\u307e\u305f\u7dda\u6761\u4f53\u30923\u90e8\u4f4d\u306b\u7d30\u5206\u5316\u3057\u3066\u8a55\u4fa1\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u7cbe\u5ea6\u306e\u9ad8\u3044\u89e3\u6790\u304c\u671f\u5f85\u3067\u304d\u308b\u3068\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002\u4e00\u822c\u306b\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u304a\u3044\u3066\u88ab\u6bbb\u5f8c\u65b9\u90e8\u304b\u3089\u96c6\u7a4d\u4f4e\u4e0b\u3092\u8a8d\u3081\u308b\u3068\u3044\u308f\u308c\u3066\u304a\u308a\u307e\u3059\u304c\u3001\u4eca\u56de\u591a\u7530\u5148\u751f\u306e\u767a\u8868\u306b\u304a\u3044\u3066\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u7fa4\u3068\u75be\u60a3\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3067\u6bd4\u8f03\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u88ab\u6bbb\u524d\u65b9\u306e\u96c6\u7a4d\u4f4e\u4e0b\u304c\u6700\u3082\u967d\u6027\u5c24\u5ea6\u6bd4\u304c\u9ad8\u3044\u3068\u306e\u7d50\u679c\u3067\u3042\u308a\u307e\u3057\u305f\u3002\u5ea7\u9577\u3084\u30d5\u30ed\u30a2\u306e\u5148\u751f\u65b9\u3082\u3053\u306e\u70b9\u306b\u8208\u5473\u3092\u6301\u305f\u308c\u305f\u69d8\u5b50\u3067\u3042\u308a\u3001\u767a\u75c7\u65e9\u671f\u3067\u306e\u691c\u8a0e\u3084\u767a\u75c7\u5e74\u6570\u3067\u306e\u89e3\u6790\u306f\u3069\u3046\u304b\u3068\u306e\u58f0\u3092\u3044\u305f\u3060\u3044\u3066\u304a\u308a\u307e\u3057\u305f\u3002
\nDaTMan\uff08DaTSPECT\u306b\u95a2\u3057\u3066\u7814\u7a76\u3059\u308b\u4eba\uff09\u3068\u3057\u3066\u3001\u591a\u7530\u5148\u751f\u306e\u4eca\u5f8c\u306e\u6d3b\u8e8d\u3092\u4e5e\u3046\u3054\u671f\u5f85\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

2\u65e5\u76ee\uff0810\u670827\u65e5\uff09\u306f\u3001\u5bae\u4e0a\u304c\u3001
\n\u300e\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u304a\u3051\u308blevodopa\u8840\u4e2d\u6fc3\u5ea6\u3068\u4e0a\u90e8\u6d88\u5316\u7ba1\u69cb\u9020\u306e\u691c\u8a0e\u300f\u00a0<\/strong>\u306b\u3064\u3044\u3066\u767a\u8868\u3092\u884c\u3044\u307e\u3057\u305f\u3002
\n\u4eca\u56de\u306f\u3001\u7279\u7570\u306a\u4e0a\u90e8\u6d88\u5316\u7ba1\u69cb\u9020\u3092\u3082\u30643\u75c7\u4f8b\u306b\u304a\u3051\u308blevodopa\u8840\u4e2d\u6fc3\u5ea6\u306b\u95a2\u3057\u3066\u767a\u8868\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u79c1\u306e\u767a\u8868\u304c\u30bb\u30c3\u30b7\u30e7\u30f3\u306e\u6700\u5f8c\u3067\u3042\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u7d42\u4e86\u5f8c\u3082\u4f55\u4eba\u304b\u306e\u5148\u751f\u65b9\u306b\u8cea\u554f\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u65e5\u672c\u533b\u79d1\u5927\u5b66\u306e\u6c38\u5c71\u5148\u751f\u304c\u5ea7\u9577\u3092\u3055\u308c\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001\u80c3\u5e7d\u9580\u90e8\uff5e\u7a7a\u8178\u4e0a\u90e8\u306e\u5916\u79d1\u7684\u5207\u9664\u3092\u884c\u3046\u524d\u5f8c\u3067levodopa\u8840\u4e2d\u6fc3\u5ea6\u3092\u6bd4\u8f03\u3057\u305f\u75c7\u4f8b\u3092\u5831\u544a\u3055\u308c\u3066\u304a\u308a\uff08Case Rep Neurol 2015;7:181-185\uff09\u3001\u79c1\u3082\u8aad\u307e\u305b\u3066\u3044\u305f\u3060\u3044\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001\u5831\u544a\u306e\u4e2d\u3067\u624b\u8853\u524d\u306b2\u56de\u6e2c\u5b9a\u3057\u305flevodopa\u8840\u4e2d\u52d5\u614b\u304c\u975e\u5e38\u306b\u518d\u73fe\u6027\u306e\u9ad8\u3044\u7d50\u679c\u3067\u3042\u3063\u305f\u3053\u3068\u304c\u8a18\u61b6\u306b\u6b8b\u3063\u3066\u304a\u308a\u3001\u8a66\u9a13\u306e\u65b9\u6cd5\u7b49\u306b\u95a2\u3057\u3066\u8cea\u554f\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u6c38\u5c71\u5148\u751f\u304b\u3089\u306f\u3001\u4e16\u754c\u7684\u306b\u307f\u3066\u3082levodopa\u8840\u4e2d\u52d5\u614b\u3092\u7814\u7a76\u3057\u3066\u3044\u308b\u65bd\u8a2d\u306f\u3055\u307b\u3069\u591a\u304f\u306a\u304f\u3001\u5b9f\u969b\u81ea\u8eab\u304c\u56fd\u969b\u5b66\u4f1a\u3067\u767a\u8868\u3057\u305f\u969b\u306b\u3082\u975e\u5e38\u306b\u6ce8\u76ee\u3092\u96c6\u3081\u305f\u3068\u6559\u308f\u308a\u307e\u3057\u305f\u3002\u5f53\u79d1\u306b\u304a\u3044\u3066\u85ac\u7269\u52d5\u614b\u3084\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\u3068\u3044\u3063\u305f\u81e8\u5e8a\u85ac\u7406\u304c\u4e00\u3064\u306e\u7279\u5fb4\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u4eca\u5f8c\u3082\u5f15\u304d\u7d9a\u304d\u8840\u4e2d\u52d5\u614b\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u3092\u7d9a\u3051\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

3\u65e5\u76ee\uff0810\u670828\u65e5\uff09\u306f\u3001\u5ee3\u702c\u5148\u751f\u304c\u3001
\n\u300e\u7247\u5074\u6027\u306e\u821e\u8e0f\u904b\u52d5\u3092\u5448\u3057\u305f\u7121\u30bb\u30eb\u30ed\u30d7\u30e9\u30b9\u30df\u30f3\u8840\u75c7\u306e\u4e00\u4f8b\u300f<\/strong>\u306b\u3064\u3044\u3066\u306e\u767a\u8868\u3092\u884c\u3044\u307e\u3057\u305f\u3002
\n\u7121\u30bb\u30eb\u30ed\u30d7\u30e9\u30b9\u30df\u30f3\u306e\u75c7\u4f8b\u3067\u3001\u7247\u5074\u306e\u5c3e\u72b6\u6838\u304c\u840e\u7e2e\u3057\u3001\u7247\u5074\u6027\u306e\u4e0d\u968f\u610f\u904b\u52d5\uff08chorea\uff09\u3092\u5448\u3057\u3066\u304a\u308a\u3001\u4ee3\u8b1d\u6027\u75be\u60a3\u306f\u307b\u3068\u3093\u3069\u5de6\u53f3\u5dee\u3092\u8a8d\u3081\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u3068\u3055\u308c\u3066\u3044\u308b\u4e2d\u3001\u753b\u50cf\u4e0a\u3082\u81e8\u5e8a\u75c7\u72b6\u4e0a\u3082\u8457\u660e\u306a\u5de6\u53f3\u5dee\u3092\u8a8d\u3081\u305f\u5e0c\u5c11\u306a\u75c7\u4f8b\u3067\u3042\u308a\u307e\u3057\u305f\u3002\u7cd6\u5c3f\u75c5\u6027\u821e\u8e0f\u75c5\u3068\u306e\u9451\u5225\u304c\u91cd\u8981\u306a\u30ad\u30fc\u30dd\u30a4\u30f3\u30c8\u306e\u4e00\u3064\u3067\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u982d\u90e8MRI\u753b\u50cf\u6240\u898b\u3084\u904e\u53bb\u306e\u75c7\u4f8b\u5831\u544a\u304b\u3089\u7121\u30bb\u30eb\u30ed\u30d7\u30e9\u30b9\u30df\u30f3\u8840\u75c7\u306b\u4f34\u3046chorea\u304c\u7591\u308f\u3057\u3044\u3068\u8aac\u660e\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u975e\u5e38\u306b\u8cb4\u91cd\u306a\u75c7\u4f8b\u3067\u3042\u308a\u3001\u5ea7\u9577\u306e\u5148\u751f\u304b\u3089\u3082\u5bfe\u5074\u306e\u5c3e\u72b6\u6838\u306e\u840e\u7e2e\u3084\u75c7\u72b6\u306e\u51fa\u73fe\u306b\u3064\u3044\u3066\u4eca\u5f8c\u306e\u7d4c\u904e\u5831\u544a\u3092\u671f\u5f85\u3059\u308b\u3068\u306e\u8a00\u8449\u3092\u3044\u305f\u3060\u3044\u3066\u304a\u308a\u307e\u3057\u305f\u3002
\n\u5ee3\u702c\u5148\u751f\u306f\u7814\u4fee\u533b1\u5e74\u76ee\u3067\u3042\u308a\u307e\u3059\u304c\u3001\u540c\u3058\u30bb\u30c3\u30b7\u30e7\u30f3\u306e\u4ed6\u306e\u5148\u751f\u306b\u3082\u5f15\u3051\u3092\u53d6\u3089\u306a\u3044\u3001\u3068\u3066\u3082\u7814\u4fee\u533b1\u5e74\u76ee\u3068\u306f\u601d\u3048\u306a\u3044\u5802\u3005\u305f\u308b\u767a\u8868\u3076\u308a\u3067\u3001\u8cea\u7591\u5fdc\u7b54\u3082\u305d\u3064\u306a\u304f\u3053\u306a\u3057\u3066\u304a\u308a\u307e\u3057\u305f\u3002\u79c1\u304c\u7814\u4fee\u533b1\u5e74\u76ee\u306e\u3068\u304d\u306f\u72fc\u72fd\u3057\u3066\u3001\u8a00\u8449\u306b\u306a\u3089\u306a\u3044\u8a00\u8449\u3092\u767a\u3057\u3066\u3044\u305f\u3088\u3046\u306a\u6c17\u304c\u3057\u307e\u3059\u3002\u975e\u5e38\u306b\u5c06\u6765\u6709\u671b\u306a\u65b9\u3067\u3042\u308a\u3001\u3053\u308c\u304b\u3089\u306e\u6d3b\u8e8d\u306b\u671f\u5f85\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

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