{"id":177,"date":"2026-09-19T09:38:03","date_gmt":"2026-09-19T09:38:03","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/?page_id=177"},"modified":"2026-09-21T03:51:22","modified_gmt":"2026-09-21T03:51:22","slug":"nepc","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/%e7%a0%94%e7%a9%b6%e3%83%86%e3%83%bc%e3%83%9e\/nepc\/","title":{"rendered":"NEPC"},"content":{"rendered":"\n
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\u795e\u7d4c\u5185\u5206\u6ccc\u524d\u7acb\u817a\u304c\u3093\uff08NEPC\uff09<\/h3>\n\n\n\n

\u795e\u7d4c\u5185\u5206\u6ccc\u524d\u7acb\u817a\u304c\u3093\uff08Neuroendocrine Prostate Cancer: NEPC\uff09\u306f\u3001\u524d\u7acb\u817a\u304c\u3093\u306e\u4e2d\u3067\u3082\u6cbb\u7642\u62b5\u6297\u6027\u304c\u9ad8\u304f\u3001\u4e88\u5f8c\u4e0d\u826f\u306a\u75c5\u578b\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n\n\n\n

NEPC\u306b\u306f\u8a3a\u65ad\u6642\u304b\u3089\u795e\u7d4c\u5185\u5206\u6ccc\u5f62\u8cea\u3092\u793a\u3059\u3082\u306e\u306b\u52a0\u3048\u3001\u9032\u884c\u524d\u7acb\u817a\u304c\u3093\u306b\u5bfe\u3059\u308b\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u306a\u3069\u306e\u6cbb\u7642\u904e\u7a0b\u3067\u3001\u816b\u760d\u7d30\u80de\u306e\u6027\u8cea\u304c\u5909\u5316\u3057\u3066\u751f\u3058\u308b\u6cbb\u7642\u8a98\u5c0e\u6027NEPC\uff08t-NEPC\uff09<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u79c1\u305f\u3061\u306f\u3001\u3053\u306e\u6cbb\u7642\u62b5\u6297\u6027\u7372\u5f97\u306e\u904e\u7a0b\u3067\u751f\u3058\u308b\u816b\u760d\u7d30\u80de\u306e\u53ef\u5851\u6027\uff08lineage plasticity\uff09\u3068\u3001\u305d\u308c\u3092\u53d6\u308a\u5dfb\u304f\u816b\u760d\u5fae\u5c0f\u74b0\u5883<\/strong>\u306b\u6ce8\u76ee\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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Watanabe R, Haffner M, Nelson P et al. Urol. Oncol. 2026<\/p>\n<\/div>\n<\/div>\n\n\n\n

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\u816b\u760d\u306f\u3069\u306e\u3088\u3046\u306bNEPC\u3078\u5909\u5316\u3059\u308b\u306e\u304b<\/h3>\n\n\n\n

\u540c\u3058\u60a3\u8005\u3055\u3093\u306e\u6cbb\u7642\u524d\u306e\u524d\u7acb\u817a\u817a\u764c\u3068\u6cbb\u7642\u5f8c\u306b\u51fa\u73fe\u3057\u305fNEPC\u306e\u7d44\u7e54<\/strong>\u3092\u6bd4\u8f03\u3057\u3001\u9ad8\u89e3\u50cf\u5ea6\u7a7a\u9593\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u816b\u760d\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u306e\u5468\u56f2\u306b\u5b58\u5728\u3059\u308b\u9593\u8cea\u7d30\u80de\u3084\u514d\u75ab\u7d30\u80de\u3092\u542b\u3081\u3066\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001NEPC\u3078\u306e\u5206\u5316\u306b\u4f34\u3063\u3066\u751f\u3058\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u3068\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7279\u306b\u3001SASP\u3001\u708e\u75c7\u3001TGF-\u03b2\u3001NF-\u03baB\u3001IFN\u30b7\u30b0\u30ca\u30eb<\/strong>\u306a\u3069\u306b\u7740\u76ee\u3057\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3068NEPC\u3078\u306e\u5206\u5316\u3092\u652f\u3048\u308b\u74b0\u5883\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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Watanabe et al. Int J Mol Sci 2023<\/p>\n\n\n\n

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\u5168\u56fd\u30b3\u30db\u30fc\u30c8\u306b\u3088\u308bNEPC\u306e\u5206\u5b50\u75c5\u614b\u89e3\u660e<\/h3>\n\n\n\n

NEPC\u306f\u5e0c\u5c11\u306a\u75c5\u614b\u3067\u3042\u308a\u3001\u5358\u4e00\u65bd\u8a2d\u306e\u307f\u3067\u591a\u6570\u306e\u75c7\u4f8b\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3059\u3002<\/p>\n\n\n\n

\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3001\u5168\u56fd\u306e\u533b\u7642\u6a5f\u95a2\u3068\u9023\u643a\u3057\u3066NEPC\u75c7\u4f8b\u3092\u96c6\u7a4d\u3057\u3001RNA\u30b7\u30fc\u30b1\u30f3\u30b9\u304a\u3088\u3073\u7a7a\u9593\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7a7a\u9593\u89e3\u6790\u306b\u3088\u3063\u3066NEPC\u3078\u306e\u5909\u5316\u3092\u8a73\u7d30\u306b\u6349\u3048\u3001\u3055\u3089\u306b\u5168\u56fd\u30b3\u30db\u30fc\u30c8\u3067\u691c\u8a3c\u3059\u308b\u3053\u3068\u3067\u3001NEPC\u306e\u5206\u5b50\u5206\u985e\u3001\u767a\u751f\u4e88\u6e2c\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6a19\u7684\u306e\u540c\u5b9a<\/strong>\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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NEPC\u3092\u4e88\u6e2c\u3057\u3001\u6cbb\u7642\u3059\u308b\u305f\u3081\u306b<\/h3>\n\n\n\n

\u79c1\u305f\u3061\u306e\u6700\u7d42\u7684\u306a\u76ee\u6a19\u306f\u3001NEPC\u304c\u767a\u751f\u3057\u3066\u304b\u3089\u8a3a\u65ad\u3059\u308b\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u3069\u306e\u3088\u3046\u306a\u524d\u7acb\u817a\u304c\u3093\u304cNEPC\u3078\u9032\u5c55\u3059\u308b\u306e\u304b\u3092\u4e88\u6e2c\u3057\u3001\u305d\u306e\u904e\u7a0b\u306b\u65e9\u671f\u306b\u4ecb\u5165\u3059\u308b\u3053\u3068<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n

\u60a3\u8005\u691c\u4f53\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u3092PDX\u30fb\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u306a\u3069\u306e\u30e2\u30c7\u30eb\u3067\u691c\u8a3c\u3057\u3001\u65b0\u305f\u306a\u8a3a\u65ad\u30fb\u6cbb\u7642\u6226\u7565\u306e\u958b\u767a\u3078\u3064\u306a\u3052\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

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\u95a2\u9023\u8ad6\u6587<\/h2>\n\n\n\n

Enzalutamide promotes an early plasticity-associated transcriptional state without terminal neuroendocrine differentiation in prostate cancer cells<\/strong>
Watanabe R, Chosei M, Arai H, Miura N, Kikugawa T, Saika T.
Front Oncol. 2026;16:1870253.<\/em>
PMID: 42568401<\/a><\/p>\n\n\n\n

Cellular plasticity and tumor ecosystem dynamics in prostate cancer: insights from single-cell and spatial transcriptomics<\/strong>
Watanabe R, Chu T, Miura N, Kikugawa T, Nelson PS, Saika T.
Am J Clin Exp Urol. 2026;14(3):64-85.<\/em>
PMID: 42488354<\/a><\/p>\n\n\n\n

Molecular pathology of rare histologic variants and treatment-resistant lineages of prostate cancer<\/strong>
Watanabe R, Miura N, Kikugawa T, Saika T, Haffner MC, Nelson PS.
Urol Oncol. 2026;44(4):110987.<\/em>
PMID: 41605126<\/a><\/p>\n\n\n\n

Paired-sample Analysis of ERG Expression and TMPRSS2-ERG Fusion in Treatment-induced Neuroendocrine Prostate Cancer<\/strong>
Watanabe R, Shigehisa R, Kawada T, Yamamoto S, Katayama S, Takamoto A, Nishimura K, Miura N, Araki M, Inoue K, Saika T; Chu-shikoku Japan Urological Consortium (CsJUC) Research Collaboration.
Anticancer Res. 2026;46(4):1929-1942.<\/em>
PMID: 41895744<\/a><\/p>\n\n\n\n

Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer<\/strong>
Watanabe R, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Int J Mol Sci. 2023;24(10):8955.<\/em>
PMID: 37240308<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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