{"id":179,"date":"2026-09-19T09:38:14","date_gmt":"2026-09-19T09:38:14","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/?page_id=179"},"modified":"2026-09-21T03:51:52","modified_gmt":"2026-09-21T03:51:52","slug":"psma","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/%e7%a0%94%e7%a9%b6%e3%83%86%e3%83%bc%e3%83%9e\/psma\/","title":{"rendered":"PSMA"},"content":{"rendered":"\n
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PSMA \u2015 \u8a3a\u65ad\u30fb\u6cbb\u7642\u6a19\u7684\u304b\u3089\u816b\u760d\u751f\u7269\u5b66\u3078<\/h3>\n\n\n\n

Prostate-Specific Membrane Antigen\uff08PSMA\uff09\u306f\u3001\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\u306b\u9ad8\u767a\u73fe\u3059\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u73fe\u5728\u3067\u306fPSMA-PET\u306b\u3088\u308b\u753b\u50cf\u8a3a\u65ad\u3084\u3001PSMA\u3092\u6a19\u7684\u3068\u3057\u305f\u653e\u5c04\u6027\u30ea\u30ac\u30f3\u30c9\u7642\u6cd5\u306a\u3069\u3001\u524d\u7acb\u817a\u304c\u3093\u306e\u8a3a\u7642\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u5206\u5b50\u6a19\u7684\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u79c1\u305f\u3061\u306fPSMA\u3092\u5358\u306a\u308b\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3067\u306f\u306a\u304f\u3001\u304c\u3093\u306e\u9032\u5c55\u3084\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306b\u95a2\u308f\u308b\u6a5f\u80fd\u5206\u5b50<\/strong>\u3068\u3057\u3066\u6349\u3048\u3001\u305d\u306e\u751f\u7269\u5b66\u7684\u5f79\u5272\u3092\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

\u3000Watanabe et al. The Prostate 2021<\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

<\/p>\n\n\n\n

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PSMA\u306f\u816b\u760d\u8840\u7ba1\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3059\u308b\u306e\u304b<\/h3>\n\n\n\n

\u79c1\u305f\u3061\u306f\u3001\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u308bPSMA\u967d\u6027\u819c\u6210\u5206<\/strong>\u304c\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3001\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3059\u308b\u72b6\u614b\u3078\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3053\u306e\u7814\u7a76\u304b\u3089\u3001PSMA\u306f\u816b\u760d\u7d30\u80de\u8868\u9762\u306b\u5b58\u5728\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u816b\u760d\u7d30\u80de\u3068\u5468\u56f2\u306e\u8840\u7ba1\u3092\u3064\u306a\u3050\u5206\u5b50\u6a5f\u69cb<\/strong>\u306b\u3082\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

Watanabe et al. The Prostate 2021<\/p>\n\n\n\n

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\u524d\u7acb\u817a\u304c\u3093\u304b\u3089\u814e\u7d30\u80de\u304c\u3093\u3078<\/h3>\n\n\n\n

PSMA\u306f\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u814e\u7d30\u80de\u304c\u3093\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u306e\u816b\u760d\u8840\u7ba1<\/strong>\u306b\u3082\u767a\u73fe\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u79c1\u305f\u3061\u306f\u814e\u7d30\u80de\u304c\u3093\u306b\u304a\u3044\u3066\u3001\u304c\u3093\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u308b\u5c0f\u80de\u304c\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306ePSMA\u767a\u73fe\u3092\u8a98\u5c0e\u3057\u3001\u8840\u7ba1\u65b0\u751f\u80fd\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001\u9ad8\u89e3\u50cf\u5ea6\u7a7a\u9593\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u3092\u7528\u3044\u3066PSMA\u967d\u6027\u816b\u760d\u8840\u7ba1\u306e\u5206\u5b50\u7279\u6027\u3092\u89e3\u6790\u3057\u3001\u816b\u760d\u518d\u767a\u306e\u4e88\u6e2c\u30de\u30fc\u30ab\u30fc\u304a\u3088\u3073\u65b0\u305f\u306a\u6cbb\u7642\u6a19\u7684<\/strong>\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u3092\u691c\u8a0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

Watanabe et al. Cells 2025<\/p>\n\n\n\n

<\/p>\n\n\n\n

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PSMA\u306f\u5358\u306a\u308b\u300c\u30de\u30fc\u30ab\u30fc\u300d\u3067\u306f\u306a\u3044<\/h3>\n\n\n\n

PSMA\u306f\u524d\u7acb\u817a\u304c\u3093\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u5f79\u5272\u306f\u7d30\u80de\u8868\u9762\u306e\u30de\u30fc\u30ab\u30fc\u306b\u3068\u3069\u307e\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

PSMA\u306f\u9175\u7d20\u6d3b\u6027\u3092\u6301\u3064\u819c\u30bf\u30f3\u30d1\u30af\u8cea<\/strong>\u3068\u3057\u3066\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u30fb\u8449\u9178\u4ee3\u8b1d\u306a\u3069\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3068\u3082\u306b\u3001PI3K\u2013AKT\u2013mTOR\u7d4c\u8def\u3084\u7d30\u80de\u63a5\u7740\u3001\u8840\u7ba1\u65b0\u751f\u306a\u3069\u3001\u304c\u3093\u306e\u9032\u5c55\u306b\u95a2\u308f\u308b\u3055\u307e\u3056\u307e\u306a\u5206\u5b50\u6a5f\u69cb\u3068\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001PSMA\u306f\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u814e\u7d30\u80de\u304c\u3093\u3001\u80ba\u304c\u3093\u3001\u7532\u72b6\u817a\u304c\u3093\u3001\u795e\u7d4c\u81a0\u82bd\u816b\u306a\u3069\u8907\u6570\u306e\u304c\u3093\u7a2e\u306e\u816b\u760d\u8840\u7ba1\u5185\u76ae\u306b\u3082\u767a\u73fe<\/strong>\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3055\u3089\u306bPSMA\u306f\u7d30\u80de\u819c\u4e0a\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u7d30\u80de\u5185\u3078\u306e\u53d6\u308a\u8fbc\u307f\uff08internalization\uff09\u3068\u518d\u5faa\u74b0\uff08recycling\uff09<\/strong>\u3092\u884c\u3046\u6027\u8cea\u3092\u6301\u3061\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u7279\u5fb4\u306f\u3001PSMA\u3092\u5229\u7528\u3057\u305f\u753b\u50cf\u8a3a\u65ad\u3084\u85ac\u5264\u9001\u9054\u3001\u6a19\u7684\u6cbb\u7642\u3092\u8003\u3048\u308b\u4e0a\u3067\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Watanabe et al. Mol. Med. Rep 2026<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u95a2\u9023\u8ad6\u6587<\/h2>\n\n\n\n

Prostate-specific membrane antigen: Molecular functions and emerging roles as a therapeutic target (Review)<\/strong>
Watanabe R, Sakaue T, Miura N, Kikugawa T, Saika T.
Mol Med Rep. 2026;33(4):122.<\/em>
PMID: 41789574<\/a><\/p>\n\n\n\n

Vesicles Secreted by Renal Cell Carcinoma Cells Cause Vascular Endothelial Cells to Express PSMA and Drive Tumor Progression<\/strong>
Watanabe R, Kagimoto K, Chosei M, Sakaue T, Kurata M, Miura N, Kitazawa R, Kikugawa T, Higashiyama S, Saika T.
Cells. 2025;14(3):165.<\/em>
PMID: 39936957<\/a><\/p>\n\n\n\n

PSMA-positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state<\/strong>
Watanabe R, Maekawa M, Kiyoi T, Kurata M, Miura N, Kikugawa T, Higashiyama S, Saika T.
Prostate. 2021;81(16):1390-1401.<\/em>
PMID: 34516672<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

PSMA \u2015 \u8a3a\u65ad\u30fb\u6cbb\u7642\u6a19\u7684\u304b\u3089\u816b\u760d\u751f\u7269\u5b66\u3078 Prostate-Specific Membrane Antigen\uff08PSMA\uff09\u306f\u3001\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\u306b\u9ad8\u767a\u73fe\u3059\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u73fe\u5728\u3067\u306fPSMA-PET\u306b\u3088\u308b\u753b\u50cf\u8a3a\u65ad\u3084\u3001PS […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":31,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"sns_share_botton_hide":"","vkExUnit_sns_title":"","_vk_print_noindex":"","sitemap_hide":"","vkExUnit_sitemap":"","_veu_custom_css":"","veu_display_promotion_alert":"","_exclude_from_list_pages":"","vkexunit_cta_each_option":"","vkExUnit_childPageIndex":"","vkExUnit_pageList_ancestor":"","vkExUnit_contact_enable":"","_lightning_design_setting":{"layout":"col-one-no-subsection"},"footnotes":""},"class_list":["post-179","page","type-page","status-publish","hentry"],"veu_head_title_object":{"title":"","add_site_title":""},"_links":{"self":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages\/179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/comments?post=179"}],"version-history":[{"count":6,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages\/179\/revisions"}],"predecessor-version":[{"id":240,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages\/179\/revisions\/240"}],"up":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages\/31"}],"wp:attachment":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/media?parent=179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}