{"id":183,"date":"2026-09-19T09:38:44","date_gmt":"2026-09-19T09:38:44","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/?page_id=183"},"modified":"2026-09-21T03:52:53","modified_gmt":"2026-09-21T03:52:53","slug":"%ef%bd%8dhnpc","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/%e7%a0%94%e7%a9%b6%e3%83%86%e3%83%bc%e3%83%9e\/%ef%bd%8dhnpc\/","title":{"rendered":"\uff4dHNPC"},"content":{"rendered":"\n
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\u8ee2\u79fb\u6027\u30db\u30eb\u30e2\u30f3\u611f\u53d7\u6027\u524d\u7acb\u817a\u304c\u3093\uff08mHNPC\uff09<\/h3>\n\n\n\n

\u8ee2\u79fb\u6027\u30db\u30eb\u30e2\u30f3\u611f\u53d7\u6027\u524d\u7acb\u817a\u304c\u3093\uff08metastatic hormone-na\u00efve prostate cancer: mHNPC\uff09\u306f\u3001\u9060\u9694\u8ee2\u79fb\u3092\u6709\u3059\u308b\u3082\u306e\u306e\u3001\u307e\u3060\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u4fdd\u3063\u3066\u3044\u308b\u524d\u7acb\u817a\u304c\u3093\u3067\u3059\u3002<\/p>\n\n\n\n

\u8fd1\u5e74\u3001\u5f37\u529b\u306a\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u3084\u5316\u5b66\u7642\u6cd5\u3092\u65e9\u671f\u304b\u3089\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u6cbb\u7642\u6210\u7e3e\u306f\u5411\u4e0a\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u540c\u3058mHNPC\u3067\u3042\u3063\u3066\u3082\u6cbb\u7642\u3078\u306e\u53cd\u5fdc\u3084\u305d\u306e\u5f8c\u306e\u7d4c\u904e\u306f\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u79c1\u305f\u3061\u306f\u3001\u305d\u306e\u80cc\u666f\u306b\u3042\u308b**\u6cbb\u7642\u958b\u59cb\u524d\u304b\u3089\u5b58\u5728\u3059\u308b\u816b\u760d\u7d30\u80de\u306e\u591a\u69d8\u6027\uff08heterogeneity\uff09**\u306b\u6ce8\u76ee\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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\u4e00\u3064\u306e\u816b\u760d\u306e\u4e2d\u306b\u7570\u306a\u308b\u7d30\u80de\u72b6\u614b\u304c\u5b58\u5728\u3059\u308b<\/h3>\n\n\n\n

\u79c1\u305f\u3061\u306f\u3001\u6cbb\u7642\u524dmHNPC\u306e\u60a3\u8005\u691c\u4f53\u3092\u7528\u3044\u3066\u30b7\u30f3\u30b0\u30eb\u30bb\u30ebRNA\u30b7\u30fc\u30b1\u30f3\u30b9\u89e3\u6790<\/strong>\u3092\u884c\u3044\u3001\u816b\u760d\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u3092\u4e00\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u305d\u306e\u7d50\u679c\u3001\u6cbb\u7642\u524d\u306e\u6bb5\u968e\u3067\u3059\u3067\u306b\u3001\u5178\u578b\u7684\u306aLuminal\/AR<\/strong>\u578b\u306e\u816b\u760d\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001Basal\/Stem-like<\/strong>\u3001EMT\/stromal-like<\/strong>\u306a\u3069\u3001\u7570\u306a\u308b\u7279\u5fb4\u3092\u6301\u3064\u4e0a\u76ae\u7d30\u80de\u96c6\u56e3\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n\n\n\n

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\u6cbb\u7642\u524d\u304b\u3089\u5b58\u5728\u3059\u308b\u300c\u62b5\u6297\u6027\u306e\u82bd\u300d<\/h3>\n\n\n\n

Basal-associated\u306a\u7279\u5fb4\u3092\u6301\u3064\u816b\u760d\u3067\u306f\u3001Stem-like\u3001EMT\u3001TGF-\u03b2\u3001p53\u306a\u3069\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3084\u816b\u760d\u9032\u5c55\u306b\u95a2\u9023\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u306e\u4ea2\u9032\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u4e00\u65b9\u3001\u4eca\u56de\u89e3\u6790\u3057\u305f\u6cbb\u7642\u524dmHNPC\u3067\u306f\u3001\u660e\u78ba\u306a\u795e\u7d4c\u5185\u5206\u6ccc\u816b\u760d\u7d30\u80de\u96c6\u56e3\u306f\u8a8d\u3081\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n

\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u524d\u7acb\u817a\u304c\u3093\u304c\u6cbb\u7642\u3092\u53d7\u3051\u3066\u521d\u3081\u3066\u591a\u69d8\u306b\u306a\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u6cbb\u7642\u958b\u59cb\u524d\u304b\u3089\u5c06\u6765\u306e\u6cbb\u7642\u62b5\u6297\u6027\u306b\u3064\u306a\u304c\u308a\u5f97\u308b\u7d30\u80de\u72b6\u614b\u3092\u5185\u5305\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027<\/strong>\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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\u816b\u760d\u91cf\u3060\u3051\u3067\u306a\u304f\u300c\u816b\u760d\u751f\u7269\u5b66\u300d\u3092\u898b\u308b<\/h3>\n\n\n\n

\u73fe\u5728\u306emHNPC\u6cbb\u7642\u3067\u306f\u3001\u8ee2\u79fb\u91cf\u3084\u81e8\u5e8a\u7684\u30ea\u30b9\u30af\u306a\u3069\u3092\u3082\u3068\u306b\u6cbb\u7642\u5f37\u5ea6\u3092\u691c\u8a0e\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u540c\u3058\u81e8\u5e8a\u5206\u985e\u306e\u60a3\u8005\u3055\u3093\u3067\u3082\u3001\u816b\u760d\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u72b6\u614b\u306f\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u79c1\u305f\u3061\u306f\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u306a\u3069\u3092\u7528\u3044\u3066\u3001\u6cbb\u7642\u524d\u306e\u6bb5\u968e\u3067\u816b\u760d\u306e\u751f\u7269\u5b66\u7684\u306aaggressiveness\u3084\u6cbb\u7642\u62b5\u6297\u6027\u3092\u6349\u3048\u3001\u305d\u308c\u305e\u308c\u306e\u60a3\u8005\u3055\u3093\u306b\u9069\u3057\u305f\u6cbb\u7642\u9078\u629e\u306b\u3064\u306a\u304c\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a<\/strong>\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

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\u95a2\u9023\u8ad6\u6587<\/h2>\n\n\n\n

Single-Cell Analysis Reveals Pre-Existing Basal-Associated Epithelial States in Metastatic Hormone-Na\u00efve Prostate Cancer<\/strong>
Watanabe R, Chosei M, Sakaue T, Miura N, Kikugawa T, Saika T.
Int J Mol Sci. 2026 Jun 16;27(12):5405.<\/em>
PMID: 42353123<\/a><\/p>\n\n\n\n

Enzalutamide promotes an early plasticity-associated transcriptional state without terminal neuroendocrine differentiation in prostate cancer cells<\/strong>
Watanabe R, Chosei M, Arai H, Miura N, Kikugawa T, Saika T.
Front Oncol. 2026 Jul 24;16:1870253.<\/em>
PMID: 42568401<\/a><\/p>\n\n\n\n

Cellular plasticity and tumor ecosystem dynamics in prostate cancer: insights from single-cell and spatial transcriptomics<\/strong>
Watanabe R, Chu T, Miura N, Kikugawa T, Nelson PS, Saika T.
Am J Clin Exp Urol. 2026 Jun 15;14(3):64-85.<\/em>
PMID: 42488354<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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