{"id":202,"date":"2026-09-19T10:06:38","date_gmt":"2026-09-19T10:06:38","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/?page_id=202"},"modified":"2026-09-21T04:01:55","modified_gmt":"2026-09-21T04:01:55","slug":"dna%e4%bf%ae%e5%be%a9","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/%e7%a0%94%e7%a9%b6%e3%83%86%e3%83%bc%e3%83%9e\/dna%e4%bf%ae%e5%be%a9\/","title":{"rendered":"SPOP\u3068DNA\u4fee\u5fa9"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">\u524d\u7acb\u817a\u304c\u3093\u306e\u5206\u5b50\u6a5f\u69cb\u3068DNA\u4fee\u5fa9<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">SPOP\uff08Speckle-type POZ protein\uff09\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u89e3\u3092\u5236\u5fa1\u3059\u308b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u95a2\u308f\u308b\u5206\u5b50\u3067\u3001<strong>\u524d\u7acb\u817a\u304c\u3093\u3067\u9ad8\u983b\u5ea6\u306b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u8a8d\u3081\u308b\u5206\u5b50\u306e\u4e00\u3064<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79c1\u305f\u3061\u306f\u3001SPOP\u304c\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\u306b\u304a\u3051\u308bDNA\u4fee\u5fa9\u3068\u30b2\u30ce\u30e0\u5b89\u5b9a\u6027\u306e\u7dad\u6301\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u304b\u3092\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001DNA\u8907\u88fd\u306b\u4f34\u3063\u3066\u751f\u3058\u308bDNA\u640d\u50b7\u3068\u3001\u30c8\u30dd\u30a4\u30bd\u30e1\u30e9\u30fc\u30bc2A\uff08TOP2A\uff09\u3068\u306e\u95a2\u4fc2\u306b\u6ce8\u76ee\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"341\" src=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP1-1024x341.png\" alt=\"\" class=\"wp-image-260\" srcset=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP1-1024x341.png 1024w, https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP1-300x100.png 300w, https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP1-768x256.png 768w, https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP1-1536x512.png 1536w, https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP1-2048x683.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">SPOP\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3088\u308aDNA\u640d\u50b7\u304c\u84c4\u7a4d\u3059\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">AR\u967d\u6027\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\u306b\u304a\u3044\u3066SPOP\u3092\u6291\u5236\u3059\u308b\u3068\u3001DNA\u640d\u50b7\u306e\u6307\u6a19\u3067\u3042\u308b<strong>\u03b3H2AX\u304c\u5897\u52a0<\/strong>\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001SPOP\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3088\u308a\u3001DNA\u306b\u7d50\u5408\u3057\u305fTOP2A\u304c\u5341\u5206\u306b\u9664\u53bb\u3055\u308c\u305a\u3001<strong>TOP2A\u2013DNA cleavage complex\u304c\u84c4\u7a4d<\/strong>\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"516\" height=\"647\" src=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP2-2.png\" alt=\"\" class=\"wp-image-261\" srcset=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP2-2.png 516w, https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP2-2-239x300.png 239w\" sizes=\"auto, (max-width: 516px) 100vw, 516px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">TOP2A\u3092DNA\u304b\u3089\u53d6\u308a\u9664\u304f\u4ed5\u7d44\u307f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">TOP2A\u306fDNA\u8907\u88fd\u306b\u4f34\u3046\u69cb\u9020\u7684\u306a\u554f\u984c\u3092\u89e3\u6d88\u3059\u308b\u91cd\u8981\u306a\u9175\u7d20\u3067\u3059\u304c\u3001\u305d\u306e\u904e\u7a0b\u3067\u4e00\u6642\u7684\u306bDNA\u3068\u5171\u6709\u7d50\u5408\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79c1\u305f\u3061\u306e\u7814\u7a76\u304b\u3089\u3001SPOP\u306f<strong>TDP1\u30fbTDP2\u306a\u3069\u306eDNA\u4fee\u5fa9\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4ecb\u3057\u3066\u3001DNA\u306b\u7d50\u5408\u3057\u305fTOP2A\u306e\u9664\u53bb\u306b\u95a2\u4e0e\u3059\u308b<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SPOP\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u306a\u3044\u3068TOP2A\u304cDNA\u4e0a\u306b\u84c4\u7a4d\u3057\u3001DNA\u4e8c\u672c\u9396\u5207\u65ad\u3084\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"431\" height=\"488\" src=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP3.png\" alt=\"\" class=\"wp-image-262\" srcset=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP3.png 431w, https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP3-265x300.png 265w\" sizes=\"auto, (max-width: 431px) 100vw, 431px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">\u304c\u3093\u95a2\u9023SPOP\u5909\u7570\u304cDNA\u4fee\u5fa9\u3092\u5909\u5316\u3055\u305b\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u524d\u7acb\u817a\u304c\u3093\u95a2\u9023SPOP\u5909\u7570\u306e\u4e00\u3064\u3067\u3042\u308b<strong>F133V<\/strong>\u3092\u767a\u73fe\u3055\u305b\u308b\u3068\u3001TOP2A\u306e\u6838\u5185\u84c4\u7a4d\u3068\u03b3H2AX\u306e\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305fF133V\u3067\u306fTDP2\u3084MRE11\u306e\u767a\u73fe\u4f4e\u4e0b\u3082\u8a8d\u3081\u3089\u308c\u3001SPOP\u5909\u7570\u306b\u3088\u308bDNA\u4fee\u5fa9\u6a5f\u69cb\u306e\u7570\u5e38\u304c\u3001\u524d\u7acb\u817a\u304c\u3093\u306b\u304a\u3051\u308b<strong>\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u3084\u816b\u760d\u9032\u5c55<\/strong>\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"522\" height=\"633\" src=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP5.png\" alt=\"\" class=\"wp-image-265\" srcset=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP5.png 522w, https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP5-247x300.png 247w\" sizes=\"auto, (max-width: 522px) 100vw, 522px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">\u5206\u5b50\u6a5f\u69cb\u306e\u7406\u89e3\u304b\u3089\u65b0\u3057\u3044\u6cbb\u7642\u6226\u7565\u3078<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">DNA\u4fee\u5fa9\u6a5f\u69cb\u306e\u7570\u5e38\u306f\u3001\u524d\u7acb\u817a\u304c\u3093\u306e\u767a\u751f\u30fb\u9032\u5c55\u3060\u3051\u3067\u306a\u304f\u3001\u6cbb\u7642\u3078\u306e\u53cd\u5fdc\u306b\u3082\u95a2\u4fc2\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SPOP\u3001TOP2A\u3001AR\u30b7\u30b0\u30ca\u30eb\u3068DNA\u4fee\u5fa9\u306e\u95a2\u4fc2\u3092\u3055\u3089\u306b\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u524d\u7acb\u817a\u304c\u3093\u306e\u5206\u5b50\u7279\u6027\u306b\u5fdc\u3058\u305f\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565<\/strong>\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"510\" height=\"213\" src=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP4.png\" alt=\"\" class=\"wp-image-264\" srcset=\"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP4.png 510w, https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-content\/uploads\/2026\/09\/SPOP4-300x125.png 300w\" sizes=\"auto, (max-width: 510px) 100vw, 510px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Watanabe et al. Mol. Bio. of the Cell 2020<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u8ad6\u6587<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex<\/strong><br>Watanabe R, Maekawa M, Hieda M, Taguchi T, Miura N, Kikugawa T, Saika T, Higashiyama S.<br><em>Mol Biol Cell. 2020 Mar 15;31(6):478-490.<\/em><br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31967940\/\" target=\"_blank\" rel=\"noopener\">PMID: 31967940<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u524d\u7acb\u817a\u304c\u3093\u306e\u5206\u5b50\u6a5f\u69cb\u3068DNA\u4fee\u5fa9 SPOP\uff08Speckle-type POZ protein\uff09\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u89e3\u3092\u5236\u5fa1\u3059\u308b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u95a2\u308f\u308b\u5206\u5b50\u3067\u3001\u524d\u7acb\u817a\u304c\u3093\u3067\u9ad8\u983b\u5ea6\u306b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u8a8d\u3081\u308b\u5206\u5b50\u306e\u4e00\u3064\u3067\u3059\u3002 \u79c1\u305f\u3061\u306f\u3001S [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":31,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"sns_share_botton_hide":"","vkExUnit_sns_title":"","_vk_print_noindex":"","sitemap_hide":"","vkExUnit_sitemap":"","_veu_custom_css":"","veu_display_promotion_alert":"","_exclude_from_list_pages":"","vkexunit_cta_each_option":"","vkExUnit_childPageIndex":"","vkExUnit_pageList_ancestor":"","vkExUnit_contact_enable":"","_lightning_design_setting":{"layout":"col-one-no-subsection"},"footnotes":""},"class_list":["post-202","page","type-page","status-publish","hentry"],"veu_head_title_object":{"title":"","add_site_title":""},"_links":{"self":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages\/202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/comments?post=202"}],"version-history":[{"count":5,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages\/202\/revisions"}],"predecessor-version":[{"id":311,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages\/202\/revisions\/311"}],"up":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/pages\/31"}],"wp:attachment":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/wp-json\/wp\/v2\/media?parent=202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}