{"id":358,"date":"2026-09-21T08:20:05","date_gmt":"2026-09-21T08:20:05","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/?page_id=358"},"modified":"2026-09-21T09:42:35","modified_gmt":"2026-09-21T09:42:35","slug":"idc-p","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/epcrc\/en\/research-themes\/idc-p\/","title":{"rendered":"IDC-P"},"content":{"rendered":"\n
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Intraductal Carcinoma of the Prostate (IDC-P)<\/h3>\n\n\n\n

Intraductal carcinoma of the prostate (IDC-P)<\/strong> is characterized by the growth of highly aggressive prostate cancer cells within pre-existing prostatic ducts and glands and is associated with high-grade disease, treatment resistance, and poor clinical outcomes<\/strong>.<\/p>\n\n\n\n

Our research aims to understand how IDC-P develops and progresses, define its molecular pathogenesis, and translate these findings into new diagnostic and therapeutic strategies<\/strong>.<\/p>\n<\/div>\n\n\n\n

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\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Watanabe R, Haffner M, Nelson P et al. Urol. Oncol. 2026<\/p>\n\n\n\n

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How Does Prostate Cancer Progress to IDC-P?<\/h3>\n\n\n\n

Using spatial transcriptomic analysis<\/strong>, we investigate distinct prostate cancer states coexisting within the same tissue while preserving their spatial context.<\/p>\n\n\n\n

By comparing gene expression and clonal alterations across spatially defined tumor regions, we aim to reconstruct the clonal evolution from lower-grade prostate cancer to IDC-P<\/strong> and identify the molecular changes associated with malignant progression.<\/p>\n<\/div>\n\n\n\n

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\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Watanabe et al. Int J Mol Sci 2024<\/p>\n\n\n\n

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Exploring Molecular Alterations for Diagnosis and Treatment<\/h3>\n\n\n\n

We perform spatial gene expression profiling and genomic analyses<\/strong> of prostate cancer tissues containing IDC-P to identify molecular alterations associated with this aggressive disease.<\/p>\n\n\n\n

By analyzing not only tumor cells but also the surrounding tumor microenvironment<\/strong>, we aim to identify signaling pathways involved in IDC-P progression as well as novel biomarkers and therapeutic targets<\/strong>.<\/p>\n<\/div>\n\n\n\n

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Related Publications<\/h2>\n\n\n\n

Genetic Analysis of Intraductal Carcinoma of the Prostate Detected in High-Grade Prostatic Intraepithelial Neoplasia Cases<\/strong>
Watanabe R, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Cureus. 2024 Dec 21;16(12):e76165.<\/em>
PMID: 39840193<\/a><\/p>\n\n\n\n

Unveiling the Genomic Landscape of Intraductal Carcinoma of the Prostate Using Spatial Gene Expression Analysis<\/strong>
Watanabe R, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Int J Mol Sci. 2024 Apr 28;25(9):4818.<\/em>
PMID: 38732035<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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