{"id":138,"date":"2021-03-15T17:18:00","date_gmt":"2021-03-15T08:18:00","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/?page_id=138"},"modified":"2026-03-18T13:05:31","modified_gmt":"2026-03-18T04:05:31","slug":"english","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/publications\/english","title":{"rendered":"\u82f1\u8a9e\u8ad6\u6587"},"content":{"rendered":"\n

Saida M<\/span>, Saeki N<\/span>, Sakai H<\/span>, Iwanami J, Yokoyama A, Sawatsubashi S, Kanagawa M, Sato N, Imai Y<\/span>.
\u03b2-Nicotinamide mononucleotide preserves muscle strength in septic male mice
Sci Rep.<\/strong> 2026 Mar 13;16:8905. doi: 10.1038\/s41598-026-43172-w.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Haraguchi R, Kitazawa R, Yanagihara Y<\/span>, Imai Y<\/span>, Kitazawa S.
Dissecting Hhip1 Function In Vivo Using a Conditional Knockout Mouse Model
Acta Histochem Cytochem.<\/strong> 2025 Dec 24;58(6):187-198. doi: 10.1267\/ahc.25-00028. Epub 2025 Nov 14.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Wang L, Lu S, Feng J, Ma K, Duan F, Wang R, Cheng X, Liu Y, Imai Y<\/span>, Chen H, Gl\u00fcer CC, Guglielmi G, Vlug AG, Liu J, Engelke K, Li M, Sim M, Minisola S, Jiang X.
Muscle Imaging Assessments in Sarcopenia: A Statement from China National Center for Orthopedics (NCO) and the East Meets West Action Group of the European Calcified Tissue Society (ECTS)
Calcif Tissue Int. <\/strong>2025 Dec 1;116:144. doi: 10.1007\/s00223-025-01447-w.
[ PubMed <\/a>]<\/p>\n\n\n\n

Arai O<\/span>, Yanagihara Y<\/span>, Arai H<\/span>, Watanabe R, Miura N, Kikugawa T, Saika T, Imai Y<\/span>.
CDH11 contributes to bladder cancer progression via regulation of mitochondrial energy metabolism
Cancer Med.<\/strong> 2025 Nov 20;14(22):e71399. doi: 10.1002\/cam4.71399.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Ikedo A<\/span>, Aoki R, Sakai H<\/span>, Saeki N<\/span>, Yanagihara Y<\/span>, Moody J, Kojima M, Kouno T, Ando Y, Hino K, Kinoshita T, Carninci P, Shin JW, Hon CC, Uezumi A, Kamei Y, Imai Y<\/span>.
Estrogen signaling in PDGFR\u03b1+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice
JBMR Plus. <\/strong>2025 Nov 7;10(1):ziaf178. doi: 10.1093\/jbmrpl\/ziaf178. eCollection 2026 Jan.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Yanagihara Y<\/span>, Takahashi M, Izumi Y, Kinoshita T, Takao M, Bamba T, Imai Y<\/span>.
Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes
Nat Commun.<\/strong> 2025 Nov 4;16:9492. doi: 10.1038\/s41467-025-65145-9.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Ikedo A<\/span>, Yamashita M, Hoshino M, Okuno Y, Koike M, Uga M, Tanifuji K, Segawa H, Fukumoto S, Imai Y<\/span>.
Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation
J Bone Miner Res.<\/strong> 2026 Mar 2;41(3):324-335. doi: 10.1093\/jbmr\/zjaf129.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Imai Y.<\/span>
Integrative single cell multi-omics analysis captures a role of IRF8 as a gatekeeper for osteoclastogenesis
J Bone Miner Res. <\/strong>2025 Jul 23;40(10):1104-1105. doi: 10.1093\/jbmr\/zjaf103.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Sawada Y<\/span>, Kikugawa T, Onishi T<\/span>, Arai O<\/span>, Iio H<\/span>, Miura N, Yoshida S<\/span>, Ikedo A<\/span>, Yanagihara Y<\/span>, Saeki N<\/span>, Sakakibara I, Gy\u0151rffy B, Kishida T, Okubo Y, Nakamura Y, Sato S, Miyagi Y, Saika T, Imai Y<\/span>. 
CTHRC1 promotes bone metastasis in prostate cancer
Int J Cancer.<\/strong> 2025 Dec 1;157(11):2399-2412. doi: 10.1002\/ijc.70012. Epub 2025 Jun 21.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Aoto M, Sakai H<\/span>, Tokunaga N, Miyazaki M, Kiyoi T, Ohkubo N, Imai Y<\/span>, Mitsuda N.
The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis
Sci Rep. <\/strong>2025 Apr 23;15:14017. doi: 10.1038\/s41598-025-98851-x.
[ PubMed <\/a>]<\/p>\n\n\n\n

Goto A, Komura S, Kato K, Maki R, Hirakawa A, Aoki H, Tomita H, Taguchi J, Ozawa M, Matsushima T, Kishida A, Kimura T, Asahara H, Imai Y<\/span>, Yamada Y, Akiyama H.
PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration
Nat Commun. <\/strong>2025 Apr 20;16:3734. doi: 10.1038\/s41467-025-59010-y.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Onishi T<\/span>, Sakai H<\/span>, Uno H<\/span>, Sakakibara I, Uezumi A, Honda M, Kai T, Higashiyama S, Miura N, Kikugawa T, Saika T, Imai Y<\/span>.
Epidermal growth factor receptor contributes to indirect regulation of skeletal muscle mass by androgen.
Endocr J.<\/strong> 2025 Mar 3;72(3):259-272. doi: 10.1507\/endocrj.EJ24-0410.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Kodama N, Matsubara T, Yoshimura A, Nagano K, Hino J, Tsuji K, Ikedo A<\/span>, Imai Y<\/span>, Yaginuma T, Yuan Q, Morikawa K, Ono Y, Shirakawa T, Addison WN, Yoshioka I, Kokabu S.
BMP3b regulates bone mass by inhibiting BMP signaling
Bone.<\/strong> 2025 Jan:190:117303. doi: 10.1016\/j.bone.2024.117303. Epub 2024 Oct 24.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Sakai H<\/span>, Uno H<\/span>, Yamakawa H<\/span>, Tanaka K, Ikedo A<\/span>, Uezumi A, Ohkawa Y, Imai Y<\/span>.
The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice
Proc Natl Acad Sci U S A.<\/strong> 2024 Sep 24;121(39):e2407768121. doi: 10.1073\/pnas.2407768121. Epub 2024 Sep 18.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Kawaue H, Matsubara T, Nagano K, Ikedo A<\/span>, Rojasawasthien T, Yoshimura A, Nakatomi C, Imai Y<\/span>, Kakuta Y, Addison WN, Kokabu S.
KIF22 regulates mitosis and proliferation of chondrocyte cells
iScience.<\/strong> 2024 May 31;27(7):110151. doi: 10.1016\/j.isci.2024.110151. eCollection 2024 Jul 19.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Ikedo A<\/span>, Imai Y<\/span>.
Dietary restriction plus exercise change gene expression of Cxcl12 abundant reticular cells in female mice
J Bone Miner Metab.<\/strong> 2024 May;42(3):271-281. doi: 10.1007\/s00774-024-01506-6. Epub 2024 Apr 1.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Yoshida S<\/span>, Ikedo A<\/span>, Yanagihara Y<\/span>, Sakaue T, Saeki N<\/span>, ImaiY<\/span>.
Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNF\u03b1-mediated osteoclastogenesis
J Bone Miner Res.<\/strong> 2024 Apr 19;39(3):341-356. doi: 10.1093\/jbmr\/zjae015.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Sakai H<\/span>, Imai Y<\/span>.
Cell-specific functions of androgen receptor in skeletal muscles
Endocr J.<\/strong> 2024 May 23;71(5):437-445. doi: 10.1507\/endocrj.EJ23-0691. Epub 2024 Jan 27.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Arakawa Y, Tano Y, Fujii M, Imai Y<\/span>, Norimatsu Y, Yasukawa M, Watanabe M, Yamada T.
The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4+ T cells
Cytokine. <\/strong> 2024 Mar:175:156506. doi: 10.1016\/j.cyto.2024.156506. Epub 2024 Jan 19.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Lee JW, Lee IH, Watanabe H, Liu Y, Sawada K, Maekawa M, Uehara S, Kobayashi Y, Imai Y<\/span>, Kong SW, Iimura T.
Centrosome clustering control in osteoclasts through CCR5-mediated signaling
Sci Rep.<\/strong> 2023 Nov 27;13(1):20813. doi: 10.1038\/s41598-023-48140-2.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Jono A<\/span>, Yanagihara Y<\/span>, Kinoshita T, Takao M, Imai Y<\/span>.
Establishment of a uniform histological evaluation method for early stage osteophytes in the destabilization of the medial meniscus mouse model
Osteoarthr Cartil Open<\/strong>. 2023 Dec;5(4):100409. doi:10.1016\/j.ocarto.2023.100409.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Yamanaka S, Furihata H, Yanagihara Y<\/span>, Taya A, Nagasaka T, Usui M, Nagaoka K, Shoya Y, Nishino K, Yoshida S<\/span>, Kosako H, Tanokura M, Miyakawa T, Imai Y<\/span>, Shibata N, Sawasaki T.
Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation
Nat Commun.<\/strong> 2023 Aug 18;14:4683. doi: 10.1038\/s41467-023-40385-9.
[ <\/a>PubMed <\/a>]<\/p>\n\n\n\n

Koizumi S, Okada Y, Miura S, Imai Y<\/span>, Igase K, Ohyagi Y, Igase M.
Ingestion of a collagen peptide containing high concentrations of prolyl-hydroxyproline and hydroxyprolyl-glycine reduces advanced glycation end products levels in the skin and subcutaneous blood vessel walls: a randomized, double-blind, placebo-controlled study
Biosci Biotechnol Biochem.<\/strong> 2023 Jul 24;87(8):883-889. doi: 10.1093\/bbb\/zbad065.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Saeki N<\/span>, Imai Y<\/span>.
Crosstalk between synovial macrophages and fibroblasts in rheumatoid arthritis
Histol Histopathol<\/strong>. 2023 Nov;38(11):1231-1238. doi: 10.14670\/HH-18-628. Epub 2023 May 12.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Yabu A, Suzuki A, Hayashi K, Hori Y, Terai H, Orita K, Habibi H, Salimi H, Kono H, Toyoda H, Maeno T, Takahashi S, Tamai K, Ozaki T, Iwamae M, Ohyama S, Imai Y<\/span>, Nakamura H. 
Periostin increased by mechanical stress upregulates interleukin-6 expression in the ligamentum flavum
FASEB J.<\/strong> 2023 Feb;37(2):e22726. doi: 10.1096\/fj.202200917RR.
[ PubMed <\/a>]<\/p>\n\n\n\n

Nakata T, Okada M, Nishihara E, Ikedo A<\/span>, Asoh S, Takagi T, Tokunaga N, Hato N, Imai Y<\/span>. 
Effect of hormonal therapy on the otoconial changes caused by estrogen deficiency
Sci Rep.<\/strong> 2022 Dec 30;12:22596. doi: 10.1038\/s41598-022-27240-5.
[ PubMed<\/a> <\/a>]<\/p>\n\n\n\n

Yoshioka H, Komura S, Kuramitsu N, Goto A, Hasegawa T, Amizuka N, Ishimoto T, Ozasa R, Nakano T, Imai Y<\/span>, Akiyama H.
Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in spontaneous bone fractures
J Bone Miner Metab.<\/strong> 2022 Sep;40(5):839-852. doi: 10.1007\/s00774-022-01354-2.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Kato H<\/span>, Saeki N<\/span>, Imai M, Onji H, Yano A, Yoshida Y<\/span>, Sakaue T, Fujioka T, Sugiyama T, Imai Y<\/span>.
LIM1 contributes to the malignant potential of endometrial cancer
Front. Oncol<\/strong>. 2023 Mar 10;13:1082441.doi: 10.3389\/fonc.2023.1082441. eCollection 2023.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Saeki N<\/span>, Imai Y<\/span>.
Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
J Vis Exp.<\/strong><\/strong> 2023 Feb 24;(192):e65196. doi: 10.3791\/65196.
[ PubMed <\/a>]<\/p>\n\n\n\n

Satake T, Komura S, Aoki H, Hirakawa A, Imai Y<\/span>, Akiyama H.
Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells
BMC Mol Cell Biol.<\/strong> 2022 Jul 23;23:30. doi: 10.1186\/s12860-022-00431-8.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Nakamura Y, Saitou M, Komura S, Matsumoto K, Ogawa H, Miyagawa T, Saitou T, Imamura T, Imai Y<\/span>, Takayanagi H, Akiyama H.
Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3\/periostin\/NF-\u03baB axis
Sci Rep.<\/strong> 2022 Jul 16;12(1):12207. doi: 10.1038\/s41598-022-16585-6.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Saeki N<\/span>, Inoue K, Ideta-Otsuka M, Watamori K, Mizuki S, Takenaka K, Igarashi K, Miura H, Takeda S, Imai Y<\/span>.
Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner
J Clin Invest.<\/strong> 2022 Jun 1;132(11):e150533. doi: 10.1172\/JCI150533.
[ PubMed<\/a> ]
Sakai H<\/span>, Sawada Y, Tokunaga N, Tanaka K, Nakagawa S, Sakakibara I, Ono Y, Fukada S, Ohkawa Y, Kikugawa T, Saika T, Imai Y<\/span>.
Uhrf1 governs the proliferation and differentiation of muscle satellite cells
iScience.<\/strong> 2022 Mar 18;25(3):103928. doi: 10.1016\/j.isci.2022.103928.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Haraguchi R, Kitazawa R, Kohara Y, Imai Y<\/span>, Kitazawa S.
Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage
Cell Tissue Res.<\/strong> 2022 Apr;388(1):63-73. doi: 10.1007\/s00441-022-03578-0. Epub 2022 Jan 24.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Xia Y, Ikedo A<\/span>, Lee JW, Iimura T, Inoue K, Imai Y<\/span>.
Histone H3K27 demethylase, Utx, regulates osteoblast-to-osteocyte differentiation
Biochem Biophys Res Commun.<\/strong> 2022 Jan 29;590:132-138. doi: 10.1016\/j.bbrc.2021.12.102.
[ PubMed<\/a> ] <\/p>\n\n\n\n

Kohara Y, Kitazawa R, Haraguchi R, Imai Y<\/span>, Kitazawa S.
Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice
Bone.<\/strong> 2022 Jan;154:116200. doi: 10.1016\/j.bone.2021.116200. Epub 2021 Sep 14.
[ PubMed<\/a> ] <\/p>\n\n\n\n

Ikedo A<\/span>, Imai Y<\/span>.
Estrogen receptor \u03b1 in mature osteoblasts regulates the late stage of bone regeneration
Biochem Biophys Res Commun.<\/strong> 2021 Jun 25;559:238-244. doi: 10.1016\/j.bbrc.2021.04.112.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Sakakibara I<\/span>, Yanagihara Y<\/span>, Himori K, Yamada T, Sakai H<\/span>, Sawada Y<\/span>, Takahashi H, Saeki N<\/span>, Hirakawa H, Yokoyama A, Fukada S, Sawasaki T, Imai Y<\/span>.
Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4
iScience. <\/strong> 2021 Apr 23;24(4):102303. doi: 10.1016\/j.isci.2021.102303.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Ueyama H, Ohta Y, Imai Y<\/span>, Suzuki A, Sugama R, Minoda Y, Takaoka K, Nakamura H.
Topical co-administration of zoledronate with recombinant human bone morphogenetic protein-2 can induce and maintain bone formation in the bone marrow environment
BMC Musculoskelet Disord.<\/strong> 2021 Jan 20;22(1):94. doi: 10.1186\/s12891-021-03971-w.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Iio H<\/span>, Kikugawa T, Sawada Y, Sakai H<\/span>, Yoshida S<\/span>, Yanagihara Y<\/span>, Ikedo A<\/span>, Saeki N<\/span>, Fukada S, Saika T, Imai Y<\/span>.
DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration
Biochem Biophys Res Commun. <\/strong>2021 Jan 1;534:79-85. doi: 10.1016\/j.bbrc.2020.11.116. Epub 2020 Dec 10.
[ PubMed<\/a> <\/a>]<\/p>\n\n\n\n

Kanou M<\/span>, Nakamura K, Horie K, Sakai H<\/span>, Yanagihara Y<\/span>, Sakakibara I, Yamana K, Imai Y<\/span>.
Polyamine pathway is associated with muscle anabolic effects by androgen receptor ligand
JCSM Rapid Commun. <\/strong>2021 Jan;4(1):57-74. doi: 10.1002\/rco2.28. <\/p>\n\n\n\n

Saeki N<\/span>, Imai Y<\/span>.
Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions
Cell Commun Signal.<\/strong> 2020 Nov 30;18(1):188. doi: 10.1186\/s12964-020-00678-8.
[ PubMed <\/a>]<\/p>\n\n\n\n

Kiel DP, Kemp JP, Rivadeneira F, Westendorf JJ, Karasik D, Duncan E, Imai Y<\/span>, M\u00fcller R, Flannick J, Bonewald L, Burtt N.
The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community
J Bone Miner Res.<\/strong> 2020 Sep;35(9):1626-1633. doi: 10.1002\/jbmr.4147.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Seko D, Fujita R, Kitajima Y, Nakamura K, Imai Y<\/span>, Ono Y.
Estrogen receptor \u03b2 controls muscle growth and regeneration in young female mice
Stem Cell Reports.<\/strong> <\/strong>2020 Sep 8;15(3):577-586. doi: 10.1016\/j.stemcr.2020.07.017.  Epub 2020 Aug 20.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Kohara Y, Haraguchi R, Kitazawa R, Imai Y<\/span>, Kitazawa S.
Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo<\/em> in Macrophage\/Osteoclast Lineage Prevents Age-Related Bone Loss
Int. J. Mol. Sci.<\/strong> 2020 Apr 15;21(8):2745. doi: 10.3390\/ijms21082745.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Sakai H<\/span>, Sato T, Kanagawa M, Fukada S, Imai Y<\/span>.
Androgen receptor in satellite cells is not essential for muscle regenerations
Experimental Results.<\/strong> 2020 July 29. 1, e21, 1-9. doi:10.1017\/exp.2020.14.<\/p>\n\n\n\n

Nishihara E, Okada M, Kiyoi T, Shudou M, Imai Y<\/span>, Hato N.
Evaluation of the structure of the otoconial layer using micro-computed tomography.
Auris Nasus Larynx.<\/strong> 2020 Oct;47(5):734-739. doi: 10.1016\/j.anl.2020.02.013. Epub 2020 Mar 13.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Sawada Y<\/span>, Kikugawa T, Iio H<\/span>, Sakakibara I, Yoshida S<\/span>, Ikedo A<\/span>, Yanagihara Y<\/span>, Saeki N<\/span>, Gy\u0151rffy B, Kishida T, Okubo Y, Nakamura Y, Miyagi Y, Saika T, Imai Y<\/span>.
GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer.
Int J Cancer. <\/strong>2020 Mar 1;146(5):1369-1382. doi: 10.1002\/ijc.32554. Epub 2019 Jul 22.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Ikedo A<\/span>, Kido K, Ato S, Sato K, Lee JW, Fujita S and Imai Y<\/span>.
The effects of resistance training on bone mineral density and bone quality in type 2 diabetic rats.
Physiol Rep.<\/strong> 2019 Mar; 7(6), e14046. doi:10.14814\/phy2.14046.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Yanagihara Y<\/span>, Inoue K, Saeki N<\/span>, Sawada Y<\/span>, Yoshida S<\/span>, Lee JW, Iimura T and Imai Y<\/span>.
Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin.
Bone.<\/strong> 2019 May;122:93-100. doi: 10.1016\/j.bone.2019.02.011. Epub 2019 Feb 13.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Haraguchi R, Kitazawa R, Kohara Y, Ikedo A<\/span>, Imai Y<\/span>, Kitazawa S.
Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate
Int. J. Mol. Sci.<\/strong> 2019 Nov 20;20(23):5840; doi: 10.3390\/ijms20235840.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Hayashi K, Suzuki A, Terai H, Ahmadi SA, Rahmani MS, Hasib MM, Habibi H, Hori Y, Yamada K, Hoshino M, Toyoda H, Takahashi S, Tamai K, Ohyama S, Imai Y<\/span>, Nakamura H.
Fibroblast Growth Factor 9 Is Upregulated Upon Intervertebral Mechanical Stress-Induced Ligamentum Flavum Hypertrophy in a Rabbit Model
Spine.<\/strong> 2019 Oct 15;44(20):E1172-E1180. doi: 10.1097\/BRS.0000000000003089.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Kojima A, Sakaue T, Okazaki M, Shikata F, Kurata M, Imai Y<\/span>, Nakaoka H, Masumoto J, Uchita S, Izutani H.
A simple mouse model of pericardial adhesions.
J Cardiothorac Surg.<\/strong> 2019 Jun 28;14(1):124. doi: 10.1186\/s13019-019-0940-9.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Ono Y, Miyakoshi N, Kasukawa Y, Imai Y<\/span>, Nagasawa H, Tsuchie H, Akagawa M, Nagahata I, Yuasa Y, Sato C, Kawatani M, Shimada Y.
Micro-CT imaging analysis for the effects of ibandronate and eldecalcitol on secondary osteoporosis and arthritis in adjuvant-induced arthritis rats.
Biomed Res. <\/strong>2019;40(5):197-205. doi: 10.2220\/biomedres.40.197.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y<\/span>, Saeki N<\/span>, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y<\/span>, Tokunaga F, Sawasaki T.
The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
J Biol Chem.<\/strong> 2019 Sep 20;294(38):14135-14148. doi: 10.1074\/jbc.RA119.010119. Epub 2019 Jul 31.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Yamada T, Nabe S, Toriyama K, Suzuki J, Inoue K, Imai Y<\/span>, Shiraishi A, Takenaka K, Yasukawa M, Yamashita M
Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells
J Immunol.<\/strong> 2019 Feb 15;202(4)1088-1098. doi:10.4049\/jimmunol.1801083. Epub 2019 Jan 9.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Haraguchi R, Kitazawa R, Imai Y<\/span>, Kitazawa S.
Growth plate-derived hedgehog-signal-responsive cells provide skeletal tissue components in growing bone
Histochem Cell Biol.<\/strong> 2018 Apr;149(4):365-373. doi:10.1007\/s00418-018-1641-5.Epub 2018 Jan 22.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Ishimaru Y, Oshima Y, Imai Y<\/span>, Iimura T, Takanezawa S, Hino K, Miura H.
Raman Spectroscopic Analysis to Detect Reduced Bone Quality after Sciatic Neurectomy in Mice
Molecules.<\/strong> 2018 Nov 25;23(12),3081. doi:10.3390\/molecules23123081.
[ PubMed<\/a> ]<\/p>\n\n\n\n

Suzuki J, Yamada T, Inoue K, Nabe S, Kuwahara M, Takemori N, Takemori A, Matsuda S, Kanoh M, Imai Y<\/span>, Yasukawa M, Yamashita M.
The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
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Saida M, Saeki N, Sakai H, Iwanami J, Yokoyama A, Sawatsubashi S, Kanagawa M, Sato N, Imai Y.\u03b2-Nicotinamide mo […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":107,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-138","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/pages\/138","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/comments?post=138"}],"version-history":[{"count":243,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/pages\/138\/revisions"}],"predecessor-version":[{"id":4050,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/pages\/138\/revisions\/4050"}],"up":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/pages\/107"}],"wp:attachment":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/imailab\/wp-json\/wp\/v2\/media?parent=138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}