Our department is primary concerned with investigating the molecular mechanism that govern the regulation of T cell differentiation, functions and senescence. We focus on the role of metabolic reprograming and epigenetic change in the regulation of T cell fate. The goal of our studies is to propose a novel therapeutic approach for immune disorders, particularly for allergy. In addition, we are also trying to establish a new technical basis for the cancer immunotherapy and vaccine design.
(1) Immune modulation for allergy and cancer therapy via regulation of T cell metabolism and epigenetics.
(2) Regulatory mechanism of T cell senescence and exhaustion.