{"id":43,"date":"2014-08-27T14:38:23","date_gmt":"2014-08-27T05:38:23","guid":{"rendered":"http:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/?page_id=43"},"modified":"2026-02-12T17:32:40","modified_gmt":"2026-02-12T08:32:40","slug":"%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/?page_id=43","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"

\u7814\u7a76\u696d\u7e3e(\u6cb3\u5408\u55ac\u6587)<\/strong><\/h3>\n

\u7740\u4efb\u5f8c(2026\u5e74\u4ee5\u964d)<\/h4>\n

\u3010\u539f\u8457\u8ad6\u6587\u3011<\/h4>\n
    \n
  • Ratanayotha A*, Mizutani N, Takenaga F, Kawai T*<\/u><\/strong>, Okamura Y (* corresponding author<\/em>)<\/strong>
    \nSpatiotemporal regulation of endocytic membrane trafficking by voltage-sensing phosphatase (VSP) in zebrafish enterocytes
    \nBiochim Biophys Acta.<\/em><\/strong> in press<\/em>.<\/li>\n<\/ul>\n

    \u7740\u4efb\u524d(2025\u5e74\u307e\u3067)<\/h4>\n

    \u3010\u539f\u8457\u8ad6\u6587\u3011<\/h4>\n
      \n
    • Zhou J, Andriani RT, Mizutani N, Yamamoto K, Yoshioka D, Kawanabe A, Kawai T<\/u><\/strong>, Okochi Y, Okamura Y
      \nOptical control of PI(4,5)P2<\/sub> sensitivity of ion channels by manipulation of single lysine residue
      \nJ Gen Physiol<\/em><\/strong>, 158(1):e202513811 (2026)<\/li>\n
    • Kawai T<\/u><\/strong>, Dong P, Bakhurin K, Yin HH, Yang H
      \nCalcium-Activated Ion Channels Drive Atypical Inhibition in Medial Habenula Neurons
      \nScience Advances<\/em><\/strong>, 11(12):eadq2629 (2025)<\/li>\n
    • Kaneda E, Kawai T<\/u><\/strong>, Okamura Y, Miyagawa S
      \nEffects of moderate static magnetic fields on the voltage-gated potassium ion channels in sympathetic neuron-like PC12 cells
      \nPhysiological Reports<\/em><\/strong>, 13(6):e70236. (2025)<\/li>\n
    • Kawai T*<\/u><\/strong>, Mizutani N, Okamura Y (* corresponding author<\/em>)
      \n<\/strong>Voltage- and Ca2+<\/sup>-inducible PLC activity for analyzing\u200b PI(4,5)P2<\/sub> sensitivity of ion channels in Xenopus<\/em> oocytes. Biochim Biophys Acta.<\/em><\/strong> 1867(1):18439 (2025)<\/li>\n
    • Kawai T*<\/u><\/strong>, Morioka S, Miyata H, Andriani RT, Akter S, Toma G, Nakagawa T, Oyama Y, Iida-Norita R, Sasaki J, Watanabe M, Sakimura K, Ikawa M, Sasaki Y, Okamura Y (* corresponding author<\/em>)<\/strong>
      \nThe significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase. Nature Communications<\/em><\/strong>, 15:7289 (2024).<\/li>\n
    • Ratanayotha A*, Iida A, Nomura J, Hondo E, Okamura Y, Kawai T*<\/u><\/strong> (* corresponding author<\/em>)<\/strong>
      \nInsight into the function of voltage-sensing phosphatase (VSP) in hind-gut derived pseudoplacenta of a viviparous teleost Xenotoca eiseni<\/em>. Am J Physiol.<\/em><\/strong> 326(6):R461-R471 (2024)<\/li>\n
    • Yokoyama R, Ago Y, Igarashi H, Higuchi M, Tanuma M, Shimazaki Y, Kawai T<\/u><\/strong>, Seiriki K, Hayashida M, Yamaguchi S, Tanaka H, Nakazawa T, Okamura Y, Hashimoto K, Kasai A, Hashimoto H
      \n(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice. Molecular Psychiatry<\/em><\/strong>, 29(5):1406-1416 (2024)<\/li>\n
    • Iida A, Tsuda N, Yoshida J, Nomura J, Ratanayotha A, Kawai T<\/u><\/strong>, Hondo E
      \nGlucose absorption activity and gene expression of sugar transporters in the trophotaenia of the viviparous teleost Xenotoca eiseni. Biochim Biophys Acta.<\/em><\/strong> 1867(11):130464 (2023).<\/li>\n
    • Paixao IC, Mizutani N, Matsuda M, Andriani RT, Kawai T<\/u><\/strong>, Nakagawa A, Okochi Y, Okamura Y
      \nRole of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP. Biophys J<\/em><\/strong>. 122(11):2267-2284 (2023)<\/li>\n
    • Ratanayotha A, Matsuda M, Kimura Y, Takenaga F, Mizuno T, Hossain MI, Higashijima SI, Kawai T*<\/u><\/strong>, Ogasawara M, Okamura Y* (* corresponding author<\/em>)<\/strong>
      \nVoltage-sensing phosphatase (VSP) regulates endocytosis-dependent nutrient absorption in chordate enterocytes. Communications Biology.<\/em><\/strong> 5(1):948 (2022).<\/li>\n
    • Kawai T*<\/u><\/strong>, Narita H, Konno K, Akter S, Andriani R, Iwasaki H, Nishikawa S, Yokoi N, Fukata Y, Fukata M, Wiriyasermkul P, Kongpracha P, Nagamori S, Takao K, Miyakawa T, Abe M, Sakimura K, Watanabe M, Nakagawa A, Okamura Y (* corresponding author<\/em>)<\/strong>
      \nInsight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum. Biochem J.<\/em><\/strong> 479(11):1127-1145 (2022).<\/li>\n
    • Kawai T<\/u><\/strong>, Hashimoto M, Eguchi N, Nishino J, Jinno Y, Mori-Kreiner R, Asp\u00e5ker M, Chiba D, Ohtsuka Y, Kawanabe A, Nishino A, and Okamura Y
      \nHeterologous functional expression of ascidian Nav1 channels and close relationship with the evolutionary ancestor of vertebrate Nav channels. J Biol Chem. <\/em><\/strong>296:100783 (2021)<\/li>\n
    • Kawai T<\/u><\/strong>*<\/u>, Takao K, Akter S, Abe M, Sakimura K, Miyakawa T, Okamura Y* (* corresponding author<\/em>)
      \n<\/strong>Heterogeneity of microglial proton channel in different brain regions and its relationship with aging. J Neurochem<\/em><\/strong>. 157(3):624-641 (2021)<\/li>\n
    • Kawai T<\/u><\/strong>, Kayama K, Tatsumi S, Akter S, Miyawaki N, Okochi Y, Abe M, Sakimura K, Yamamoto H, Kihara S, Okamura Y
      \nRegulation of hepatic oxidative stress by voltage-gated proton channels (Hv1\/VSOP) in Kupffer cells and its potential relationship with glucose metabolism. FASEB J<\/em><\/strong>. 34(12):15805-15821 (2020)<\/li>\n
    • Kawai T*<\/u><\/strong>, Okamura Y (* corresponding author<\/em>)<\/strong>. The Slo3\/Lrrc52 complex is sensitive to phosphoinotsitides. Channels<\/em><\/strong>. 14(1):1-3 (2020)<\/li>\n
    • Sakaguchi T, Okumura R, Ono C, Okuzaki D, Kawai T<\/u><\/strong>, Okochi Y, Tanimiura N, Murakami M, Kayama H, Umemoto E, Kioka H, Ohtani T, Sakata Y, Miyake K, Okamura Y, Baba Y, Takeda K. TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes. Cell Reports<\/em>.<\/strong> 31(10):107755 (2020)<\/li>\n
    • Kawanabe A, Mizutani N, Polat Onur K, Yonezawa T, Kawai T<\/u><\/strong>, Mori MX, Okamura Y. Engineering an enhanced voltage-sensing phosphatase. J Gen Physiol.<\/em><\/strong> 152(5): e201912491 (2020)<\/li>\n
    • Kawai T<\/u><\/strong>, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M, Okamura Y. Polarized PtdIns(4,5)P2<\/sub> distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility. Proc. Natl. Acad. Sci. U. S. A.<\/em><\/strong> 116(51):26020-26028(2019).<\/li>\n
    • Ratanayotha A, Kawai T<\/u><\/strong>, Okamura Y.\u3000Real-time functional analysis of Hv1 channel in neutrophils: a new approach from zebrafish model. Am J Physiol.<\/em><\/strong> 316(6):R819-R831(2019)<\/li>\n
    • Kawai T<\/u><\/strong>, Tatsumi S, Kihara S, Sakimura K, Okamura Y
      \nMechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP\/Hv1). Channels<\/em><\/strong>. 12(1):1-8 (2018)<\/li>\n
    • Kawai T<\/u><\/strong>, Okochi Y, Ozaki T, Imura Y, Koizumi S, Yamazaki M, Abe M, Sakimura K, Yamashita T, Okamura Y
      \nUnconventional role of voltage-gated proton channels (VSOP\/Hv1) in regulation of microglial ROS production. J Neurochem<\/em><\/strong>. 142(5):686-699 (2017)<\/li>\n
    • Ratanayotha A, Kawai T<\/u><\/strong>*, Higashijima S, Okamura Y (* corresponding author<\/em>)<\/strong>
      \nMolecular and Functional Characterization of the Voltage-Gated Proton Channel in Zebrafish Neutrophils. Physiological Reports<\/em><\/strong>. 5(15) no. e13345 (2017)<\/li>\n
    • Kawai T<\/u><\/strong>, Yoshimura A, Oka Y
      \nNeurones in the preoptic area of the male goldfish are activated by a sex pheromone 17\u03b1,20\u03b2-dihydroxy-4-pregnen-3-one. J Neuroendocrinol<\/em><\/strong>. <\/em>27(2):123-130 (2015)<\/li>\n
    • Mutua J, Jinno Y, Sakata S, Okochi Y, Ueno S, Tsutsui H, Kawai T<\/u><\/strong>, Iwao Y, Okamura Y
      \nFunctional diversity of voltage-sensing phosphatases in two urodele amphibians. Physiological Reports<\/em><\/strong>.<\/em> 2(7) no. e12061 (2014)<\/li>\n
    • Kawai T<\/u><\/strong>, Abe H, Oka Y
      \nBurst generation mediated by cholinergic input in terminal nerve-gonadotrophin releasing hormone neurones of the goldfish. J Physiol<\/em><\/strong>.<\/em> 591(22):5509-5523 (2013)<\/li>\n
    • Kawai T<\/u><\/strong>, Abe H, Oka Y
      \nDopaminergic neuromodulation of synaptic transmission between the mitral and granule cells in the teleost olfactory bulb. J Neurophysiol<\/em><\/strong>.<\/em> 107(5):1313-1324 (2012)<\/li>\n
    • Kawai T<\/u><\/strong>, Abe H, Akazome Y, Oka Y.
      \nNeuromodulatory effect of GnRH on the synaptic transmission of the olfactory bulbar neural circuit in goldfish, Carassius auratus. J Neurophysiol.<\/em><\/strong> 104(6):3540-3550 (2010)<\/li>\n
    • Kawai T<\/u><\/strong>, Abe H, Wakabayashi K, Oka Y.
      \nCalcium oscillations in the olfactory nonsensory cells of the goldfish, Carassius auratus. Biochim Biophys Acta.<\/em><\/strong> 1790(12):1681-1688 (2009)<\/li>\n<\/ul>\n

      \u3010\u7dcf\u8aac\u3011<\/h4>\n
        \n
      • Kawai T*<\/u><\/strong> and Okamura Y (* corresponding author<\/em>)<\/strong>
        \nSpotlight on the binding affinity of ion channels for phosphoinositides: From the study of sperm flagellum. Frontiers in Physiology.<\/em><\/strong> 13:834180 (2022)<\/li>\n
      • Okamura Y, Kawanabe A, Kawai T
        \n<\/u><\/strong>Voltage-Sensing Phosphatases: Biophysics, Physiology and Molecular Engineering
        \nPhysiological Reviews.<\/em><\/strong> 98(4):2097-2131 (2018)<\/li>\n
      • Kawai T<\/u><\/strong>, Oka Y, Eisthen H.
        \nThe role of the terminal nerve and GnRH in olfactory system neuromodulation.
        \nZoolog Sci.<\/em><\/strong> 26(10):669-680 (2009)<\/li>\n<\/ul>\n

        \u7814\u7a76\u696d\u7e3e(\u77e2\u91ce\u5143)<\/strong><\/h3>\n

        \u7740\u4efb\u5f8c(2010\u5e74\u4ee5\u964d)<\/h4>\n

        \u3010\u539f\u8457\u8ad6\u6587\u3011<\/h4>\n
          \n
        • Hosokawa Y, Miyoshi S, Hayashi Y, Irifune Y, Sato E, Mitani S, Choudhury M, Yano H*<\/u><\/strong>, Tanaka J, Hato N.
          \nChloride Intracellular Channel 2 Can Function as a Malignant Factor in Head and Neck Squamous Cell Carcinoma. Head Neck<\/em><\/strong>, doi: 10.1002\/hed.70133 (2025)<\/li>\n
        • Mikami K, Kigami Y, Doi T, Choudhury ME, Nishikawa Y, Takahashi R, Wada Y, Kakine H, Kawase M, Hiyama N, Yano H,<\/u><\/strong> Abe N, Nishihara T, Tanaka J.
          \nThird-party punishment-like behavior in a rat model. Sci Rep,<\/em><\/strong> 14(1):22310. doi: 10.1038\/s41598-024-71748-x (2024)<\/li>\n
        • Tanaka K, Choudhury ME, Kikuchi S, Takeda I, Umakoshi K, Miyaue N, Mikami K, Takenaga A, Yagi H, Shinabe R, Matsumoto H, Yano H,<\/u><\/strong> Nagai M, Takeba J, Tanaka J.
          \nA dopamine D1-like receptor-specific agonist improves the survival of septic mice. iScience,<\/em><\/strong> 27(4):109587. doi: 10.1016\/j.isci.2024.109587 (2024) eCollection 2024 Apr 19.<\/li>\n
        • Hayashi Y, Miyoshi S, Watanabe I, Yano N, Nagashio K, Kaneko M, Kaminota T, Sanada T, Hosokawa Y, Kitani T, Mitani S, Choudhury ME, Yano H*,<\/u><\/strong> Tanaka J, Hato N.
          \nSimultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity of head and neck squamous cell carcinoma. Auris Nasus Larynx,<\/em><\/strong> 51(3):472-480. doi: 10.1016\/j.anl.2024.01.006 (2024)<\/li>\n
        • Ohtsuka Y, Suehiro S, Inoue A, Ohnishi T, Nishikawa M, Yamashita D, Yano H, <\/u><\/strong>Choudhury ME, Ozaki S, Sampetrean O, Saya H, Watanabe H, Tanaka J, Kunieda T.
          \nBerberine as a potential enhancer for 5-ALA-mediated fluorescence in glioblastoma: increasing detectability of infiltrating glioma stem cells to optimize 5-ALA-guided surgery. J Neurosurg,<\/em><\/strong> 141(3):653-663. doi: 10.3171\/2023.12.JNS231506 (2024)<\/li>\n
        • Inoue A, Ohnishi T, Nishikawa M, Watanabe H, Kusakabe K, Taniwaki M, Yano H, <\/u><\/strong>Ohtsuka Y, Matsumoto S, Suehiro S, Yamashita D, Shigekawa S, Takahashi H, Kitazawa R, Tanaka J, Kunieda T.
          \nIdentification of CD44 as a Reliable Biomarker for Glioblastoma Invasion: Based on Magnetic Resonance Imaging and Spectroscopic Analysis of 5-Aminolevulinic Acid Fluorescence. Biomedicines,<\/em><\/strong> 11(9):2369. doi: 10.3390\/biomedicines11092369 (2023)<\/li>\n
        • Takeda H, Nakajima Y, Yamaguchi T, Watanabe I, Miyoshi S, Nagashio K, Sekine H, Motohashi H, Yano H*,<\/u><\/strong> Tanaka J.
          \nThe anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2. J Biochem, <\/em><\/strong>174(2):131-142. doi: 10.1093\/jb\/mvad030 (2023)<\/li>\n
        • Choudhury ME, Ozaki S, Miyaue N, Matsuura T, Mikami K, Islam A, Kubo M, Ando R, Yano H,<\/u><\/strong> Kunieda T, Nagai M, Tanaka J.
          \nChloride Intracellular Channel Protein 2 Promotes Microglial Invasion: A Link to Microgliosis in the Parkinson’s Disease Brain. Brain Sci,<\/em><\/strong> 13(1):55. doi: 10.3390\/brainsci13010055 (2022)<\/li>\n
        • Nishikawa Y, Choudhury ME, Mikami K, Matsuura T, Kubo M, Nagai M, Yamagishi S, Doi T, Hisai M, Yamamoto H, Yajima C, Nishihara T, Abe N, Yano H,<\/u><\/strong> Yorozuya T, Tanaka J.
          \nAnti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model. Neurochem Int,<\/em><\/strong> 163:105479. doi: 10.1016\/j.neuint.2023.105479 (2023)<\/li>\n
        • Taguchi S, Choudhury ME, Mikami K, Utsunomiya R, Yano H<\/u><\/strong>, Tanaka J.
          \nTreadmill Exercise as a Preventive Measure Against Age-Related Anxiety and Social Behavioral Disorders in Rats: When Is It Worth Starting? Ann Rehabil Med,<\/em><\/strong> 46(6):320-328. doi: 10.5535\/arm.22105 (2022)<\/li>\n
        • Takeda H, Yoshimura Y, Takagi M, Sato A, Kihara N, Choudhury ME, Yano H*,<\/u><\/strong> Tanaka J.
          \nBromovalerylurea modulates GABAA receptor-mediated inhibitory neurotransmission while inducing sleep. Biochem Biophys Res Commun,<\/em><\/strong> 638:176-183. doi: 10.1016\/j.bbrc.2022.11.062 (2023)<\/li>\n
        • Utsunomiya R, Mikami K, Doi T, Choudhury ME, Jogamoto T, Tokunaga N, Ishii E, Eguchi M, Yano H,<\/u><\/strong> Tanaka J.
          \nRearing in an Enriched Environment Ameliorates the ADHD-like Behaviors of Lister Hooded Rats While Suppressing Neuronal Activities in the Medial Prefrontal Cortex. Cells,<\/em><\/strong> 11(22):3649. doi: 10.3390\/cells11223649 (2022)<\/li>\n
        • Matsumoto S, Choudhury ME, Takeda H, Sato A, Kihara N, Mikami K, Inoue A, Yano H<\/u><\/strong>, Watanabe H, Kumon Y, Kunieda T, Tanaka J.
          \nMicroglial re-modeling contributes to recovery from ischemic injury of rat brain: A study using a cytokine mixture containing granulocyte-macrophage colony-stimulating factor and interleukin-3. Front Neurosci,<\/em><\/strong> 16:941363. doi: 10.3389\/fnins.2022.941363. eCollection 2022 (2022)<\/li>\n
        • Yoshino Y, Kumon H, Shimokawa T, Yano H<\/u><\/strong>, Ochi S, Funahashi Y, Iga JI, Matsuda S, Tanaka J, Ueno SI.
          \nImpact of Gestational Haloperidol Exposure on miR-137-3p and Nr3c1 mRNA Expression in Hippocampus of Offspring Mice. Int J Neuropsychopharmacol,<\/em><\/strong> 25(10):853-862. doi: 10.1093\/ijnp\/pyac044 (2022)<\/li>\n
        • Nishioka R, Nishi Y, Choudhury ME, Miyaike R, Shinnishi A, Umakoshi K, Takada Y, Sato N, Aibiki M, Yano H<\/u><\/strong>, Tanaka J.
          \nSurgical stress quickly affects the numbers of circulating B-cells and neutrophils in murine septic and aseptic models through a \u03b22 adrenergic receptor. J Immunotoxicol,<\/em><\/strong> 19(1):8-16. doi: 10.1080\/1547691X.2022.2029630 (2022)<\/li>\n
        • Choudhury ME, Mikami K, Nakanishi Y, Matsuura T, Utsunomiya R, Yano H<\/u><\/strong>, Kubo M, Ando R, Iwanami J, Yamashita M, Nagai M, Tanaka J.
          \nInsomnia and depressive behavior of MyD88-deficient mice: Relationships with altered microglial functions. J Neuroimmunol, <\/em><\/strong>363:577794. doi:10.1016\/j.jneuroim. 2021. 577794 (2022)<\/li>\n
        • Ozaki S, Umakoshi A, Yano H<\/u><\/strong>, Ohsumi S, Sumida Y, Hayase E, Usa E, Islam A, Choudhury ME, Nishi Y, Yamashita D, Ohtsuka Y, Nishikawa M, Inoue A, Suehiro S, Kuwabara J, Watanabe H, Takada Y, Watanabe Y, Nakano I, Kunieda T, Tanaka J.
          \nChloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis. Neoplasia, <\/em><\/strong>23(8):754-765. doi: 10.1016\/j.neo.2021.06.001 (2021)<\/li>\n
        • Inoue A, Nishikawa M, Ohnishi T, Yano H<\/u><\/strong>, Kanemura Y, Ohtsuka Y, Ozaki S, Nakamura Y, Matsumoto S, Suehiro S, Yamashita D, Shigekawa S, Watanabe H, Kitazawa R, Tanaka J, Kunieda T.
          \nPrediction of Glioma Stemlike Cell Infiltration in the Non-Contrast-Enhancing Area by Quantitative Measurement of Lactate on Magnetic Resonance Spectroscopy in Glioblastoma. World Neurosurg,<\/em> <\/strong>153:e76-e95. doi: 10.1016\/j.wneu.2021.06.044 (2021)<\/li>\n
        • Nishikawa M, Inoue A, Ohnishi T, Yano H<\/u><\/strong>, Ozaki S, Kanemura Y, Suehiro S, Ohtsuka Y, Kohno S, Ohue S, Shigekawa S, Watanabe H, Kitazawa R, Tanaka J, Kunieda T.
          \nHypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma. Transl Oncol,<\/em><\/strong> 14(8):101137. doi: 10.1016\/j.tranon.2021.101137 (2021)<\/li>\n
        • Nishikawa M, Inoue A, Ohnishi T, Yano H<\/u><\/strong>, Kanemura Y, Kohno S, Ohue S, Ozaki S, Matsumoto S, Suehiro S, Nakamura Y, Shigekawa S, Watanabe H, Kitazawa R, Tanaka J, Kunieda T.
          \nCD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma. Cancer Med,<\/em><\/strong> 10(6):2013-2025. doi: 10.1002\/cam4.3767 (2021)<\/li>\n
        • Tanaka J, Takahashi H, Yano H<\/u><\/strong>, Nakanishi H.
          \nGeneration of CSF1-independent ramified microglia-like cells from Leptomeninges in vitro.<\/em> Cells<\/strong><\/em>,<\/strong>\u00a010 <\/em>(1):doi.org\/10.3390\/cells10010024 (2021)<\/li>\n
        • Jogamoto T, Utsunomiya R, Sato A, Kihara N, Choudhury ME, Miyanishi K, Kubo M, Nagai M, Nomoto M, Yano H<\/u><\/strong>, Shimizu YI, Fukuda M, Ishii E, Eguchi M, Tanaka J.
          \nLister hooded rats as a novel animal model of attention-deficit\/hyperactivity disorder. Neurochem Int,<\/em><\/strong> 141:104857. doi: 10.1016\/j.neuint.2020.104857 (2020)<\/li>\n
        • Nishihara T, Tanaka J, Sekiya K, Nishikawa Y, Abe N, Hamada T, Kitamura S, Ikemune K, Ochi S, Choudhury ME, Yano H<\/u><\/strong>, Yorozuya T.
          \nChronic constriction injury of the sciatic nerve in rats causes different activation modes of microglia between the anterior and posterior horns of the spinal cord. Neurochem. Int, <\/em><\/strong>134:104672, doi: 10.1016\/j.neuint.2020.104672 (2020)<\/li>\n
        • Umakoshi K, Choudhury ME, Nishioka R, Matsumoto H, Abe N, Nishikawa Y, Kikuchi S, Takeba J, Yano H<\/u><\/strong>, Yorozuya T, Sato N, Aibiki, M, Tanaka J.
          \nB lymphocytopenia and Bregs in a Not-To-Die murine sepsis model. Biochem Biophys Res Commun<\/em><\/strong>, 523:202-207, doi: 10.1016\/j.bbrc.2019.12.041 (2020)<\/li>\n
        • Taguchi S, Choudhury ME, Miyanishi K, Nakanishi Y, Kameda K, Abe N, Yano H<\/u><\/strong>, Yorozuya T, Tanaka J.
          \nAggravating effects of treadmill exercises during the early-onset period in a rat traumatic brain injury model: When should rehabilitation exercises be initiated? IBRO Rep<\/em>, <\/strong>7:82-89, doi: 10.1016\/j.ibror.2019.10.002 (2019)<\/li>\n
        • Choudhury ME, Miyanishi K, Takeda H, Islam A, Matsuoka N, Kubo M, Matsumoto S, Kunieda T, Nomoto M, Yano H<\/u><\/strong>,<\/u> Tanaka J.
          \nPhagocytic elimination of synapses by microglia during sleep. Glia,<\/strong><\/em> doi: 10.1002\/glia.23698 (2019)<\/li>\n
        • Sanada T, Islam A, Kaminota T, Kirino Y, Tanimoto R, Yoshimitsu H, Yano<\/u><\/strong>\u00a0H*<\/strong><\/u> Mizuno Y, Okada M, Mitani S, Ugumori T, Tanaka J, Hato N.
          \nElevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma. Laryngoscope<\/em><\/strong>, <\/strong>doi: 10.1002\/lary.28142 (2019)<\/li>\n
        • Miyanishi K, Choudhury ME, Watanabe M, Kubo M, Nomoto M, Yano H<\/u><\/strong>, Tanaka J.
          \nBehavioral tests predicting striatal dopamine level in a rat hemi-Parkinson’s disease model. Neurochem Int,<\/em> <\/strong>122:38-46 (2019)<\/li>\n
        • Ueno Y, Ozaki S, Umakoshi A, Yano H<\/u><\/strong>, Choudhury ME, Abe N, Sumida Y, Kuwabara J, Uchida R, Islam A, Ogawa K, Ishimaru K, Yorozuya T, Kunieda T, Watanabe Y, Takada Y, Tanaka J.
          \nChloride intracellular channel protein 2 in cancer and non-cancer human tissues: relationship with tight junctions. Tissue Barriers, <\/em><\/strong>doi.org\/10.1080\/21688370 (2019)<\/li>\n
        • Abe N, Choudhury ME, Watanabe M, Kawasaki S, Nishihara T, Yano H<\/u><\/strong>, Matsumoto S, Kunieda T, Kumon Y, Yorozuya T, Tanaka J.
          \nComparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: A study using a hypnotic bromovalerylurea. Glia,<\/em><\/strong> doi: 10.1002\/glia.23469 (2018)<\/li>\n
        • Islam A, Choudhury ME, Kigami Y, Utsunomiya R, Matsumoto S, Watanabe H, Kumon Y, Kunieda T, Yano H<\/u><\/strong>, Tanaka J.
          \nSustained anti-inflammatory effects of TGF-\u03b21 on microglia\/macrophages. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease,<\/em> <\/strong>1864:721-734 (2018)<\/li>\n
        • Nishikawa M, Inoue A, Ohnishi T, Kohno S, Ohue S, Matsumoto S, Suehiro S, Yamashita D, Ozaki S, Watanabe H, Yano H<\/u><\/strong>, Takahashi H, Kitazawa R, Tanaka J, Kunieda T.
          \nSignificance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma. Stem Cells International,<\/em><\/strong> Article ID 5387041, 15 pages, https:\/\/doi.org\/10.1155\/2018\/5387041 (2018)<\/li>\n
        • Kuwabara J, Umakoshi A, Abe N, Sumida Y, Ohsumi S, Usa E, Taguchi K, Choudhury ME, Yano H<\/u><\/strong>, Matsumoto S, Kunieda T, Takahashi H, Yorozuya T, Watanabe Y, Tanaka J.
          \nTruncated CD200 stimulates tumor immunity leading to fewer lung metastases in a novel Wistar rat metastasis model. Biochem Biophys Res Commun,<\/em> <\/strong>496:542-548 (2018)<\/li>\n
        • Kaminota T, Yano H*<\/u><\/strong>, Shiota K, Nomura N, Yaguchi H, Kirino Y, Ohara K, Tetsumura I, Sanada T, Ugumori T, Tanaka J, Hato N.
          \nElevated Na+<\/sup>\/H+<\/sup> exchanger-1 expression enhances the metastatic collective migration of head and neck squamous cell carcinoma cells. Biochem, Biophys, Res, Commun,<\/em> <\/strong>486:101-107 (2017)<\/li>\n
        • Kawasaki S, Abe N, Ohtake F, Islam A, Choudhury ME, Utsunomiya R, Kikuchi S, Nishihara T, Kuwabara J, Yano H<\/u><\/strong>, Watanabe Y, Aibiki M, Yorozuya T, Tanaka J.
          \nEffects of hypnotic bromovalerylurea on microglial BV2 cells. J Pharmacol Sci,<\/em> <\/strong>134:116-123, (2017)<\/li>\n
        • Yano Y, Yano H<\/u><\/strong>, Takahashi H, Yoshimoto K, Tsuda S, Fujiyama K, Shimizu YI, Motoie R, Ito M, Tanaka J, Ishii E Fukuda M.
          \nGoreisan suppresses cerebral edema associated with hypoxic-ischemic encephalopathy in juvenile rats possibly via inhibition of aquaporin 4. Evid Based Complement Alternat Med,<\/em> <\/strong>Article ID 3209219, https:\/\/doi.org\/10.1155\/2017\/3209219 (2017)<\/li>\n
        • Aono H, Choudhury ME, Higaki H, Miyanishi K, Kigami Y, Fujita K, Akiyama J, Takahashi H, Yano H<\/u><\/strong>, Kubo M, Nishikawa N, Nomoto M, Tanaka J.
          \nMicroglia may compensate for dopaminergic neuron loss in experimental parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus. GLIA,<\/em><\/strong> 65:1833-1847 (2017)<\/li>\n
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          \nHigh mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in developing rats. Metabolic Brain Disease,<\/em> <\/strong>32:2095-2014 (2017)<\/li>\n
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          \nThe hypnotic bromovalerylurea ameliorates 6-hydroxydopamineinduced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia. Neurochem Int,<\/em><\/strong> 99:158-168 (2016)<\/li>\n
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          \nA Truncated form of CD200 (CD200S) expressed on glioma cells prolonged survival in a gat glioma model by Induction of a dendritic cell-like phenotype in tumor-associated macrophages. Neoplasia<\/em>, <\/strong>18:229-241 (2016)<\/li>\n
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          \nTreadmill exercise ameliorates ischemia-induced brain edema while suppressing Na+<\/sup>\/H+<\/sup> exchanger 1 expression. Experimental Neurology,<\/em> <\/strong>277:150\u2013161 (2016)<\/li>\n
        • Takahashi H, Inoue A, Kawabe Y, Hosokawa Y, Iwata S, Sugimoto K, Yano H<\/u><\/strong>, Yamashita D, Harada H, Kohno S, Ohue S, Ohnishi T, Tanaka J.
          \nOct-3\/4 promotes tumor angiogenesis through VEGF production in glioblastoma. Brain Tumor Pathol<\/em><\/strong>,<\/em><\/strong> 32:31-40 (2015)<\/li>\n
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          \nOct-3\/4 modulates the drug-resistant phenotype of glioblastoma cells through expression of ATP binding cassette transporter G2. Biochem Biophys Acta,<\/em><\/strong> 1850:1197-1205 (2015)<\/li>\n
        • Kikuchi S, Nishihara T, Kawasaki S, Abe N, Kuwabara J, Choudhury ME, Takahashi H, Yano H<\/u><\/strong>, Nagaro T, Watanabe Y, Aibiki M, Tanaka J.
          \nThe ameliorative effects of a hypnotic bromvalerylurea in sepsis. Biochem Biophys Res Commun,<\/em> <\/strong>459:319-326 (2015)<\/li>\n
        • Matsumoto S, Tanaka J, Yano H<\/u><\/strong>, Takahashi H, Sugimoto K, Ohue S, Inoue A, Aono H, Kusakawa A, Watanabe H, Kumon Y, Ohnishi T.
          \nCD200+ and CD200- macrophages accumulated in ischemic lesions of rat brain: the two populations cannot be classified as either M1 or M2 macrophages. J Neuroimmunol.<\/em><\/strong> 282:7-20 (2015)<\/li>\n
        • Ishii Y, Yamaizumi A, Kawakami A, Islam A, Choudhury ME, Takahashi H, Yano H<\/u><\/strong>, Tanaka J.
          \nAnti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NF\u03baB nuclear translocation and subsequent STAT1 phosphorylation. Neurochem Int,<\/em><\/strong> 90:56-66 (2015)<\/li>\n
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          \nActivated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-\u03b21. GLIA,<\/em><\/strong> 62:185-198 (2014)<\/li>\n
        • Tei N, Tanaka J, Sugimoto K, Nishihara T, Nishioka R, Takahashi H, Yano H, <\/u><\/strong>Matsumoto S, Ohue S, Watanabe H, Kumon T, Ohnishi T.
          \nExpression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions. J Neurosci Res,<\/em><\/strong> 91:681-693 (2013)<\/li>\n
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          \nOct3\/4 promotes migration and invasion of glioblastoma cells. J Cell Biochem,<\/em><\/strong> 113:508-517, (2012)<\/li>\n
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          \nPremetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes. Oral Oncology,<\/em> <\/strong>48:663-758 (2012)<\/li>\n
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          \nSubcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Exp. Neurol,<\/em> <\/strong>229:507-516 (2011)<\/li>\n
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          \nTransient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages. Brain Res,<\/em><\/strong> 1420:114-124 (2011)<\/li>\n
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          \nA cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats. Brain Behav,<\/em> <\/strong>1:26-43 (2011)<\/li>\n
        • Smirkin A, Matsumoto H, Takahashi H, Inoue A, Tagawa M, Ohue S, Watanabe H, Yano H,<\/u><\/strong> Kumon Y, Ohnishi T, Tanaka J.
          \nIba1(+)\/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain. J Cereb Blood Flow Metab,<\/em><\/strong> 30:603-615 (2010)<\/li>\n
        • Inoue A, Takahashi H, Harada H, Kohno S, Ohue S, Kobayashi K, Yano H,<\/u><\/strong> Tanaka J, Ohnishi T.
          \nCancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity. Int J Oncol,<\/em> <\/strong>37:1121-1131 (2010)<\/li>\n<\/ul>\n

          \u3010\u7dcf\u8aac\u3011<\/h4>\n
            \n
          • Inoue A, Ohnishi T, Nishikawa M, Ohtsuka Y, Kusakabe K, Yano H, Tanaka J, Kunieda T.
            \nA Narrative Review on CD44’s Role in Glioblastoma Invasion, Proliferation, and Tumor Recurrence. Cancers (Basel),<\/em><\/strong> 15(19):4898. doi: 10.3390\/cancers15194898 (2023<\/li>\n
          • Takeda H, Yamaguchi T, Yano H<\/u><\/strong>, Tanaka J.
            \nMicroglial metabolic disturbances and neuroinflammation in cerebral infarction. J Pharmacol Sci,<\/em><\/strong> 145, 130-139. doi: 10.1016\/j.jphs.2020.11.007 (2021)<\/li>\n
          • Yano H,<\/u><\/strong> Choudhury ME, Islam A. Cellular mechanotransduction of physical force and organ response to exercise-induced mechanical stimuli. J Phys Fitness Sports Med<\/em>, <\/strong>4:83-92 (2015)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

            \u7814\u7a76\u696d\u7e3e(\u6cb3\u5408\u55ac\u6587) \u7740\u4efb\u5f8c(2026\u5e74\u4ee5\u964d) \u3010\u539f\u8457\u8ad6\u6587\u3011 Ratanayotha A*, Mizutani N, Takenaga F, Kawai T*, Okamura Y (* corresponding au […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":11,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-43","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=\/wp\/v2\/pages\/43","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43"}],"version-history":[{"count":32,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=\/wp\/v2\/pages\/43\/revisions"}],"predecessor-version":[{"id":349,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=\/wp\/v2\/pages\/43\/revisions\/349"}],"up":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=\/wp\/v2\/pages\/11"}],"wp:attachment":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/mcp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}