{"id":777,"date":"2020-04-03T10:48:26","date_gmt":"2020-04-03T01:48:26","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/neuropsychiatry\/?p=777"},"modified":"2020-04-03T10:58:49","modified_gmt":"2020-04-03T01:58:49","slug":"ctla4%e9%96%a2%e9%80%a3%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%b2%be%e7%a5%9e%e7%a5%9e%e7%b5%8c%e7%96%be%e6%82%a3%e3%81%ae%e9%96%a2%e9%80%a3%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e8%a7%a3","status":"publish","type":"post","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/neuropsychiatry\/news\/information\/ctla4%e9%96%a2%e9%80%a3%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%b2%be%e7%a5%9e%e7%a5%9e%e7%b5%8c%e7%96%be%e6%82%a3%e3%81%ae%e9%96%a2%e9%80%a3%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e8%a7%a3","title":{"rendered":"CTLA4\u95a2\u9023\u907a\u4f1d\u5b50\u3068\u7cbe\u795e\u795e\u7d4c\u75be\u60a3\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306e\u89e3\u6790\u306e\u304a\u77e5\u3089\u305b"},"content":{"rendered":"

CTLA4<\/strong>\u95a2\u9023\u907a\u4f1d\u5b50\u3068\u7cbe\u795e\u795e\u7d4c\u75be\u60a3\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306e\u89e3\u6790<\/strong><\/p>\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n

\u7cbe\u795e\u75be\u60a3(<\/span>\u7d71\u5408\u5931\u8abf\u75c7\u3001\u3046\u3064\u75c5\u3001\u8e81\u3046\u3064\u75c5)<\/span>\u306f\u672a\u3060\u306b\u75c5\u614b\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u3089\u305a\u3001\u7cbe\u795e\u75be\u60a3\u304a\u3088\u3073\u8a8d\u77e5\u75c7(<\/span>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7)<\/span>\u306b\u304a\u3044\u3066\u30d2\u30c8\u672b\u68a2\u8840\u3067\u81e8\u5e8a\u7684\u306b\u5341\u5206\u6709\u7528\u3068\u3055\u308c\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u308c\u307e\u3067\u5f53\u79d1\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u4e0a\u8a18\u306e\u7cbe\u795e\u75be\u60a3\u304a\u3088\u3073\u8a8d\u77e5\u75c7\u60a3\u8005\u306e\u8840\u6db2\u3092\u7528\u3044\u3066\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u89e3\u6790\u3084\u30e1\u30c1\u30eb\u5316\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u305d\u308c\u305e\u308c\u306e\u75be\u60a3\u306e\u75c5\u614b\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u767a\u898b\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u306a\u308a\u3046\u308b\u907a\u4f1d\u5b50\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f[Nakata Shunsuke et al. 2019, Yoshino Yuta et al. 2017, Mise Ayano et al. 2017.]<\/span>\u3002\u305d\u3053\u3067\u4eca\u56de\u79c1\u305f\u3061\u306fCTLA4 (Cytotoxic T lymphocyte associated protein 4) <\/span>\u907a\u4f1d\u5b50\u306e\u7cbe\u795e\u75be\u60a3\u304a\u3088\u3073\u8a8d\u77e5\u75c7\u3078\u306e\u95a2\u4e0e\u3092\u691c\u8a0e\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002CTLA4<\/span>\u907a\u4f1d\u5b50\u306fT<\/span>\u7d30\u80de\u523a\u6fc0\u53d7\u5bb9\u4f53\u306eCD28<\/span>\u3068\u30ea\u30ac\u30f3\u30c9\u3092\u5171\u6709\u3057\u3066\u3001T<\/span>\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u6291\u5236\u7684\u306b\u50cd\u304f\u3053\u3068\u3067\u3001T<\/span>\u7d30\u80de\u306e\u514d\u75ab\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u65e2\u5831\u306b\u3066\u7d71\u5408\u5931\u8abf\u75c7\u60a3\u8005\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u8840\u6db2\u4e2d\u306eCTLA4 mRNA<\/span>\u767a\u73fe\u306bCTLA4<\/span>\u907a\u4f1d\u5b50\u306e\u4e00\u5869\u57fa\u591a\u578b\u3084\u30e1\u30c1\u30eb\u5316\u304c\u5f71\u97ff\u3092\u4e0e\u3048\u3001CTLA4 mRNA<\/span>\u767a\u73fe\u304c\u5065\u5e38\u5bfe\u8c61\u8005\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u5897\u52a0\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u307e\u3059[Kordi-Tamandani Dor Mohammad et al. 2013.]<\/span>\u3002\u79c1\u305f\u3061\u306e\u77e5\u308b\u9650\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068CTLA4<\/span>\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u76f4\u63a5\u793a\u3059\u5831\u544a\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001CTLA4<\/span>\u907a\u4f1d\u5b50\u3068\u540c\u69d8\u306bT<\/span>\u7d30\u80de\u306e\u514d\u75ab\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308bPD-1<\/span>\u907a\u4f1d\u5b50\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u795e\u7d4c\u708e\u75c7\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059[Saresella Marina et al. 2012.]<\/span>\u3002\u305d\u3053\u3067\u672c\u7814\u7a76\u306f\u7cbe\u795e\u75be\u60a3\u304a\u3088\u3073\u8a8d\u77e5\u75c7\u306e\u7c21\u4fbf\u306a\u81e8\u5e8a\u7684\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3001CTLA4<\/span>\u907a\u4f1d\u5b50\u306b\u6ce8\u76ee\u3057\u3001\u5f53\u79d1\u306b\u3059\u3067\u306b\u4fdd\u5b58\u3057\u3066\u3044\u308b\u60a3\u8005\u306e\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\uff08\u8133\u3068\u3053\u3053\u308d\u306e\u75c5\u6c17\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u7814\u7a76\u306e\u305f\u3081\u306e\u30d0\u30f3\u30af\u69cb\u7bc9\u3000\u627f\u8a8d\u756a\u53f730<\/span>\uff0d5<\/span>\uff09\u3092\u7528\u3044\u3066CTLA4<\/span>\u907a\u4f1d\u5b50\u306e\u4e00\u5869\u57fa\u591a\u578b\u3084\u907a\u4f1d\u5b50\u767a\u73fe\u3001\u53ef\u80fd\u3067\u3042\u308c\u3070\u30e1\u30c1\u30eb\u5316\u7387\u3084CTLA4<\/span>\u907a\u4f1d\u5b50\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u767a\u73fe(PD1<\/span>\u3001CD28<\/span>\u7b49)<\/span>\u7b49\u3092\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3001\u5e74\u9f62\u3084\u6027\u5225\u3001\u7f79\u75c5\u671f\u9593\u3084\u767a\u75c7\u5e74\u9f62\u3001\u5185\u670d\u85ac\u3001\u795e\u7d4c\u5fc3\u7406\u5b66\u7684\u691c\u67fb\u3001\u8840\u6db2\u691c\u67fb\u7b49\u306e\u5404\u7a2e\u81e8\u5e8a\u30c7\u30fc\u30bf\u3068\u306e\u95a2\u9023\u3092\u89e3\u6790\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u7d50\u679c\u304b\u3089\u3001\u8a3a\u65ad\u306e\u78ba\u5b9a\u3001\u6cbb\u7642\u306e\u8a55\u4fa1\u3001\u518d\u767a\u306e\u6307\u6a19\u3068\u306a\u308b\u30c7\u30fc\u30bf\u7b49\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u5c06\u6765\u7684\u306b\u3001\u75be\u60a3\u306b\u6709\u7528\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u4f5c\u6210\u306b\u5f79\u7acb\u3064\u3053\u3068\u306b\u52a0\u3048\u3001\u75c5\u56e0\u306b\u95a2\u308f\u308b\u60c5\u5831\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n

<\/a>\u53c2\u8003\u6587\u732e<\/h1>\n

1)Nakata S et al. (2019). Differential expression of the ghrelin-related mRNAs GHS-R1a, GHS-R1b, and MBOAT4 in Japanese patients with schizophrenia. Psychiatry research, 272, 334-339.<\/strong><\/p>\n

2) Yoshino Y, et al. (2017) INPP5D mRNA Expression and Cognitive Decline in Japanese Alzheimer’s Disease Subjects. J Alzheimers Dis. 58(3):687-694<\/strong><\/p>\n

3) Mise A et al. (2017) TOMM40 and APOE Gene Expression and Cognitive Decline in Japanese Alzheimer’s Disease Subjects. J Alzheimers Dis. 60(3):1107-1117<\/strong><\/p>\n

4) Kordi-Tamandani, D. M et al (2013). Evaluation of polymorphism, hypermethylation and expression pattern of CTLA4 gene in a sample of Iranian patients with schizophrenia. Molecular biology reports, 40(8), 5123-5128.<\/strong><\/p>\n

5) Saresella M et al. (2012). A potential role for the PD1\/PD-L1 pathway in the neuroinflammation of Alzheimer’s disease. Neurobiology of aging, 33(3), 624-e11.<\/strong><\/p>\n

\u7814\u7a76\u4ee3\u8868\u8005<\/strong><\/p>\n

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    \n
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    \u7814\u7a76\u306e\u958b\u793a<\/strong><\/p>\n

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    \n<\/span>\u4f0a\u8cc0\u3000\u6df3\u4e00
    \nTel: 089-960-5315<\/span><\/p>\n

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