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\u3010\u7814\u7a76\u8ab2\u984c\u540d\u3011
\n\u81a0\u82bd\u816b\u306b\u304a\u3051\u308bBevacizumab\u306e\u6709\u7528\u6027\u3068\u6295\u4e0e\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u95a2\u3059\u308b\u89b3\u5bdf\u7814\u7a76<\/p>\n
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\u3010\u7814\u7a76\u306e\u76ee\u7684\u3011
\n\u3000\u81a0\u82bd\u816b\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066 DNA\u30e1\u30c1\u30eb\u5316\u5264\u30c6\u30e2\u30be\u30ed\u30df\u30c9\uff08TMZ\uff09\u306e\u5c0e\u5165\u306f\u5927\u304d\u306a\u30d6\u30ec\u30fc\u30af\u30b9\u30eb\u30fc\u3067\u3057\u305f\u304c\u3001TMZ \u8010\u6027\u75c7\u4f8b\u3082\u591a\u304f\u5316\u5b66\u7642\u6cd5\u5264\u5358\u72ec\u306b\u3088\u308b\u81a0\u82bd\u816b\u6cbb\u7642\u3078\u306e\u9650\u754c\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u816b\u760d\u751f\u7269\u5b66\u7684\u7279\u6027\u3092\u5229\u7528\u3057\u305f\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u3067\u3042\u308bBevacizumab\u306e\u6709\u52b9\u6027\u3082\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u75c5\u614b\u306e\u4e00\u6642\u7684\u306a\u6539\u5584\u52b9\u679c\u306f\u5f97\u3089\u308c\u308b\u3082\u306e\u306e\u6709\u610f\u306a\u751f\u5b58\u5ef6\u9577\u52b9\u679c\u306f\u78ba\u8a8d\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u591a\u304f\u306e\u81a0\u82bd\u816b\u306e\u60a3\u8005\u3055\u3093\u306b\u304a\u3044\u3066Bevacizumab\u306e\u5c0e\u5165\u306b\u3088\u308a\u72b6\u614b\u304c\u5287\u7684\u306b\u6539\u5584\u3059\u308b\u3053\u3068\u306f\u4e8b\u5b9f\u3067\u3042\u308a\u3001\u81a0\u82bd\u816b\u306e\u4e2d\u306b\u306fBevacizumab\u306b\u8457\u3057\u304f\u8010\u6027\u3092\u6301\u3064\u30b5\u30d6\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u6211\u3005\u306f\u81a0\u82bd\u816b\u306e\u6d78\u6f64\u5148\u7aef\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u816b\u760d\u5e79\u7d30\u80de\uff08cancer stem cell\uff1aCSC\uff09\u306e\u4e2d\u3067\u5e79\u7d30\u80de\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bCD44\u3092\u9ad8\u767a\u73fe\u3059\u308bCSC\u306f\u6d78\u6f64\u6027\u304c\u8457\u3057\u304f\u9ad8\u304f\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3067\u3042\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u307e\u3057\u305f\uff08M Nishikawa, A Inoue et al. Stem cell international\uff09\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001CD44\u9ad8\u767a\u73fe\u306eCSC\u7531\u6765\u306e\u81a0\u82bd\u816b\u3053\u305d\u304cBevacizumab\u4e0d\u5fdc\u6027\u306e\u81a0\u82bd\u816b\u3067\u306f\u306a\u3044\u304b\u3068\u306e\u8003\u3048\u306b\u81f3\u308a\u3001\u5f53\u9662\u3067\u7d4c\u9a13\u3057\u305fBevacizumab\u6295\u4e0e\u60a3\u8005\u306e\u6458\u51fa\u7d44\u7e54\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3053\u306e\u4eee\u8aac\u3092\u8a3c\u660e\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u672c\u7814\u7a76\u306f\u81a0\u82bd\u816b\u306e\u60a3\u8005\u3055\u3093\u306b\u304a\u3051\u308bBevacizumab\u62b5\u6297\u6027\u306e\u539f\u56e0\u3092\u89e3\u660e\u3057\u3001\u9069\u5207\u306aBevacizumab\u306e\u4f7f\u7528\u6642\u671f\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3001\u81a0\u82bd\u816b\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3059\u3002<\/p>\n
\u3010\u7814\u7a76\u306e\u65b9\u6cd5\u3011
\n\uff08\u5bfe\u8c61\u3068\u306a\u308b\u60a3\u8005\u3055\u3093\uff092014\u5e744\u6708\u304b\u30892020\u5e7412\u6708\u306b\u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3092\u53d7\u8a3a\u3055\u308c\u305f\u65b9\u306e\u3046\u3061\u81a0\u82bd\u816b\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u3055\u3093
\n\uff08\u5229\u7528\u3059\u308b\u30ab\u30eb\u30c6\u60c5\u5831\uff09\u6027\u5225\u3001\u5e74\u9f62\u3001\u767a\u75c7\u6642\u671f\u3001\u5408\u4f75\u75c7\u3001\u65e2\u5f80\u6b74\u3001\u8eab\u4f53\u6240\u898b\u3001\u8840\u6db2\u691c\u67fb\u30c7\u30fc\u30bf\u3001\u753b\u50cf\u691c\u67fb\u30c7\u30fc\u30bf\u3001\u6cbb\u7642\u72b6\u6cc1\u3001\u816b\u760d\u30c7\u30fc\u30bf\uff08\u907a\u4f1d\u60c5\u5831\u3092\u542b\u3080\uff09\u7b49
\n\uff08\u5229\u7528\u3059\u308b\u753b\u50cf\uff09\u901a\u5e38\u306e\u8a3a\u7642\u304a\u3088\u3073\u624b\u8853\u3067\u53d6\u5f97\u3057\u305f\u753b\u50cf<\/p>\n
\u3010\u7814\u7a76\u7d50\u679c\u306e\u516c\u8868\u3011
\nMasahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Hajime Yano, Yonehiro Kanemura, Shohei Kohno, Shiro Ohue, Saya Ozaki, Shirabe Matsumoto, Satoshi Suehiro, Yawara Nakamura, Seiji Shigekawa, Hideaki Watanabe, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda. (2021) CD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma. Cancer Medicine: 2021; 00: 1-13, doi: 10.1002\/CAM4.3767<\/p>\n
\u3010\u500b\u4eba\u60c5\u5831\u306e\u53d6\u308a\u6271\u3044\u3011
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\u3010\u304a\u554f\u3044\u5408\u308f\u305b\u5148\u3011
\n\u611b\u5a9b\u5927\u5b66\u5927\u5b66\u9662\u3000\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u3000\u8133\u795e\u7d4c\u5916\u79d1\u5b66\u3000\u8b1b\u5e2b\u3000\u4e95\u4e0a\u660e\u5b8f
\n791-0295\u3000\u611b\u5a9b\u770c\u6771\u6e29\u5e02\u5fd7\u6d25\u5ddd454
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