{"id":1521,"date":"2021-06-11T22:01:50","date_gmt":"2021-06-11T13:01:50","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/neurosurgery\/?p=1521"},"modified":"2021-06-11T22:04:26","modified_gmt":"2021-06-11T13:04:26","slug":"%e8%87%a8%e5%ba%8a%e7%a0%94%e7%a9%b6%e3%80%8c%e3%82%b0%e3%83%aa%e3%82%aa%e3%83%bc%e3%83%9e%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%89%b9%e7%95%b0%e7%9a%84%e5%9b%a0%e5%ad%90%e3%81%ae%e6%a4%9c%e7%b4%a2","status":"publish","type":"post","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/neurosurgery\/1521","title":{"rendered":"\u81e8\u5e8a\u7814\u7a76\u300c\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u304a\u3051\u308b\u7279\u7570\u7684\u56e0\u5b50\u306e\u691c\u7d22\u304a\u3088\u3073\u6cbb\u7642\u52b9\u679c\u5224\u5b9a\u300d\u306e\u7d50\u679c\u5831\u544a\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>\u304a\u77e5\u3089\u305b<\/p>\n<p>\u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3067\u306f\u3001\u533b\u5b66\u30fb\u533b\u7642\u306e\u767a\u5c55\u306e\u305f\u3081\u306b\u69d8\u3005\u306a\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u4eca\u56de\u793a\u3057\u307e\u3059\u4ee5\u4e0b\u306e\u7814\u7a76\u3067\u306f\u3001\u4ee5\u524d\u306b\u304a\u77e5\u3089\u305b\u81f4\u3057\u307e\u3057\u305f\u3088\u3046\u306b\u3001\u5f53\u79d1\u306b\u3066\u52a0\u7642\u3092\u884c\u3063\u305f\u60a3\u8005\u3055\u3093\u306e\u30ab\u30eb\u30c6\u8a18\u9332\u3084\u753b\u50cf\u60c5\u5831\u3092\u4f7f\u7528\u81f4\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306b\u95a2\u3057\u3066\u306f\u5f53\u79d1\u306b\u3066\u89e3\u6790\u304c\u65e2\u306b\u7d42\u4e86\u3057\u3066\u304a\u308a\u3001\u300c<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1936523321001297?via%3Dihub\"><em>Translational Oncology<\/em><\/a>\u300d\u306b\u7d50\u679c\u3092\u516c\u8868\u81f4\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u5185\u5bb9\u306e\u8a73\u7d30\u3092\u77e5\u308a\u305f\u3044\u65b9\u306f\u3001\u4e0b\u8a18\u3010\u304a\u554f\u3044\u5408\u308f\u305b\u5148\u3011\u307e\u3067\u3054\u9023\u7d61\u4e0b\u3055\u3044\u3002<\/p>\n<p>\u3010\u7814\u7a76\u8ab2\u984c\u540d\u3011<\/p>\n<p>\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u304a\u3051\u308b\u7279\u7570\u7684\u56e0\u5b50\u306e\u691c\u7d22\u304a\u3088\u3073\u6cbb\u7642\u52b9\u679c\u5224\u5b9a<\/p>\n<p>\u3010\u7814\u7a76\u6a5f\u95a2\u3011\u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3000\u8133\u795e\u7d4c\u5916\u79d1<\/p>\n<p>\u3010\u7814\u7a76\u8cac\u4efb\u8005\u3011\u4e95\u4e0a\u660e\u5b8f\uff08\u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3000\u8133\u795e\u7d4c\u5916\u79d1\u3000\u8b1b\u5e2b\uff09<\/p>\n<p>\u3010\u7814\u7a76\u4ee3\u8868\u8005\u3011\u4e95\u4e0a\u660e\u5b8f\uff08\u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3000\u8133\u795e\u7d4c\u5916\u79d1\u3000\u8b1b\u5e2b\uff09<\/p>\n<p>\u3010\u7814\u7a76\u306e\u76ee\u7684\u3011<\/p>\n<p>\u3000\u81a0\u82bd\u816b\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066 DNA\u30e1\u30c1\u30eb\u5316\u5264\u30c6\u30e2\u30be\u30ed\u30df\u30c9\uff08TMZ\uff09\u306e\u5c0e\u5165\u306f\u5927\u304d\u306a\u30d6\u30ec\u30fc\u30af\u30b9\u30eb\u30fc\u3067\u3057\u305f\u304c\u3001TMZ \u8010\u6027\u75c7\u4f8b\u3082\u591a\u304f\u5316\u5b66\u7642\u6cd5\u5264\u5358\u72ec\u306b\u3088\u308b\u81a0\u82bd\u816b\u6cbb\u7642\u3078\u306e\u9650\u754c\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u816b\u760d\u751f\u7269\u5b66\u7684\u7279\u6027\u3092\u5229\u7528\u3057\u305f\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u3067\u3042\u308bBevacizumab\u306e\u6709\u52b9\u6027\u3082\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u75c5\u614b\u306e\u4e00\u6642\u7684\u306a\u6539\u5584\u52b9\u679c\u306f\u5f97\u3089\u308c\u308b\u3082\u306e\u306e\u6709\u610f\u306a\u751f\u5b58\u5ef6\u9577\u52b9\u679c\u306f\u78ba\u8a8d\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u6211\u3005\u306f\u6d78\u6f64\u6027\u306e\u9ad8\u3044\u81a0\u82bd\u816b\u306e\u816b\u760d\u8fba\u7e01\u90e8\u306bCD44\u3092\u9ad8\u767a\u73fe\u3059\u308bCSC\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u540c\u7d30\u80de\u7fa4\u306e\u518d\u767a\u6a5f\u5e8f\u306b\u95a2\u3057\u3066\u306f\u672a\u3060\u5b9a\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff08M Nishikawa, A Inoue et al. Stem cell international\uff09\u3002\u305d\u3053\u3067\u3001\u4eca\u56de\u6211\u3005\u306fCD44\u306e\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308bOsteopontin\uff08OPN\uff09\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002OPN\u306f\u4f4e\u9178\u7d20\u4e0b\u3067CD44\u3068\u7279\u7570\u7684\u7d50\u5408\u3092\u793a\u3059\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001CD44\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u816b\u760d\u5897\u6b96\u3084stem cell\u306e\u5e79\u7d30\u80de\u6027\u7dad\u6301\u306b\u50cd\u304f\u3068\u3044\u3046\u904e\u53bb\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u6211\u3005\u306fOPN\u304c\u81a0\u82bd\u816b\u306b\u304a\u3051\u308b\u6d78\u6f64\u304b\u3089\u5897\u6b96\u3078\u3068phenotypic transition\u3092\u8d77\u3053\u3059\u5206\u5b50\u306a\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u4eca\u56de\u6211\u3005\u306f\u3053\u306eOPN\u306b\u7740\u76ee\u3057\u3001\u305d\u306e\u767a\u73fe\u304a\u3088\u3073\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u81a0\u82bd\u816b\u518d\u767a\u306e\u5206\u5b50\u75c5\u614b\u306b\u3064\u3044\u3066\u691c\u8a0e\u3092\u884c\u3046\u3068\u5171\u306b\u3001\u672c\u7d50\u679c\u3092\u6d3b\u7528\u3057\u3066\u81a0\u82bd\u816b\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3059\u3002<\/p>\n<p>\u3010\u7814\u7a76\u306e\u65b9\u6cd5\u3011<\/p>\n<p>\uff08\u5bfe\u8c61\u3068\u306a\u308b\u60a3\u8005\u3055\u3093\uff092017\u5e744\u6708\u304b\u30892019\u5e7412\u6708\u306b\u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3092\u53d7\u8a3a\u3055\u308c\u305f\u65b9\u306e\u3046\u3061\u81a0\u82bd\u816b\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u3055\u3093<\/p>\n<p>\uff08\u5229\u7528\u3059\u308b\u30ab\u30eb\u30c6\u60c5\u5831\uff09\u6027\u5225\u3001\u5e74\u9f62\u3001\u767a\u75c7\u6642\u671f\u3001\u5408\u4f75\u75c7\u3001\u65e2\u5f80\u6b74\u3001\u8eab\u4f53\u6240\u898b\u3001\u8840\u6db2\u691c\u67fb\u30c7\u30fc\u30bf\u3001\u753b\u50cf\u691c\u67fb\u30c7\u30fc\u30bf\u3001\u6cbb\u7642\u72b6\u6cc1\u3001\u816b\u760d\u30c7\u30fc\u30bf\uff08\u907a\u4f1d\u60c5\u5831\u3092\u542b\u3080\uff09\u7b49<\/p>\n<p>\uff08\u5229\u7528\u3059\u308b\u753b\u50cf\uff09\u901a\u5e38\u306e\u8a3a\u7642\u304a\u3088\u3073\u624b\u8853\u3067\u53d6\u5f97\u3057\u305f\u753b\u50cf<\/p>\n<p>\u3010\u7814\u7a76\u7d50\u679c\u306e\u516c\u8868\u3011<\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1936523321001297?via%3Dihub\">Masahiro Nishikawa, <strong><em><u>Akihiro Inoue<\/u><\/em><\/strong>, Takanori Ohnishi, Hajime Yano, Saya Ozaki, Yonehiro Kanemura, Satoshi Suehiro, Yoshihiro Ohtsuka, Shohei Kohno, Shiro Ohue, Seiji Shigekawa, Hideaki Watanabe, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda. (2021) Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma. <strong><em>Translational Oncology<\/em><\/strong>: <em>2021<\/em>;<em> 14 (8)<\/em>:<em> 101137,<\/em> \u3000\u3000\u3000\u3000\u3000doi: 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089-960-5338<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u304a\u77e5\u3089\u305b \u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3067\u306f\u3001\u533b\u5b66\u30fb\u533b\u7642\u306e\u767a\u5c55\u306e\u305f\u3081\u306b\u69d8\u3005\u306a\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u4eca\u56de\u793a\u3057\u307e\u3059\u4ee5\u4e0b\u306e\u7814\u7a76\u3067\u306f\u3001\u4ee5\u524d\u306b\u304a\u77e5\u3089\u305b\u81f4\u3057\u307e\u3057\u305f\u3088\u3046\u306b\u3001\u5f53\u79d1\u306b\u3066\u52a0\u7642\u3092\u884c\u3063\u305f\u60a3\u8005\u3055\u3093\u306e\u30ab\u30eb\u30c6\u8a18\u9332\u3084\u753b\u50cf\u60c5\u5831\u3092\u4f7f\u7528\u81f4\u3057\u307e\u3057 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