愛媛大学 大学院・医学系研究科 寄生病原体学分野 教室員  橘 

    橘 真由美, B Ed
    助教
JICAからニジェールに出向 2002-2004
愛媛大学教育学部卒業, 1994
住所   郵便番号791−0295
愛媛県東温市志津川
電話/FAX   (089)−960−5286/(089)−960−5287
電子メール(画像)  
学術的興味   分子生物学一般・電子顕微鏡などの技術
資格   小学校教員免許第一種・臨床検査技師免許
    研究テーマ :: 業績

 
研究テーマ

熱帯熱マラリア原虫の転写・翻訳調節機構の解析

業績

原著論文

arrowTachibana M, Miura K, Takashima E, Morita M, Nagaoka H, Zhou L, Long CA, Richter King C, Torii M, Tsuboi T*, Ishino T*. Identification of domains within Pfs230 that elicit transmission blocking antibody responses. Vaccine. 2019 Mar 22;37(13):1799-1806. doi: 10.1016/j.vaccine.2019.02.021. [Abstract]

arrowJenwithisuk R, Kangwanrangsan N, Tachibana M, Thongkukiatkul A, Otsuki H, Sattabongkot J, Tsuboi T, Torii M, Ishino T*. Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes. Malar J. 2018 Dec 13;17(1):466. doi: 10.1186/s12936-018-2617-6. [Abstract]

arrowTachibana M, Ishino T, Tsuboi T, Torii M. The Plasmodium yoelii microgamete surface antigen (PyMiGS) induces anti-malarial transmission blocking immunity that reduces microgamete motility/release from activated male gametocytes. Vaccine. 2018 Nov 26;36(49):7463-7471. doi: 10.1016/j.vaccine.2018.10.067. [Abstract]

arrowIshino T, Murata E, Tokunaga N, Baba M, Tachibana M, Thongkukiatkul A, Tsuboi T, Torii M. Rhoptry neck protein 2 expressed in Plasmodium sporozoites plays a crucial role during invasion of mosquito salivary glands. Cell Microbiol. 2018 Oct 11:e12964. doi: 10.1111/cmi.12964. [Abstract]

arrowOda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T, Tsuboi T. Plasmodium RON12 localizes to the rhoptry body in sporozoites. Parasitol Int. 2018 Oct 2. pii: S1383-5769(18)30290-3. doi: 10.1016/j.parint.2018.10.001. [Abstract] [full-text until Nov.28]

arrowIriko H, Ishino T, Otsuki H, Ito D, Tachibana M, Torii M, Tsuboi T. Plasmodium falciparum Exported Protein 1 is localized to dense granules in merozoites. Parasitol Int. Jun 8;67(5):637-639. doi: 10.1016/j.parint.2018.06.001. [Abstract]

arrowTachibana M, Ishino T, Takashima E, Tsuboi T, Torii M. A male gametocyte osmiophilic body and microgamete surface protein of the rodent malaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in male osmiophilic body formation and exflagellation. Cell Microbiol. 2018 May;20(5):e12821. doi: 10.1111/cmi.12821. [Abstract] [full-text]

arrowSakamoto H, Takeo S, Takashima E, Miura K, Kanoi BN, Kaneko T, Han ET, Tachibana M, Matsuoka K, Sattabongkot J, Udomsangpetch R, Ishino T, Tsuboi T.Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission. Parasitol Int. 2017 Dec 5;67(2):203-208. doi: 10.1016/j.parint.2017.12.002. [Abstract]

arrowOtsuki H, Yokouchi Y, Iyoku N, Tachibana M, Tsuboi T, Torii M. The rodent malaria lactate dehydrogenase assay provides a high throughput solution for in vivo vaccine studies. Parasitol Int. 2015 Aug;64(4):60-3. doi: 10.1016/j.parint.2015.02.001. [Abstract]

arrowTachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, Kaneko A, Herrera S, Torii M, Tsuboi T. Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization. Vaccine. 2015Apr 15;33(16):1901-8. doi: 10.1016/j.vaccine.2015.03.008. [Abstract]

arrowShinzawa N, Ishino T, Tachibana M, Tsuboi T, Torii M. Phenotypic Dissection of a Plasmodium-Refractory Strain of Malaria Vector Anopheles stephensi: The Reduced Susceptibility to P. berghei and P. yoelii. PLoS One. 2013 May 23;8(5):e63753.
[Abstract]

arrowKangwanrangsan N, Tachibana M, Jenwithisuk R, Tsuboi T, Riengrojpitak S, Torii M, Ishino T. A member of the CPW-WPC protein family is expressed in and localized to the surface of developing ookinetes. Malar J. 2013 Apr 15;12(1):129.
[Abstract]

Tachibana M, Sato C, Otsuki H, Sattabongkot J, Kaneko O, Torii M, Tsuboi T. Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidate. Vaccine. 2012 Feb 27;30(10):1807-12. [Abstract]

Miyata T, Harakuni T, Tsuboi T, Sattabongkot J, Ikehara A, Tachibana M, Torii M, Matsuzaki G, Arakawa T. Tricomponent immunopotentiating system as a novel molecular design strategy for malaria vaccine development. Infect Immun. 2011 Oct;79(10):4260-75. [Abstract]

Tachibana M, Wu Y, Iriko H, Muratova O, MacDonald NJ, Sattabongkot J, Takeo S, Otsuki H, Torii M, Tsuboi T. N-terminal prodomain of Pfs230 synthesized using a cell-free system is sufficient to induce complement-dependent malaria transmission-blocking activity. Clin Vaccine Immunol. 2011 Aug;18(8):1343-50. [Abstract]

Doi M, Tanabe K, Tachibana S, Hamai M, Tachibana M, Mita T, Yagi M, Zeyrek FY, Ferreira MU, Ohmae H, Kaneko A, Randrianarivelojosia M, Sattabongkot J, Cao YM, Horii T, Torii M, Tsuboi T. Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax. Vaccine. 2011 Jun 10;29(26):4308-15. [Abstract]

Miyata T, Harakuni T, Sugawa H, Sattabongkot J, Kato A, Tachibana M, Torii M, Tsuboi T, Arakawa T. Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine. Vaccine. 2011 Mar 24;29(15):2720-6. [Abstract]

Miyata T, Harakuni T, Tsuboi T, Sattabongkot J, Kohama H, Tachibana M, Matsuzaki G, Torii M, Arakawa T. Plasmodium vivax ookinete surface protein Pvs25 linked to cholera toxin B subunit induces potent transmission-blocking immunity by intranasal as well as subcutaneous immunization. Infect Immun. 2010 Sep;78(9):3773-82. [Abstract]

Arakawa T, Tachibana M, Miyata T, Harakuni T, Kohama H, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Torii M, Tsuboi T. Malaria ookinete surface protein-based vaccination via the intranasal route completely blocks parasite transmission in both passive and active vaccination regimens in a rodent model of malaria infection. Infect Immun. 2009 Dec;77(12):5496-500. [Abstract]

Otsuki H, Kaneko O, Thongkukiatkul A, Tachibana M, Iriko H, Takeo S, Tsuboi T, Torii M. Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence.Proc Natl Acad Sci U S A.  106(17):7167-72, 2009. [Abstract]

Cao J, Kaneko O, Thongkukiatkul A, Tachibana M, Otsuki H, Gao Q, Tsuboi T, Torii M. Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites.Parasitol Int.  58(1):29-35, 2009 . [Abstract]

Kobayashi F, Waki S, Niikura M, Tachibana M, Tsuboi T, Torii M, Kamiya S. Plasmodium berghei XAT: Protective 155/160 kDa antigens are located in parasitophorous vacuoles of schizont-stage parasite. Exp Parasitol 116(4):450-457,2007 [Abstract]

Kaneko O, Templeton TJ, Iriko H, Tachibana M, Otsuki H, Takeo S, Sattabongkot J, Torii M, Tsuboi T.  The Plasmodium vivax homolog of the ookinete adhesive micronemal protein, CTRP Parasitol Int 55:227-231 (2006).
[Abstract]

Tsuboi T, Kaneko O, Cao YM, Tachibana M, Yakushijin Y, Nagao T, Kanbara H, Torii M.  A rapid genotyping method for the vivax malaria transmission-blocking vaccine candidates, Pvs25 and Pvs28.  Parasitol Int 53:211–6 (2004)
[Abstract]

Sattabongkot J, Tsuboi T, Hisaeda H, Tachibana M, Suwanabun N, Rungruang T, Cao YM, Stowers AW, Sirichaisinthop J, Coleman RE, Torii M. Blocking of transmission to mosquitoes by antibody to Plasmodium vivax malaria vaccine candidates Pvs25 and Pvs28 despite antigenic polymorphism in field isolates.  Am J Trop Med Hyg
69(5):536-541 (2003)

Tachibana M, Tsuboi T, Kaneko O, Khuntirat B, Torii M. "Two types of Plasmodium ovale defined by SSU rRNA have distinct sequences for ookinete surface proteins."Mol Biochem Parasitol 122:223-6 (2002)
[No Abstract]

Kaneko O, Tsuboi T, Ling IT, Howell S, Shirano M, Tachibana M,Cao YM, Holder AA, Torii M,   2001. The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and P. yoeliiMol Biochem Parasitol 118(2):223-31.
[Abstract]

Tachibana M, Tsuboi T, Templeton TJ, Kaneko O, Torii M. 2001.  Presence of three distinct ookinete surface protein genes, Pos25, Pos28-1, and Pos28-2 in Plasmodium ovale.  Mol Biochem Parasitol 113:341-4.
[No Abstract]

Shirano M, Tsuboi T, Kaneko O, Tachibana M, Adams JH, Torii M, 2001.  Conserved Regions of the Plasmodium yoelii Rhoptry Protein RhopH3 Revealed by Comparison with the P. falciparum Homologue. Mol Biochem Parasitol   112:297-9.
[No Abstract]


Langer RC, Hayward RE, Tsuboi T, Tachibana M, Torii M, Vinetz JM. 2000. Micronemal Transport of Plasmodium Ookinete Chitinases to the Electron-Dense Area of the Apical Complex for Extracellular Secretion. Infect Immun 68(11):6461-6465.
[Abstract] [Full Text]

Tsuboi T, Kaslow DC, Gozar MM, Tachibana M, Cao YM, Torii M.  1998.  Sequence polymorphism in two novel Plasmodium vivax ookinete surface proteins, Pvs25 and Pvs28, that are malaria transmission-blocking vaccine candidates. Mol Med 4(12):772-82.
[Abstract]

総説など

arrowArumugam TU, Ito D, Takashima E, Tachibana M, Ishino T, Torii M, Tsuboi T. Application of wheat germ cell-free protein expression system for novel malaria vaccine candidate discovery. Expert Rev Vaccines. 2013 Dec 5. [Abstract]

Tsuboi T, Tachibana M, Kaneko O, Torii M. 2003. " Transmission-blocking vaccine of vivax malaria." Parasitol Int 52(1):1-11.
[Abstract]


坪井敬文, 橘真由美, 薬師神芳洋, 矢野幸, 曹雅明, 鳥居本美 1999 「マラリア伝搬阻止ワクチンの開発」 愛媛医学
18(3)353-7.

鳥居本美,坪井敬文,金子修,橘真由美. 2001. マラリア感染の生物学Progr Med 21(2):325-9.


口頭発表(国際学会)

Tachibana M, Tsuboi T, Templeton TJ, Torii M. "Gene Cloningof Ookinete surface proteins from Plasmodium ovale reveals the presence of a third P25 and P21/28 paralogue" 49th Annual meeting of the Am Soc Trop Med Hyg, Houston, TX, USA (Oct, 2000)

Sattabongkot J, Tsuboi T, Suwanabun N, Tachibana M, Torii M, Hisaeda H, Stowers AW, Coleman RE. "Evaluation of the efficacy of Plasmodium vivax transmission blocking antibody against naturally circulating human isolates from Thailand." 49th Annual meeting of the Am Soc Trop Med Hyg, Houston, TX, USA (Oct, 2000)

Tsuboi T, Tachibana M, Sattabongkot J, Suwanabun N, Kaneko A, Nagao T, Kanbara H, Kaslow DC, Torii M "Sequence diversity in Pvs25 and Pvs28 that are malaria transmission-blocking vaccine antigen of Plasmodium vivax" 49th Annual meeting of the Am Soc Trop Med Hyg, Houston, TX, USA (Oct, 2000)

Shirano M, Tsuboi T, Kaneko O, Tachibana M, Adams JH, Torii M. "Conserved regions revealed by the comparison of Plasmodium yoelii 100kDa rhoptry protein with P. falciparum homologue (PfRhopH3)" 49th Annual meeting of the Am Soc Trop Med Hyg, Houston, TX, USA (Oct, 2000)

Kaneko O, Tsuboi T, Shirano M, Tachibana M, Ling IT, Howell S, Cao YM, Otsuki H, Holder AA, Torii M, "The high molecular mass rhoptry protein, RhopH1, is coded by members of the multigene family in Plasmodium falciparum and P. yoelii." 50th Annual meeting of the Am Soc Trop Med Hyg, Atlanta, Georgia , USA (Nov, 2001)

Tachibana M, Tsuboi T, Kaneko O, Khuntirat B, Torii M, "Sequence polymorphism in three distinct ookinete surface proteins of Plasmodium ovale isolated in Thailand." 50th Annual meeting of the Am Soc Trop Med Hyg, Atlanta, Georgia , USA (Nov, 2001)


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