愛媛大学 大学院・医学系研究科 寄生病原体学分野 教室員 石野 

    石野 智子, Ph.D
    准教授
東京大学薬学部 薬学科卒業, 1996
東京大学大学院 薬学系研究科 微生物薬品化学教室において薬学博士取得, 2001
三重大学大学院 医学系研究科 医動物学講座, ポスドク研究員, 2001-2005
三重大学大学院 医学系研究科 医動物学講座, 助手, 2005-2009
フランス、パスツール研究所, ポスドク研究員, 2006-2009
住所   郵便番号791−0295
愛媛県東温市志津川
電話/FAX   (089)−960−5286/(089)−960−5287
電子メール  
学術的興味   マラリア原虫の宿主細胞侵入機構
手技手法   分子生物学・細胞生物学
趣味 海外旅行、スキューバダイビング



愛媛大学教育研究者要覧
 
現在の研究テーマ

マラリア原虫スポロゾイトの肝臓感染機構の解明

業績

原著論文

arrowGupta DK, Dembele L, Voorberg-van der Wel A, Roma G, Yip A, Chuenchob V, Kangwanrangsan N, Ishino T, Vaughan AM, Kappe SH, Flannery EL, Sattabongkot J, Mikolajczak SA, Bifani P, Kocken CHM, Diagana TT. The Plasmodium Liver-Specific Protein 2 (LISP2) is an early marker of liver stage development. Elife. 2019 May 16;8. pii: e43362. doi: 10.7554/eLife.43362. [Abstract]

arrowNagaoka H, Sasaoka C, Yuguchi T, Kanoi BN, Ito D, Morita M, Udomsangpetch R, Sattabongkot J, Ishino T, Tsuboi T, Takashima. EPfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47). Sci Rep. 2019 Apr 11;9(1):5923. doi: 10.1038/s41598-019-42366-9.[Abstract]

arrowTachibana M, Miura K, Takashima E, Morita M, Nagaoka H, Zhou L, Long CA, Richter King C, Torii M, Tsuboi T*, Ishino T*. Identification of domains within Pfs230 that elicit transmission blocking antibody responses. Vaccine. 2019 Mar 22;37(13):1799-1806. doi: 10.1016/j.vaccine.2019.02.021. [Abstract]

arrowJenwithisuk R, Kangwanrangsan N, Tachibana M, Thongkukiatkul A, Otsuki H, Sattabongkot J, Tsuboi T, Torii M, Ishino T*. Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes. Malar J. 2018 Dec 13;17(1):466. doi: 10.1186/s12936-018-2617-6. [Abstract]

arrowSilvia A Arredondo, Kristian E Swearingen, Thomas Martinson, Ryan Steel, Dorender A Dankwa, Anke Harupa, Nelly Camargo, William Betz, Vladimir Vigdorovich, Brian G Oliver, Niwat Kangwanrangsan, Tomoko Ishino, Noah Sather, Sebastian Alexander Mikolajczak, Ashley M Vaughan, Motomi Torii, Robert L Moritz, Stefan HI Kappe. The micronemal Plasmodium proteins P36 and P52 act in concert to establish the replication-permissive compartment within infected hepatocytes. Frontiers in Cellular and Infection Microbiology. 2018 8:413 https://doi.org/10.3389/fcimb.2018.00413 [Full-text]

arrowTachibana M, Ishino T*, Tsuboi T, Torii M. The Plasmodium yoelii microgamete surface antigen (PyMiGS) induces anti-malarial transmission blocking immunity that reduces microgamete motility/release from activated male gametocytes. Vaccine. 2018 Nov 26;36(49):7463-7471. doi: 10.1016/j.vaccine.2018.10.067. [Abstract]

arrowTohmoto T, Takashima E, Takeo S, Morita M, Nagaoka H, Udomsangpetch R, Sattabongkot J, Ishino T, Torii M, Tsuboi T. Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro. Parasitol Int. 2018 Oct 30;69:25-29. doi: 10.1016/j.parint.2018.10.012. [Abstract]

arrowAliprandini E, Tavares J, Panatieri RH, Thiberge S, Yamamoto MM, Silvie O, Ishino T, Yuda M, Dartevelle S, Traincard F, Boscardin SB, Amino R. Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin. Nat Microbiol. 2018 Nov;3(11):1224-1233. doi: 10.1038/s41564-018-0254-z. [Abstract]

arrowIto D, Takashima E, Yamasaki T, Hatano S, Hasegawa T, Miura K, Morita M, Thongkukiatkul A, Diakite M, Long CA, Sattabongkot J, Udomsangpetch R, Iriko H, Ishino T, Tsuboi T. Antibodies against a Plasmodium falciparum RON12 inhibit merozoite invasion into erythrocytes. Parasitol Int. 2019 Feb;68(1):87-91. doi: 10.1016/j.parint.2018.10.006. [Abstract]

arrowIshino T*, Murata E, Tokunaga N, Baba M, Tachibana M, Thongkukiatkul A, Tsuboi T, Torii M. Rhoptry neck protein 2 expressed in Plasmodium sporozoites plays a crucial role during invasion of mosquito salivary glands. Cell Microbiol. 2018 Oct 11:e12964. doi: 10.1111/cmi.12964. [Abstract]

arrowOda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T*, Tsuboi T*. Plasmodium RON12 localizes to the rhoptry body in sporozoites. Parasitol Int. 2018 Oct 2. pii: S1383-5769(18)30290-3. doi: 10.1016/j.parint.2018.10.001. [Abstract]

arrowIriko H, Ishino T, Otsuki H, Ito D, Tachibana M, Torii M, Tsuboi T. Plasmodium falciparum Exported Protein 1 is localized to dense granules in merozoites. Parasitol Int. Jun 8;67(5):637-639. doi: 10.1016/j.parint.2018.06.001. [Abstract]

arrowMiura T, Takeo S, Ntege EH, Otsuki H, Sawasaki T, Ishino T, Takashima E, Tsuboi T. The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library. Biochem Biophys Res Commun. 2018 Jun 2;500(2):261-267. doi: 10.1016/j.bbrc.2018.04.056. [Abstract]

arrowTachibana M, Ishino T*, Takashima E, Tsuboi T, Torii M. A male gametocyte osmiophilic body and microgamete surface protein of the rodent malaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in male osmiophilic body formation and exflagellation. Cell Microbiol. 2018 May;20(5):e12821. doi: 10.1111/cmi.12821. [Abstract] [full-text]

arrowSakamoto H, Takeo S, Takashima E, Miura K, Kanoi BN, Kaneko T, Han ET, Tachibana M, Matsuoka K, Sattabongkot J, Udomsangpetch R, Ishino T, Tsuboi T.Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission. Parasitol Int. 2017 Dec 5;67(2):203-208. doi: 10.1016/j.parint.2017.12.002. [Abstract]

arrowItani S, Torii M, Ishino T*. D-Glucose concentration is the key factor facilitating liver stage maturation of Plasmodium. Parasitol Int. 2014 Aug;63(4):584-90. doi: 10.1016/j.parint.2014.03.004. Epub 2014 Mar 30.[Abstract]

arrowZhao H, Aoshi T, Kawai S, Mori Y, Konishi A, Ozkan M, Fujita Y, Haseda Y, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C. Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria. Cell Host Microbe. 2014 May 14;15(5):551-63. doi: 10.1016/j.chom.2014.04.008. [Abstract]

arrowShinzawa N, Ishino T, Tachibana M, Tsuboi T, Torii M. Phenotypic Dissection of a Plasmodium-Refractory Strain of Malaria Vector Anopheles stephensi: The Reduced Susceptibility to P. berghei and P. yoelii. PLoS One. 2013 May 23;8(5):e63753.[Abstract]

arrowKangwanrangsan N, Tachibana M, Jenwithisuk R, Tsuboi T, Riengrojpitak S, Torii M, Ishino T*. A member of the CPW-WPC protein family is expressed in and localized to the surface of developing ookinetes. Malar J. 2013 Apr 15;12(1):129.[Abstract]

Orito Y*, Ishino T*, Iwanaga S, Kaneko I, Kato T, Menard R, Chinzei Y, Yuda M.(*: equally contributed) Liver-specific protein 2: a Plasmodium protein exported to the hepatocyte cytoplasm and required for merozoite formation. Mol Microbiol. 2012 Dec 10. doi: 10.1111/mmi.12083.[Abstract]

Gueirard P, Tavares J, Thiberge S, Bernex F, Ishino T, Milon G, Franke-Fayard B, Janse CJ, Me´nard R, Amino R. Development of the malaria parasite in the skin of the mammalian host. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18640-5.[Abstract]

Ishino T, Boisson B, Orito Y, Lacroix C, Bischoff E, Loussert C, Janse C, Menard R, Yuda M, Baldacci P.  LISP1 is important for the egress of Plasmodium parasites from liver cells.
Cell Microbiol Sep;11(9):1329-39. (2009).[Abstract]

Amino R, Giovannini D, Thiberge S, Gueirard P, Boisson B, Dubremetz JF, Prevost MC, Ishino T, Yuda M, Menard R. Host cell traversal is important for progression of the malaria parasite through the dermis to the liver.  Cell Host Microbe. 3(2):88-96 (2008/02).[Abstract]

Ishino T, Kunieda T, Natori S, Sekimizu K, Kubo T.Identification of novel members of the Xenopus Ca2+ -dependent lectin family and analysis of their gene expression during tail regeneration and development. J Biochem. 141(4):479-88 (2007/04).[Abstract]

Kariu T*, Ishino T*, Yano K, Chinzei Y, Yuda M.(*: equally contributed) CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hosts. Mol Microbiol. 59(5):1369-79 (2006/03).[Abstract]

Ishino T, Orito Y, Chinzei Y, Yuda M. A calcium-dependent protein kinase regulates Plasmodium ookinete access to the midgut epithelial cell.  Mol Microbiol. 59(4):1175-84 (2006/02).[Abstract]

Ishino T, Chinzei Y, Yuda M. Two proteins with 6-cys motifs are required for malarial parasites to commit to infection of the hepatocyte.  Mol Microbiol. 58(5):1264-75 (2005/12).[Abstract]

Ishino T, Chinzei Y, Yuda M. A Plasmodium sporozoite protein with a membrane attack complex domain is required for breaching the liver sinusoidal cell layer prior to hepatocyte infection.  Cell Microbiol. 7(2):199-208 (2005/02).[Abstract]

Kadota K, Ishino T, Matsuyama T, Chinzei Y, Yuda M. Essential role of membrane-attack protein in malarial transmission to mosquito host.  Proc Natl Acad Sci U S A. 101(46):16310-5 (2004/11).[Abstract]

Ishino T, Yano K, Chinzei Y, Yuda M. Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer.  PLoS Biol. 2(1):16310-5 (2004/01).[Abstract]

Ishino T, Shirai M, Kunieda T, Sekimizu K, Natori S, Kubo T. Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method.  Dev Dyn. 226(2):317-25 (2003/02).[Abstract]

Ishino T, Ohtsuki S, Homma K, Natori S. cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells.  J Biochem. 123(3):540-5 (1998/03).[Abstract]


総説

arrowIshino T, Tsuboi T. Progress toward a transmission-blocking vaccine against malaria. Lancet Infect Dis. 2018 Sep;18(9):927-928. doi: 10.1016/S1473-3099(18)30358-X.


arrowNtege EH, Takashima E, Morita M, Nagaoka H, Ishino T, Tsuboi T. Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates. Expert Rev Vaccines. 2017 Aug;16(8):769-779. doi: 10.1080/14760584.2017.1341317. [Abstract] 

石野 智子 巧みな寄生戦略をもつマラリア原虫への挑戦 実験医学 2013 vol.31 No.19

arrowArumugam TU, Ito D, Takashima E, Tachibana M, Ishino T, Torii M, Tsuboi T. Application of wheat germ cell-free protein expression system for novel malaria vaccine candidate discovery. Expert Rev Vaccines. 2013 Dec 5.[Abstract]

石野 智子 連載・分子寄生虫学入門 第4回 マラリア原虫の最弱点を攻略する 〜遺伝子targeting法によるマラリア撲滅へのアプローチ〜 細胞工学 2006年 1月号

Yuda M, Ishino T. Liver invasion by malarial parasites--how do malarial parasites break through the host barrier?  Cell Microbiol. 6(12):199-208 (2004/12).[Abstract]


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