{"id":17,"date":"2018-04-19T18:52:43","date_gmt":"2018-04-19T09:52:43","guid":{"rendered":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/?page_id=17"},"modified":"2026-04-02T17:47:57","modified_gmt":"2026-04-02T08:47:57","slug":"research","status":"publish","type":"page","link":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/research\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<p><strong>RNA<\/strong><strong>\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8ceaAcin1<\/strong><strong>\u306e\u751f\u7406\u6a5f\u80fd\u306e\u89e3\u6790<\/strong><\/p>\n<p>\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306f\u8ee2\u5199\u30ec\u30d9\u30eb\u3060\u3051\u3067\u306a\u304f\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3001mRNA\u306e\u5316\u5b66\u4fee\u98fe\u3001\u6838\u5916\u8f38\u9001\u3001\u5b89\u5b9a\u6027\u306e\u8abf\u7bc0\u3001\u7ffb\u8a33\u5236\u5fa1\u306a\u3069\u3001\u591a\u6bb5\u968e\u306b\u308f\u305f\u308b\u8ee2\u5199\u5f8c\u8abf\u7bc0\u306b\u3088\u3063\u3066\u7cbe\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u904e\u7a0b\u306b\u306f\u591a\u7a2e\u591a\u69d8\u306aRNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u306a\u304b\u3067\u3082\u9078\u629e\u7684\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\uff08AS\uff09\u306f\u7279\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3044\u3001\u5358\u4e00\u306e\u907a\u4f1d\u5b50\u304b\u3089\u69cb\u9020\u30fb\u7d30\u80de\u5185\u5c40\u5728\u30fb\u767a\u73fe\u91cf\u30fb\u751f\u7269\u5b66\u7684\u6a5f\u80fd\u306e\u7570\u306a\u308b\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3092\u751f\u307f\u51fa\u3059\u4e3b\u8981\u306a\u6a5f\u69cb\u3067\u3042\u308b\u3002\u30d2\u30c8\u907a\u4f1d\u5b50\u306e90\uff05\u4ee5\u4e0a\u304c\u305d\u306e\u5bfe\u8c61\u3068\u306a\u308a\u3001AS\u306e\u7834\u7dbb\u306f\u7d30\u80de\u30fb\u7d44\u7e54\u30fb\u500b\u4f53\u30ec\u30d9\u30eb\u3067\u306e\u91cd\u7be4\u306a\u6a5f\u80fd\u7570\u5e38\u3084\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3046\u308b\u305f\u3081\u3001\u305d\u306e\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e\u306f\u304d\u308f\u3081\u3066\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3042\u308b\u3002<\/p>\n<p>\u6211\u3005\u306f\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u6642\u306e\u30af\u30ed\u30de\u30c1\u30f3\u51dd\u7e2e\u8a98\u5c0e\u56e0\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305fAcin1\uff08Acinus\uff09\u304c\u3001RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u3082\u6a5f\u80fd\u3059\u308b\u70b9\u306b\u7740\u76ee\u3057\u3066\u3044\u308b\u3002Acin1\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30ca\u30eb\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3001\u5404\u7d44\u7e54\u306b\u304a\u3051\u308bAcin1\u306e\u751f\u4f53\u9ad8\u6b21\u6a5f\u80fd\u306e\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u308b\uff08Aoto M et al., Sci Rep. 2025\uff09\u3002\u3055\u3089\u306b\u3001\u65b0\u898fAcin1\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u63a2\u7d22\u3092\u901a\u3058\u3066\u3001RNA\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u306b\u304a\u3051\u308bAcin1\u306e\u751f\u5316\u5b66\u7684\u5f79\u5272\u306e\u5168\u5bb9\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u795e\u7d4c\u7d30\u80de\u306e\u5206\u5316\u3084\u8133\u306e\u767a\u751f\u6a5f\u5e8f\u306e\u89e3\u660e<\/strong><\/p>\n<p>\u795e\u7d4c\u5e79\u7d30\u80de\u306f\u81ea\u5df1\u8907\u88fd\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u8133\u3092\u69cb\u6210\u3059\u308b\u795e\u7d4c\u7d30\u80de\u3084\u5404\u7a2e\u30b0\u30ea\u30a2\u7d30\u80de\u306b\u5206\u5316\u3092\u3057\u307e\u3059\u3002\u3053\u306e\u5206\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u307e\u3060\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u8fd1\u5e74Zfp521\u3068\u3044\u3046\u56e0\u5b50\u304c\u795e\u7d4c\u7d30\u80de\u3078\u306e\u5206\u5316\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u6211\u3005\u306fZfp521\u907a\u4f1d\u5b50\u3092\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3001\u305d\u306e\u751f\u4f53\u3067\u306e\u5f79\u5272\u3092\u8abf\u3079\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3053\u306e\u30de\u30a6\u30b9\u306f\u7d71\u5408\u5931\u8abf\u75c7\u69d8\u306e\u884c\u52d5\u3092\u898b\u305b\u308b\u3053\u3068\uff08Ohkubo N et al., PLoS One, 2014, Ohkubo N et al., Ehime Med. J., 2016\uff09\u3001\u8133\u5185\u30e2\u30ce\u30a2\u30df\u30f3\u91cf\u306e\u5909\u5316\u304c\u3042\u308b\u3053\u3068\uff08Ohkubo N et al., Life Sci., 2019\uff09\u306a\u3069\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306e\u6210\u679c\u306f\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u5206\u5316\u6a5f\u69cb\u3084\u8133\u306e\u767a\u751f\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u7cbe\u795e\u75be\u60a3\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3084\u6cbb\u7642\u6cd5\u306b\u7d50\u3073\u3064\u304f\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u8840\u6db2\u306e\u5fae\u5c0f\u5faa\u74b0\u306e\u5236\u5fa1\u306b\u95a2\u308f\u308b\u56e0\u5b50\u306e\u63a2\u7d22<\/strong><\/p>\n<p>\u8840\u6db2\u306e\u5fae\u5c0f\u5faa\u74b0\u3068\u306f\u3001\u7d30\u52d5\u8108\u30fb\u6bdb\u7d30\u8840\u7ba1\u30fb\u7d30\u9759\u8108\u30ec\u30d9\u30eb\u3067\u884c\u308f\u308c\u308b\u8840\u6db2\u5faa\u74b0\u306e\u3053\u3068\u3067\u3059\u3002\u5168\u8eab\u306e\u7d30\u80de\u306b\u9178\u7d20\u3068\u6804\u990a\u3092\u5c4a\u3051\u3001\u8001\u5ec3\u7269\u3092\u56de\u53ce\u3059\u308b\u3068\u3044\u3046\u3001\u3044\u308f\u3070\u300c\u751f\u547d\u7dad\u6301\u306e\u6700\u524d\u7dda\u300d\u306e\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u5fae\u5c0f\u8840\u7ba1\u306f\u5168\u8840\u7ba1\u306e95%\u4ee5\u4e0a\u3092\u5360\u3081\u3066\u304a\u308a\u3001\u7d30\u80de\u306e\u4ee3\u8b1d\u3084\u514d\u75ab\u5fdc\u7b54\u3001\u7d44\u7e54\u306e\u4fee\u5fa9\u306b\u6b20\u304b\u305b\u307e\u305b\u3093\u3002\u6211\u3005\u306f\u3001\u3053\u306e\u5fae\u5c0f\u5faa\u74b0\u306e\u5236\u5fa1\u306b\u95a2\u308f\u308b\u7269\u8cea\u306e\u63a2\u7d22\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8ceaAcin1\u306e\u751f\u7406\u6a5f\u80fd\u306e\u89e3\u6790 \u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306f\u8ee2\u5199\u30ec\u30d9\u30eb\u3060\u3051\u3067\u306a\u304f\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3001mRNA\u306e\u5316\u5b66\u4fee\u98fe\u3001\u6838\u5916\u8f38\u9001\u3001\u5b89\u5b9a\u6027\u306e\u8abf\u7bc0\u3001\u7ffb\u8a33\u5236\u5fa1\u306a\u3069\u3001\u591a\u6bb5\u968e\u306b\u308f\u305f\u308b\u8ee2\u5199\u5f8c\u8abf\u7bc0\u306b\u3088\u3063\u3066\u7cbe\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/research\/\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;\u7814\u7a76\u5185\u5bb9&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/wp-json\/wp\/v2\/pages\/17"}],"collection":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":6,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":157,"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/wp-json\/wp\/v2\/pages\/17\/revisions\/157"}],"wp:attachment":[{"href":"https:\/\/www.m.ehime-u.ac.jp\/school\/physiology2\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}