Our main research topics include:
■ 1. SLFN11 and the DNA damage response
– Molecular basis for drug sensitivity
– Replication fork regulation
– TP53-independent apoptosis
■ 2. Single-stranded DNA gaps (ssDNA gaps)
– Mechanisms of gap formation
– ssDNA-induced cell death
– Tumor-specific gap signatures
■ 3. Evolutionary biology of the Schlafen family
– Functional comparison across mammals
– Links to antiviral pathways
■ 4. Clinical & translational applications
– SLFN11 as a predictive biomarker
– Strategies to overcome chemoresistance
– Integration with novel SLFN11-relevant DNA-damaging agents and ADCs