主要論文
Molecular pathology of rare histologic variants and treatment-resistant lineages of prostate cancer
Watanabe R, Miura N, Kikugawa T, Saika T, Haffner MC, Nelson PS.
Urol Oncol. 2026 Apr;44(4):110987.
PMID: 41605126
Spatial gene expression profiling reveals the distinct microenvironment of tuberous sclerosis complex-associated angiomyolipoma
Watanabe R, Fukumoto T, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Sci Rep. 2025 Nov 27;15(1):42470.
PMID: 41309810
Vesicles Secreted by Renal Cell Carcinoma Cells Cause Vascular Endothelial Cells to Express PSMA and Drive Tumor Progression
Watanabe R, Kagimoto K, Chosei M, Sakaue T, Kurata M, Miura N, Kitazawa R, Kikugawa T, Higashiyama S, Saika T.
Cells. 2025 Jan 22;14(3):165.
PMID: 39936957
CTHRC1 promotes bone metastasis in prostate cancer.
Sawada Y, Kikugawa T, Onishi T, Arai O, Iio H, Miura N, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Sakakibara I, Győrffy B, Kishida T, Okubo Y, Nakamura Y, Sato S, Miyagi Y, Saika T, Imai Y.
Int J Cancer. 2025 Dec 1;157(11):2399-2412.PMID: 40542593
Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer
Watanabe R, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Int J Mol Sci. 2023 May 18;24(10):8955.
PMID: 37240308
PSMA-positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state
Watanabe R, Maekawa M, Kiyoi T, Kurata M, Miura N, Kikugawa T, Higashiyama S, Saika T.
Prostate. 2021 Dec;81(16):1390-1401.
PMID: 34516672
SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex
Watanabe R, Maekawa M, Hieda M, Taguchi T, Miura N, Kikugawa T, Saika T, Higashiyama S.
Mol Biol Cell. 2020 Mar 15;31(6):478-490.
PMID: 31967940
当研究組織の研究成果を、新しいものから年代順に掲載しています。
2026年
Editorial Comment to “Perioperative Systemic Treatment Patterns and Postoperative Mortality Among Patients With Muscle-Invasive Bladder Cancer Undergoing Radical Cystectomy in Japan: WAKKA-MIBC Study”
Watanabe R.
Int J Urol. 2026 Aug;33(8):e70604.PMID: 42583697
Clinical Outcomes of Single-Dose Flomoxef Prophylaxis for Transrectal Prostate Biopsy: A Single-Center Study of 834 Cases
Sugihara N, Sawada T, Arai H, Nishida K, Ohnishi T, Watanabe R, Nishimura K, Fukumoto T, Miura N, Miyauchi Y, Saika T.
Int J Urol. 2026 Aug;33(8):e70595.PMID: 42576438
Validation of the NCCN Subclassification for Intermediate-Risk Prostate Cancer in a Japanese Radical Prostatectomy Cohort: Results From the MICAN Study
Oono T, Terashita M, Mori S, Oka A, Matsuzaki S, Yano A, Matsumura M, Ninomiya I, Shinomori K, Ogawa T, Onishi T, Shirato A, Watanabe Y, Hashine K, Yamashita N, Watanabe R, Miura N, Saika T.
Int J Urol. 2026 Aug;33(8):e70592.PMID: 42576432
Enzalutamide promotes an early plasticity-associated transcriptional state without terminal neuroendocrine differentiation in prostate cancer cells
Watanabe R, Chosei M, Arai H, Miura N, Kikugawa T, Saika T.
Front Oncol. 2026 Jul 24;16:1870253.PMID: 42568401
Dynamic Loss of Psoas Muscle Volume During Induction Chemotherapy Predicts Survival in Patients with Advanced Urothelial Carcinoma Receiving Avelumab Maintenance: A Multicenter Retrospective Study
Shimizu R, Morizane S, Yamaguchi N, Katayama S, Kawada T, Bekku K, Kobayashi K, Shiraishi K, Miura N, Watanabe R, Tohi Y, Naito H, Yamamoto S, Inoue K, Takamoto A, Daizumoto K, Furukawa J, Ogawa K, Wada K, Takenaka A.
Nutr Cancer. 2026;78(7):539-549.PMID: 42394479
Single-Cell Analysis Reveals Pre-Existing Basal-Associated Epithelial States in Metastatic Hormone-Naïve Prostate Cancer
Watanabe R, Chosei M, Sakaue T, Miura N, Kikugawa T, Saika T.
Int J Mol Sci. 2026 Jun 16;27(12):5405.PMID: 42353123
Cellular plasticity and tumor ecosystem dynamics in prostate cancer: insights from single-cell and spatial transcriptomics
Watanabe R, Chu T, Miura N, Kikugawa T, Nelson PS, Saika T.
Am J Clin Exp Urol. 2026 Jun 15;14(3):64-85.PMID: 42488354
Paired-sample Analysis of ERG Expression and TMPRSS2-ERG Fusion in Treatment-induced Neuroendocrine Prostate Cancer
Watanabe R, Shigehisa R, Kawada T, Yamamoto S, Katayama S, Takamoto A, Nishimura K, Miura N, Araki M, Inoue K, Saika T; Chu-shikoku Japan Urological Consortium (CsJUC) Research Collaboration.
Anticancer Res. 2026 Apr;46(4):1929-1942.PMID: 41895744
Prostate‑specific membrane antigen: Molecular functions and emerging roles as a therapeutic target (Review)
Watanabe R, Sakaue T, Miura N, Kikugawa T, Saika T.
Mol Med Rep. 2026 Apr;33(4):122.PMID: 41789574
Molecular pathology of rare histologic variants and treatment-resistant lineages of prostate cancer
Watanabe R, Miura N, Kikugawa T, Saika T, Haffner MC, Nelson PS.
Urol Oncol. 2026 Apr;44(4):110987.PMID: 41605126
Spatial transcriptomics of urothelial carcinoma with basal/squamous differentiation identifies Galectin-7 as a specific marker of squamous lineage commitment
Haga S, Watanabe R, Kurata M, Miura N, Liu S, Kikugawa T, Kitazawa R, Mogi M, Saika T.
Discov Oncol. 2026 Mar 31;17(1):722.PMID: 41917522
Impact of the 2025 NCCN Definition Change for Very High-Risk Prostate Cancer on Surgical Outcomes After Robot-Assisted Radical Prostatectomy: A Retrospective Cohort
Miura N, Shimbo M, Shishido K, Nobumori S, Sugihara N, Sawada T, Haga S, Arai H, Nishida K, Arai O, Onishi T, Watanabe R, Nishimura K, Fukumoto T, Miyauchi Y, Kikugawa T, Nishino T, Endo F, Hattori K, Saika T.
Int J Urol. 2026 Feb;33(2):e70366.PMID: 41623210
A feasibility study of a novel irrigation technique for reducing intrapelvic pressure during ureterorenoscopy using conventional devices
Sugihara N, Kono R, Sogabe H, Saiki K, Arai H, Arai O, Onishi T, Kakuda T, Hara K, Watanabe R, Miura N, Ozawa A, Iseda T, Saika T.
BMC Urol. 2026 Jan 10;26(1):36.PMID: 41514222
An inadequate number of first-line chemotherapy cycles provides poor survival outcomes in patients with metastatic urothelial carcinoma receiving avelumab maintenance: results from the chu-shikoku Japan urological consortium
Katayama S, Iwata T, Nishimura S, Bekku K, Kobayashi K, Fujii N, Nishimura K, Miura N, Tohi Y, Kato T, Yamamoto S, Fukuhara H, Takamoto A, Shimizu R, Morizane S, Sasaki Y, Daizumoto K, Nagami T, Wada K, Araki M; Chu-shikoku Japan Urological Consortium.
Jpn J Clin Oncol. 2026 Jan 9;56(1):89-96.PMID: 41124086
DNA Methylation Levels at the C3orf37 Loci Correlate With Prostate Cancer Grade
Watanabe R.
Int J Urol. 2026 Jan;33(1):e70317.PMID: 41368771
2025年
Precision Medicine in Prostate Cancer with a Focus on Emerging Therapeutic Strategies
Watanabe R, Miura N, Kikugawa T, Saika T.
Biomedicines. 2025 Dec 25;14(1):52.PMID: 41595588
Spatial gene expression profiling reveals the distinct microenvironment of tuberous sclerosis complex-associated angiomyolipoma
Watanabe R, Fukumoto T, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Sci Rep. 2025 Nov 27;15(1):42470.PMID: 41309810
CDH11 Contributes to Bladder Cancer Progression via Regulation of Mitochondrial Energy Metabolism
Arai O, Yanagihara Y, Arai H, Watanabe R, Miura N, Kikugawa T, Saika T, Imai Y.
Cancer Med. 2025 Nov;14(22):e71399.PMID: 41263259
Robot-Assisted Radical Prostatectomy for Locally Advanced Prostate Cancer: Oncological Potential and Limitations as the Primary Treatment
Miura N, Shimbo M, Shishido K, Nobumori S, Sugihara N, Sawada T, Haga S, Arai H, Nishida K, Arai O, Onishi T, Watanabe R, Nishimura K, Fukumoto T, Miyauchi Y, Kikugawa T, Nishino T, Endo F, Hattori K, Saika T.
Cancers (Basel). 2025 Oct 10;17(20):3286.PMID: 41154343
Editorial Comment to “VIRMA Accelerates the Tumorigenesis of Prostate Cancer via Regulating the m6A Modification of NSMCE2 to Eliminate the Generation of Reactive Oxygen Species”
Watanabe R.
Int J Urol. 2025 Sep;32(9):1283-1284.PMID: 40524379
Case Report: Chronic Prostatitis as an Extraintestinal Manifestation of Ulcerative Colitis
Sugihara N, Watanabe R, Miura N, Saika T, Ohashi K.
IJU Case Rep. 2025 Aug 15;8(5):521-524.PMID: 40909304
Evaluation of the New Robotic Platform “HINOTORI™” in Urologic Robot-Assisted Surgery: From a Comparison with da Vinci® Surgical System in Sacrocolpopexy
Fukumoto T, Sawada T, Nishida K, Onishi T, Watanabe R, Nishimura K, Miura N, Miyauchi Y, Kikugawa T, Saika T.
J Clin Med. 2025 Apr 24;14(9):2954.PMID: 40363986
Recent advances in basic research on prostate cancer: Where we are heading?
Obinata D, Yamada Y, Sumiyoshi T, Tanegashima T, Watanabe R, Kobayashi H, Ito D, Urabe F; Japanese Young Urologist Basic Research Collaboration.
Int J Urol. 2025 Mar;32(3):219-228.PMID: 39474871
Extended Lymph Node Dissection May Not Provide a Therapeutic Benefit in Patients with Intermediate-to High-Risk Prostate Cancer Treated with Robotic-Assisted Radical Prostatectomy
Miura N, Shimbo M, Okawa D, Sakamoto M, Sugihara N, Sawada T, Haga S, Arai H, Nishida K, Arai O, Onishi T, Watanabe R, Nishimura K, Fukumoto T, Miyauchi Y, Kikugawa T, Nishino T, Endo F, Hattori K, Saika T.
Cancers (Basel). 2025 Feb 14;17(4):655.PMID: 40002250
Vesicles Secreted by Renal Cell Carcinoma Cells Cause Vascular Endothelial Cells to Express PSMA and Drive Tumor Progression
Watanabe R, Kagimoto K, Chosei M, Sakaue T, Kurata M, Miura N, Kitazawa R, Kikugawa T, Higashiyama S, Saika T.
Cells. 2025 Jan 22;14(3):165.PMID: 39936957
Robot-Assisted Radical Nephroureterectomy in a Patient With Horseshoe Kidney: A Case Report
Shiode R, Watanabe R, Kakuda T, Suzuki D, Nobumori S, Sugihara N, Yamakawa M, Saiki K, Kono R, Noda T, Nishimura K, Fukumoto T, Miura N, Miyauchi Y, Kikugawa T, Saika T.
Asian J Endosc Surg. 2025 Jan-Dec;18(1):e70054.PMID: 40210236
CTHRC1 promotes bone metastasis in prostate cancer.
Sawada Y, Kikugawa T, Onishi T, Arai O, Iio H, Miura N, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Sakakibara I, Győrffy B, Kishida T, Okubo Y, Nakamura Y, Sato S, Miyagi Y, Saika T, Imai Y.
Int J Cancer. 2025 Dec 1;157(11):2399-2412.PMID: 40542593
2024年
Genetic Analysis of Intraductal Carcinoma of the Prostate Detected in High-Grade Prostatic Intraepithelial Neoplasia Cases
Watanabe R, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Cureus. 2024 Dec 21;16(12):e76165.PMID: 39840193
A case of dedifferentiated liposarcoma discovered due to an intrascrotal calcified ossification
Arai H, Sogabe H, Morikawa S, Arai O, Watanabe R, Ozawa A, Hida AI, Iseda T, Kohashi K, Oda Y.
Int Cancer Conf J. 2024 Apr 30;13(3):301-305.PMID: 38962045
Unveiling the Genomic Landscape of Intraductal Carcinoma of the Prostate Using Spatial Gene Expression Analysis
Watanabe R, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Int J Mol Sci. 2024 Apr 28;25(9):4818.PMID: 38732035
2023年
Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer
Watanabe R, Miura N, Kurata M, Kitazawa R, Kikugawa T, Saika T.
Int J Mol Sci. 2023 May 18;24(10):8955.PMID: 37240308
2022年
CD21(lo) B Cells Could Be a Potential Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma
Nishimura K, Konishi T, Ochi T, Watanabe R, Noda T, Fukumoto T, Miura N, Miyauchi Y, Kikugawa T, Takenaka K, Saika T.
J Pers Med. 2022 May 28;12(6):888.PMID: 35743673
Uhrf1 governs the proliferation and differentiation of muscle satellite cells.
Sakai H, Sawada Y, Tokunaga N, Tanaka K, Nakagawa S, Sakakibara I, Ono Y, Fukada SI, Ohkawa Y, Kikugawa T, Saika T, Imai Y.
iScience. 2022 Feb 14;25(3):103928.PMID: 35243267
2021年
PSMA-positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state
Watanabe R, Maekawa M, Kiyoi T, Kurata M, Miura N, Kikugawa T, Higashiyama S, Saika T.
Prostate. 2021 Dec;81(16):1390-1401.PMID: 34516672
Extended robot-assisted laparoscopic prostatectomy and extended pelvic lymph node dissection as a monotherapy in patients with very high-risk prostate cancer Patients
Miura N, Sugihara N, Funaki K, Kakuda T, Koyama K, Watanabe R, Sawada Y, Noda T, Nishimura K, Fukumoto T, Miyauchi Y, Kikugawa T, Saika T.
Cancer Med. 2021 Nov;10(22):7968-7976.PMID: 34562303
Predictors of Hypotension after Adrenalectomy for Pheochromocytoma
Koyama K, Miura N, Watanabe R, Sawada Y, Noda T, Nishimura K, Asai S, Fukumoto T, Yanagihara Y, Miyauchi Y, Kikugawa T, Saika T.
Acta Med Okayama. 2021 Jun;75(3):345-349.PMID: 34176938
Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4.
Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada SI, Sawasaki T, Imai Y.
iScience. 2021 Mar 13;24(4):102303.PMID: 33870126
2020年
Development and validation of a prediction model for failed shockwave lithotripsy of upper urinary tract calculi using computed tomography information: the S(3)HoCKwave score
Yoshioka T, Ikenoue T, Hashimoto H, Otsuki H, Oeda T, Ishito N, Watanabe R, Saika T, Araki M, Fukuhara S, Yamamoto Y; Okayama-Ehime S.W.L. Study Group.
World J Urol. 2020 Dec;38(12):3267-3273.PMID: 32088747
SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex
Watanabe R, Maekawa M, Hieda M, Taguchi T, Miura N, Kikugawa T, Saika T, Higashiyama S.
Mol Biol Cell. 2020 Mar 15;31(6):478-490.PMID: 31967940
2019年
Feasibility of Laparoscopic Radical Cystectomy in Elderly Patients: A Comparative Analysis of Clinical Outcomes in a Single Institution
Yanagihara Y, Nishida K, Watanabe R, Koyama K, Sawada Y, Noda T, Asai S, Fukumoto T, Miura N, Miyauchi Y, Kikugawa T, Saika T.
Acta Med Okayama. 2019 Oct;73(5):417-418.PMID: 31649367
A Case Report of Synchronous Prostate Cancer and Rectal Gastrointestinal Stromal Tumor and its Management
Watanabe R, Ozawa A, Iseda T, Hatano H.
Urol J. 2019 Jun 17;16(3):322-325.PMID: 30206927
2018年
New classification of hydronephrosis on 18F-FDG-PET/CT predicts post-operative renal function and muscle-invasive disease in patients with upper urinary tract urothelial carcinoma
Asai S, Fukumoto T, Watanabe R, Koyama K, Sawada Y, Noda T, Miura N, Yanagihara Y, Miyauchi Y, Miyagawa M, Kikugawa T, Saika T.
Jpn J Clin Oncol. 2018 Nov 1;48(11):1022-1027.PMID: 30252103
2017年
A case of retroperitoneal fibrosis responding to steroid therapy
Watanabe R, Ozawa A, Iseda T.
Int Braz J Urol. 2017 Nov-Dec;43(6):1185-1189.PMID: 28379669
2016年
A case of a urethral diverticular adenocarcinoma after the fenestration of the anterior vaginal wall for pelvic floor abscess
Watanabe R, Sugahara T, Hamada H.
J Surg Case Rep. 2016 Mar 2;2016(3):rjw024.PMID: 26941237