分子病態医学

• Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network. Ieda T, Tazawa H, Okabayashi H, Yano S, Shigeyasu K, Kuroda S, Ohara T, Noma K, Kishimoto H, Nishizaki M, Kagawa S, Shirakawa Y, Saitou T, Imamura T, Fujiwara T. Sci Rep. 2019 Nov 8;9(1):16378. doi: 10.1038/s41598-019-52816-z.
• Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics. Inoue M, Takeuchi A, Manita S, Horigane SI, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H. Cell. 2019 May 16;177(5):1346-1360.e24. doi: 10.1016/j.cell.2019.04.007. Epub 2019 May 9
• Tissue Intrinsic Fluorescence Spectra-Based Digital Pathology of Liver Fibrosis by Marker-Controlled Segmentation. Saitou T, Takanezawa S, Ninomiya H, Watanabe T, Yamamoto S, Hiasa Y, Imamura T. Front Med (Lausanne). 2018 Dec 11;5:350. doi: 10.3389/fmed.2018.00350. eCollection 2018.
• A Highly Photostable Near-Infrared Labeling Agent Based on a Phospha-rhodamine for Long-Term and Deep Imaging. Grzybowski M, Taki M, Senda K, Sato Y, Ariyoshi T, Okada Y, Kawakami R, Imamura T, Yamaguchi S. Angew Chem Int Ed Engl. 2018 Aug 6;57(32):10137-10141. doi: 10.1002/anie.201804731. Epub 2018 Jul 16.
• Quantitative Morphometry for Osteochondral Tissues Using Second Harmonic Generation Microscopy and Image Texture Information. Saitou T, Kiyomatsu H, Imamura T. Sci Rep. 2018 Feb 12;8(1):2826. doi: 10.1038/s41598-018-21005-9.
• Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Yoon JH, Sudo K, Kuroda M, Kato M, Lee IK, Han JS, Nakae S, Imamura T, Kim J, Ju JH, Kim DK, Matsuzaki K, Weinstein M, Matsumoto I, Sumida T, Mamura M. Nat Commun. 2015 Jul 21;6:7600. doi: 10.1038/ncomms8600.
• Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Sakaue-Sawano A, Kurokawa H, Morimura T, Hanyu A, Hama H, Osawa H, Kashiwagi S, Fukami K, Miyata T, Miyoshi H, Imamura T, Ogawa M, Masai H, Miyawaki A. Cell. 2008 Feb 8;132(3):487-98. doi: 10.1016/j.cell.2007.12.033.
• Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T. Cell. 2000 Dec 22;103(7):1085-97.
• HNPCC associated with germline mutation in the TGF-beta type II receptor gene. Lu SL, Kawabata M, Imamura T, Akiyama Y, Nomizu T, Miyazono K, Yuasa Y. Nat Genet. 1998 May;19(1):17-8. No abstract available.
• Smad6 inhibits signalling by the TGF-beta superfamily. Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, Miyazono K. Nature. 1997 Oct 9;389(6651):622-6.

スタッフ紹介

• 今村 健志 (教授)
• 川上 良介 (准教授)
• 齋藤 卓 (助教)