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Introduction
Organ and Morphology
Department of Circulatory Physiology
【Contact】
Organ and Morphology
Department of Circulatory Physiology
Shitsukawa, Toon, Ehime 791-0295, Japan
TEL (+81)-89-960-5245 FAX (+81)-89-960-5246
Research content
This laboratory is promoting a research by the protein level, the transgenic animal level and the human body level about the aging of blood and brain.
The blood research group is studying the mechanism producing age-related functional disorder of microcirculation system and the prophylaxis for it. And this group is also studying the molecular mechanism of erythroblast differentiation.
The brain research group is studying the specialization mechanism of a nerve cell and the developmental mechanism of brain.
Result
- Abnormal behaviors and developmental disorder of hippocampus in zinc finger protein 521 (ZFP521) mutant mice.
Ohkubo N, Matsubara E, Yamanouchi J, Akazawa R, Aoto M, Suzuki Y, Sakai I, Abe T, Kiyonari H, Matsuda S, Yasukawa M, Mitsuda N.
PLoS One. 2014 Mar 27;9(3):e92848. - Accelerated destruction of erythrocytes in Tie2 promoter-driven STAT3 conditional knockout mice.
Ohkubo N, Suzuki Y, Aoto M, Yamanouchi J, Hirakawa S, Yasukawa M, Mitsuda N.
Life Sci. 2013 Sep 17;93(9-11):380-7. - Essential role of p38 MAPK in caspase-independent, iPLA(2)-dependent cell death under hypoxia/low glucose conditions.
Aoto M, Shinzawa K, Suzuki Y, Ohkubo N, Mitsuda N, Tsujimoto Y.
FEBS Lett. 2009 May 19;583(10):1611-8.
Staff
Staff list
- Professor：MITSUDA, Noriaki
- Associate Professor：AOTO, Mamoru
- Assistant Professor：OHKUBO, Nobutaka
