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Introduction
Molecule and Funtion
Department of Dermatology
【Contact】
Molecule and Funtion
Department of Dermatology
Shitsukawa, Toon, Ehime 791-0295, Japan
TEL (+81)-89-960-5350 FAX (+81)-89-960-5352
Research content
We study growth factor-mediated keratinocyte growth and differentiation. As a clinical application, we generate artificial skin and use for the treatment of chronic leg ulcers and epidermolysis bullosa. We are now improving the gene-delivery system utilizing three-dimensional artificial skin model to make it possible to treat recalcitrant skin disorders. Epidermis is the first line of immune defense. We study the mechanisms of pathogen recognition by epidermal keratinocyte and the defense by keratinocyte-delivered antimicrobial peptides.
Result
- Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K. Mite allergen is a danger signal for the skin via activation of the inflammasome in keratinocytes. J Allergy Clin Immunol. 2011; 127: 806-814.
- Sayam K, Kujiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K. Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-dificient mice. PLoS One. 2010; 5: e11275.
- Sayama K. Yamamoto M, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, Hashimoto K. E2 polyubiquitin-conjugating enzyme Ubc 13 in keratinocytes is essential for epidermal integrity. J Biol Chem. 2010; 285: 30042-30049.
Staff
Staff list
- ：
- Associate Professor：MURAKAMI, Masamoto
- Associate Professor：NAKAOKA, Hiroki
- MORI, Hideki
- Senior Assistant Professor：MUTO, Jun
- SHIRAISHI Ken
- Assistant Professor：NAMBA Chika
- ：
- Assistant Professor：NISHIHARA, Katsuhiko
- Assistant Professor：YATSUZUKA, Kazuki
