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Department of Molecular Medicine for Pathogenesis

Introduction

Molecule and Funtion
Department of Molecular Medicine for Pathogenesis

【Contact】
Molecule and Funtion
Department of Molecular Medicine for Pathogenesis
Shitsukawa, Toon, Ehime 791-0295, Japan
TEL (+81)-89-960-5045　FAX (+81)-89-960-5052

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Research contents

The in vivo fluorescent and bioluminescent imaging systems are a promising method. There has been a growing interest in applying these optical imaging approaches to study different disease process and complex biology in vivo. In this laboratory, we applied the fluorescent imaging systems to study the roles of carcinogenesis and cancer metastasis in vivo. The in vivo fluorescent and bioluminescent imaging allows quantitative and qualitative visualization of the cell function as well as microenvironment. The in vivo optical imaging systems will be a powerful technique in cancer biology.

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Result

  • Tsubakihara Y, Hikita A, Yamamoto S, Matsushita S, Matsushita N, Oshima Y, Miyazawa, Imamura T. Arkadia enhances BMP signaling through ubiquitylation and degradation of Smad6. The Journal of Biochemistry (2015) in press
  • Kiyomatsu H, Oshima Y, Saitou T, Miyazaki T, Hikita A, Miura H, Iimura T. Quantitative SHG imaging in osteoarthritis model mice, implying a diagnostic application. Biomedical Optics Express 6(2): 405-420, 2015.
  • Koga S, Oshima Y, Honkura N, Iimura T,Kameda K, Sato K, Yoshida M, Yamamoto Y, Watanabe Y, Hikita A, Imamura T. In vivo subcellular imaging of tumors in mouse models using a fluorophore-conjugated anti-CEA antibody in TPEM, Cancer Science 105(10): 1299-306, 2014.
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