業績　Publications

2021.

1) Nishiyama K, Maekawa M, Nakagita T, Nakayama J, Kiyoi T, Chosei M, Murakami A, Kamei Y, Takeda H, Takada Y, Higashiyama S. CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP. Life Sci. Alliance. 4 (9):e202101095. (2021).

2) Suzuki T, Terada N, Higashiyama S, Kametani K, Shirai Y, Honda M, Kai T, Li W, Tabuchi K. Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices. Life Sci. Alliance. 4(7):e202000945. (2021).

3) Imoto I, Saito M, Suga K, Kohmoto T, Otsu M, Horiuchi K, Nakayama H, Higashiyama S, Sugimoto M, Sasaki A, Homma Y, Shono M, Nakagawa R, Hayabuchi Y, Tange S, Kagami S, Masuda K. Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1. Sci. Rep. 11(1):9552. (2021).

4) Higashi H, Nishimura T, Aono J, Sakaue T, Kurata M, Izutani H, Yamaguchi O. Pathological Evidence of Native Aortic Valve Injury After Impella Support. Circ. Heart Fail. 14(2): e007571. (2021).

5) Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Higashiyama S, Yamamoto H. Roles of Pyk2 in signal transduction after gonadotropin-releasing hormone receptor stimulation. J. Cell. Physiol. 236(4): 3033-3043. (2021).

2020.

1) Akazawa Y, Inaba S, Sakaue T, Kurata M, Aono J, Yasugi T, Moritani T, Nishiyama H, Higaki T, Eguchi M, Yamaguchi O. Active aneurysm thrombosis after Kawasaki disease in an adult: Insight into anticoagulation therapy. J. Cardiol. Cases. 23(5):206-209. (2020).

2) Nakayama H, Nakahara M, Matsugi E, Soda M, Hattori T, Hara K, Usami A, Kusumoto C, Higashiyama S, Kitaichi K. Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells. Molecules. 26 (1): E90. (2020).

3) Nagasawa T, Ishimaru K, Higashiyama S, Hama Y, Mitsutake S. Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion. Food Funct. 11 (12): 10534-10541. (2020).

4) Tanaka M, Nakamura S, Maekawa M, Higashiyama S, Hara H. ANKFY1 is essential for retinal endothelial cell proliferation and migration via VEGFR2/Akt/eNOS pathway. Biochem. Biophys. Res. Commun. 533 (4): 1406-1412. (2020).

5) Maekawa M, Higashiyama S. The roles of SPOP in DNA damage response and DNA replication. Int. J. Mol. Sci. 21 (19). 7293. (2020). 

6) Tezuka-Kagajo M, Maekawa M, Ogawa A, Hatta Y, Ishii E, Eguchi M, Higashiyama S. Development of human CBF1-targeting single-stranded DNA aptamers with anti-angiogenic activity in vitro. Nucleic Acid Ther. 30 (6): 365-378. (2020).

7) Maekawa M, Higashiyama S. KCTD10 biology: An adaptor for the ubiquitin E3 complex meets multiple substrates. BioEssays. 42 (8): 1900256. (2020).

8) Watanabe R, Maekawa M, Hieda M, Taguchi T, Miura N, Kikugawa T, Saika T, Higashiyama S. SPOP is essential for DNA-protein crosslink repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex. Mol. Biol. Cell. 31 (6): 478-490. (2020).

2019.

1) Kinoshita K, Munesue T, Toki F, Isshiki M, Higashiyama S, Barrandon Y, Nishimura EK, Yanagihara Y, Nanba D. Automated collective motion analysis validates human keratinocyte stem cell cultures. Sci Rep. 9(1):18725. (2019). 

2) Sakaue T, Hamaguchi M, Aono J, Nakashiro K, Shikata F, Kawakami N, Oshima Y, Kurata M, Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H. Valve interstitial cell-specific cyclooxygenase-1 associated with calcification of aortic valves. Ann. Thorac. Surg. S0003-4975 (19): 31717-5. (2019).

4) Yang Y, Park M, Maekawa M and Fairn GD. Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P₂ distribution and the localization of small G-proteins. Sci. Rep. 9: 14789. (2019).

5) Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T. The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. J. Biol. Chem. 294 (38): 14135-14148. (2019).

6) Maekawa M, Hiyoshi H, Nakayama J, Kido K, Sawasaki T, Semba K, KubotaE, Joh T, Higashiyama S. Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells. Biochem. Biophys. Res. Commun. 516, 4: 1116-1122. (2019).

7) Kojima A, Sakaue T, Okazaki M, Shikata F, Kurata M, Imai Y, Nakaoka H, Masumoto J, Uchita S, Izutani H. A simple mouse model of pericardial adhesions. J. Cardiothorac. Surg. 14(1):124. (2019).

8) Tanigawa K, Maekawa M, Kiyoi T, Nakayama J, Kitazawa R, Kitazawa S, Semba K, Taguchi T, Akita S, Yoshida M, Ishimaru K, Watanabe Y, Higashiyama S. SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9. J. Cell. Physiol. 234: 17280-17294. (2019).

9) Usuki S, Tamura N, Tamura T, Higashiyama S, Tanji K, Mitsutake S, Inoue A, Aoki J, Mukai K, Igarashi Y. Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism. Biochem. Biophys. Rep. 17:132-138. (2019).

10) Murakami A, Maekawa M, Kawai K, Nakayama J, Araki N, Semba K, Taguchi T, Kamei Y, Takada Y, Higashiyama S. Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells. Cancer Sci. 110:650-661. (2019).

11) Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Takahashi H, Higashiyama S, Yamamoto H. Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells. J Cell Physiol. 234:6865-6875. (2019). 

2018.

1) Nakayama H, Kusumoto C, Nakahara M, Fujiwara A, Higashiyama S. Semaphorin 3F and Netrin-1: The Novel Function as a Regulator of Tumor Microenvironment. Front. Physiol. 9:1662. (2018). 

2) Sakaue T, Nakaoka H, Shikata F, Aono J, Kurata M, Uetani T, Hamaguchi M, Kojima A, Uchita S, Yasugi T, Higashi H, Suzuki J, Ikeda S, Higaki J, Higashiyama S, Izutani H. Biochemical and histological evidence of deteriorated bioprosthetic valve leaflets: the accumulation of fibrinogen and plasminogen. Biol Open. 7 (8). pii: bio034009. (2018).

3) Ahmat Amin MKB, Shimizu A, Zankov DP, Sato A, Kurita S, Ito M, Maeda T, Yoshida T, Sakaue T, Higashiyama S, Kawauchi A, Ogita H. Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1. Oncogene. 37 (40):5416-5434. (2018).

4) Nakayama H, Sakaue T, Maekawa M, Fujisaki A, Higashiyama S. Cullin 3 regulates ADAMs-mediated ectodomain shedding of amphiregulin. Biochem. Biophys. Res. Commun. 499, 1: 17-23. (2018).

5) Nagasawa T, Nakamichi H, Hama Y, Higashiyama S, Igarashi Y, Mitsutake S. Phytosphingosine is a novel activator of GPR120. J Biochem. 164 (1): 27-32. (2018).

6) Kovacevic I, Sakaue T, Majolee J, Pronk MC, Maekawa M, Geerts D, Fernandez-Borja M, Higashiyama S, Hordijk PL. The Cullin3-Rbx1-KCTD10 complex controls endothelial barrier function via K63-ubiquitination of RhoB. J. Cell Biol. 217, 3: 1015-1032. (2018).

7) Inoue Y, Shimazawa M, Nakamura S, Takata S, Hashimoto Y, Izawa H, Masuda T, Tsuruma K, Sakaue T, Nakayama H, Higashiyama S, Hara H. Both autocrine signaling and paracrine signaling of HB-EGF enhance ocular neovascularization. Arterioscler Thromb Vasc Biol. 38, 1: 174-185. (2018)

2017.

1) Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T and Higashiyama S. Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells. Biol. Open. 6, 11: 1707-1719. (2017)

2) Hirama T, Lu SM, Kay JG, Maekawa M, Kozlov M, Grinstein S and Fairn GD. Membrane curvature induced by proximity of anionic phospholipids is sufficient to initiate endocytosis. Nat. Commun. 8: 1393. (2017)

3) Sakaue T, Maekawa M, Nakayama H and Higashiyama S. Prospect of divergent roles of the CUL3 system in vascular endothelial cell function and angiogenesis. J. Biochem. 162: 237-245. (2017)

4) Joko T, Shiraishi A, Kobayashi T, Ohashi Y, Higashiyama S. Mechanism of Proliferation of Cultured Human Corneal Endothelial Cells. Cornea. 36; S41-S45. (2017)

5) Sakaue T, Suzuki J, Hamaguchi M, Suehiro C, Tanino A, Nagao T, Uetani T, Aono J, Nakaoka H, Kurata M, Sakaue T, Okura T, Yasugi T, Izutani H, Higaki J, Ikeda S.Perivascular Adipose Tissue Angiotensin II Type 1 Receptor Promotes Vascular Inflammation and Aneurysm Formation. Hypertension. 12:e0177343. (2017)

6) Ohno Y, Koizumi M, Nakayama H, Watanabe T, Hirooka M, Tokumoto Y, Kuroda T, Abe M, Fukuda S, Higashiyama S, Kumagi T, Hiasa Y. Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma. PLoS One. 12: e0177343. (2017)

7) Iwakura Y, Wang R, Inamura N, Araki K, Higashiyama S, Takei N, Nawa H. Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons. PLoS One. 12: e0174780. (2017)

8) Maekawa M. D4 domain (D4) of Perfringolysin O to visualize cholesterol in cellular membranes – the update. Sensors (Basel). 17: E504. (2017)

9) Sakaue T, Sakakibara I, Uesugi T, Fujisaki A, Nakashiro KI, Hamakawa H, Kubota E, Joh T, Imai YK, Izutani H, Higashiyama S, The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells. Sci Rep. 7: 42845. (2017).

10) Sakaue T, Shikata F, Utsunomiya K, Fukae S, Kurata M, Nakaoka H, Okazaki M, Kawanishi Y, Kojima A, Higashiyama S, Izutani H, Proteomics-based analysis of lung injury-induced proteins in a mouse model of common bile duct ligation. Surgery. 161(6):1525-1535. (2017).

11) Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S, Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function. Cancer Sci. 108: 208-215. (2017).

2016.

1) Maekawa M, Lee M, Wei K, Ridgway ND and Fairn GD. Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine. Sci. Rep. 6: 35762. (2016)

2) Maekawa M, Yang Y and Fairn GD. Perfringolysin O theta toxin as a tool to monitor the distribution and inhomogeneity of cholesterol in cellular membranes. Toxins (Basel). 8 (3): E67. (2016)

3) Nishida-Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, Fukuda S, Sakaue T, Shirakata Y, Sayama K, Hashimoto K, Detmar M, Higashiyama S, Hirakawa S, Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A). J Biol Chem. 291: 10490-500. (2016).

4) Hiraoka C, Toki F, Shiraishi K, Sayama K, Nishimura EK, Miura H, Higashiyama S, Nanba D, Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability. J Dermatol Sci. 82: 84-94. (2016).

5) Groth E, Pruessmeyer J, Babendreyer A, Schumacher J, Pasqualon T, Dreymueller D, Higashiyama S, Lorenzen I, Grotzinger J, Cataldo D, Ludwig A, Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes. Biochim Biophys Acta. 1863: 2795-808. (2016).

6) Fukuda S, Nishida-Fukuda H, Nanba D, Nakashiro K, Nakayama H, Kubota H, Higashiyama S, Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system. Sci Rep. 6: 20209. (2016).

 

2015以前の業績集は現在作成中。