Other Research Projects

patial Characterization of the Molecular Landscape of TSC-AML

Tuberous sclerosis complex (TSC) is a hereditary disorder caused by alterations in the TSC1/TSC2 genes and is frequently associated with renal angiomyolipoma (AML).

We perform spatial transcriptomic analyses of TSC-associated AML (TSC-AML) to characterize molecular heterogeneity within the tumor and its microenvironment.

By comparing TSC-AML with sporadic AML and renal cell carcinoma, we aim to identify molecular features specific to TSC-AML and translate these findings into novel diagnostic and therapeutic strategies.

How Do Cancer Cells Change Their Phenotype?

A subset of urothelial carcinomas undergoes basal/squamous differentiation during tumor progression.

Using spatial transcriptomic analysis, we investigate the molecular changes associated with the transition from conventional urothelial carcinoma to squamous differentiation and identified Galectin-7 (LGALS7) as a characteristic molecule associated with this phenotype.

We are currently investigating the potential of Galectin-7 as a diagnostic biomarker and therapeutic target.

Extending Technologies Developed in Prostate Cancer Research to Other Diseases

We apply technologies established through our prostate cancer research—including single-cell analysis, spatial transcriptomics, and molecular pathology—to a broad range of diseases, including renal cell carcinoma and urothelial carcinoma.

By exploring molecular mechanisms that transcend individual diseases and organs, we aim to translate these approaches into the discovery of novel diagnostic methods and therapeutic targets.