Publications

Ehime University Graduate School of Medicine,

Immunology / Infections and Host Defenses投稿

English Original Articles

2023

Okamoto M, Omori-Miyake M, Kuwahara K, Okabe M, Eguchi M, Yamashita M : The inhibition of glycolysis in T cells by a Jak inhibitor ameliorates the pathogenesis of allergic contact dermatitis in mice J. Investigative Dermatology (2023) DOI:https://doi.org/10.1016/j.jid.2023.03.1667

2022

Suemori K , Taniguchi Y, Okamoto A , Murakami A , Ochi F , Aono H , Hato N, Osawa H, Miyamoto H, Sugiyama T , Yamashita M , Tauchi H, Takenaka K : Two-Year Seroprevalence Surveys of SARS-CoV-2 Antibodies among Outpatients and Healthcare Workers in Ehime, Japan. Jpn J Infect Dis. 2022 Sep 22;75(5):523-526. doi: 10.7883/yoken.JJID.2022.155.

2021

Choudhury ME, Mikami K, Nakanishi Y, Matsuura T, Utsunomiya R, Yano H, Kubo M, Ando R, Iwanami J, Yamashita M, Nagai M, Tanaka J: Insomnia and depressive behavior of MyD88-deficient mice: Relationships with altered microglial functions. J Neuroimmunol. (2021) doi: 10.1016/j.jneuroim.2021.577794.
Konishi A, Suzuki J, Kuwahara M, Matsumoto A, Nomura S, Soga T, Yorozuya T, Yamashita M : Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response. Biochem. Biophys. Res. Commun. (2021) https://doi.org/10.1016/j.bbrc.2021.12.050
Inoue T, Omori-Miyake M, Maruyama S, Okabe M, Kuwahara M, Honda H, Miura H, Yamashita M : The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatiti. J.Immunol. (2021) doi: 10.4049/jimmunol.2001160.

Tohyama M, Matsumoto A, Tsuda T, Dai X, Shiraishi K, Sayama K:Suppression of IL-17A-induced CCL20 production by cytokine inducible SH2-containing protein 1 in epidermal keratinocytes. J. Dermatological Science (2021) DOI:https://doi.org/10.1016/j.jdermsci.2021.01.005

2020

Yagi Y, Kuwahara M, Suzuki J, Imai Y, Yamashita M : Glycolysis and subsequent mevalonate biosynthesis play an important role in Th2 cell differentiation. Biochem. Biophys. Res. Commun. (2020) https://doi.org/10.1016/j.bbrc.2020.08.009
Toriyama K, Kuwahara M, Kondoh H, Mikawa T, Takemori N, Konishi A,
Yorozuya T, Yamada T, Soga T, Shiraishi A, Yamashita M : T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Communications Biology 3, Article number: 394 (2020) doi.org/10.1038/s42003-020-01122-w

Takemori A, Butcher DS, Harman VM, Brownridge PJ, Shima K, Higo D, Ishizaki J, Hasegawa H, Suzuki J, Yamashita M, Loo JA, Ogorzalek Loo RR, Beynon RJ, Anderson LC, Takemori N: PEPPI-MS: polyacrylamide gel-based prefractionation for analysis of intact proteoforms and protein complexes by mass spectrometry. J Proteome Res. (2020) doi.org/10.1021/acs.jproteome.0c00303
Omori-Miyake M, Watarai H, Sato K, Ziegler SF, Yagi J : An accumulation of two populations of dendritic cells in skin-draining lymph nodes in response to the expression of thymic stromal lymphopoietin in the skin. Cellular Immunology 353 (2020) 104116. doi: 10.1016/j.cellimm.2020.104116.

2019

Nomura S, Takahashi H, Suzuki J, Kuwahara M, Yamashita M, Sawasaki T : Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro. Sci Rep. 2019 Nov 22;9(1):17335. doi: 10.1038/s41598-019-53856-1.
Fu Y, Koh B, Kuwahara M, Ulrich BJ, Kharwadkar R, Yamashita M, Kaplan MH : BATF-Interacting Proteins Dictate Specificity in Th Subset Activity. J Immunol. 2019 Aug 26. pii: ji1900128. doi: 10.4049/jimmunol.1900128.

Onuma H, Kawamura R, Tabara Y, Yamashita M, Ohashi J, Kawasaki E, Imagawa A, Yamada Y, Chujo D, Takahashi K, Suehiro T, Takata Y, Osawa H, Makino H:Variants in the BACH2 and CLEC16A gene may be associated with susceptibility to insulin-triggered type 1 diabetes. J Diabetes Investig. 2019 Apr 10. doi: 10.1111/jdi.13057
Yamada T, Nabe S, Toriyama K, Suzuki J, Inoue K, Imai Y, Shiraishi A, Takenaka K, Yasukawa M, Yamashita M：Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells. J Immunol. 2019 Feb 15;202(4):1088-1098. doi: 10.4049/jimmunol.1801083.

2018

Nabe S, Yamada T, Suzuki J, Toriyama K, Yasuoka T, Kuwahara M, Shiraishi A, Takenaka K, Yasukawa M, Yamashita M: Reinforce the antitumor activity of CD8+ T cells via glutamine restriction. Cancer Sci. 2018 Oct 9. doi: 10.1111/cas.13827, 1-14
Suzuki J, Yamada T, Inoue K, Nabe S, Kuwahara M, Takemori N, Takemori A, Matsuda S, Kanoh M, Imai Y, Yasukawa M, Yamashita M. :The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation.Nat Commun. DOI: 10.1038/s41467-018-05854-6, 2018 Aug 17; 9(1): 3296
Yamashita M, Kuwahara M. : The critical role of Bach2 in regulating type-2 chronic airway inflammation. Int Immunol. Feb 24/ doi: 10.1093/intimm/dxy020., 2018 Aug 30; 30(9) 397-402

2017

Matsui-Hasumi A, Sato Y, Uto-Konomi A, Yamashita S, Uehori J, Yoshimura A, Yamashita M, Asahara H, Suzuki S, Kubo M.：E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation. Int Immunol. Mar 1;29(3):133-143,2017.
Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K,：Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis. J Biol Chem. Nov 3;292(44):18098-18112, 2017
Kitani T, Maruyama S, Aoishi K, Nishida N, Ogawa H, Abe Y, Hayashi Y, Yamashita M, Hato N. : Suppressive Effect of a Thioamide-Related Compound SH-2251 on a Murine Allergic Rhinitis Model. J. Allergy Ther, Vol.8(4) ,2017. DOI: 10.4172/2155-6121.1000267

2016

Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M, Yamashita M.: Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection. J Immunol. Nov 15;197(10):4079-4089, 2016.
Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M. Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop. Nat Commun. Sep;1;7:12596, 2016
Yasuoka T, Kuwahara M, Yamada T, Maruyama S, Suzuki J, Taniguchi M, Yasukawa M and Yamashita M.: The transcriptional repressor Gfi1 plays a critical role in the development of NKT1- and NKT2-type iNKT cells. PLoS ONE. Jun; 10;11(6):e0157395, 2016
Yagi S, Abe M, Yamashita M, Mori K, Yamanishi H, Arimitsu E, Yamamoto Y, Takeshita E, Ikeda Y and Hiasa Y.: Carbonic anhydrate I epitope peptide improves inflammation in a murine model of inflammatory bowel disease. Inflamm Bowel Dis. Aug;22(8):1835-46,2016
Suzuki J, Maruyama S, Tamauchi H, Kuwahara M, Horiuchi M, Mizuki M, Ochi M, Sawasaki T, Zhu J, Yasukawa M, Yamashita M. Gfi1, a transcriptional repressor, inhibits the induction of the T helper type1 programme in activated CD4 T cells. Immunology. Apr;147(4):476-87, 2016.

2015

Nagy-Szakal D, Mir SA, Harris RA, Dowd SE, Yamada T, Lacorazza HD, Tatevian N, Smith CW, de Zoeten EF, Klein J, Kellermayer R.:Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis. FASEB J. Aug;29(8):3151-9, 2015.
Lee PH, Yamada T, Park CS, Shen Y, Puppi M, Lacorazza HD.:G0S2 modulates homeostatic proliferation of naïve CD8⁺ T cells and inhibits oxidative phosphorylation in mitochondria. Immunol Cell Biol. Aug;93(7):605-15, 2015.
Kanoh M, Maruyama S, Shen H, Matsumoto A, Shinomiya H, Przybilla K, Gouin E, Cossart P, Goebel W, Asano Y.: Listeria arpJ gene modifies T helper type 2 subset differentiation. J Infect Dis. Jul 15;212(2):223-33, 2015.
Maruyama S, Kanoh M, Matsumoto A, Kuwahara M, Yamashita M and Asano Y.: A novel function of Interferon regulatory factor-1: Inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection. Int. Immunol. 27(3):143-152,2015.

2014

- Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami SI, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T and Nakajima H.: Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORgt induction as downstream targets of Stat3. J. Exp. Med. pii: jem: 20130791, 2014
- Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I, Minamino T.Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway. PLoS One, June;9(6)：e100359,2014
- Kuwahara M, Suzuki J, Tofukuji S, Yamada T, Kanoh M, Matsumoto A, Maruyama S, Kometani K, Kurosaki T, Ohara O, Nakayama T and Yamashita M.: Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat. Commun. 5: 3555, 2014
- Omori-Miyake M, Yamashita M, Tunemi Y, Kawashima M and Yagi J.: In vitro assessment of IL-4- or IL-13-mediated changes in the structural components of keratinocytes in mice and humans. J. Invest. Dermatol. 134: 1342-1350, 2014
- Yamada T, Park CS, Shen Y, Rabin KR and Lacorazza HD.
  G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol. Leukemia Res. Feb; 38: 210-217, 2014
- Kubota T, Shimojo N, Nonaka K, Yamashita M, Ohara O, Igoshi Y, Ozawa N, Nakano T, Morita Y, Inoue Y, Arima T, Chiba K, Nakamura Y, Ikegami S, Masuda K and Kohno Y.: Prebiotic consumption in pregnant and lactating women increases IL-27 expression in human milk. British J. Nutrition 111: 625-632, 2014

2013

Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N and Minamino T.: Haploinsufficiency of Akt1 prolongs the life span of mice. PLoS ONE 8: e69178, 2013
Kanoh M, Maruyama S, and Asano Y,
Listeria infection inhibits IgE production in regional lymph nodes by suppressing the chemotaxis of basophils to lymph nodes. Microbiology & Immunology, 57(12), 842-848, 2013.
Yamada T, Park CS, Lacorazza H.D. Genetic control of quiescence in hematopoietic stem cells. Cell Cycle, Aug;12(15):2376-2383, 2013.
Matsumoto A, Maruyama S, Takahashi S, Miyoshi Y, Kanoh M, Kuwahara M, Yamada T, Yamashita M and Asano Y.
Autophagic control of Listeria determines the infectionInduced death of macrophages. J. Vaccine Immunotechnology, 1:1-6, 2013.
Suzuki J, Kuwahara M, Tofukuji S, Imamura M, Kato F, Nakayama T, Ohara O and Yamashita M,
A novel small compaund SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus. Plos one, April; 8(4):e61785, 2013.

2012

- Kuwahara M, Yamashita M, Shinoda K, Tofukuji S, Onodera A, Shinnakasu R, Motohashi S, Hosokawa H, Tumes D, Iwamura C, Lefebvre V, and Nakayama T.
  The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nat. Immunol. 13:778-786, 2012
- Watanabe M, Nakajima S, Ohnuki K, Ogawa S, Yamashita M, Nakayama T, Murakami Y, Tanabe K, and Abe R.: AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling. Eur. J. Immunol. 42:1850-1862, 2012
- Tofukuji S, Kuwahara M, Suzuki J, Ohara O, Nakayama T, and Yamashita M.: Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFβ.J. Immunol. 188:4846-4857, 2012
- Park CS, Lee P-H, Yamada T, Burns A, Puppi M, and Lacorazza H.D. Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and
  maintains the number of conventional dendritic cells in the spleen. J. Leukocyte Biology, May; 91(5):739-50, 2012
- Yamada T, Park CS, Burns A, Nakada D, Lacorazza H.D. The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells. Plos One, May;7(5):e38280, 2012

2008～2011

Endo Y, Iwamura C, Kuwahara M, Suzuki A, Sugaya K, Tumes J. D, Tokoyoda K, Hosokawa H, Yamashita M, and Nakayama T.: Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 35:733-745, 2011
Kitajima M, Ito T, Tumes J. D, Endo Y, Onodera A, Hashimoto K, Motohashi S, Yamashita M, Nishimura T, Ziegler F. S, and Nakayama T.: Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. Cancer Res. 71:4790-4798, 2011
Hirasaki Y, Iwamura C, Yamashita M, Ito T, Kitajima M, Shinoda K, Namiki T, Terasawa K, and Nakayama T.: Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses. Clin. Immunol. 139:267-276, 2011
Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, Kanai A, Suzuki Y, and Nakayama T.: STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207:2493-2506, 2010
Okita K, Motohashi S, Shinnakasu R, Nagato K, Yamasaki K, Sato Y, Kitamura H, Hijikata A, Yamashita M, Shimizu K, Fujii S, Ohara O, Taniguchi M, Sakaida I, and Nakayama T.: A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy. Cancer Sci. 101:2333-2340, 2010
Suzuki A, Iwamura C, Shinoda K, Tumes J. D, Kimura Y. M, Hosokawa H, Endo Y, Horiuchi S, Tokoyoda K, Koseki H, Yamashita M, and Nakayama T.: Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. J. Immunol. 184:4510-4520, 2010
Yamada T, Gierach K, Lee PH, Wang X, Lacorazza D. Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. J. Immunol. Oct;185(7):3824-8, 2010
Miki H. T, Hasegawa A, Iwamura C, Shinoda K, Tofukuji S, Watanabe Y, Hosokawa H, Motohashi S, Hashimoto K, Shirai M, Yamashita M, and Nakayama T.: CD69 controls the pathogenesis of allergic airway inflammation. J. Immunol. 183:8203-8215 (2009)
Kohu K, Ohmori H, Wong W. F, Onda D, Wakoh T, Kon S, Yamashita M, Nakayama T, Kubo M, and Satake M.: The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. J. Immunol. 183:7817-7824, 2009
Kitajima M, Iwamura C, Miki H. T, Shinoda K, EndoY, Watanabe Y, Shinnakasu R, Hosokawa H, Hashimoto K, Motohashi S, Koseki H, Ohara O, Yamashita M, and Nakayama T.: Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. J. Immunol. 183:5388-5396, 2009
Yamada T, Park CS, Mamonkin M, Lacorazza D. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Nature Immunol.June;10(6):618-626, 2009
Shinnakasu R, Yamashita M, Kuwahara M, Hosokawa H, Hasegawa A, Motohashi S, and Nakayama T.: Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. J. Biol. Chem. 283:28216-28225, 2008
Hossain M. B, Hosokawa H, Hasegawa A, Watarai H, Taniguchi M, Yamashita M, and Nakayama T.: Lymphoid enhancer factor (LEF1) interacts with GATA3 and controls its function in T helper type 2 cells. Immunology 125:377-386, 2008
Hirahara K, Yamashita M, Iwamura C, Shinoda K, Hasegawa A, Yoshizawa H, Koseki H, Gejyo F, and Nakayama T.: Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. J. Allergy Clin. Immunol. 122:512-520.e11, 2008
Ito T, Hasegawa A, Hosokawa H, Yamashita M, Motohashi S, Naka T, Okamoto Y, Fujita Y, Ishii Y, Taniguchi M, Yano I, and Nakayama T.: Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. Int. Immunol. 20:849-860, 2008
Yamashita M, Kuwahara M, Suzuki A, Hirahara K, Shinnakasu R, Hosokawa H, Hasegawa A, Motohashi S, Iwama A, and Nakayama T.: Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205:1109-1120, 2008
Shinnakasu R, Yamashita M, Kuwahara M, Hosokawa H, Hasegawa A, Motohashi S, Nakayama T. Gfi1-mediated stabilization of GATA3
protein is required for Th2 cell differentiation. J. Biol. Chem. 283, 28216-28335, 2008

～2007

wamura C, Kimura YM, Shinoda K, Endo Y, Hasegawa A, Yamashita M, Nakayama T. Schurri-2 regulates Th2-dependent airway
inflammation and airway hyperresponsiveness. Int. Immunol. 19, 755-762, 2007
Kimura YM, Iwamura C, Suzuki A, Miki T, Hasegawa A, Sugaya K, Yamashita M, Ishii S, Nakayama T.
Schunurri-2 controls memory Th1 and Th2 cell number in vivo. J. Immunol. 178, 4926-4936, 2007
Kaneko T, Hosokawa H, Yamashita M, Wang CR, Hasegawa A, Kimura YM, Kitajima M, Kimura F,Miyazaki M, Nakayama T.
Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. Mol. Immunol. 44, 2249-2256, 2007
Hosokawa H, Kimura YM, Shinnakasu R, Suzuki A, Miki T, Koseki H, van Lohuizen M, Yamashita M, Nakayama T.
Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J. Immunol. 177, 5801-5810, 2006
Shinnakasu R, Yamashita M, Shinoda K, Endo Y, Hosokawa H, Hasegawa A, Ikemizu S, Nakayama T.
Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. J. Immunol. 177, 5801-5810, 2006
Tenda Y, Yamashita M, Kimura YM, Hasegawa A, Shimizu C, Kitajima M, Onodera A, Suzuki A, Seki N, Nakayama T.
Hyperresponsive Th2 cell with enhanced NF-kB activation induce apoptosis dermatitis-like lesions inNC/Nga mice. J. Allergy Clin. Immunol.118, 725-733, 2006
Yamashita M, Hirahara K, Shinnakasu R, Hosokawa H, Norikane S, Kimura YM, Hasegawa A, Nakayama T. Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24, 611-622, 2006
#Nigo IY, #Yamashita M, Hirahara K, Shinnakasu R, Inami M, Kimura M, Hasegawa A, Kohno Y, Nakayama T. (#equally contributed)
Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA
103, 2286-2291, 2006
Hasegawa A, Miki T, Hosokaw H, Hossain HB, Shimizu C, Hashimoto K, Kimura YM, Yamashita M, Nakayama T. Impaired
GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuate allergic airway inflammation in aging mice. J. Immunol.176:2546-2554, 2006
Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, Nimer SD. The transcription factor MEF/ELF4 regulates the quiescence
of primitive hematopoietic cells. Cancer Cell Mar;9(3):175-87, 2006
Yamashita M, Shinnakasu R, Asou H, Kimura M, Hasegawa A, Hashimoto K, Hatano N, Ogata M, Nakayama T.
Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through Ubiquitin-Proteasome pathway.
J. Biol. Chem. 280, 29409-29419, 2005
Miyamoto T, Kaneko T, Yamashita M, Tenda Y, Inami M, Suzuki A, Ishii S, Kimura M, Hashimoto K, Shimada H, Yahata H,
Ochiai T, Saito I, DeGregori J, Nakayama T. Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration.
Int. Immunol. 17, 759-768, 2005
Kimura Y M, Hosokawa H, Yamashita M, Hasegawa A, Iwamura,C, Watarai H, Taniguchi M,Takagi T, Ishii S, Nakayama T.
Regulation of Th2 cell differentiation by murine Schnurri-2. J. Exp. Med. 201, 397-408, 2005
Katsumoto T, Kimura M, Yamashita M, Hosokawa H, Hashimoto K, Hasegawa A, Omori M, Miyamoto T, Taniguchi M, Nakayama T.
STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells. J. Immunol. 173, 4967-4975, 2004
Yamashita M, Shinnakasu R, Nigo Y, Kimura M, Hasegawa A, Taniguchi M, Nakayama T. Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. J. Biol. Chem. 279, 39454-39464, 2004
#Yamashita M, #Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T. (#equally contributed) Essential role of GATA3 for the maintenance of Th2 cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279, 26983-26990, 2004
Inami M, Yamashita M, Tenda Y, Hasegawa A, Kimura M, Hashimoto K, Seki N, Taniguchi M, Nakayama,T. CD28 costimulation controls histone hyperacetylation of the IL-5 gene locus in developing Th2 cells. J. Biol. Chem. 279, 23123-23133, 2004
Yamada T, Watanabe N, Nakamura T, Iwamoto A. Antibody-dependent cellular cytotoxicity via humoral immune epitope of Nef protein expressed on cell surface. J. Immunol. Feb 172: 2401-2406, 2004
#Omori M, #Yamashita M, Inami M, Ukai-Tadenuma M, Kimura M, Nigo Y, Hosokawa H, Hasegawa A, Taniguchi M, Nakayama T.
(#equally contributed) CD8 T cell-specific downregulation of histonehyperacetylation and gene activation of the IL-4 gene locus byROG,
repressor of GATA. Immunity19, 281-294, 2003
Murata K, Inami M, Hasegawa A, Kubo S, Kimura M, Yamashita M, Hosokawa H, Nagao T, SuzukiK, Hashimoto K, Shinkai H, Koseki H, Taniguchi M, Ziegler S F, Nakayama T. CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int. Immun
ol. 15, 987-992, 2003
Shirai T, Magara KK, Motohashi S, Yamashita M, Kimura M, Suwazomo Y, Nogawa K, Kuriyama T,Taniguchi M, Nakayama T.
TH1-biased immunity induced by exposure to Antarctic winter. J. Allergy Clinical Immunol. 111, 1353-1360, 2003
#Kamata T, #Yamashita M, Kimura M, Murata K, Inami M, Shimizu C, Sugaya K, Wang C-R, Taniguchi M, Nakayama T. (#equally contributed) SH2 domain containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J. Clin. Invest.
111, 109-119, 2003
Yamada T, Kaji N, Odawara T, Chiba J, Iwamoto A, Kitamura Y. Proline 78 is crucial for human immunodeficiency virus type 1 Nef to
down-regulate class I human leukocyte antigen.　J. Virol. Jan 77(2)1589-1594, 2003
Asai K, Hachimura S, Kimura M, Toraya T, Yamashita M, Nakayama T, Kaminogawa S. T cell hyporesponsiveness induced by oral
administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip1 degradation. J. Immunol. 169, 4723-4731, 2002
Yamashita M, Ukai-Tadenuma M, Kimura M, Omori M, Inami M, Taniguchi M, Nakayama T. Identification of a conserved GATA3 respons
e element upstream proximal from the IL-13 gene locus. J. Biol. Chem. 277, 42399-42408, 2002
Shibata Y, Kamata T, Kimura M, Yamashita M, Wang CR, Murata K, Miyazaki M, Taniguchi M, Watanabe N, Nakayama T. Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. J. Immunol. 169, 2134-2140,2002
#Kikkawa E, #Yamashita M, Kimura M, Omori M, Sugaya K, Shimizu C, Katsumoto T, Ikekita M, Taniguchi M, Nakayama T. (#equally contributed) Th1/Th2 cell differentiation of developing CD4-single positive thymocytes. Int. Immunol. 14, 943-951, 2002
Nakayama T, Kasprowicz DJ, Yamashita M, Schubert LA, Gillard G, Kimura M, Didierlaurent A, Koseki H, Ziegler S F. The generation
of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol. 168, 87-94, 2002
Nakayama T, Yamashita M, Kawano T, Shimizu C, Shibata Y, Kamata T, Kaneko Y, Kobayashi S,Takeda U, Motohashi S, Cui J,
Taniguchi M. The role α-GalCer-activated Vα14 NKT cells in the regulation of Th2 cell differentiation. Int. Arch. Allergy Immunol.
124, 38-42, 2001
Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, Kitamura T, Taniguchi M, Koseki H, Nakayama T. Regulation
of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity 15, 275-287, 2001
Tobiume M, Takahoko M, Yamada T, Tatsumi M, Iwamoto A, Matsuda M. Inefficient enhancement of viral infectivity and CD4
downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors.
J Virol. 2002 Jun;76(12):5959-65.
Shimizu C, Kawamoto H, Yamashita M, Kimura M, Kondo E, Kaneko Y, Okada K, Tokuhisa T, Yokoyama M, Taniguchi M, Katsura Y,
Nakayama T. Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity. Int. Immunol. 13, 105-117, 2001
Shimoda K, Kato K, Aoki K, Masuda T, Miyamoto A, Shibamori M, Yamashita M, Numata,A, Takase K, Kobayashi S, Shibata S,
Asano Y, Gondo H, Sekiguchi K, Nakayama K, Nakayama T, Okamura T, Okamura S, Niho Y, Nakayama K. Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function. Immunity 13, 561-571, 2000
Yamada T, Iwamoto A. Comparison of proviral accessory genes between long-term nonprogressors and progressors of human immunodeficiency
virus type 1 infection. Arch Virol. 2000;145(5):1021-7.
Kimura M, Yamashita M, Kubo M, Iwashima M, Shimizu C, Tokoyoda K, Chiba J, Taniguchi M, Katsumata M, Nakayama T. Impaired
Ca/calcineurin pathway in in vivo anergized CD4 T cells. Int. Immunol. 12, 817-824, 2000
Yamashita M, Katsumata M, Iwashima M, Kimura M, Shimizu C, Kamata T, Shin T, Seki N, Suzuki S, Taniguchi M, Nakayama T.
TCR-induced calcineurin activation regulates Th2 cell development by modifying the IL-4 receptor signaling complex. J. Exp. Med. 191,
1869-1879, 2000
Ito K, Karasawa M, Kawano T, Akasaka T, Koseki H, Akutsu Y, Kondo E, Sekiya S, Sekikawa K, Harada M, Yamashita M, Nakaya
ma T, Taniguchi M. Involvement of decidual Vα14 NKT cells in abortion. Proc. Natl. Acad. Sci. USA 97, 740-744, 2000
Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, Gejo F, Nakayama T, Taniguchi M. Augmentation of Vα14 NKT cell-mediated cytotoxicity by IL-4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191, 105-114, 2000
Yamada T, Iwamoto A. Expression of a novel Nef epitope on the surface of HIV type 1-infected cells. AIDS Res Retroviruses. 20;15(11):1001-9, 1999.
Cui J, Watanabe N, Kawano T, Yamashita M, Kamata T, Shimizu C, Kimura M, Shimizu E, Koike J, Koseki H, Tanaka Y, Taniguchi M.
Nakayama T. Inhibition of Th2 cell differentiation and IgE response by ligand-activated Vα14 NKT cells. J. Exp. Med. 190, 783-792, 1999
Kubo M, Yamashita M, Abe R, Tada T, Okumura K, Ransom J. T, Nakayama T. CD28 costimulation accelerates IL-4 receptor
sensitivity and IL-4-mediated Th2 differentiation. J. Immunol. 163, 2432-2442, 1999
Sato H, Nakayama T, Tanaka Y, Yamashita M, Shibata Y, Kondo E, Saito Y, Taniguchi M.Induction of differentiation of pre-NKT
cells to mature Vα14 NKT cells by GM-CSF. Proc. Natl. Acad. Sci. USA 96, 7439-7444, 1999
Yamashita M, Kimura M, Kubo M, Shimizu C, Tada T, Permutter RM, Nakayama T. TCR-mediated activation of Ras/MAPK
pathway controls IL-4 receptor function and Th2 cell differentiation. Proc. Natl. Acad. Sci. USA 96, 1024-1029, 1999
Yamashita M, Hashimoto K, Kimura M, Kubo M, Tada T, Nakayama T. Requirement for p56lck tyrosine kinase activation in
The subset differentiation. Int. Immunol. 10, 577-591, 1998
Hasegawa A, Ueno Y, Yamashita M, Nakayama T, Tada T. Regulation of T cell autoreactivity to MHC class II by controlling
CD80 (B7-1) expression on B cells. Int. Immunol. 10, 147-158, 1998
Mizuhara H, Kuno M, Seki N, Yu W-G, Yamaoka M, Yamashita M, OgawaT, Kaneda K,Fujii T, Senoh H, Fujiwara H.
Strain difference in the induction of T-cell activation-associated, interferon gamma-dependent hepatic injury in mice.
Hepatology 27, 513-519, 1998
Morimoto H, Yamashita M, Matsuda A, Ohori M, Miyake H, Fujii T. Characterization of dextran sulfate-induced guinea pig tracheal plasma
extravasation. Jpn. J. Pharmacol. 72, 217-221, 1996
Mizuhara H, Uno M, Seki N, Yamashita M, Yamaoka M, Ogawa T, Kaneda K, Fujii T, Senoh H, Fujiwara H. Critical involvment of
interferon gamma in the pathogenesis T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations
of hepatitis. Hepatology 23, 1608-1615, 1996
Yamashita M, Yamaoka M, Seki N, Fujii, T. Non-T cell-derived IL-4 plays an important role in IgE production induced by antigen
resensitization and is resistant to FK506. J. Immunol. 157, 714-719, 1996
Mizuguchi H, Ito S, Shevchenko VI, Nagasawa Y, Yamashita M, Imamura I, Horio Y, Fujimoto K, Fukui H. Expression and characterizati
on of the bovine histamine H1 receptor in cDNA-transfected C6 astroglioma cells. J. Biochem. (Tokyo) 115, 1155-1161, 1994
Morimoto H, Yamashita M, Imazumi K, Matsuda A, Ochi T, Seki N, Mizuhara H, Fujii T, Senoh H. Effects of adenosine A2 receptor
agonists on the excitation of capsaici-sensitive afferent sensory nerves in airway tissues. Eur. J. Pharmacol. 240, 121-126, 1993
Morimoto H, Yamashita M, Matsuda A, Miyake H, Fujii T. Effects of FR113680 and FK224, novel tachykinin receptor antagonists,
on cigarette smoke-induced rat tracheal plasma extravasation. Eur. J. Pharmacol. 224, 1-5, 1992

English Review

Yamada T, Park CS, Lacorazza H.D. Genetic control of quiescence in hematopoietic stem cells. Cell Cycle, Aug; 12(15):2376, 2013.
Nakayama T, Yamashita M. The TCR-mediated signaling pathways that control the direction of helper T cell differentiation. Semin. Immunol. 22, 303-309, 2010
Nakayama T, Yamashita M. Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory. Semin. Immunol. 21, 78-83, 2009
Yamashita M, Nakayama T. Progress in allergy signal research on mast cells: Regulation of allergic airway inflammation through toll-like receptor 4-mediated
modification of mast cell function. J. Pharmacol. Sci.106, 332-335, 2008
Nakayama T, Yamashita M. Initiation and maintenance of Th2 cell identity. Truncated title: Regulation of Th2 responses. Curr. Opin. Immunol. 20, 265-271 2008
Yamashita M, Onodera A, Nakayama T. Immune mechanisms of allergic airway disease: Regulation by transcription factors. Crit. Rev. Imm. 27, 539-546, 2007

Japanese Review

山田武司　ウイルス性胃腸炎　（Umesh D. Parashar, Roger I. Glass）日本語版ハリソン内科学　第18版 part8 section 15, 190,メディカルサイエンスインターナショナル, 2013
山下政克、中山俊憲　アレルギー疾患発症を制御するTh2細胞分化のエピジェネティクス
細胞工学　28, 560-566, 2009
山下政克　 Th2細胞分化とアレルギー発症のエピジェネティクス
実験医学増刊アレルギー疾患の免疫機構　27, 23-29, 2009
山田武司　ウイルス性胃腸炎　（Umesh D. Parashar, Roger I. Glass）日本語版ハリソン内科学　第17版 part6 section 15, 183,メディカルサイエンスインターナショナル, 2009
新中須亮、山下政克、中山俊憲　メモリーTh2細胞機能のエピジェネティック制御
細胞工学　27, 150-155, 2008
山下政克、中山俊憲　メモリーTh2細胞機能のエピジェネティック制御
分子細胞治療　7, 141-148, 2008
山下政克　メモリーCD4 T細胞機能のエピジェネティック制御
Annual Review免疫2008, 84-93, 2007
山下政克　クロマチン免疫沈降−DNAチップ（ChIP-on-chip）法を用いたTh2細胞分化機構の解析
BIO バイオテクノロジージャーナル　7, 292-294, 2007
山下政克、中山俊憲　 TLR4を介した肥満細胞活性化とアレルギー性気道炎症
メディカル・サイエンス・ダイジェスト　426, 936-939, 2007
山下政克 Th2細胞分化とアレルギー性疾患
遺伝子医学Mookシグナル伝達病を知る　6, 206-211, 2006
山下政克　 Th2細胞分化のエピジェネティック制御
実験医学増刊　免疫研究最前線2007　24, 15-121, 2006
山下政克、中山俊憲　メモリーTh2細胞のTh2サイトカイン産生維持メカニズム−Th2サイトカイン遺伝子座における転写記憶
医学のあゆみ　216, 343-340, 2006
山下政克　クロマチン免疫沈降法（ChIPアッセイ）
Surgery Frontier 13, 96-101, 2006
山下政克、中山俊憲　 BCGによるI型アレルギー疾患治療の可能性
山下政克、中山俊憲　 SHP-1によるTh2細胞分化とアレルギー性気道炎症の制御
臨床免疫44, 32-37, 2005
山下政克、中山俊憲メモリーTh2細胞におけるTh2サイトカイン産生維持のメカニズム
Annual Review免疫2006, 157-165, 2005
山下政克、中山俊憲　 Th2細胞の分化誘導・維持とTh2サイトカイン遺伝子座クロマチンリモデリング
臨床免疫44, 585-590, 2005
山下政克、中山俊憲　 Th2細胞分化とシグナル伝達
アレルギーの臨床　25, 69-73, 2005
山下政克、中山俊憲　 Th2/Tc2細胞分化に伴うTh2サイトカイン遺伝子（IL-4, IL-5, IL-13）座のクロマチンリモデリング
実験医学増刊　22, 64-71, 2004
山田武司　ウイルス性胃腸炎　（Umesh D. Parashar, Roger I. Glass）日本語版ハリソン内科学　第16版 part6 section 15, 174,メディカルサイエンスインターナショナル, 2004
山下政克、中山俊憲　クロマチン修飾を介した免疫反応の制御：Th2細胞分化をモデルに
細胞工学　23, 1166-1170, 2004
山下政克、中山俊憲　 Th2細胞分化に伴うTh2サイトカイン遺伝子座のクロマチンリモデリング
Molecular Medicine臨時増刊号　免疫2005, 41:11-19, 2004
山下政克　 Th2サイトカイン遺伝子座のクロマチンリモデリングとTh2、Tc2細胞分化制御
医学のあゆみ　207, 225-230, 2003
山田武司　ウイルス性胃腸炎　（Harry B.Greenberg）日本語版ハリソン内科学　第15版 part7, 192,メディカルサイエンスインターナショナル, 2003
山田武司　ハイブリダイゼーションプローブを用いたreal-time PCR法によるRNA定量　実験医学別冊　羊土社　第4章　p163-179, 2003
山下政克、中山俊憲　 Th2細胞分化とクロマチンリモデリング
Annual Review 2003免疫, 17-23, 2002
山田武司　 HIVのNef蛋白による免疫制御　臨床免疫　科学評論社　37巻　3号, 2002
山下政克、中山俊憲
Th1/Th2細胞分化におけるT細胞抗原レセプターシグナルの役割−Ca2+/カルシニューリン経路を中心に
実験医学　19, 42-47, 2001
山下政克、中山俊憲　 Th1/Th2細胞分化におけるT細胞抗原受容体シグナルの役割
臨床免疫　36, 507-514, 2001
清水千織、山下政克、中山俊憲　 Th1/Th2細胞分化を制御するRas/MAPKカスケード、Ca²⁺/カルシニューリン経路
臨床免疫　35, 191-200, 2001
清水千織、山下政克、中山俊憲　 T細胞抗原受容体からのシグナル伝達によって調節されるTh1/Th2細胞分化
アレルギー科　12, 167-176, 2001
木村元子、山下政克、中山俊憲　 Th1/Th2細胞の分化制御—サイトカイン、転写因子研究からクロマチンリモデリング研究へ-
アレルギー科　10, 128-134, 2000
山下政克、中山俊憲　活性化Va14NKT細胞によるアレルギー反応制御機構
アレルギー科　10, 215-220, 2000
山下政克、中山俊憲　 T細胞抗原受容体シグナルとTh2細胞分化
臨床免疫　33, 669-667, 2000
山下政克、中山俊憲　 Th1、Th2細胞分化を制御するT細胞抗原受容体からのシグナル伝達
アレルギー／免疫　7, 729-739, 2000
山下政克、中山俊憲　 Ras/MAPキナーゼカスケードによるTh1/Th2細胞の分化制御
最新医学９月増刊号 136-146, 1999
山田武司　成人Ｔ細胞白血病ウイルス(HTLV-1) 臨床と微生物　近代出版　Vol.26　増刊号　P086-091, 1999
山下政克、中山俊憲　 T細胞の胸腺内分化にかかわるシグナル伝達機構
臨床免疫31, 180-189, 1999
山下政克、中山俊憲　 Th1/Th2細胞の分化制御とRas/MAPKカスケードの活性化
臨床免疫32, 532-539, 1999

Awards

2006年12月1日　　第一回日本免疫学会研究奨励賞受賞　(山下　政克)
2007年5月20日　　平成19年度とやま賞受賞　(山下　政克)
2009年6月17日　　第一回千葉医学会賞受賞　(山下　政克)