Ehime University Graduate School of Medicine,

Immunology / Infections and Host Defenses


English Original Articles






  • Matsui-Hasumi A, Sato Y, Uto-Konomi A, Yamashita S, Uehori J, Yoshimura A, Yamashita M, Asahara H, Suzuki S, Kubo M.:E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation. Int Immunol. Mar 1;29(3):133-143,2017.
  • Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K,:Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis. J Biol Chem. Nov 3;292(44):18098-18112, 2017
  • Kitani T, Maruyama S, Aoishi K, Nishida N, Ogawa H, Abe Y, Hayashi Y, Yamashita M, Hato N. : Suppressive Effect of a Thioamide-Related Compound SH-2251 on a Murine Allergic Rhinitis Model. J. Allergy Ther, Vol.8(4) ,2017. DOI: 10.4172/2155-6121.1000267


  • Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M, Yamashita M.: Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection. J Immunol. Nov 15;197(10):4079-4089, 2016.
  • Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M. Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop. Nat Commun. Sep;1;7:12596, 2016
  • Yasuoka T, Kuwahara M, Yamada T, Maruyama S, Suzuki J, Taniguchi M, Yasukawa M and Yamashita M.: The transcriptional repressor Gfi1 plays a critical role in the development of NKT1- and NKT2-type iNKT cells. PLoS ONE. Jun; 10;11(6):e0157395, 2016
  • Yagi S, Abe M, Yamashita M, Mori K, Yamanishi H, Arimitsu E, Yamamoto Y, Takeshita E, Ikeda Y and Hiasa Y.: Carbonic anhydrate I epitope peptide improves inflammation in a murine model of inflammatory bowel disease. Inflamm Bowel Dis. Aug;22(8):1835-46,2016
  • Suzuki J, Maruyama S, Tamauchi H, Kuwahara M, Horiuchi M, Mizuki M, Ochi M, Sawasaki T, Zhu J, Yasukawa M, Yamashita M. Gfi1, a transcriptional repressor, inhibits the induction of the T helper type1 programme in activated CD4 T cells. Immunology. Apr;147(4):476-87, 2016.


  • Nagy-Szakal D, Mir SA, Harris RA, Dowd SE, Yamada T, Lacorazza HD, Tatevian N, Smith CW, de Zoeten EF, Klein J, Kellermayer R.:Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis. FASEB J. Aug;29(8):3151-9, 2015.
  • Lee PH, Yamada T, Park CS, Shen Y, Puppi M, Lacorazza HD.:G0S2 modulates homeostatic proliferation of naïve CD8⁺ T cells and inhibits oxidative phosphorylation in mitochondria. Immunol Cell Biol. Aug;93(7):605-15, 2015.
  • Kanoh M, Maruyama S, Shen H, Matsumoto A, Shinomiya H, Przybilla K, Gouin E, Cossart P, Goebel W, Asano Y.: Listeria arpJ gene modifies T helper type 2 subset differentiation. J Infect Dis. Jul 15;212(2):223-33, 2015.
  • Maruyama SKanoh MMatsumoto AKuwahara MYamashita M and Asano Y.: A novel function of Interferon regulatory factor-1: Inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection. Int. Immunol. 27(3):143-152,2015.


    • Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami SI, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T and Nakajima H.: Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORgt induction as downstream targets of Stat3. J. Exp. Med. pii: jem: 20130791, 2014
    • Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I, Minamino T.Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway. PLoS One, June;9(6):e100359,2014
    • Kuwahara M, Suzuki J, Tofukuji S, Yamada T, Kanoh M, Matsumoto A, Maruyama S, Kometani K, Kurosaki T, Ohara O, Nakayama T and Yamashita M.: Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat. Commun. 5: 3555, 2014
    • Omori-Miyake M, Yamashita M, Tunemi Y, Kawashima M and Yagi J.: In vitro assessment of IL-4- or IL-13-mediated changes in the structural components of keratinocytes in mice and humans. J. Invest. Dermatol. 134: 1342-1350, 2014
    • Yamada T, Park CS, Shen Y, Rabin KR and Lacorazza HD.
      G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol. Leukemia Res. Feb; 38: 210-217, 2014
    • Kubota T, Shimojo N, Nonaka K, Yamashita M, Ohara O, Igoshi Y, Ozawa N, Nakano T, Morita Y, Inoue Y, Arima T, Chiba K, Nakamura Y, Ikegami S, Masuda K and Kohno Y.: Prebiotic consumption in pregnant and lactating women increases IL-27 expression in human milk. British J. Nutrition 111: 625-632, 2014


  • Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N and Minamino T.: Haploinsufficiency of Akt1 prolongs the life span of mice. PLoS ONE 8: e69178, 2013
  • Kanoh MMaruyama S, and Asano Y,
    Listeria infection inhibits IgE production in regional lymph nodes by suppressing the chemotaxis of basophils to lymph nodes. Microbiology & Immunology, 57(12), 842-848, 2013.
  • Yamada T, Park CS, Lacorazza H.D.  Genetic control of quiescence in hematopoietic stem cells. Cell Cycle, Aug;12(15):2376-2383, 2013.
  • Matsumoto AMaruyama S, Takahashi S, Miyoshi Y, Kanoh MKuwahara MYamada TYamashita M and Asano Y.
    Autophagic control of Listeria determines the infectionInduced death of macrophages. J. Vaccine Immunotechnology, 1:1-6, 2013.
  • Suzuki JKuwahara M, Tofukuji S, Imamura M, Kato F, Nakayama T, Ohara O and Yamashita M,
    A novel small compaund SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus. Plos one, April; 8(4):e61785, 2013.


    • Kuwahara MYamashita M, Shinoda K, Tofukuji S, Onodera A, Shinnakasu R, Motohashi S, Hosokawa H, Tumes D, Iwamura C, Lefebvre V, and Nakayama T.
      The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nat. Immunol. 13:778-786, 2012
    • Watanabe M, Nakajima S, Ohnuki K, Ogawa S, Yamashita M, Nakayama T, Murakami Y, Tanabe K, and Abe R.: AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling. Eur. J. Immunol. 42:1850-1862, 2012
    • Tofukuji S, Kuwahara M, Suzuki J, Ohara O, Nakayama T, and Yamashita M.: Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFβ.J. Immunol. 188:4846-4857, 2012
    • Park CS, Lee P-H, Yamada T, Burns A, Puppi M, and Lacorazza H.D. Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and
      maintains the number of conventional dendritic cells in the spleen. J. Leukocyte Biology, May; 91(5):739-50, 2012
    • Yamada T, Park CS, Burns A, Nakada D, Lacorazza H.D. The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells. Plos One, May;7(5):e38280, 2012


  • Endo Y, Iwamura C, Kuwahara M, Suzuki A, Sugaya K, Tumes J. D, Tokoyoda K, Hosokawa H, Yamashita M, and Nakayama T.: Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 35:733-745, 2011
  • Kitajima M, Ito T, Tumes J. D, Endo Y, Onodera A, Hashimoto K, Motohashi S, Yamashita M, Nishimura T, Ziegler F. S, and Nakayama T.: Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. Cancer Res. 71:4790-4798, 2011
  • Hirasaki Y, Iwamura C, Yamashita M, Ito T, Kitajima M, Shinoda K, Namiki T, Terasawa K, and Nakayama T.: Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses. Clin. Immunol. 139:267-276, 2011
  • Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, Kanai A, Suzuki Y, and Nakayama T.: STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207:2493-2506, 2010
  • Okita K, Motohashi S, Shinnakasu R, Nagato K, Yamasaki K, Sato Y, Kitamura H, Hijikata A, Yamashita M, Shimizu K, Fujii S, Ohara O, Taniguchi M, Sakaida I, and Nakayama T.: A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy. Cancer Sci. 101:2333-2340, 2010
  • Suzuki A, Iwamura C, Shinoda K, Tumes J. D, Kimura Y. M, Hosokawa H, Endo Y, Horiuchi S, Tokoyoda K, Koseki H, Yamashita M, and Nakayama T.: Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. J. Immunol. 184:4510-4520, 2010
  • Yamada T, Gierach K, Lee PH, Wang X, Lacorazza D. Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. J. Immunol. Oct;185(7):3824-8, 2010
  • Miki H. T, Hasegawa A, Iwamura C, Shinoda K, Tofukuji S, Watanabe Y, Hosokawa H, Motohashi S, Hashimoto K, Shirai M, Yamashita M, and Nakayama T.: CD69 controls the pathogenesis of allergic airway inflammation. J. Immunol. 183:8203-8215 (2009)
  • Kohu K, Ohmori H, Wong W. F, Onda D, Wakoh T, Kon S, Yamashita M, Nakayama T, Kubo M, and Satake M.: The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. J. Immunol. 183:7817-7824, 2009
  • Kitajima M, Iwamura C, Miki H. T, Shinoda K, EndoY, Watanabe Y, Shinnakasu R, Hosokawa H, Hashimoto K, Motohashi S, Koseki H, Ohara O, Yamashita M, and Nakayama T.: Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. J. Immunol. 183:5388-5396, 2009
  • Yamada T, Park CS, Mamonkin M, Lacorazza D. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Nature Immunol.June;10(6):618-626, 2009
  • Shinnakasu R, Yamashita M, Kuwahara M, Hosokawa H, Hasegawa A, Motohashi S, and Nakayama T.: Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. J. Biol. Chem. 283:28216-28225, 2008
  • Hossain M. B, Hosokawa H, Hasegawa A, Watarai H, Taniguchi M, Yamashita M, and Nakayama T.: Lymphoid enhancer factor (LEF1) interacts with GATA3 and controls its function in T helper type 2 cells. Immunology 125:377-386, 2008
  • Hirahara K, Yamashita M, Iwamura C, Shinoda K, Hasegawa A, Yoshizawa H, Koseki H, Gejyo F, and Nakayama T.: Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. J. Allergy Clin. Immunol. 122:512-520.e11, 2008
  • Ito T, Hasegawa A, Hosokawa H, Yamashita M, Motohashi S, Naka T, Okamoto Y, Fujita Y, Ishii Y, Taniguchi M, Yano I, and Nakayama T.: Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. Int. Immunol. 20:849-860, 2008
  •  Yamashita M, Kuwahara M, Suzuki A, Hirahara K, Shinnakasu R, Hosokawa H, Hasegawa A, Motohashi S, Iwama A, and Nakayama T.: Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205:1109-1120, 2008
  • Shinnakasu R, Yamashita M, Kuwahara M, Hosokawa H, Hasegawa A, Motohashi S, Nakayama T. Gfi1-mediated stabilization of GATA3
    protein is required for Th2 cell differentiation.  J. Biol. Chem. 283, 28216-28335, 2008


  • wamura C, Kimura YM, Shinoda K, Endo Y, Hasegawa A, Yamashita M, Nakayama T. Schurri-2 regulates Th2-dependent airway
    inflammation and airway hyperresponsiveness. Int. Immunol. 19, 755-762, 2007
  • Kimura YM, Iwamura C, Suzuki A, Miki T, Hasegawa A, Sugaya K, Yamashita M, Ishii S,  Nakayama T.
    Schunurri-2 controls memory Th1 and Th2 cell number in vivo.  J. Immunol. 178, 4926-4936, 2007
  • Kaneko T, Hosokawa H, Yamashita M, Wang CR, Hasegawa A, Kimura YM, Kitajima M, Kimura F,Miyazaki M, Nakayama T.
    Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells.  Mol. Immunol. 44, 2249-2256, 2007
  • Hosokawa H, Kimura YM, Shinnakasu R, Suzuki A, Miki T, Koseki H, van Lohuizen M, Yamashita M, Nakayama T.
    Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J. Immunol. 177, 5801-5810, 2006
  • Shinnakasu R, Yamashita M, Shinoda K, Endo Y, Hosokawa H, Hasegawa A, Ikemizu S, Nakayama T.
    Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. J. Immunol. 177, 5801-5810, 2006
  • Tenda Y, Yamashita M, Kimura YM, Hasegawa A, Shimizu C, Kitajima M, Onodera A, Suzuki A, Seki N, Nakayama T.
    Hyperresponsive Th2 cell with enhanced NF-kB activation induce apoptosis dermatitis-like lesions inNC/Nga mice.  J. Allergy Clin. Immunol.118, 725-733, 2006
  • Yamashita M, Hirahara K, Shinnakasu R, Hosokawa H, Norikane S, Kimura YM, Hasegawa A, Nakayama T.  Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24, 611-622, 2006
  • #Nigo IY, #Yamashita M, Hirahara K, Shinnakasu R, Inami M, Kimura M, Hasegawa A, Kohno Y, Nakayama T. (#equally contributed)
  • Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA
    103, 2286-2291, 2006
  • Hasegawa A, Miki T, Hosokaw H, Hossain HB, Shimizu C, Hashimoto K, Kimura YM, Yamashita M, Nakayama T.  Impaired
    GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuate allergic airway inflammation in aging mice.  J. Immunol.176:2546-2554, 2006
  • Lacorazza HD, Yamada T, Liu Y, Miyata Y, Sivina M, Nunes J, Nimer SD. The transcription factor MEF/ELF4 regulates the quiescence
    of primitive hematopoietic cells. Cancer Cell Mar;9(3):175-87, 2006
  • Yamashita M, Shinnakasu R, Asou H, Kimura M, Hasegawa A, Hashimoto K, Hatano N, Ogata M, Nakayama T.
    Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through Ubiquitin-Proteasome pathway.  
    J. Biol. Chem.
     280, 29409-29419, 2005
  • Miyamoto T, Kaneko T, Yamashita M, Tenda Y, Inami M, Suzuki A, Ishii S, Kimura M, Hashimoto K, Shimada H, Yahata H,
    Ochiai T, Saito I, DeGregori J, Nakayama T.  Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration.
    Int. Immunol. 17, 759-768, 2005
  • Kimura Y M, Hosokawa H, Yamashita M, Hasegawa A, Iwamura,C, Watarai H, Taniguchi M,Takagi T, Ishii S, Nakayama T.
    Regulation of Th2 cell differentiation by murine Schnurri-2.   J. Exp. Med. 201, 397-408, 2005
  • Katsumoto T, Kimura M, Yamashita M, Hosokawa H, Hashimoto K, Hasegawa A, Omori M, Miyamoto T, Taniguchi M, Nakayama T.
    STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells.  J. Immunol. 173, 4967-4975, 2004
  • Yamashita M, Shinnakasu R, Nigo Y, Kimura M, Hasegawa A, Taniguchi M, Nakayama T. Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. J. Biol. Chem. 279, 39454-39464, 2004
  • #Yamashita M, #Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T. (#equally contributed)  Essential role of GATA3 for the maintenance of Th2 cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279, 26983-26990, 2004
  • Inami M, Yamashita M, Tenda Y, Hasegawa A, Kimura M, Hashimoto K, Seki N, Taniguchi M, Nakayama,T.  CD28 costimulation controls histone hyperacetylation of the IL-5 gene locus in developing Th2 cells.  J. Biol. Chem. 279, 23123-23133, 2004
  • Yamada T, Watanabe N, Nakamura T, Iwamoto A. Antibody-dependent cellular cytotoxicity via humoral immune epitope of Nef protein expressed on cell surface. J. Immunol. Feb 172: 2401-2406, 2004
  • #Omori M, #Yamashita M, Inami M, Ukai-Tadenuma M, Kimura M, Nigo Y, Hosokawa H, Hasegawa A, Taniguchi M, Nakayama T.
    (#equally contributed)  CD8 T cell-specific downregulation of histonehyperacetylation and gene activation of the IL-4 gene locus byROG,
    repressor of GATA.  Immunity19, 281-294, 2003
  • Murata K, Inami M, Hasegawa A, Kubo S, Kimura M, Yamashita M, Hosokawa H, Nagao T, SuzukiK, Hashimoto K, Shinkai H, Koseki H, Taniguchi M, Ziegler S F, Nakayama T. CD69-null mice protected from arthritis induced with anti-type II collagen antibodies.  Int. Immun
    15, 987-992, 2003
  • Shirai T, Magara KK, Motohashi S, Yamashita M, Kimura M, Suwazomo Y, Nogawa K, Kuriyama T,Taniguchi M, Nakayama T.
    TH1-biased immunity induced by exposure to Antarctic winter.  J. Allergy Clinical Immunol. 111, 1353-1360, 2003
  • #Kamata T, #Yamashita M, Kimura M, Murata K, Inami M, Shimizu C, Sugaya K, Wang C-R, Taniguchi M, Nakayama T. (#equally contributed)  SH2 domain containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.  J. Clin. Invest.
    111, 109-119, 2003
  • Yamada T, Kaji N, Odawara T, Chiba J, Iwamoto A, Kitamura Y. Proline 78 is crucial for human immunodeficiency virus type 1 Nef to
    down-regulate class I human leukocyte antigen. J. Virol. Jan 77(2)1589-1594, 2003
  • Asai K, Hachimura S, Kimura M, Toraya T, Yamashita M, Nakayama T, Kaminogawa S.  T cell hyporesponsiveness induced by oral
    administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip1 degradation.  J. Immunol. 169, 4723-4731, 2002
  • Yamashita M, Ukai-Tadenuma M, Kimura M, Omori M, Inami M, Taniguchi M, Nakayama T. Identification of a conserved GATA3 respons
    e element upstream proximal from the IL-13 gene locus. J. Biol. Chem. 277, 42399-42408, 2002
  • Shibata Y, Kamata T, Kimura M, Yamashita M, Wang CR, Murata K, Miyazaki M, Taniguchi M, Watanabe N, Nakayama T.  Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation.  J. Immunol. 169, 2134-2140,2002
  • #Kikkawa E, #Yamashita M, Kimura M, Omori M, Sugaya K, Shimizu C, Katsumoto T, Ikekita M, Taniguchi M, Nakayama T. (#equally contributed)  Th1/Th2 cell differentiation of developing CD4-single positive thymocytes.  Int. Immunol. 14, 943-951, 2002
  • Nakayama T, Kasprowicz DJ, Yamashita M, Schubert LA, Gillard G, Kimura M, Didierlaurent A, Koseki H, Ziegler S F.  The generation
    of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression.  J. Immunol. 168, 87-94, 2002
  • Nakayama T, Yamashita M, Kawano T, Shimizu C, Shibata Y, Kamata T, Kaneko Y, Kobayashi S,Takeda U, Motohashi S, Cui J,
    Taniguchi M.  The role α-GalCer-activated Vα14 NKT cells in the regulation of Th2 cell differentiation.  Int. Arch. Allergy Immunol.
    124, 38-42, 2001
  • Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, Kitamura T, Taniguchi M, Koseki H, Nakayama T.  Regulation
    of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity 15, 275-287, 2001
  • Tobiume M, Takahoko M, Yamada T, Tatsumi M, Iwamoto A, Matsuda M. Inefficient enhancement of viral infectivity and CD4
    downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors.
    J Virol. 2002 Jun;76(12):5959-65.
  • Shimizu C, Kawamoto H, Yamashita M, Kimura M, Kondo E, Kaneko Y, Okada K, Tokuhisa T, Yokoyama M, Taniguchi M, Katsura Y,
    Nakayama T. Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity. Int. Immunol. 13, 105-117, 2001
  • Shimoda K, Kato K, Aoki K, Masuda T, Miyamoto A, Shibamori M, Yamashita M, Numata,A, Takase K, Kobayashi S, Shibata S,
    Asano Y, Gondo H, Sekiguchi K, Nakayama K, Nakayama T, Okamura T, Okamura S, Niho Y, Nakayama K. Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function.  Immunity 13, 561-571, 2000
  • Yamada T, Iwamoto A. Comparison of proviral accessory genes between long-term nonprogressors and progressors of human immunodeficiency
    virus type 1 infection. Arch Virol. 2000;145(5):1021-7.
  • Kimura M, Yamashita M, Kubo M, Iwashima M, Shimizu C, Tokoyoda K, Chiba J, Taniguchi M, Katsumata M, Nakayama T. Impaired
    Ca/calcineurin pathway in in vivo anergized CD4 T cells. Int. Immunol. 12, 817-824, 2000
  • Yamashita M, Katsumata M, Iwashima M, Kimura M, Shimizu C, Kamata T, Shin T, Seki N, Suzuki S, Taniguchi M, Nakayama T.
    TCR-induced calcineurin activation regulates Th2 cell development by modifying the IL-4 receptor signaling complex. J. Exp. Med. 191,
    1869-1879, 2000
  • Ito K, Karasawa M, Kawano T, Akasaka T, Koseki H, Akutsu Y, Kondo E, Sekiya S, Sekikawa K,  Harada M, Yamashita M, Nakaya
    ma T, Taniguchi M.  Involvement of decidual Vα14 NKT cells in abortion. Proc. Natl. Acad. Sci. USA 97, 740-744, 2000
  • Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, Gejo F, Nakayama T, Taniguchi M. Augmentation of Vα14 NKT cell-mediated cytotoxicity by IL-4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191, 105-114, 2000
  • Yamada TIwamoto A. Expression of a novel Nef epitope on the surface of HIV type 1-infected cells. AIDS Res Retroviruses. 20;15(11):1001-9, 1999.
  • Cui J, Watanabe N, Kawano T, Yamashita M, Kamata T, Shimizu C, Kimura M, Shimizu E, Koike J, Koseki H, Tanaka Y, Taniguchi M.
    Nakayama T. Inhibition of Th2 cell differentiation and IgE response by ligand-activated Vα14 NKT cells. J. Exp. Med. 190, 783-792, 1999
  • Kubo M, Yamashita M, Abe R, Tada T, Okumura K, Ransom J. T, Nakayama T. CD28 costimulation accelerates IL-4 receptor
    sensitivity and IL-4-mediated Th2 differentiation. J. Immunol. 163, 2432-2442, 1999
  • Sato H, Nakayama T, Tanaka Y, Yamashita M, Shibata Y, Kondo E, Saito Y, Taniguchi M.Induction of differentiation of pre-NKT
    cells to mature Vα14 NKT cells by GM-CSF. Proc. Natl. Acad. Sci. USA 96, 7439-7444, 1999
  • Yamashita M, Kimura M, Kubo M, Shimizu C, Tada T, Permutter RM, Nakayama T. TCR-mediated activation of Ras/MAPK
    pathway controls IL-4 receptor function and Th2 cell differentiation.  Proc. Natl. Acad. Sci. USA 96, 1024-1029, 1999
  • Yamashita M, Hashimoto K, Kimura M, Kubo M, Tada T, Nakayama T. Requirement for p56lck tyrosine kinase activation in
    The subset differentiation.  Int. Immunol. 10, 577-591, 1998
  • Hasegawa A, Ueno Y, Yamashita M, Nakayama T, Tada T.  Regulation of T cell autoreactivity to MHC class II by controlling
    CD80 (B7-1) expression on B cells.  Int. Immunol. 10, 147-158, 1998
  • Mizuhara H, Kuno M, Seki N, Yu W-G, Yamaoka M, Yamashita M, OgawaT, Kaneda K,Fujii T,  Senoh H, Fujiwara H.
    Strain difference in the induction of T-cell activation-associated, interferon gamma-dependent hepatic injury in mice.
    Hepatology 27, 513-519, 1998
  • Morimoto H, Yamashita M, Matsuda A, Ohori M, Miyake H, Fujii T. Characterization of dextran sulfate-induced guinea pig tracheal plasma
    extravasation.  Jpn. J. Pharmacol. 72, 217-221, 1996
  • Mizuhara H, Uno M, Seki N, Yamashita M, Yamaoka M, Ogawa T, Kaneda K, Fujii T, Senoh H, Fujiwara H. Critical involvment of
    interferon gamma in the pathogenesis T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations
    of hepatitis. Hepatology 23, 1608-1615, 1996
  • Yamashita M, Yamaoka M, Seki N, Fujii, T. Non-T cell-derived IL-4 plays an important role in IgE production induced by antigen
    resensitization and is resistant to FK506. J. Immunol. 157, 714-719, 1996
  • Mizuguchi H, Ito S, Shevchenko VI, Nagasawa Y, Yamashita M, Imamura I, Horio Y, Fujimoto K, Fukui H. Expression and characterizati
    on of the bovine histamine H1 receptor in cDNA-transfected C6 astroglioma cells.  J. Biochem. (Tokyo) 115, 1155-1161, 1994
  • Morimoto H, Yamashita M, Imazumi K, Matsuda A, Ochi T, Seki N, Mizuhara H, Fujii T, Senoh H. Effects of adenosine A2 receptor
    agonists on the excitation of capsaici-sensitive afferent sensory nerves in airway tissues. Eur. J. Pharmacol. 240, 121-126, 1993
  • Morimoto H, Yamashita M, Matsuda A, Miyake H, Fujii T.  Effects of FR113680 and FK224, novel tachykinin receptor antagonists,
    on cigarette smoke-induced rat tracheal plasma extravasation.  Eur. J. Pharmacol. 224, 1-5, 1992

English Review

  • Yamada T, Park CS, Lacorazza H.D. Genetic control of quiescence in hematopoietic stem cells. Cell Cycle, Aug; 12(15):2376, 2013.
  • Nakayama T, Yamashita M. The TCR-mediated signaling pathways that control the direction of helper T cell differentiation. Semin. Immunol. 22, 303-309, 2010
  • Nakayama T, Yamashita M. Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory. Semin. Immunol. 21, 78-83, 2009
  • Yamashita M, Nakayama T. Progress in allergy signal research on mast cells: Regulation of allergic airway inflammation through toll-like receptor 4-mediated
    modification of mast cell function.  J. Pharmacol. Sci.106, 332-335, 2008
  • Nakayama T, Yamashita M. Initiation and maintenance of Th2 cell identity. Truncated title: Regulation of Th2 responses. Curr. Opin. Immunol. 20, 265-271 2008
  • Yamashita M, Onodera A, Nakayama T. Immune mechanisms of allergic airway disease: Regulation by transcription factors. Crit. Rev. Imm. 27, 539-546, 2007

Japanese Review

  • 山田武司  ウイルス性胃腸炎 (Umesh D. Parashar, Roger I. Glass)日本語版ハリソン内科学 第18版 part8 section 15, 190,メディカルサイエンスインターナショナル, 2013
  • 山下政克、中山俊憲  アレルギー疾患発症を制御するTh2細胞分化のエピジェネティクス
    細胞工学 28, 560-566, 2009
  • 山下政克  Th2細胞分化とアレルギー発症のエピジェネティクス
    実験医学増刊アレルギー疾患の免疫機構 27, 23-29, 2009
  • 山田武司  ウイルス性胃腸炎 (Umesh D. Parashar, Roger I. Glass)日本語版ハリソン内科学 第17版 part6 section 15, 183,メディカルサイエンスインターナショナル, 2009
  • 新中須亮、山下政克、中山俊憲  メモリーTh2細胞機能のエピジェネティック制御
    細胞工学 27, 150-155, 2008
  • 山下政克、中山俊憲  メモリーTh2細胞機能のエピジェネティック制御
    分子細胞治療 7, 141-148, 2008
  • 山下政克  メモリーCD4 T細胞機能のエピジェネティック制御
    Annual Review免疫2008, 84-93, 2007
  • 山下政克  クロマチン免疫沈降−DNAチップ(ChIP-on-chip)法を用いたTh2細胞分化機構の解析
    BIO バイオテクノロジージャーナル 7, 292-294, 2007
  • 山下政克、中山俊憲  TLR4を介した肥満細胞活性化とアレルギー性気道炎症
    メディカル・サイエンス・ダイジェスト 426, 936-939, 2007
  • 山下政克  Th2細胞分化とアレルギー性疾患
    遺伝子医学Mookシグナル伝達病を知る 6, 206-211, 2006
  • 山下政克  Th2細胞分化のエピジェネティック制御
    実験医学増刊 免疫研究最前線2007 24, 15-121, 2006
  • 山下政克、中山俊憲  メモリーTh2細胞のTh2サイトカイン産生維持メカニズム−Th2サイトカイン遺伝子座における転写記憶
    医学のあゆみ 216, 343-340, 2006
  • 山下政克  クロマチン免疫沈降法(ChIPアッセイ)
    Surgery Frontier 13, 96-101, 2006
  • 山下政克、中山俊憲  BCGによるI型アレルギー疾患治療の可能性
  • 山下政克、中山俊憲  SHP-1によるTh2細胞分化とアレルギー性気道炎症の制御
    臨床免疫44, 32-37, 2005
  • 山下政克、中山俊憲  メモリーTh2細胞におけるTh2サイトカイン産生維持のメカニズム
    Annual Review免疫2006, 157-165, 2005
  • 山下政克、中山俊憲  Th2細胞の分化誘導・維持とTh2サイトカイン遺伝子座クロマチンリモデリング
    臨床免疫44, 585-590, 2005
  • 山下政克、中山俊憲  Th2細胞分化とシグナル伝達
    アレルギーの臨床 25, 69-73, 2005
  • 山下政克、中山俊憲  Th2/Tc2細胞分化に伴うTh2サイトカイン遺伝子(IL-4, IL-5, IL-13)座のクロマチンリモデリング
    実験医学増刊 22, 64-71, 2004
  • 山田武司  ウイルス性胃腸炎 (Umesh D. Parashar, Roger I. Glass)日本語版ハリソン内科学 第16版 part6 section 15, 174,メディカルサイエンスインターナショナル, 2004
  • 山下政克、中山俊憲  クロマチン修飾を介した免疫反応の制御:Th2細胞分化をモデルに
    細胞工学 23, 1166-1170, 2004
  • 山下政克、中山俊憲  Th2細胞分化に伴うTh2サイトカイン遺伝子座のクロマチンリモデリング
    Molecular Medicine臨時増刊号 免疫2005, 41:11-19, 2004
  • 山下政克  Th2サイトカイン遺伝子座のクロマチンリモデリングとTh2、Tc2細胞分化制御
    医学のあゆみ 207, 225-230, 2003
  • 山田武司  ウイルス性胃腸炎 (Harry B.Greenberg)日本語版ハリソン内科学 第15版 part7, 192,メディカルサイエンスインターナショナル, 2003
  • 山田武司  ハイブリダイゼーションプローブを用いたreal-time PCR法によるRNA定量 実験医学別冊 羊土社 第4章 p163-179, 2003
  • 山下政克、中山俊憲  Th2細胞分化とクロマチンリモデリング
    Annual Review 2003免疫, 17-23, 2002
  • 山田武司  HIVのNef蛋白による免疫制御  臨床免疫 科学評論社 37巻 3号, 2002
  • 山下政克、中山俊憲
    実験医学 19, 42-47, 2001
  • 山下政克、中山俊憲  Th1/Th2細胞分化におけるT細胞抗原受容体シグナルの役割
    臨床免疫 36, 507-514, 2001
  • 清水千織、山下政克、中山俊憲  Th1/Th2細胞分化を制御するRas/MAPKカスケード、Ca2+/カルシニューリン経路
    臨床免疫 35, 191-200, 2001
  • 清水千織、山下政克、中山俊憲  T細胞抗原受容体からのシグナル伝達によって調節されるTh1/Th2細胞分化
    アレルギー科 12, 167-176, 2001
  • 木村元子、山下政克、中山俊憲  Th1/Th2細胞の分化制御—サイトカイン、転写因子研究からクロマチンリモデリング研究へ-
    アレルギー科 10, 128-134, 2000
  • 山下政克、中山俊憲  活性化Va14NKT細胞によるアレルギー反応制御機構
    アレルギー科 10, 215-220, 2000
  •  山下政克、中山俊憲  T細胞抗原受容体シグナルとTh2細胞分化
    臨床免疫 33, 669-667, 2000
  • 山下政克、中山俊憲  Th1、Th2細胞分化を制御するT細胞抗原受容体からのシグナル伝達
    アレルギー/免疫 7, 729-739, 2000
  • 山下政克、中山俊憲  Ras/MAPキナーゼカスケードによるTh1/Th2細胞の分化制御
    最新医学9月増刊号 136-146, 1999
  • 山田武司  成人T細胞白血病ウイルス(HTLV-1) 臨床と微生物 近代出版 Vol.26 増刊号 P086-091, 1999
  • 山下政克、中山俊憲  T細胞の胸腺内分化にかかわるシグナル伝達機構
    臨床免疫31, 180-189, 1999
  • 山下政克、中山俊憲  Th1/Th2細胞の分化制御とRas/MAPKカスケードの活性化
    臨床免疫32, 532-539, 1999


  • 2006年12月1日  第一回日本免疫学会研究奨励賞受賞 (山下 政克)
  • 2007年5月20日  平成19年度とやま賞受賞 (山下 政克)
  • 2009年6月17日  第一回千葉医学会賞受賞 (山下 政克)