スタッフ紹介

古川慎哉准教授

経歴

平成3年3月21日 広島学院高校卒業
平成3年4月1日 愛媛大学医学部医学科入学
平成9年3月24日 同医学科卒業
平成9年5月6日 医師免許証下付（医籍登録番号389511号）
平成9年6月1日 愛媛大学医学部附属病院第三内科医員（研修医）に採用
平成10年5月31日 同辞職
平成10年6月1日 済生会松山病院内科医員に採用
平成12年5月31日 同辞職
平成12年6月1日 宇和島社会保険病院内科医師に採用
平成13年5月31日 同辞職
平成13年4月1日 愛媛大学大学院医学研究科博士課程入学
平成17年3月24日 同博士課程修了、博士（医学）の学位授与
平成17年4月1日 愛媛大学医学部附属病院医員に採用
平成18年1月1日 愛媛大学医学部附属病院助教・特任講師に採用
平成23年7月1日 愛媛大学医学部附属病院講師に採用
平成25年2月1日 愛媛大学大学院医学研究科公衆衛生・健康医学講座准教授に採用

業績

三宅教授との共著は研究成果をご参照ください。

    欧文原著論文

    1. Takeshita E, Kumagi T, Matsui H, Abe M, Furukawa S, Ikeda Y, Matsuura B, Michitaka K, Horiike N, Onji M. Esophagogastric varices as a prognostic factor for the determination of clinical stage in patients with primary biliary cirrhosis. J Gastroenterol. 2003; 38: 1060-5.
    2. Fazle Akbar SM, Furukawa S, Onji M, Murata Y, Niiya T, Kanno S, Murakami H, Horiike N. Safety and efficacy of hepatitis B surface antigen-pulsed dendritic cells in human volunteers. Hepatol Res. 2004; 29: 136-141.
    3. Akbar SM, Furukawa S, Hasebe A, Horiike N, Michitaka K, Onji M. Production and efficacy of a dendritic cell-based therapeutic vaccine for murine chronic hepatitis B virus carrierer. Int J Mol Med. 2004; 14: 295-9.
    4. Furukawa S, Akbar SM, Hasebe A, Horiike N, Onji M. Induction and maintenance of anti-HBs in immunosuppressed murine hepatitis B virus carriers by a novel vaccination approach: implications for use in hepatitis B virus-infected subjects with liver transplantation. J Gastroenterol. 2004; 39: 851-8.
    5. Furukawa S, Akbar SM, Hasebe A, Horiike N, Onji M. Production of hepatitis B surface antigen-pulsed dendritic cells from immunosuppressed murine hepatitis B virus carrier: evaluation of immunogenicity of antigen-pulsed dendritic cells in vivo. Immunobiology. 2004; 209: 551-7.
    6. Takeshita E, Matsui H, Shibata N, Furukawa S, Yokota T, Murakami H, Ikeda Y, Hiasa Y, Matsuura B, Michitaka K, Onji M. Earlier recurrence of esophageal varices, following therapy, in patients with primary biliary cirrhosis (PBC) compared with non-PBC patients. J Gastroenterol. 2004; 39: 1085-9.
    7. Kumagi T, Horiike N, Michitaka K, Hasebe A, Kawai K, Tokumoto Y, Nakanishi S, Furukawa S, Hiasa Y, Matsui H, Kurose K, Matsuura B, Onji M. Recent clinical features of Wilson's disease with hepatic presentation. J Gastroenterol. 2004; 39: 1165-9.
    8. Akbar SM, Furukawa S, Nakanishi S, Abe M, Horiike N, Onji M. Therapeutic efficacy of decreased nitrite production by bezafibrate in patients with primary biliary cirrhosis. J Gastroenterol. 2005; 40: 157-63.
    9. Hasebe A, Akbar SM, Furukawa S, Horiike N, Onji M. Impaired functional capacities of liver dendritic cells from murine hepatitis B virus (HBV) carriers: relevance to low HBV-specific immune responses. Clin Exp Immunol. 2005; 139: 35-42.
    10. Miyake T, Miyaoka H, Abe M, Furukawa S, Shigematsu S, Furukawa E, Ikeda R, Okita S, Okada T, Yoshida O, Murata Y, Akbar SM, Matsuura B, Michitaka K, Horiike N, Hiasa Y, Onji M. Clinical characteristics of autoimmune hepatitis in older aged patients. Hepatol Res. 2006; 36: 139-42.
    11. Murata Y, Abe M, Furukawa S, Kumagi T, Matsui H, Matsuura K, Matsuura B, Hiasa Y, Onji M. Clinical features of symptomatic primary biliary cirrhosis initially complicated with esophageal varices J Gastroenterol. 2006; 41: 1220-6.
    12. Nakanishi S, Matsuura B, Hirooka M, Ueda T, Niiya T, Furukawa S, Abe M, Hiasa Y, Kubo Y, Onji M. Clinical usefulness of quantitative evaluation of visceral fat by ultrasonography Journal of Medical Ultrasonics 2007; 34: 151-7.
    13. Toshimitsu K, Matsuura B, Ohkubo I, Niiya T, Furukawa S, Hiasa Y, Kawamura M, Ebihara K, Onji M. Dietary habits and nutrient intake in non-alcoholic steatohepatitis. Nutrition. 2007; 23: 46-52.
    14. Michitaka K, Takahashi K, Furukawa S, Inoue G, Hiasa Y, Horiike N, Onji M, Abe N, Mishiro S. Prevalence of hepatitis E virus among wild boar in the Ehime area of western Japan. Hepatol Res. 2007; 37: 214-20.
    15. Fazle Akbar SM, Furukawa S, Yoshida O, Hiasa Y, Horiike N, Onji M. Induction of anti-HBs in HB vaccine nonresponders in vivo by hepatitis B surface antigen-pulsed blood dendritic cells. J Hepatol. 2007; 47: 60-6.
    16. Tokunaga H, Matsuura B, Dong M, Miller LJ, Ueda T, Furukawa S, Hiasa Y, Onji M. Mutational analysis of predicted intracellular loop domains of human motilin receptor. Am J Physiol Gastrointest Liver Physiol. 2008; 294: 460-6.
    17. Murata Y, Abe M, Hiasa Y, Azemoto N, Kumagi T, Furukawa S, Matsuura B, Michitaka K, Horiike N, Onji M. Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis. J Gastroenterol. 2008; 43: 632-6.
    18. Konishi I, Hiasa Y, Shigematsu S, Hirooka M, Furukawa S, Abe M, Matsuura B, Michitaka K, Horiike N, Onji M. Diabetes pattern on the 75 g oral glucose tolerance test is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus. Liver Int. 2009; 29: 1194-201.
    19. Konishi I, Hiasa Y, Tokumoto Y, Abe M, Furukawa S, Toshimitsu K, Matsuura B, Onji M. Aerobic exercise improves insulin resistance and decreases body fat and serum levels of leptin in patients with hepatitis C virus. Hepatol Res. 2011; 41: 928-35.
    20. Hamada M, Abe M, Miyake T, Kawasaki K, Tada F, Furukawa S, Matsuura B, Hiasa Y, Onji M. B cell-activating factor controls the production of adipokines and induces insulin resistance. Obesity (Silver Spring). 2011; 19: 1915-22.
    21. Ueda T, Matsuura B, Miyake T, Furukawa S, Abe M, Hiasa Y, Onji M. Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a. Regul Pept. 2011; 166: 28-35.
    22. Moritoyo T, Hasunuma T, Harada K, Tateishi T, Watanabe M, Kotegawa T, Nagai M, Kumagai Y, Fujitani T, Okura T, Fukuoka T, Miyoshi K, Matsuura B, Furukawa S, Kobori T, Moritoyo H, Nishikawa N, Tsujii T, Iwaki H, Nakamura M, Makino S, Ohnuma K, Yuji K, Hashimoto M, Takasu M, Hashizume Y, You K, Matsumura T, Tanaka Y, Matsumoto N, Nakamura J, Miura J, Akizawa T, Kitazawa K, Shibata T, Kuroki A, Honda H, Mukai M, Ohashi K, Morimoto T, Imai H, Okudaira T, Sato F, Imanaga J, Tanaka K, Nomoto M. Effect of renal impairment on the pharmacokinetics of memantine. J Pharmacol Sci. 2012; 119: 324-9.
    23. Nunoi H, Matsuura B, Utsunomiya S, Ueda T, Miyake T, Furukawa S, Kumagi T, Ikeda Y, Abe M, Hiasa Y, Onji M. A relationship between motilin and growth hormone secretagogue receptors. Regul Pept. 2012; 176: 28-35.
    24. Miyake T, Kumagi T, Hirooka M, Koizumi M, Furukawa S, Ueda T, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M. Metabolic markers and ALT cutoff level for diagnosing nonalcoholic fatty liver disease: a community-based cross-sectional study. J Gastroenterol. 2012; 47: 696-703.
    25. Furukawa S, Kumagi T, Miyake T, Ueda T, Niiya T, Nishino K, Murakami S, Murakami M, Matsuura B, Onji M. Suicide attempt by an overdose of sitagliptin, an oral hypoglycemic agent: a case report and a review of the literature. Endocr J. 2012; 59: 329-33.
    26. Miyake T, Hiasa Y, Hirooka M, Tokumoto Y, Watanabe T, Furukawa S, Ueda T, Yamamoto S, Kumagi T, Miyaoka H, Abe M, Matsuura B, Onji M. High serum palmitic acid is associated with low antiviral effects of interferon-based therapy for hepatitis C virus. Lipids. 2012; 47:1053-62.
    27. Kawasaki K, Abe M, Tada F, Tokumoto Y, Chen S, Miyake T, Furukawa S, Matsuura B, Hiasa Y, Onji M. Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. Lab Invest. 2013; 93: 311-21.
    28. Miyauchi S, Matsuura B, Ueda T, Eguchi T, Tamaru M, Yamamoto S, Miyake T, Furukawa S, Abe M, Hiasa Y, Onji M. Interleukin-18 induces insulin resistance in the hyperthyroid state. Endocr J. 2013; 60: 449-55.
    29. Utsunomiya S, Matsuura B, Ueda T, Miyake T, Furukawa S, Kumagi T, Ikeda Y, Abe M, Hiasa Y, Onji M. Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity. Regul Pept. 2013;180: 17-25.
    30. Miyake T, Kumagi T, Hirooka M, Furukawa S, Koizumi M, Tokumoto Y, Ueda T, Yamamoto S, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M. Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community-based retrospective longitudinal cohort study. J Gastroenterol. 2013; 48: 413-22.
    31. Furukawa S, Saito I, Yamamoto S, Miyake T, Ueda T, Niiya T, Torisu M, Kumagi T, Sakai T, Minami H, Miyaoka H, Sakurai S, Matsuura B, Onji M, Tanigawa T. Nocturnal intermittent hypoxia as an associated risk factor for microalbuminuria in Japanese patients with type 2 diabetes mellitus. Eur J Endocrinol. 2013;169: 239-46.
    32. Kuroda T, Kumagi T, Yokota T, Seike H, Nishiyama M, Imai Y, Inada N, Shibata N, Imamine S, Okada S, Koizumi M, Yamanishi H, Azemoto N, Miyaike J, Tanaka Y, Tatsukawa H, Utsunomiya H, Ohno Y, Miyake T, Hirooka M, Furukawa S, Abe M, Ikeda Y, Matsuura B, Hiasa Y, Onji M; EPOCH Study Group. Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era: a collaborative retrospective multicenter clinical review of 1,082 patients. BMC Gastroenterol. 2013; 13: 134.
    33. Miyake T, Abe M, Tokumoto Y, Hirooka M, Furukawa S, Kumagi T, Hamada M, Kawasaki K, Tada F, ueda T, Hiasa Y, Matsuura B, Onji M. B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease. Hapato Int 2013; 7: 539-47.
    34. Imai H, Watanabe M, Fujita T, Watanabe H, Harada K, Moritoyo T; ANTCliPh (Academic Network for Trials in Clinical Pharmacology) (Furukawa S, 30 authors listed in Appendix).Trial 04 Study Group. Pharmacokinetics of teriparatide after subcutaneous administration to volunteers with renal failure: a pilot study. Int J Clin Pharmacol Ther. 2014; 52:166-74.
    35. Furukawa S, Sakai T, Niiya T, Yamamoto S, Todo Y, Miyake T, Ueda T, Maruyama K, Miyaoka H, Kumagi T, Senba H, Minami H, Hiasa Y, Matsuura B, Onji M, Tanigawa T. Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus Endocr J 2014; 61: 1011-8.
    36. Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Abe M, Kitai K, Matsuura B, Hiasa Y. Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study. PLoS One. 2014; 9: e107882.
    37. Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y. Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study. J Gastroenterol. 2015; 50: 230-7.
    38. Chen S, Akbar SM, Miyake T, Abe M, Al-Mahtab M, Furukawa S, Matsuura B, Hiasa Y. Diminished immune response to vaccinations in obesity: Role of myeloid-derived suppressor and other myeloid cells. Obes Res Clin Pract 2015; 9: 35-44.
    39. Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y. Short sleep duration reduces the risk of nonalcoholic fatty liver disease onset in men: a community-based longitudinal cohort study. J Gastroenterol. 2015; 50: 583-9.
    40. Maruyama K, Nishioka S, Miyoshi N, Higuchi K, Mori H, Tanno S, Tomooka K, Eguchi E, Furukawa S, Saito I, Sakurai S, Nishida W, Osawa H, Tanigawa T. The impact of masticatory ability as evaluated by salivary flow rates on obesity in Japanese: The Toon health study. Obesity 2015; 23: 1296-302.
    41. Miyake T, Kumagi T, Hirooka M, Furukawa S, Yoshida O, Koizumi M, Yamamoto S, Watanabe T, Yamamoto Y, Tokumoto Y, Takeshita E, Abe M Kitai K, Matusura B, Hiasa Y. Lower alcohol consumption increases the risk of impaired glucose tolerance in patients with non-alcoholic fatty liver disease. J Gastroenterol. 2016 (in Press).

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