2026

Kenji Takagi, Junpei Suzuki, Yuko Matsuoka, Makoto Kuwahara, Taro Oshikiri, Masakatsu Yamashita: Ezh2 Inhibits the Differentiation of Short-Lived Effector CD8+ T Cells and Promotes T Cell-Dependent Antitumor Immunity. Cancer Sci. (2026). https://doi.org/10.1111/cas.70439

Shintaro Terashita, Yasuhito Yahara, Jun-Dal Kim, Amane Mizutani, Hitoshi Uchida, Keisuke Yaku, Masakatsu Yamashita, Chihaya Imai, Takashi Nakagawa: Conditional deletion of glutaminase 1 in Tnfrsf11a-expressing cells reduces bone mass and induces postnatal growth retardation in mice. Biochemical and Biophysical Research Communications(2026) 794, 153048. https://doi.org/10.1016/j.bbrc.2025.153048

2025

Miyuki Omori-Miyake, Ryosuke Kawakami, Makoto Kuwahara, Masataka Okabe, Jun Muto, Takeshi Imamura, Masakatsu Yamashita: Loss of Bach2 in T cells causes prolonged allergic inflammation through accumulation of effector T cells and disruption of epidermal barrier. J. Allergy Clin. Immunol. (2025) 155:2009-2021. https://doi.org/10.1016/j.jaci.2025.01.036

2024

Jun-ichi Iga, Yuta Yoshino, Tomoki Ozaki, Ayumi Tachibana, Hiroshi Kumon, Yu Funahashi, Hiroaki Mori, Mariko Ueno, Yuki Ozaki, Kiyohiro Yamazaki, Shinichiro Ochi, Masakatsu Yamashita, and Shu-ichi Ueno: Blood RNA transcripts show changes in inflammation and lipid metabolism in Alzheimer’s disease and mitochondrial function in mild cognitive impairment. Journal of Alzheimer’s Disease Reports (2024) Volume 8, Issue 1: Pages 1690-1703. https://doi.org/10.1177/25424823241307878

Yuichiro Ukon, Takashi Kaito, Hiromasa Hirai, Takayuki Kitahara, Masayuki Bun, Joe Kodama, Daisuke Tateiwa, Shinichi Nakagawa, Masato Ikuta, Takuya Furuichi, Yuya Kanie, Takahito Fujimori, Shota Takenaka, Tadashi Yamamuro, Satoru Otsuru, Seiji Okada, Masakatsu Yamashita, Takeshi Imamura: Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis.Aging Cell(2024) 00:e14254. https://doi.org/10.1111/acel.14254

Waichi Yamamoto, Taisuke Hamada, Junpei Suzuki, Yuko Matsuoka,
Miyuki Omori‐Miyake, Makoto Kuwahara, Akira Matsumoto, Shunsuke Nomura, Amane Konishi, Toshihiro Yorozuya, Masakatsu Yamashita: Suppressive effect of the anesthetic propofol on the T cell function and T cell‐dependent immune responses. Scientific reports(2024) 14:19337. https://doi.org/10.1038/s41598-024-69987-z

2023

Kakuda T, Suzuki J, Matsuoka Y, Kikugawa T, Saika T, Yamashita M: Senescent CD8+ T cells acquire NK cell-like innate functions to promote antitumor immunity. Cancer Sci.(2023) 114 (7): 2810-2820 https://doi.org/10.1111/cas.15824

Noda H, Suzuki J, Matsuoka Y, Matsumoto A, Kuwahara M, Kamei Y, Takada Y, Yamashita M: The histone demethylase Utx controls CD8+ T-cell-dependent antitumor immunity via epigenetic regulation of the effector function. Cancer Sci.(2023) 114 (7): 2787-2797 https://doi.org/10.1111/cas.15814

Okamoto M*, Omori-Miyake M*, Kuwahara M, Okabe M, Eguchi M, Yamashita M: The inhibition of glycolysis in T cells by a Jak inhibitor ameliorates the pathogenesis of allergic contact dermatitis in mice. J. Invest. Dermatol.(2023) 143 (10): 1972-1982.e5 https://doi.org/10.1016/j.jid.2023.03.1667

Ikeda N, Kubota H,Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Miyako M, Asahina Y,Hayashi Y,Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara M, Yamashita M, Shichino S, Tanaka M, Asano K: The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Rep. (2023) 42 (3): 112165 https://doi.org/10.1016/j.celrep.2023.112165

Taniguchi Y, Suemori K, Tanaka K, Okamoto A, Murakami A, Miyamoto H, Takasuka Y, Yamashita M, Takenaka K: Long-term transition of antibody titers in healthcare workers following the first to fourth doses of mRNA COVID-19 vaccine: Comparison of two automated SARS-CoV-2 immunoassays. J. Infect. Chemother.  (2023) 29 (5): 534-538 https://doi.org/10.1016/j.jiac.2023.01.007

2022

Suemori K , Taniguchi  Y, Okamoto A , Murakami A , Ochi F , Aono H , Hato N, Osawa H, Miyamoto H, Sugiyama T ,Yamashita M, Tauchi H, Takenaka K: Two-Year Seroprevalence Surveys of SARS-CoV-2 Antibodies among Outpatients and Healthcare Workers in Ehime, Japan. Jpn. J. Infect. Dis.  (2022) 75 (5): 523-526 https://doi.org/10.7883/yoken.JJID.2022.155

Choudhury ME, Mikami K, Nakanishi Y, Matsuura T, Utsunomiya R, Yano H, Kubo M, Ando R, Iwanami J, Yamashita M, Nagai M, Tanaka J: Insomnia and depressive behavior of MyD88-deficient mice: Relationships with altered microglial functions. J. Neuroimmunol. (2022) 363: 577794 https://doi.org/10.1016/j.jneuroim.2021.577794

Konishi A, Suzuki J, Kuwahara M, Matsumoto A, Nomura S, Soga T, Yorozuya T,Yamashita M: Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response. Biochem. Biophys. Res. Commun. (2022) 588: 34-40 https://doi.org/10.1016/j.bbrc.2021.12.050