業績

 

2023年
Matsunuma M, Kan R, Yamada Y, Hamada K, Kanagawa M, Nomizu M, Kikkawa Y.
Chain-specificity of laminin α1-5 LG45 modules in the recognition of carbohydrate-linked receptors and intramolecular binding.
Sci Rep. 2023 Jun 27;13(1):10430. doi: 10.1038/s41598-023-37533-y.



2022年

Kikkawa Y, Matsunuma M, Kan R, Yamada Y, Hamada K, Nomizu M, Negishi Y, Nagamori S, Toda T, Tanaka M, Kanagawa M.
Laminin α5_CD239_Spectrin is a candidate association that compensates the linkage between the basement membrane and cytoskeleton in skeletal muscle fibers.
Matrix Biology Plus. 2022: 15, 100118.
https://doi.org/10.1016/j.mbplus.2022.100118.

Tokuoka H, Imae R, Nakashima H, Manya H, Masuda C, Hoshino S, Kobayashi K, Lefeber DJ, Matsumoto R, Okada T, Endo T,
Kanagawa M, Toda T.
CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model.
Nat Commun. 2022, 13(1):1847. doi: 10.1038/s41467-022-29473-4.

Ikenaga C, Date H,Kanagawa M, Mitsui J, Ishiura H, Yoshimura J, Pinal-Fernandez I, Mammen AL, Lloyd TE, Tsuji S, Shimizu J, Toda T, Goto J.
Muscle transcriptomics shows overexpression of cadherin 1 in inclusion body myositis.
Ann Neurol. 2022 Jan 22. doi: 10.1002/ana.26304.

 


2021年

Kanagawa M. Dystroglycanopathy: From Elucidation of Molecular and Pathological Mechanisms to Development of Treatment Methods. Int. J. Mol. Sci. 22(23), 13162. 2021

Bai HY, Min LJ, Shan BS, Iwanami J, Kan-No H, Kanagawa M, Mogi M, Horiuchi M. Angiotensin II and Amyloid-β Synergistically Induce Brain Vascular Smooth Muscle Cell Senescence.Am J Hypertens. 34(5):552-562. 2021.


2020年

Furukawa JI, Hanamatsu H, Nishikaze T, Manya H, Miura N, Yagi H, Yokota I, Akasaka-Manya K, Endo T, Kanagawa M, Iwasaki N, Tanaka K. Lactone-Driven Ester-to-Amide Derivatization for Sialic Acid Linkage-Specific Alkylamidation. Anal Chem. 92(21):14383-14392. 2020.

Morioka S, Sakaguchi H, Mohri H, Taniguchi-Ikeda M, Kanagawa M, Suzuki T, Miyagoe-Suzuki Y, Toda T, Saito N, Ueyama T. Congenital hearing impairment associated with peripheral cochlear nerve dysmyelination in glycosylation-deficient muscular dystrophy. PLoS Genet. 16(5):e1008826. 2020.

Min LJ, Iwanami J, Shudou M, Bai HY, Shan BS, Higaki A, Mogi M, Horiuchi M. Deterioration of cognitive function after transient cerebral ischemia with amyloid-β infusion-possible amelioration of cognitive function by AT2 receptor activation. J Neuroinflammation. 17(1):106. 2020.

Seki T, Kanagawa M, Kobayashi K, Kowa H, Yahata N, Maruyama K, Iwata N, Inoue H, Toda T. Galectin 3-binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein. J Biol Chem. 13;295(11): 3678-3691. 2020.

Kuwabara N, Imae R, Manya H, Tanaka T, Mizuno M, Tsumoto H, Kanagawa M, Kobayashi K, Toda T, Senda T, Endo T, Kato R. Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.
Nat Commun. 11(1):303. 2020.


2019年

Ujihara Y, Kanagawa M, Mohri S, Takatsu S, Kobayashi K, Toda T, Naruse K, Katanosaka Y. Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure. Nat Commun. 10(1):5754. 2019.

Sugawara Y, Hamada K, Yamada Y, Kumai J, Kanagawa M, Kobayashi K, Toda T, Negishi Y, Katagiri F, Hozumi K, Nomizu M, Kikkawa Y. Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment. Sci Rep. 9(1):13037. 2019.

Sekiya H, Kowa H, Koga H, Takata M, Satake W, Futamura N, Funakawa I, Jinnai K, Takahashi M, Kondo T, Ueno Y, Kanagawa M, Kobayashi K, Toda T. Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation. Acta Neuropathol. 137(3):455-466. 2019.

Kukida M, Mogi M, Kan-No H, Tsukuda K, Bai HY, Shan BS, Yamauchi T, Higaki A, Min LJ, Iwanami J, Okura T, Higaki J, Horiuchi M.
AT2 receptor stimulation inhibits phosphate-induced vascular calcification. Kidney Int. 95(1):138-148. 2019.


2018年

Uenaka T, Satake W, Cha PC, Hayakawa H, Baba K, Jiang S, Kobayashi K, Kanagawa M, Okada Y, Mochizuki H, Toda T. In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease. Hum Mol Genet. 27(22):3974-3985. 2018.

Orlandi C, Omori Y, Wang Y, Cao Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA. Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors. Cell Rep. 25(1):130-145.e5. 2018.

Imae R, Manya H, Tsumoto H, Osumi K, Tanaka T, Mizuno M, Kanagawa M, Kobayashi K, Toda T, Endo T. CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan. J Biol Chem. 293(31):12186-12198. 2018.

Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, Umeda M. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 9(1):2049. 2018.

Sudo A, Kanagawa M, Kondo M, Ito C, Kobayashi K, Endo M, Minami Y, Aiba A, Toda T. Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage. Hum Mol Genet. 27(7):1174-1185. 2018.

Nishihara R, Kobayashi K, Imae R, Tsumoto H, Manya H, Mizuno M, Kanagawa M, Endo T, Toda T. Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5. Biochem Biophys Res Commun. 497(4):1025-1030. 2018.

Mogi M, Iwanami J, Wang XL, Tsukuda K, Kan-No H, Bai HY, Shan BS, Higaki A, Min LJ, Horiuchi M. Deletion of interferon- regulatory factor-1 results in cognitive impairment. Hypertens Res. 41(10):809-816. 2018.

Shan BS, Mogi M, Iwanami J, Bai HY, Kan-No H, Higaki A, Min LJ, Horiuchi M. Attenuation of stroke damage by angiotensin II type 2 receptor stimulation via peroxisome proliferator-activated receptor-gamma activation.Hypertens Res. 41(10): 839-848. 2018.

Higaki A, Mogi M, Iwanami J, Min LJ, Bai HY, Shan BS, Kan-No H, Ikeda S, Higaki J, Horiuchi M. Recognition of early stage thigmotaxis in Morris water maze test with convolutional neural network.PLoS One. 13(5):e0197003. 2018.

Yamauchi T, Mogi M, Kan-No H, Shan BS, Higaki A, Min LJ, Higaki T, Iwanami J, Ishii EI, Horiuchi M. Roles of angiotensin II type 2 receptor in mice with fetal growth restriction. Hypertens Res. 41(3):157-164. 2018.

Higaki A, Mogi M,Iwanami J, Min LJ, Bai HY, Shan BS, Kukida M, Yamauchi T, Tsukuda K, Kan-No H, Ikeda S, Higaki J, Horiuchi M. Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor.J Am Heart Assoc. 7(3):e008121. 2018.

Higaki A, Mogi M,Iwanami J, Min LJ, Bai HY, Shan BS, Kukida M, Kan-No H, Ikeda S, Higaki J, Horiuchi M. Predicting outcome of Morris water maze test in vascular dementia mouse model with deep learning.PLoS One. 13(2):e0191708. 2018.



2017年
Kamizaki K, Doi R, Hayashi M, Saji T, Kanagawa M, Toda T, Fukada SI, Ho HH, Greenberg ME, Endo M, Minami Y. The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle.J Biol Chem. 292(38):15939-15951. 2017.

Min LJ, Kobayashi Y, Mogi M, Tsukuda K, Yamada A, Yamauchi K, Abe F, Iwanami J, Xiao JZ, Horiuchi M. Administration of bovine casein-derived peptide prevents cognitive decline in Alzheimer disease model mice. PLoS One. 12(2):e0171515. 2017.



2016年
Manya H, Yamaguchi Y, Kanagawa M, Kobayashi K, Tajiri M, Akasaka-Manya K, Kawakami H, Mizuno M, Wada Y, Toda T, Endo T. The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan. J Biol Chem. 291(47):24618-24627. 2016.

Kuwabara N, Manya H, Yamada T, Tateno H, Kanagawa M, Kobayashi K, Akasaka-Manya K, Hirose Y, Mizuno M, Ikeguchi M, Toda T, Hirabayashi J, Senda T, Endo T, Kato R. Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan.Proc Natl Acad Sci U S A. 113(33):9280-5. 2016.

Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa JI, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T. Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy.Cell Rep. 14(9):2209-2223. 2016.

Tsukuda K, Mogi M, Iwanami J, Kanno H, Nakaoka H, Wang XL, Bai HY, Shan BS, Kukida M, Higaki A, Yamauchi T, Min LJ, Horiuchi M. Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade. PLoS One. 11(12):e0167704. 2016.

Wang XL, Iwanami J, Min LJ, Tsukuda K, Nakaoka H, Bai HY, Shan BS, Kan-No H, Kukida M, Chisaka T, Yamauchi T, Higaki A, Mogi M, Horiuchi M. Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function. NPJ Aging Mech Dis. 2:16024. 2016.

Nakaoka H, Mogi M, Suzuki J, Kan-No H, Min LJ, Iwanami J, Horiuchi M.Interferon regulatory factor 1 attenuates vascular remodeling; roles of angiotensin II type 2 receptor.J Am Soc Hypertens. 10(10):811-818. 2016.

Bai HY, Mogi M, Nakaoka H, Kan-No H, Tsukuda K, Wang XL, Shan BS, Kukida M, Yamauchi T, Higaki A, Min LJ, Iwanami J, Horiuchi M. Synergistic Inhibitory Effect of Rosuvastatin and Angiotensin II Type 2 Receptor Agonist on Vascular Remodeling. J Pharmacol Exp Ther. 358(2):352-8. 2016.

Kukida M, Mogi M, Ohshima K, Nakaoka H,Iwanami J, Kanno H, Tsukuda K, Chisaka T, Min LJ, Wang XL, Bai HY, Shan BS, Higaki A, Yamauchi T, Okura T, Higaki J, Horiuchi M. Angiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPARγ. Am J Hypertens. 29(6):727-36. 2016.


2015年以前の業績は作成中