2023年

Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21

Jun Muto, Shinji Fukuda, Kenji Watanabe, Xiuju Dai, Teruko Tsuda, Takeshi Kiyoi, Kenji Kameda, Ryosuke Kawakami, Hideki Mori, Ken Shiraishi, Masamoto Murakami, Takeshi Imamura, Shigeki Higashiyama, Yasuhiro Fujisawa, Yoichi Mizukami, Koji Sayama
Commun Biol. 2023 Jan 6;6(1):13. doi: 10.1038/s42003-022-04408-3.
PMID: 36609486 PMCID: PMC9822918 DOI: 10.1038/s42003-022-04408-3

PubMed

2023年

Motor training promotes both synaptic and intrinsic plasticity of layer V pyramidal neurons in the primary motor cortex

H Kida, R Kawakami, K Sakai, H Otaku, K Imamura, Thiri-Zin Han, Y Sakimoto, Dai Mitsushima
J Physiol. 2023 Jan;601(2):335-353. doi: 10.1113/JP283755. Epub 2022 Dec 26.
PMID: 36515167 DOI: 10.1113/JP283755

PubMed

2022年

NIR-II-Excitable Dye-Loaded Nanoemulsions for Two-Photon Microscopy Imaging of Capillary Blood Vessels in the Entire Hippocampal CA1 Region of Living Mice

Hitomi Matsuura, Ryosuke Kawakami, Maki Isoe, Masaharu Hoshihara, Yuya Minami, Kazuki Yatsuzuka, Teruko Tsuda, Masamoto Murakami, Yasutaka Suzuki, Jun Kawamata, Takeshi Imamura, Shingo Hadano, Shigeru Watanabe, Yosuke Niko
ACS Appl Mater Interfaces. 2022 Sep 14;14(36):40481-40490. doi: 10.1021/acsami.2c03299. Epub 2022 Sep 5.
PMID: 36063083 DOI: 10.1021/acsami.2c03299

PubMed

2022年

Identification of Quiescent LGR5+ Stem Cells in the Human Colon

Keiko Ishikawa, Shinya Sugimoto, Mayumi Oda, Masayuki Fujii, Sirirat Takahashi, Yuki Ohta, Ai Takano, Kazuhiro Ishimaru, Mami Matano, Kosuke Yoshida, Hikaru Hanyu, Kohta Toshimitsu, Kazuaki Sawada, Mariko Shimokawa, Megumu Saito, Kenta Kawasaki, Ryota Ishii, Koji Taniguchi, Takeshi Imamura, Takanori Kanai, Toshiro Sato
Gastroenterology. 2022 Nov;163(5):1391-1406.e24. doi: 10.1053/j.gastro.2022.07.081. Epub 2022 Aug 11.
PMID: 35963362 DOI: 10.1053/j.gastro.2022.07.081

PubMed

2022年

Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis

Yutaka Nakamura, Mitsuru Saitou, Shingo Komura, Kazu Matsumoto, Hiroyasu Ogawa, Takaki Miyagawa, Takashi Saitou, Takeshi Imamura, Yuuki Imai, Hiroshi Takayanagi, Haruhiko Akiyama
Sci Rep. 2022 Jul 16;12(1):12207. doi: 10.1038/s41598-022-16585-6.
PMID: 35842459 PMCID: PMC9288549 DOI: 10.1038/s41598-022-16585-6

PubMed

2022年

Cell-matrix interface regulates dormancy in human colon cancer stem cells

Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Nature. 2022 Aug;608(7924):784-794. doi: 10.1038/s41586-022-05043-y. Epub 2022 Jul 7.
PMID: 35798028 DOI: 10.1038/s41586-022-05043-y

PubMed

2022年

Computer-Aided Detection of Quantitative Signatures for Breast Fibroepithelial Tumors Using Label-Free Multi-Photon Imaging

Kana Kobayashi-Taguchi, Takashi Saitou, Yoshiaki Kamei, Akari Murakami, Kanako Nishiyama, Reina Aoki, Erina Kusakabe, Haruna Noda, Michiko Yamashita, Riko Kitazawa, Takeshi Imamura, Yasutsugu Takada
Molecules 2022, 27(10), 3340; doi:10.3390/molecules27103340
PMID: 35630817 PMCID: PMC9144626 DOI: 10.3390/molecules27103340

PubMed

2022年

Differences in interaction lead to the formation of different types of insulin amyloid

Wakako Mori, Ryosuke Kawakami, Yosuke Niko, Tomohiro Haruta, Takeshi Imamura, Kentaro Shiraki, Tamotsu Zako
Sci Rep. 2022 May 20;12(1):8556. doi: 10.1038/s41598-022-12212-6.
PMID: 35595809 PMCID: PMC9123177 DOI: 10.1038/s41598-022-12212-6

PubMed

2022年

Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut

Yusuke Yoshimatsu, Tomohisa Sujino, Kentaro Miyamoto, Yosuke Harada, Shun Tanemoto, Keiko Ono, Satoko Umeda, Kosuke Yoshida, Toshiaki Teratani, Takahiro Suzuki, Yohei Mikami, Nobuhiro Nakamoto, Nobuo Sasaki, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Kazuaki Sawada, Takeshi Imamura, Akihiko Yoshimura, Takanori Kanai
Cell Rep. 2022 May 10;39(6):110773. doi: 10.1016/j.celrep.2022.110773.
PMID: 35545035 DOI:10.1016/j.celrep.2022.110773

PubMed

2022年

Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment

Hiroshi Tazawa, Kunitoshi Shigeyasu, Kazuhiro Noma, Shunsuke Kagawa, Fuminori Sakurai, Hiroyuki Mizuguchi, Hisataka Kobayashi, Takeshi Imamura, Toshiyoshi Fujiwara
Cancer Sci. 2022 Jun;113(6):1919-1929. doi: 10.1111/cas.15369. Epub 2022 Apr 18.Review
PMID: 35398956 PMCID: PMC9207361 DOI: 10.1111/cas.15369

PubMed