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Nature. 2011 Nov 27;480(7378):557-60.
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Imai Y, Kouzmenko A, Kato S
Targeting Fas/FasL signaling, a new strategy for maintaining bone health
Expert Opin Ther Targets 2011 Oct;15(10):1143-5.
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Manaka T, Suzuki A, Takayama K, Imai Y, Nakamura H, Takaoka K.
Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation.
Biomaterials. 2011 Dec;32(36):9642-8.
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Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS, Brown M.
Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer
Cancer Cell 2011 Jul 12;20(1):119-31.
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Okamoto M, Murai J, Imai Y, Ikegami D, Kamiya N, Kato S, Mishina Y, Yoshikawa H, Tsumaki N
Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice.
J Bone Miner Res. 2011 Oct;26(10):2511-22.
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Takahashi S, Watanabe T, Okada M, Inoue K, Ueda T, Takada I, Watabe T, Yamamoto Y, Fukuda T, Nakamura T, Akimoto C, Fujimura T, Hoshino M, Imai Y, Metzger D, Miyazono K, Minami Y, Chambon P, Kitamura T, Matsumoto T, Kato S.
A non-canonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4938-43
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Yasuda T, Kometani K, Takahashi N, Imai Y, Aiba Y, Kurosaki T.
ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation.
Sci Signal. 2011 Apr 19;4(169):ra25.
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Eguchi Y, Wakitani S, Imai Y, Naka Y, Hashimoto Y, Nakamura H, Takaoka K.
Antitumor necrotic factor agent promotes BMP-2-induced ectopic bone formation.
J Bone Miner Metab. 2010 Mar;28(2):157-64.
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Imai Y, Kondoh S, Kouzmenko A, Kato S.
Minireview: Osteoprotective Action of Estrogens Is Mediated by Osteoclastic Estrogen Receptor α
Mol Endocrinol. 2010 May;24(5):877-85.
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Kitano T, Imai Y, Morita M, Nakagawa K, Wada M, Sakai T, Eguchi Y, Kuroda T.
New treatment method for developmental dysplasia of the hips after walking age: arthroscopic reduction with limboplasty based on the findings of preoperative imaging.
J Orthop Sci. 2010 Jul;15(4):443-51.
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Takada I, Tsuji N, Youn MY, Fujiyama S, Okada M, Imai Y, Kondo S, Kitakawa H, Yasuda H, Kato S.
Purification and identification of estrogen receptor alpha co-regulators in osteoclasts.
Ann N Y Acad Sci. 2010 Mar;1192(1):201-7.
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Tokuhara Y, Wakitani S, Imai Y, Kawaguchi A, Fukunaga K, Kim M, Kadoya Y, Takaoka K.
Repair of experimentally induced large osteochondral defects in rabbit knee with various concentrations of Escherichia coli-derived recombinant human bone morphogenetic protein-2.
Int Orthop. 2010 Jun;34(5):761-7.
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Tokuhara Y, Wakitani S, Imai Y, Nomura C, Hoshino M, Yano K, Taguchi S, Kim M, Kadoya Y, Takaoka K.
Local delivery of rolipram, a phosphodiesterase-4-specific inhibitor, augments bone morphogenetic protein-induced bone formation.
J Bone Miner Metab. 2010;28(1):17-24.
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Youn MY, Fujiyama-Nakamura S, Takada I, Imai Y, Kato S.
Identification of osteoclastic factors in the nuclear envelope of mature, multinucleated osteoclasts
Biosci Biotechnol Biochem. 2010 Sep 23;74(9):1956-9.
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Youn MY, Takada I, Imai Y, Yasuda H, Kato S.
Transcriptionally active nuclei are selective in mature multinucleated osteoclasts
Genes Cells. 2010 Oct;15(10):1025-35.
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Dohzono S, Imai Y, Nakamura H, Wakitani S, Takaoka K.
Successful Spinal Fusion by E. coli-derived BMP-2-adsorbed Porous beta-TCP Granules: A Pilot Study.
Clin Orthop Relat Res. 2009 Dec;467(12):3206-12.
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Imai Y, Kondoh S, Kouzmenko A, Kato S.
Regulation of bone metabolism by nuclear receptors.
Mol Cell Endocrinol. 2009 Oct 30;310(1-2):3-10.
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Imai Y, Nakamura T, Matsumoto T, Takaoka K, Kato S.
Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism.
J Bone Miner Metab. 2009;27(2):127-30.
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Imai Y, Youn MY, Kondoh S, Nakamura T, Kouzmenko A, Matsumoto T, Takada I, Takaoka K, Kato S.
Estrogens Maintain Bone Mass by Regulating Expression of Genes Controlling Function and Life Span in Mature Osteoclasts
Ann N Y Acad Sci. 2009 Sep;1173 Suppl 1:E31-9.
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Kawaguchi A, Nakaya H, Okabe T, Tensho K, Nawata M, Eguchi Y, Imai Y, Takaoka K, Wakitani S.
Blocking of tumor necrosis factor activity promotes natural repair of osteochondral defects in rabbit knee.
Acta Orthop. 2009 Oct;80(5):606-11.
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Nakao Y, Koike T, Ohta Y, Manaka T, Imai Y, Takaoka K.
Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3′, 5′-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cells.
Bone. 2009 May;44(5):872-7.
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Takayama K, Suzuki A, Manaka T, Taguchi S, Hashimoto Y, Imai Y, Wakitani S, Takaoka K.
RNA interference for noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitro.
J Bone Miner Metab. 2009;27(4):402-11.
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Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K.
Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.
J Bone Miner Metab. 2009;27(3):355-63.
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Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H.
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Science. 2008 Feb 1;319(5863):624-7.
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Nomura-Furuwatari C, Wakitani S, Hashimoto Y, Imai Y, Ohta Y, Nakagawa K, Nakao Y, Takayama K, Manaka T, Takaoka K.
Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells.
J Bone Miner Metab. 2008;26(2):152-8.
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Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K.
Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB pathway.
J Bone Miner Metab. 2008;26(5):478-84.
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Oshimo T, Fukai K, Higashi N, Kitano T, Imai Y, Shintaku H, Ishii M.
A novel LMX1B nonsense mutation in a family with nail-patella syndrome.
J Dermatol Sci. 2008 Oct;52(1):57-60.
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Imai Y, Kitano T, Nakagawa K, Takaoka K.
Calcaneal apophyseal avulsion fracture.
Arch Orthop Trauma Surg. 2007 Jul;127(5):331-3.
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Nakagawa K, Imai Y, Ohta Y, Takaoka K.
Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation.
Bone. 2007 Oct;41(4):543-8.
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Nakamura T*, Imai Y*, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S. (*; These authors equally contributed to this work.)
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.
Cell. 2007 Sep 7;130(5):811-23.
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Sugama R, Koike T, Imai Y, Nomura-Furuwatari C, Takaoka K.
Bone morphogenetic protein activities are enhanced by 3′,5′-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells.
Bone. 2006 Feb;38(2):206-14.
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Imai Y, Terai H, Nomura-Furuwatari C, Mizuno S, Matsumoto K, Nakamura T, Takaoka K.
Hepatocyte growth factor contributes to fracture repair by upregulating the expression of BMP receptors.
J Bone Miner Res. 2005 Oct;20(10):1723-30.
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Ohta H, Wakitani S, Tensho K, Horiuchi H, Wakabayashi S, Saito N, Nakamura Y, Nozaki K, Imai Y, Takaoka K.
The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2.
J Bone Miner Metab.2005;23(6):420-5.
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Yoneda M, Terai H, Imai Y, Okada T, Nozaki K, Inoue H, Miyamoto S, Takaoka K.
Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant.
Biomaterials. 2005 Sep;26(25):5145-52.
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Sasaoka R, Terai H, Toyoda H, Imai Y, Sugama R, Takaoka K.
A prostanoid receptor EP4 agonist enhances ectopic bone formation induced by recombinant human bone morphogenetic protein-2.
Biochem Biophys Res Commun. 2004 Jun 4;318(3):704-9.
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Nakatsuka H, Takamatsu K, Koshimune M, Imai Y, Enomoto M, Yamano Y.
Experimental study of polarity in reversing cable nerve grafts.
J Reconstr Microsurg. 2002 Aug;18(6):509-15.
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