Multiplexed single‑cell pathology reveals the association of CD8 T‑cell heterogeneity with prognostic outcomes in renal cell carcinoma

Tetsushi Murakami, Nobuyuki Tanaka, Kimiharu Takamatsu, Kyohei Hakozaki, Keishiro Fukumoto, Tsukasa Masuda, Shuji Mikami, Toshiaki Shinojima, Kazuhiro Kakimi, Tatsuhiko Tsunoda, Kazuaki Sawada, Takeshi Imamura, Ryuichi Mizuno, Mototsugu Oya
Cancer Immunol Immunother. 2021 Oct;70(10):3001-3013. doi: 10.1007/s00262-021-03006-2. Epub 2021 Jul 14.
PMID: 34259900 DOI: 10.1007/s00262-021-03006-2

Wide Field Light-Sheet Microscopy with Lens-axicon Controlled Two-photon Bessel Beam Illumination

Sota Takanezawa, Takashi Saitou, Takeshi Imamura
Nat Commun. 2021 May 20;12(1):2979. doi: 10.1038/s41467-021-23249-y.
PMID: 34016994　PMCID: PMC8137944　DOI:10.1038/s41467-021-23249-y

Donor–acceptor–acceptor-type near-infrared fluorophores that contain dithienophosphole oxide and boryl groups: Effect of the boryl group on the nonradiative decay

Yoshiaki Sugihara, Naoto Inai, Thomas Baumgartner, Ryosuke Kawakami, Takashi Saitou, Takeshi Imamura, Masayasu Taki, Takeshi Yanai and Shigehiro Yamaguchi
Chem Sci. 2021 Mar 25;12(18):6333-6341. doi: 10.1039/d1sc00827g.
PMID: 34084431 PMCID: PMC8115064 DOI:10.1039/D1SC00827G

New fluorescent three-dimensional and deep-imaging technique confirms a direct relationship between the acrosyringium and vesicles/pustules of palmoplantar pustulosis

Masamoto Murakami, Ryosuke Kawakami, Yosuke Niko, Teruko Tsuda, Kazuki Yatsuzuka, Hideki Mori, Takeshi Imamura, Koji Sayama
J Dermatol Sci. 2021 May;102(2):130-132. doi: 10.1016/j.jdermsci.2021.03.004. Epub 2021 Mar 19.
PMID: 33810900 DOI: 10.1016/j.jdermsci.2021.03.004

Integrated Fluorescent Nanoprobe Design for High‐Speed In Vivo Two‐Photon Microscopic Imaging of Deep‐Brain Vasculature in Mice

A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

Junichi Kushioka, Takashi Kaito, Rintaro Okada, Hiroyuki Ishiguro, Zeynep Bal, Joe Kodama, Ryota Chijimatsu, Melanie Pye, Masahiro Narimatsu, Jeffrey L. Wrana, Yasumichi Inoue, Hiroko Ninomiya, Shin Yamamoto, Takashi Saitou, Hideki Yoshikawa, Takeshi Imamura
Bone Res. 2020 Nov 23;8(1):41. doi: 10.1038/s41413-020-00115-z.
PMID: 33298874　PMCID: PMC7680794 　DOI: 10.1038/s41413-020-00115-z

High-quality Fluorescence Imaging of the Human Acrosyringium Using a Transparency: Enhancing Technique and an Improved, Fluorescent Solvatochromic Pyrene Probe

Masamoto Murakami, Ryosuke Kawakami, Yosuke Niko, Teruko Tsuda, Hideki Mori, Kazuki Yatsuzuka, Takeshi Imamura, Koji Sayama
Acta Histochem Cytochem. 2020 Dec 25;53(6):131-138. doi: 10.1267/ahc.20-00020. Epub 2020 Nov 21.
PMID: 33437099 PMCID: PMC7785460 DOI: 10.1267/ahc.20-00020

Therapeutic effects of the PKR inhibitor C16 suppressing tumor proliferation and angiogenesis in hepatocellular carcinoma in vitro and in vivo

Takao Watanabe, Hiroko Ninomiya, Takashi Saitou, Sota Takanezawa, Shin Yamamoto, Yusuke Imai, Osamu Yoshida, Ryosuke Kawakami, Masashi Hirooka, Masanori Abe, Takeshi Imamura, Yoichi Hiasa
Sci Rep. 2020 Mar 20;10(1):5133. doi: 10.1038/s41598-020-61579-x.
PMID: 32198380  PMCID: PMC7083831 DOI: 10.1038/s41598-020-61579-x

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence

Chiharu Miyajima, Yuki Kawarada, Yasumichi Inoue, Chiaki Suzuki, Kana Mitamura, Daisuke Morishita, Nobumichi Ohoka, Takeshi Imamura, Hidetoshi Hayashi
Cells. 2020 Jan 9;9(1):171. doi: 10.3390/cells9010171.
PMID: 31936650 PMCID: PMC7016652  DOI: 10.3390/cells9010171

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network

Takeshi Ieda, Hiroshi Tazawa, Hiroki Okabayashi, Shuya Yano, Kunitoshi Shigeyasu, Shinji Kuroda, Toshiaki Ohara, Kazuhiro Noma, Hiroyuki Kishimoto, Masahiko Nishizaki, Shunsuke Kagawa, Yasuhiro Shirakawa, Takashi Saitou, Takeshi Imamura, Toshiyoshi Fujiwara
Sci Rep. 2019 Nov 8;9(1):16378. doi: 10.1038/s41598-019-52816-z.
PMID: 31705021  PMCID: PMC6841984   DOI: 10.1038/s41598-019-52816-z