運動器健康科学研究ユニットResearch Unit for Skeletal Health and Diseases

Outreach業績・報告

2022年度

Iwasa M, Ando W, Uemura K, Hamada H, Takao M, Sugano N.
Association between magnitude of femoral head collapse and quality of life in patients with osteonecrosis of the femoral head
Mod Rheumatol. 2023 Mar 2;33(2):416-421. doi: 10.1093/mr/roac023.

Saeki N, Imai Y.
Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
J Vis Exp. 2023 Feb 24;(192):e65196. doi: 10.3791/65196.

PubMed

Uemura K, Takao M, Otake Y, Takashima K, Hamada H, Ando W, Sato Y, Sugano N.
The effect of patient positioning on measurements of bone mineral density of the proximal femur: a simulation study using computed tomographic images
Arch Osteoporos. 2023 Feb 24;18(1):35. doi: 10.1007/s11657-023-01225-x.

PubMed

Yabu A, Suzuki A, Hayashi K, Hori Y, Terai H, Orita K, Habibi H, Salimi H, Kono H, Toyoda H, Maeno T, Takahashi S, Tamai K, Ozaki T, Iwamae M, Ohyama S, Imai Y, Nakamura H.
Periostin increased by mechanical stress upregulates interleukin-6 expression in the ligamentum flavum
FASEB J. 2023 Feb;37(2):e22726. doi: 10.1096/fj.202200917RR.

PubMed

Tani T, Takao M, Soufi M, Otake Y, Fukuda N, Hamada H, Uemura K, Sato Y, Sugano N.
Rotational-motion measurement of the sacroiliac joint using upright MRI scanning and intensity-based registration: is there a sex difference?
Int J Comput Assist Radiol Surg. 2023 Jan;18(1):79-84. doi: 10.1007/s11548-022-02806-w. Epub 2022 Dec 24.

PubMed

Iwasa M, Takao M, Soufi M, Uemura K, Otake Y, Hamada H, Sato Y, Sugano N, Okada S.
Artificial intelligence-based volumetric analysis of muscle atrophy and fatty degeneration in patients with hip osteoarthritis and its correlation with health-related quality of life
Int J Comput Assist Radiol Surg. 2023 Jan;18(1):71-78. doi: 10.1007/s11548-022-02797-8. Epub 2022 Dec 26.

PubMed

Iwasa M, Ando W, Uemura K, Hamada H, Takao M, Sugano N.
Is There an Association Between Femoral Head Collapse and Acetabular Coverage in Patients With Osteonecrosis?
Clin Orthop Relat Res. 2023 Jan 1;481(1):51-59. doi: 10.1097/CORR.0000000000002363. Epub 2022 Aug 29.

PubMed

Nakata T, Okada M, Nishihara E, Ikedo A, Asoh S, Takagi T, Tokunaga N, Hato N, Imai Y.
Effect of hormonal therapy on the otoconial changes caused by estrogen deficiency
Sci Rep. 2022 Dec 30;12:22596. doi: 10.1038/s41598-022-27240-5.

PubMed

Ochi R, Taniyama Y, Nishiwaki H, Nishi K, Sugahara T, Yamauchi S.
Syntheses of 6-(2-hydroxy-6-phenylhexyl)-5,6-dihydro-2H-pyran-2-one derivatives and their cytotoxicities
Phytochem Lett. 2022 Dec;52:118-121. doi: 10.1016/j.phytol.2022.10.002.

Asaoka R, Kiyomatsu H, Miura H, Jono A, Kinoshita T, Takao M, Katagiri T, Oshima Y.
Prognostic potential and pathological validation of a diagnostic application using Raman spectroscopy in the characterization of degenerative changes in the cartilage of the humeral head
J Biomed Opt. 2022 Nov;27(11):115002. doi: 10.1117/1.JBO.27.11.115002.

PubMed

Kutsuna T, Hino K, Hasegawa H, Watamori K, Kidani T, Imai H, Miura H.
Psoriatic arthritis successfully treated with second-line anti-interleukin-6 treatment: a case report and review of the literature
J Med Case Rep. 2022 Nov 3;16(1):402. doi: 10.1186/s13256-022-03624-z.

PubMed

Uemura K, Takao M, Otake Y, Iwasa M, Hamada H, Ando W, Sato Y, Sugano N.
The Effect of Region of Interest on Measurement of Bone Mineral Density of the Proximal Femur: Simulation Analysis Using CT Images
Calcif Tissue Int. 2022 Nov;111(5):475-484. doi: 10.1007/s00223-022-01012-9. Epub 2022 Jul 29.

PubMed

Iwasa M, Hamada H, Uemura K, Ando W, Takao M, Sugano N.
Errors in the radiographic measurement of pelvic incidence
J Orthop Res. 2022 Nov 1. doi: 10.1002/jor.25477. Online ahead of print.

PubMed

Ogata T, Yamada K, Miura H, Hino K, Kutsuna T, Watamori K, Kinoshita T, Ishibashi Y, Yamamoto Y, Sasaki T, Matsuda S, Kuriyama S, Watanabe M, Tomita T, Tamaki M, Ishibashi T, Okazaki K, Mizu-Uchi H, Ishibashi S, Ma Y, Ito YM, Nakamura K, Tanaka S.
Feasibility and applicability of locomotive syndrome risk test in elderly patients who underwent total knee arthroplasty
Mod Rheumatol. 2022 Nov 1;roac131. doi: 10.1093/mr/roac131. Online ahead of print.

PubMed

Ohara R, Sugahara T, Sugie Y, Onda H, Yoshino N, Nishi K, Ishida M, Kikuzaki H.
Identification of components in coriander (Coriandrum sativum L.) inhibiting degranulation of RBL-2H3 cells
Fitoterapia. 2022 Nov;163:105298. doi: 10.1016/j.fitote.2022.105298.

PubMed

Ishida M, Miyagawa F, Nishi K, Sugahara T.
Aqueous extract from Cuminum cyminum L. seed alleviates ovalbumin-induced allergic rhinitis in mouse via balancing of helper T cells
Foods. 2022 Oct 15;11(20):3224. doi: 10.3390/foods11203224.

Kamihata S, Ando W, Takao M, Hamada H, Uemura K, Sugano N.
Effect of Hip Flexion Contracture on the Pelvic Sagittal Tilt in the Supine Position: A Retrospective Case-Series Study
Mod Rheumatol. 2022 Sep 9:roac110. doi: 10.1093/mr/roac110. Online ahead of print.

PubMed

Yoshioka H, Komura S, Kuramitsu N, Goto A, Hasegawa T, Amizuka N, Ishimoto T, Ozasa R, Nakano T, Imai Y, Akiyama H.
Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in spontaneous bone fractures
J Bone Miner Metab. 2022 Sep;40(5):839-852. doi: 10.1007/s00774-022-01354-2.

PubMed

Hamada H, Uemura K, Takashima K, Ando W, Takao M, Sugano N.
What Changes in Pelvic Sagittal Tilt Occur 20 Years After THA?
Clin Orthop Relat Res. 2022 Aug 30. doi: 10.1097/CORR.0000000000002382. Online ahead of print.

PubMed

Ando W, Takao M, Tani T, Uemura K, Hamada H, Sugano N.
Geographical distribution of the associated factors of osteonecrosis of the femoral head, using the designated intractable disease database in Japan
Mod Rheumatol. 2022 Aug 20;32(5):1006-1012. doi: 10.1093/mr/roab065.

PubMed

Okano S, Kiyokane Y, Kobayashi S, Okamoto T.
Effects of heat treatment of various pure metals on osteoblast cell activity
J. Mater. Res. 2022 Aug 18;37:2614-2622.

Matsumoto S, Ochi M, Akechi Y, Takei S, Senzaki K, Okada Y, Miura S, Ochi H, Igase M, Ohyagi Y. Dermal advanced glycation end-product accumulation is associated with sarcopenia-related measures in middle-aged and older men.
Arch Gerontol Geriatr. 2022; 101: 104704. doi: 10.1016/j.archger.2022.104704.

PubMed

Kitamura Y, Nishi K, Ishida M, Nishimoto S, Sugahara T.
Anti-allergic effect of aqueous extract of coriander (Coriandrum sativum L.) leaf in RBL-2H3 cells and cedar pollinosis model mice
Nutraceuticals. 2022 Jul 26;2(3):170-180. doi: 10.3390/nutraceuticals2030013.

Satake T, Komura S, Aoki H, Hirakawa A, Imai Y, Akiyama H.
Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells
BMC Mol Cell Biol. 2022 Jul 23;23:30. doi: 10.1186/s12860-022-00431-8.

PubMed

Nakamura Y, Saitou M, Komura S, Matsumoto K, Ogawa H, Miyagawa T, Saitou T, Imamura T, Imai Y, Takayanagi H, Akiyama H.
Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis
Sci Rep. 2022 Jul 16;12(1):12207. doi: 10.1038/s41598-022-16585-6.

PubMed

Sato R, Ando W, Fukushima W, Sakai T, Hamada H, Takao M, Ito K, Sugano N.
Epidemiological study of osteonecrosis of the femoral head using the national registry of designated intractable diseases in Japan
Mod Rheumatol. 2022 Jul 1;32(4):808-814. doi: 10.1093/mr/roab047.

PubMed

Himeno A, Tsujikami M, Koizumi S, Watanabe T, Igase M.
Effect of Reducing Pigmentation by Collagen Peptide Intake: A Randomized, Double-Blind, Placebo-Controlled Study
Dermatol Ther (Heidelb). 2022 ;12: 1577-1587. doi: 10.1007/s13555-022-00748-4.

PubMed

Ishida M, Ohara R, Miyagawa F, Kikuzaki H, Nishi K, Onda H, Yoshino N, Sugahara T.
Umbelliferose isolated from Cuminum cyminum L. seeds inhibits antigen-induced degranulation in rat basophilic leukemia RBL-2H3 cells
Molecules. 2022 Jun 25;27(13):4101. doi: 10.3390/molecules27134101.

PubMed

Enami H, Nakahara I, Ando W, Uemura K, Hamada H, Takao M, Sugano N.
Osteocompatibility of Si(3)N(4)-coated carbon fiber-reinforced polyetheretherketone (CFRP) and hydroxyapatite-coated CFRP with antibiotics and antithrombotic drugs
J Artif Organs. 2022 Jun 21. doi: 10.1007/s10047-022-01340-5. Online ahead of print.

PubMed

Saeki N, Inoue K, Ideta-Otsuka M, Watamori K, Mizuki S, Takenaka K, Igarashi K, Miura H, Takeda S, Imai Y.
Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner
J Clin Invest. 2022 Jun 1;132(11):e150533. doi: 10.1172/JCI150533.

PubMed

Harjadi KR, Ishida M, Nishi K, Sugahara T, Putra ABN.
Water and ethanol extracts of tamarind (Tamarindus indica) suppress lipid accumulation in 3T3-L1 cells
Canrea J Food Technol Nutr Culin J. 2022 Jun 1;5(1)1-11. doi: 10.20956/canrea.v5i1.630.

Nishikawa A, Tanaka K, Miyake Y, Nagata C, Furukawa S, Andoh A, Yokoyama T, Yoshimura N, Mori K, Ninomiya T, Yamamoto Y, Takeshita E, Ikeda Y, Saito M, Ohashi K, Imaeda H, Kakimoto K, Higuchi K, Nunoi H, Mizukami Y, Suzuki S, Hiraoka S, Okada H, Kawasaki K, Higashiyama M, Hokari R, Miura H, Miyake T, Kumagi T, Kato H, Hato N, Sayama K, Hiasa Y; Japan Ulcerative Colitis Study Group.
Active and passive smoking and risk of ulcerative colitis: A case-control study in Japan
J Gastroenterol Hepatol. 2022 Apr;37(4):653-659. doi: 10.1111/jgh.15745. Epub 2021 Dec 13.

PubMed

Fujibuchi T, Imai H, Kidani T, Miura H.
Effective examination methods for identifying the primary origins of metastatic bone tumors of unknown primary origin during the initial visit: A retrospective chart review study
SAGE Open Med. 2022 May 24;10:20503121221097582. doi: 10.1177/20503121221097582. eCollection 2022.

PubMed

Kusunoki H, Tabara Y, Tsuji S, Wada Y, Tamaki K, Nagai K, Itoh M, Sano K, Amano M, Maeda H, Sugita H, Hasegawa Y, Kishimoto H, Shimomura S, Igase M, Shinmura K.
Estimation of Muscle Mass Using Creatinine/Cystatin C Ratio in Japanese Community-Dwelling Older People.
J Am Med Dir Assoc. 2022; 23: 902.e21-902.e31. doi: 10.1016/j.jamda.2021.07.029.

PubMed

Adachi R, Nishihara T, Morino T, Sekiya K, Kitamura S, Konishi A, Takasaki Y, Miura H, Abe N, Yorozuya T.
Hemodynamic deterioration due to increased anterior and posterior cardiac compression during posterior spinal fusion for scoliosis with pectus excavatum
SAGE Open Med Case Rep. 2022 May 10;10:2050313X221090848. doi: 10.1177/2050313X221090848. eCollection 2022.

PubMed

Ishida M, Takekuni C, Nishi K, Sugahara T.
p-Synephrine suppresses inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and alleviates systemic inflammatory response syndrome in mice
Food Funct. 2022 May 10;13(9):5229-5239. doi: 10.1039/d2fo00299j.

PubMed

Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Della Briotta Parolo P, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen ME, Jørgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinger T, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Orozco L, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Schönherr S, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stančáková A, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wacher-Rodarte N, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yengo L, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W; FinnGen; eMERGE Consortium, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Hanis CL, Peyser PA, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Zeggini E, Yokota M, Rich SS, Kooperberg C, Pankow JS, Engert JC, Chen YI, Froguel P, Wilson JG, Sheu WHH, Kardia SLR, Wu JY, Hayes MG, Ma RCW, Wong TY, Groop L, Mook-Kanamori DO, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, McKean-Cowdin R, Grallert H, Cheng CY, Bottinger EP, Dehghan A, Tai ES, Dupuis J, Kato N, Laakso M, Köttgen A, Koh WP, Palmer CNA, Liu S, Abecasis G, Kooner JS, Loos RJF, North KE, Haiman CA, Florez JC, Saleheen D, Hansen T, Pedersen O, Mägi R, Langenberg C, Wareham NJ, Maeda S, Kadowaki T, Lee J, Millwood IY, Walters RG, Stefansson K, Myers SR, Ferrer J, Gaulton KJ, Meigs JB, Mohlke KL, Gloyn AL, Bowden DW, Below JE, Chambers JC, Sim X, Boehnke M, Rotter JI, McCarthy MI, Morris AP.
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Nat Genet. 2022; 54: 560-572. doi: 10.1038/s41588-022-01058-3.

PubMed
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