1．Yamaguchi, T., Kanatsuka, A., Makino, H., Ohsawa, H., and Yoshida, S.
Dual mechanism involved in the hydrolysis of polyphosphoinositides in rat pancreatic islets. Endocrinology 124: 1870-1874, 1989.

2．Ohsawa, H., Kanatsuka, A., Yamaguchi, T., Makino, H., and Yoshida, S.
Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets. Biochem Biophys Res Commun 160: 961-967, 1989

3．Kanatsuka, A., Makino, H., Ohsawa, H., Tokuyama, Y., Yamaguchi, T., Yoshida, S., and Adachi, M.
Secretion of islet amyloid polypeptide in response to glucose. FEBS Lett 259: 199-201, 1989.

4．Ohsawa, H., Kanatsuka, A., Tokuyama, Y., Yamaguchi, T., Makino, H., Yoshida, S., Horie, H., Mikata, A., and Kohen, Y.
Amyloid protein in somatostatinoma differs from human islet amyloid polypeptide. Acta Endocrinol (current Eur J Endocrinol) 124: 45-53, 1991.

5．Tokuyama, Y., Kanatsuka, A., Ohsawa, H., Yamaguchi, T., Makino, H., Yoshida, S., Nagase, H., and Inoue, S
. Hypersecretion of islet amyloid polypeptide from pancreatic islets of ventromedial hypothalamic-lesioned rats and obese Zucker rats. Endocrinology 128: 2739-2744, 1991.

6．Ohsawa, H., Kanatsuka, A., Mizuno, Y., Tokuyama, Y., Takada, K., Mikata, T., Makino, H., and Yoshida, S.
Islet amyloid polypeptide-derived amyloid deposition increases along with duration of type 2 diabetes mellitus. Diabetes Res Clin Pract 15: 17-22, 1992.

7．Tokuyama, Y., Kanatsuka, A., Ohsawa, H., Yamaguchi, T., Makino, H., Yoshida, S., Nagase, H., and Inoue, S.
Hypersecretion of IAPP from the islets of VMH-lesioned rats and obese Zucker rats. Diabetes Res Clin Pract 15: 23-29, 1992.

8．Kanatsuka, A., Makino, H., Yamaguchi, T., Ohsawa, H., Tokuyama, Y., Saitoh, T., Yamamura, K., Miyazaki, J., and Yoshida, S.
Islet amyloid polypeptide/amylin in pancreatic b-cell line derived from transgenic mouse insulinoma. Diabetes 41: 1409-1414, 1992.

9．Tokuyama, Y., Kanatsuka, A., Yamaguchi, T., Ohsawa, H., Makino, H., Nishimura, M., and Yoshida, S.
Islet amyloid polypeptide/amylin contents in pancreata increase in genetically obese and diabetic mice. Horm Metab Res 25: 289-291, 1993. 31

10. O’Doherty, R.M., Bracy, D.P., Osawa, H., Wasserman, D.H., and Granner, D.K.
Rat skeletal muscle hexokinase II mRNA and activity are increased by a single bout of exercise. Am J Physiol 266 (Endocrinol Metab) 29: E171-E178, 1994.

11. Yagui, K., Yamaguchi, T., Kanatsuka, A., Shimada, F., Huang, C.I., Tokuyama, Y., Ohsawa, H., Yamamura, K., Miyazaki, J, Mikata, A., Yoshida, S., and Makino, H.
Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin. Eur J Endocrinol 132: 487-496, 1995.

12. Osawa, H., Printz, R.L., Whitesell, R.R., and Granner, D. K.
Regulation of hexokinase II gene transcription and glucose phosphorylation by catecholamines, cyclic AMP, and insulin. Diabetes 44: 1426-1432, 1995.

13. Mandarino, L.J., Printz, R.L., Cusi, K.A., Kinchington, P., O’Doherty, R.M., Osawa, H., Sewell, C., Consoli, A., Granner, D.K., and Defronzo, R.A.
Regulation of hexokinase II and glycogen synthase mRNA, protein, and catalytic activity in human muscle. Am J Physiol 269 (Endocrinol Metab) 32: E701-708, 1995.

14. Robey, R.B., Osawa, H., Printz, R.L., and Granner, D.K.
A simple and efficient method for transient gene transfer into myotubes following differentiation in culture. BioTechniques 20: 40-42, 1996.

15 Osawa, H., Sutherland, C., Robey, R.B., Printz, R.L., and Granner, D.K.
Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin. J Biol Chem 271: 16690-16694, 1996.

16. Osawa, H., Robey, R.B., Printz, R.L., and Granner, D.K.
Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat hexokinase II gene. J Biol Chem 271: 17296-17303, 1996.

17. Onuma, H., Makino, H., Osawa, H., Suzuki, Y., Taira, M., Kanatsuka, A., and Saito, Y.
Mitogen-activated protein kinase and p70 ribosomal protein S6 kinase are not involved in the insulin-dependent stimulation of cAMP phosphodiesterase kinase in rat adipocytes. Biochim Biophys Acta (Molecular Cell Research)1402: 197-208, 1998.

18. Yamada, K., Wang, J.-C., Osawa, H., Printz, R. L., Granner, D. K.
A method for the efficient transformation of yeast. BioTechniques 24: 596-600, 1998.

19. Tang Y., Osawa, H., Onuma, H., Nishimiya, T., Ochi, M., and Makino, H.
Improvement in insulin resistance and the restoration of reduced PDE3B gene expression by pioglitazone in adipose tissue of obese, diabetic KKAy mouse. Diabetes 48: 1830-1835, 1999.

20. Yamada, K., Printz, R. L., Osawa, H., Granner, D. K.
Human ZHX1: Cloning, chromosomal location, and interaction with transcription factor NF-Y. Biochem Biophys Res Commun 261: 614-621, 1999.

21. Niiya, T., Osawa, H., Bando, S., Oto, Y., Tokuda, K., Takeda, N., Sumioka, M., Murase, M., Kida, K., and Makino, H.
A complete deficiency of coagulation factor XIII A-subunit due to a novel compound heterozygote of Ser 413 Leu missense and an nt 389 (ins G) frame shift mutations. Br J Haematol 107: 772-775, 1999.

22. Yamada, K., Osawa, H., and Granner D.K.
Identification of proteins that interact with NF-YA. FEBS Lett 460: 41-45, 1999.

23. Wang, J-C., Waltner, L.M., Yamada, K., Osawa, H., Stifiani, S., and Granner, D.K.
Transducin-like enhancer of split proteins, the human homologs of drosophila groucho, interact with hepatic nuclear factor 3_. J Biol Chem 275: 18418-18423, 2000.

24. Osawa, H., Nishimiya, T., Ochi, M., Onuma, H., Niiya, T., Kitamuro, F., Kaino, Y., Kida, K., and Makino, H.
Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin resistant patients. Clin Genet 59: 194-197, 2001.

25. Tang, Y., Osawa, H., Onuma, H., Hasegawa, M., Nishimiya, T., Ochi, M., Sugita, A, and Makino, H.
Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in obese, diabetic KKAy mouse. Eur J Endocrinol 145: 93-99, 2001.

26. Tang, Y., Osawa, H., Onuma, H., Nishimiya, T., Ochi, M., Sugita, A, and Makino, H.
Phosphodiesterase 3B gene expression is enhanced in the liver but reduced in the adipose tissue of obese insulin-resistant db/db mouse. Diabetes Res Clin Pract 54: 145-155, 2001.

27. Osawa, H., Onuma, H., Murakami, A., Ochi, M., Nishimiya, T., Kato, K., Shimizu, I., Fujii, Y., Ohashi, J., and Makino, H.
Systematic search for single nucleotide polymorphisms in the insulin gene: Evidence for a high frequency of g.-23T>A in Japanese subjects. Biochem Biophys Res Commun 286: 451-455, 2001.

28. Niiya, T., Osawa, H., Onuma, H., Suzuki, Y., Taira, M., Yamada, K., and Makino, H.
Activation of mouse phosphodiesterase 3B promoter by adipocyte differentiation in 3T3-L1 cells. FEBS Lett 505:136-140, 2001.

29. Osawa, H., Ochi, M., Nishimiya, T., Onuma, H., Nakamaru, K., Murakami, A, Kato, K., Shimizu, I., Fujii, Y., Ohashi, J., and Makino, H.
A systematic search for single nucleotide polymorphisms (SNPs) in the insulin receptor gene: Association of an sSNP with hyperlipidemia in Japanese type 2 diabetic subjects. Clin Genet 60:479-481, 2001.

30. Osawa, H., Onuma, H., Murakami, A., Ochi, M., Nishimiya, T., Kato, K., Shimizu, I., Fujii, Y., Ohashi, J., and Makino, H.
Systematic search for single nucleotide polymorphisms in the resistin gene: The absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes. Diabetes 51:863-866, 2002.

31. Takeda, H., Kawasaki, E., Shimizu, I., Konoue, E., Fujiyama, M., Murao, S., Tanaka, K., Mori, K., Tarumi,Y., Seto, I., Fujii,Y., Kato, K., Kondo, S., Takada,Y., Kitsuki, N., Kaino, Y., Kida, K., Hashimoto, N., Yamawaki, T., Onuma, H., Nishimiya, T., Osawa, H., Saito, Y., and Makino, H.
Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study). Diabetes Care 25:995-1001, 2002.

32. Kawasaki, E., Osawa H., Makino, H., and Ehime Diabetes Study Group.
The clinical heterogeneity of adult-onset diabetic patients with GAD autoantibodies in Japan: Response to Fukui et al. (Letter) Diabetes Care 25: 2364-5, 2002.

33. Hasegawa, M., Tang Y., Osawa, H., Onuma, H., Nishimiya, T., Ochi, M., Terauchi, Y., Kadowaki, T., and Makino, H.
Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice. Diabetes Res Clin Pract 58: 79-85, 2002.

34. Onuma, H., Osawa, H., Yamada, K., Ogura, T., Tanabe, F., Granner, D. K., and Makino, H.
Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 _ protein. Diabetes 51: 3362-3367, 2002.

35. Osawa, H., Onuma, H., Murakami, A., Ochi, M., Nishimiya, T., Kato, K., Shimizu, I., Fujii, Y., Ohashi, J., and Makino, H.
Systematic search for single nucleotide polymorphisms in the FOXC2 gene: The absence of evidence for the association of three frequent single nucleotide polymorphisms and four common haplotypes with Japanese type 2 diabetes. Diabetes 52: 562-567, 2003.

36. Osawa, H., Niiya, T., Onuma, H., Murakami A., Ochi, M., Nishimiya, T., Kato, K., Shimizu, I., Fujii, Y., Ohashi, J., Yamada, K., Liang, S.-J., Manganiello, V.C., Fujita-Yamaguchi, Y., Makino, H.
Systematic search for single nucleotide polymorphisms in the 5′ flanking region of the human phosphodiesterase 3B gene: Absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes. Mol Genet Metab 79: 43-51, 2003.

37. Ogura, T., Osawa, H., Tang, Y., Onuma, H., Ochi, M., Nishimiya, T., Kubota, N., Terauchi, Y., Kadowaki, T., and Makino, H.
Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor _ (+/-) mice independent of adipocyte size. FEBS Lett 542: 65-68, 2003.

38. Ochi, M., Osawa, H., Onuma, H., Murakami, A., Nishimiya, T., Shimada, F., Kato, K., Shimizu, I., Shishino, K., Murase, M., Fujii, Y., Ohashi, J., and Makino, H.
The absence of evidence for major effects of the frequent SNP 299G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes. Diabetes Res Clin Pract 61: 191-198, 2003.

39. Shimizu I., Makino, H., Osawa, H., Kounoue, E., Imagawa, A., Hanafusa, T., Kawasaki, E., and Fujii, Y.
Association of fulminant type 1 diabetes with pregnancy. Diabetes Res Clin Pract 62: 33-38, 2003.

40. Osawa, H., Yamada, K., Onuma, H., Murakami, A., Ochi, M., Kawata, H., Nishimiya, T., Niiya, T., Shimizu, I., Nishida, W., Hashiramoto, M., Kanatsuka, A., Fujii, Y., Ohashi, J., and Makino, H.
The G/G Genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am J Hum Genet 75: 678-686, 2004.

41. Murao, S., Makino, H., Kaino, Y., Konoue, E., Ohashi, J., Kida, K., Fujii, Y., Shimizu, I., Kawasaki, E., Fujiyama, M., Kondo, S., Tanaka, K., Tarumi, Y., Seto, I., Kato, K., Ohno, K., Kusunoki, Y., Ebisui, O., Takada, Y., Tanabe, K., Takemoto, K., Onuma, H., Nishimiya, T., and Osawa, H.
Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients. Diabetes 53: 2684-90, 2004.

42. Osawa H., Onuma, H., Ochi, M., Murakami, A.,Yamauchi, J., Takasuka, T., Tanabe, F., Shimizu, I., Kato, K., Nishida, W., Yamada. K., Tabara, Y., Yasukawa, M., Fujii, Y., Ohashi, J., Miki, T., and Makino, H.
Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes. Biochem Biophys Res Commun 335: 596-602, 2005.

43. Shishino K, Yoshioka Y, Hashimoto K, Ochi M, Aono K, Murase M, Osawa H, Makino H, and Saheki S.
A simple precipitation method for measuring sialic acid in apolipoprotein B-containing lipoproteins in plasma. Ann Clin Biochem 42: 298-300, 2005.

44. Onuma, H., Osawa, H., Ogura, T., Tanabe, F., Nishida, W., and Makino, H.
A newly identified 50 kDa protein which is associated with phosphodiesterase 3B is phosphorylated by insulin in rat adipocytes. Biochem Biophys Res Commun 337: 976-982, 2005.

45. Tokuyama, Y., Osawa, H., Ishizuka, T., Onuma, H., Matsui, K., Egashira, T., Makino, H., and Kanatsuka, A.
Serum resistin level is associated with insulin sensitivity in Japanese type 2 diabetes. Metabolism 56: 693-698, 2007.

46. Osawa H., Ochi M., Kato, K., Yamauchi, J., Nishida, W., Takata, Y., Kawamura, R., Onuma, H., Takasuka, T., Shimizu, I., Fujii, Y., Ohashi, J., and Makino, H.
Serum resistin is associated with the severity of microangiopathies in type 2 diabetes. Biochem Biophys Res Commun 355: 342-346, 2007.

47. Osawa H., Tabara, Y., Kawamoto, R., Ohashi, J., Ochi, M., Onuma, H., Nishida, W., Yamada, K., Nakura, J., Kohara, K., Miki, T., and Makino, H.
Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high sensitivity C-reactive protein in the Japanese general population. Diabetes Care 30: 1501-1506, 2007.

48. Ochi, M., Osawa, H., Hirota, Y., Hara, K., Tabara, Y., Tokuyama, Y., Shimizu, I., Kanatsuka, A., Fujii, Y., Ohashi, J., Miki, T., Nakamura, N., Kadowaki, T., Itakura, M., Kasuga, M., and Makino, H.
Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes. Diabetes 56: 2834-8, 2007.

49. Tabara, Y., Kawamoto, R., Osawa, H., Nakura, J., Makino, H., Miki, T., Kohara, K.
No association of INSIG2 gene rs7566605 polymorphism with being overweight in Japanese population. Obesity 16: 211-215, 2008.

50. Nakamura, M., Nishida, W., Yamada, Y., Chujo, D., Watanabe, Y., Imagawa, A., Hanafusa, T., Kawasaki, E., Onuma, H., Osawa, H., and Makino, H.
Insulin administration triggers pancreatic _-cell destruction in patients with type 2 diabetes. Diabetes Res Clin Pract 79: 220-229, 2008.

51. Kato K., Osawa, H., Ochi, M., Kusunoki, Y., Ebisui, O., Ohno, K., Shimizu, I., Ohashi, J., Fujii, Y., Tanimoto, M., and Makino, H.
Serum total and high molecular weight adiponectin is correlated with the severity of diabetic retinopathy and nephropathy. Clin Endocrinol 68: 442-449, 2008.

52. Osawa, H., Ochi, M., Tabara. Y., Kato, K., Onuma, H., Nishida, W., Takata, Y., Yamauchi, J., Kawamura, R., Shimizu, I., Fujii, Y., Miki, T., Ohashi, J., and Makino, H.
Serum resistin is positively associated with the accumulation of metabolic syndrome factors in type 2 diabetes. Clin Endocrinol 69: 74-80, 2008.

53. Yamauchi, J., Osawa, H., Takasuka, T., Ochi, M., Murakami, A., Nishida, W., Takata, Y., Onuma, H., Tabara, Y., Miki, T., Ohashi, J., and Makino, H.
Serum resistin is reduced by glucose and meal loading in healthy human subjects. Metabolism 57: 149-156, 2008.

54. Tabara, Y., Osawa H., Kawamoto, R., Imori, R., Yamamoto, M., Nakura, J., Miki, T., Makino, H., and Kohara, K.
Reduced high-molecular weight adiponectin and elevated hsCRP are synergistic risk factors for metabolic syndrome in a large scale middle-aged to elderly population: The J-SHIPP study. J Clin Endocrinol Metab 93: 715-722, 2008.

55. Tabara, Y., Igase, M., Osawa, H., Makino, H., Miki, T., and Kohara, K.
Resistin, GFR and insulin resistance. (Letter) Hypertension 51: e11, 2008.

56. Osawa, H., Yamada, K., Tabara, Y., Ochi, M., Onuma, H., Nishida, W., Shimizu, I., Kawamoto, R., Fujii, Y., Miki, T., Ohashi, J., and Makino, H.
The G/G genotype of single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2_. Clin Endocrinol 69: 36-44, 2008.

57. Miyake, K., Horikawa, Y., Hara, K., Yasuda, K., Osawa, H., Furuta, H., Hirota, Y., Yamagata, K., Hinokio, Y., Oka, Y., Iwasaki, N., Iwamoto, Y., Yamada, Y., Seino, Y., Maegawa, H., Kashiwagi, A., Yamamoto, K., Tokunaga, K., Takeda, J., Makino, H., Nanjo, K., Kadowaki, T., and Kasuga, M.
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J Hum Genet 53: 174-180, 2008.

58. Takata, Y., Osawa, H., Kurata, M., Kurokawa, M., Yamauchi, J., Ochi, M., Nishida, W., Okura, T., Higaki, J., and Makino, H.
Hyperresistinemia is associated with coexistence of hypertension and type 2 Diabetes. Hypertension 51: 534-539, 2008.

59. Murao, S., Kondoh, S, Ohashi, J., Fujii, Y., Shimizu, I., Fujiyama, M., Ohno, K., Takata, Y., Nakai, K., Yamane, Y., Osawa, H., and Makino, H.
Anti-thyroid peroxidase antibody, IA-2 antibody, and fasting C-peptide predict beta cell failure in patients with latent autoimmune diabetes in adults (LADA) -a five year follow-up of the Ehime study- Diabetes Res Clin Pract 80: 114-21, 2008.

60. Murao, S., Imagawa, A., Kawasaki, E., Yokota, K., Yamashita, T., Sekikawa, T., Osawa, H., Hanafusa, T., and Makino, H.
Pancreas histology and a longitudinal study of insulin secretion in a Japanese LADA (Latent Autoimmune Diabetes in Adult) patient. (letter) Diabetes Care 31: e69, 2008.

61. Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H., Hirota, Y., Mori, H., Jonsson, A., Sato, Y., Yamagata, K., Hinokio, Y., He-Yao Wang, H.-Y., Tanahashi, T., Nakamura, N., Oka, Y., Iwasaki, N., Iwamoto, Y., Yamada, Y., Seino, Y., Maegawa, H., Kashiwagi, A., Jun Takeda, J., Maeda, E., Shin, H.D., Young Min Cho, Y.M., Park, K.S., Hong Kyu Lee, H.K., Ng, M.C.Y., Ma, R.C.W., Wing-Yee So, W.-Y., Juliana C N Chan, J.C.N., Lyssenko, V., Tuomi, T., Nilsson, P., Groop, L., Kamatani, N., Sekine, A., Nakamura, Y., Yamamoto, K., Yoshida, T., Tokunaga, K., Itakura, M., Makino, H., Nanjo, K., Kadowaki, T., and Kasuga, M.
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40:1092-7, 2008.

62. Osawa, H., Tabara, Y., Kawamoto, R., Ohashi, J., Ochi, M., Onuma, H., Nishida, W., Yamada, K., Nakura, J., Miki, T., Makino, H., and Kohara, K.
The PPARg Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population. Clin Endocrinol 71: 341?345, 2009.

63. Tabara, Y., Osawa, H., Kawamoto, R., Onuma, H., Shimizu, I., Miki, T., Kohara, K., and Makino, H.
Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes 58: 493-8, 2009.

64. Miyake, K., Yang, W., Hara, K., Yasuda,K., Horikawa, Y., Osawa, H., Furuta, H., Ng, M.C.Y., Hirota, Y., Mori, H., Ido, K., Yamagata, K., Hinokio, Y., Oka, Y., Iwasaki, N., Iwamoto, Y., Yamada, Y., Seino, Y., Maegawa, H., Kashiwagi, A., Wang, H., Tanahashi, T., Nakamura, N., Takeda, J., Maeda, E., Yamamoto, K., Tokunaga, K., Ma, R.C.W., So, W.-Y., Chan, J.C.N., Kamatani, N., Makino, H., Nanjo, K., Kadowaki, T., and Kasuga, M.
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on eleven genes with strong evidence of the Association. J Hum Genet54: 236-241, 2009.

65. Tabara, Y., Osawa, H., Guo, H., Kawamoto, R., Onuma, H., Shimizu, I., Takara, Y., Nishida, Y., Yamamoto, M., Makino, H., Kohara, K., and Miki, T.
Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study. Int J Obesity 33: 1243-8, 2009.

66. Makino, H., Shimizu, I., Murao, S., Kondo, S., Tabara, Y., Fujiyama, M., Fujii, Y., Takada, Y., Nakai, K., Izumi, K., Ohashi, J., Kawamura, R., Yamauchi, J., Takata, Y., Nishida, W., Hashiramoto, M., Onuma, H., and Osawa, H.
A pilot study suggests that the G/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes. Endocr J 56: 1049-1058, 2009.

67. Osawa, H., Doi, Y., Makino, H., Ninomiya, T., Yonemoto, K., Kawamura, R., Hata, J., Tanizaki, Y., Iida, M., and Kiyohara, Y.
Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study. Cardiovasc Diabetol 8: 60-67, 2009 (designatad as”highly accessed”on line).

68. Kawabata, Y., Ikegami, H., Awata, T., Imagawa, A., Maruyama, T., Kawasaki, E., Tanaka S., Shimada, A., Osawa, H., Kobayashi, T., Hanafusa, T., Tokunaga, K., Makino, H.
Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly-progressive and acute-onset type 1 diabetes. Diabetologia 52: 2513-2521, 2009.

69. Osawa, H., Tabara, Y., Ohashi, J., Kawamura, R., Onuma, H., and Makino, H.
Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population? (Letter) Diabetologia 53:795-797, 2010.

70. Okamoto, K., Iwasaki, N., Nishimura, C., Doi, K., Noiri, E., Nakamura, S., Takizawa, M., Ogata, M., Fujimaki, R., Grarup, N., Pisinger, C., Borch-Johnsen, K., Lauritzen, T., Sandbaek, A., Hansen, T., Yasuda, K., Osawa, H., Nanjo, K., Kadowaki, T., Kasuga, M., Pedersen, O., Fujita, T., Kamatani, N., Iwamoto, Y., and Tokunaga, K.
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Am J Hum Genet 86: 1-11, 2010.

71. Onuma, H., Tabara, Y., Kawamura, R., Tanaka, T., Ohashi, J., Nishida, W., Takata, Y., Ochi, M., Yamada, K., Kawamoto, R., Kohara, K., Miki, T., Makino, H., and Osawa, H.
A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population. PLoS ONE 5: e9718, 2010.

72. Kawamura, R., Doi, Y., Osawa, H., Ninomiya, T., Hata, J., Yonemoto, J., Tanizaki, Y., Iida, M., Makino, H., and Kiyohara, Y.
Circulating resistin is increased with decreasing renal function in a general Japanese population: the Hisayama Study. Nephrol Dial Transplant 25: 3236-40, 2010.

73. Onuma., H., Tabara, Y., Kawamoto, R., Shimizu, I., Kawamura, R., Takata, Y., Nishida, W., Miki, T., Kohara, K., Makino, H., and Osawa, H.
The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels, and lower HOMA-IR in Japanese population. J Hum Genet 55: 600-4, 2010.

74. Tabara, Y., Osawa, H., Kawamoto, R., Onuma, H., Shimizu, I., Hideichi Makino, I., Kohara, K., and Miki, T.
Genotype risk score of common susceptible variants for prediction of type 2 diabetes in Japanese: the J-SHIPP study. Metabolism 60: 1634-1640, 2011.

75. Tabara, Y., Saito, I., Nishida, W., Kohara, K., Sakurai, S., Kawamura, R., Onuma, H., Takata, Y., Osawa, H., Miki, T., and Tanigawa, T.
Relatively lower central aortic pressure in subjects with impaired insulin sensitivity and resistance: The Toon Health Study. J Hypertens 29: 1948-54, 2011.

76. Kawamura, R., Tabara, Y., Onuma, H., Kawamoto, R., Ohashi, J., Takata, Y., Nishida, W., Kohara, K., Makino, H., Miki, T., and Osawa, H.
A single nucleotide polymorphism in the human THADA gene is associated with circulating resistin in the general Japanese population. Diabetology International 2: 190-196, 2011.

77. Onuma, H., Tohyama, M., Imagawa, A., Hanafusa, T., Kobayashi, T., Kano, Y., Ohashi, J., Hashimoto, K., Osawa, H., and Makino, H.
High frequency of HLA B62 in fulminant type 1 diabetes with the drug-induced hypersensitivity syndrome. J Clin Endocrinol Metab 97: E2277-2281, 2012.

78. Tabara, Y., Igase M., Saito, I., Nishida, W., Kohara, K., Sakurai, S., Kawamura, R., Okada, Y., Hitsumoto, S., Onuma, H., Nagai, T., Takata, Y., Uetani, E., Takita, R., Kido, T., Ochi, N., Osawa, H., Tanigawa, T., Miki, T.
Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: the J-SHIP Toon Health Study. Clin Hemorheol Microcirc 55: 297-311, 2013.

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