1. Maruyama K, Khairunnisa S, Saito I, Tanigawa T, Tomooka K, Minato-Inokawa S, Sano M, Takakado M, Kawamura R, Takata Y, Osawa H.
Association of fish and omega-3 fatty acid intake with carotid intime-media thickness in middle-age to elderly Japanese men and women: the Toon Health Study.
Nutrients 14: 3644, 2022

2. Kawamura R, Miyao S, Onuma H, Uchigata Y, Kawasaki E, Ohashi J, Shiraishi S, Nishida W, Yokomoto-Umakoshi M, Takata Y, Osawa H, Makino H.
Recurrent hyperglycemia due to a high titer of insulin antibody in response to exogenous insulin administration in two cases of type 1 daibetes.
Internal Med 61: 687-695, 2022.

3. Kawamura R, Tabara Y, Takata Y, Maruyama K, Takakado M, Hadate T, Matsushita Y, Sano M, Makino H, Saito I, Kanatsuka A, Osawa H.
Association of a SNP in the IAPP gene and hyperglycemia on β-cell dysfunction in type 2 diabetes: the Toon Genome Study.
Diabetol Int 13: 201-208, 2021

4. Uesugi Y, Maruyama K, Saito I, Tomooka K, Takata Y, Kawamura R, Osawa H, Tanigawa T, Naito Y.
A cross-sectional study of the relationship of Timed Up & Go Test with physical characteristics and physical activity in healthy Japanese: The Toon Health Study.
Healthcare 9: 933, 2021.

5. Saito I, Maruyama K, Kato T, Takata Y, Tomooka K, Kawamura R, Uesugi Y, Naito Y, Osawa H, Tanigawa T.
Influence of insulin resistance on the association between physical activity and heart rate variability: The Toon Health Study.
J Phys Act Health 17: 1075-1082, 2020.

6. Yokoyama M, Saito I, Ueno M, Kato H, Yoshida A, Kawamura R, Maruyama K, Takata Y, Osawa H, Tanigawa T, Sugiyama T.
Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study.
J Diabetes Investig 11: 1643-1650, 2020.

7. Higashioka M, Hirakawa Y, Kawamura R, Honda T, Hata J, Yoshida D, Takata Y, Kitazono T, Osawa H, Ninomiya T.
Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study.
J Diabetes Investig 11: 482-489, 2020.

8. Onuma H, Kawamura R, Tabara Y, Yamashita M, Ohashi J, Kawasaki E, Imagawa A, Yamada Y, Chujo D, Takahashi K, Suehiro T, Takata Y, Osawa H, Makino H.
Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin-triggered type 1 diabetes.
J Diabetes Investig 10: 1447-1453, 2019

9. Matsushita Y, Takata Y, Kawamura R, Takakado M, Hadate T, Osawa H.
The fluctuation in sympathetic nerve activity around wake-up time was positively associated with not only morning but also daily glycemic variability in subjects with type 2 diabetes.
Diabetes Res Clin Pract 152: 1-8, 2019

10. Minamoto-Higashioka M, Kawamura R, Umakoshi H, Yokomoto-Umakoshi M, Utsunomiya D, Osawa H, Kondo S.
Seasonal variation in severe glucose-lowering drug-induced hypoglycemia in patients with type 2 diabetes.
Intern Med 58: 1067-1072, 2019

11. Noumi Y, Kawamura R, Tabara Y, Maruyama K, Takata Y, Nishida W, Okamoto A, Nishimiya T, Onuma H, Saito I, Tanigawa T, Osawa H.
An inverse association between serum resistin levels and n-3 polyunsaturated fatty acids intake was strongest in the SNP-420 G/G genotype in the Japanese cohort: The Toon Genome Study.
Clin Endocrinol 88: 51-57, 2018

12. Saito I, Takata Y, Maruyama K, Eguchi E, Kato T, Shirahama R, Tomooka K, Kawamura R, Sano M, Tabara Y, Osawa H, Tanigawa T.
Association between heart rate variability and home blood pressure: The Toon Health Study.
Am J Hypertens 10: 1120-1126, 2018

13. Saito I, Maruyama K, Eguchi E, Kato T, Kawamura R, Takata Y, Onuma H, Osawa H, Tanigawa T.
Low heart rate variability and sympathetic dominance modifies the association between insulin resistance and metabolic syndrome – The Toon Health Study.
Circ J 81: 1447-1453, 2017

14. Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Ohyagi Y, Kamamoto R, Kohara K, Miki T, Osawa H.
Dual effects of a RETN single nucleotide polymorphism (SNP) at -420 on plasma resistin: Genotype and DNA methylation.
J Clin Endocrionol Metab 102: 884-892, 2017

15. Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H.
A genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.
Physiol Genomics 48: 874-881, 2016.

16. Saito I, Hitsumoto S, Maruyama K, Eguchi E, Kato T, Okamoto A, Kawamura R, Takata Y, Nishida W, Nishimiya T, Onuma H, Osawa H, Tanigawa T.
Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study.
Atherosclerosis 244: 79-85, 2016

17. Hamada J, Onuma H, Ochi F, Hirai H, Takemoto K, Miyoshi A, Matsushita M, Kadota Y, Ohashi J, Kawamura R, Takata Y, Nishida W, Hashida S, Ishii E, Osawa H.
Endoplasmic reticulum stress induced by tunicamycin increases resistin mRNA through the PERK-ATF4-CHOP pathway in THP-1 human monocytes.
J Diabertes Investig 7: 312-323, 2016.

18. Harase T, Nishida W, Hamakawa T, Hino S, Shigematsu K, Kobayashi S, Sako H, Ito S, Murakami H, Nishida K, Inoue H, Fujisawa M, Yoshizu H, Kawamura R, Takata Y, Onuma H, Shimizu K, Hamakawa H, Osawa H.
Clinical implication of blood glucose-monitoring in general dental offices: The Ehime Dental Diabetes Study.
BMJ Open Diabetes Res Care 3: e000151, 2015

19. Saito I, Hitsumoto S, Maruyama K, Nishida W, Eguchi E, Kato T, Kawamura R, Takata Y, Onuma H, Osawa H, Tanigawa T.
Heart rate variability, insulin resistance, and insulin sensitivity in Japanese adults: The Toon Health Study.
J Epidemiol 25: 583-591, 2015.

20. Nishida W, Nagata M, Imagawa A, Hanafusa T, Ohashi J, Takahashi K, Suehiro T, Yamada Y, Chujo D, Kawasaki E, Kawamura R, Onuma H, Osawa H, Makino H.
Insulin administration may trigger type 1 diabetes in Japanese type 2 diabetes patients with type 1 diabetes high-risk HLA class II and the insulin gene VNTR genotype.
J Clin Endocrionol Metab 99: E1793-1797, 2014

21. Shiraishi S, Miyao S, Kikuchi N, Ochi K, Sato E, Ohashi J, Kawamura R, Osawa H, Makino H.
Effects of carbohydrate counting on glycemic control and quality of life in patients with type 1 diabetes: A pilot study.
Diabetol Int 5: 181-186, 2014.

22. Onuma H, Tabara Y, Kawamura R, Ohashi Jun, Nishida W, Takata Y, Ochi M, Nishimiya T, Kawamoto R, Kohara K, Miki T, Osawa H.
Plasma resistin is associated with single nucleotide polymorphisms of a possible resistin receptor, the decorin gene, in the general Japanese population.
Diabetes 62: 649-652, 2013.

23. Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, and Miki T.
Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: The J-SHIP Toon Health Study.
Clin Hemorheol Microcirc 55: 297-311, 2013.

24. Kawamura R, Tabara Y, Onuma H, Kawamoto R, Ohashi J, Takata Y, Nishida W, Kohara K, Makino H, Miki T, and Osawa H.
A single-nucleotide polymorphism in the human THADA gene is associated with circulating resistin in the general Japanese population.
Diabetol Int 2: 190-196, 2011.

25. Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, and Tanigawa T.
Relatively lower central aortic pressure in subjects with impaired insulin sensitivity and resistance: The Toon Health Study.
J Hypertens 29: 1948-1954, 2011.

26. Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H.
The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population.
J Hum Genet 55: 600-604, 2010.

27. Kawamura R, Doi Y, Osawa H, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Iida M, Makino H, Kiyohara Y.
Circulating resistin is increased with decreasing renal function in a general Japanese population: the Hisayama Study.
Nephrol Dial Transplant 25: 3236-3240, 2010.

28. Onuma H*, Tabara Y*, Kawamura R*, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H. *上記3名が筆頭著者
A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.
PLoS One 5: e9718, 2010.

29. Osawa H, Tabara Y, Ohashi J, Kawamura R, Onuma H, Makino H.
Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?
Diabetologia 53: 795-797, 2010.

30. Osawa H, Doi Y, Makino H, Ninomiya T, Yonemoto K, Kawamura R, Hata J, Tanizaki Y, Iida M, Kiyohara Y.
Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study.
Cardiovasc Diabetol 8: 60, 2009.

31. Makino H, Shimizu I, Murao S, Kondo S, Tabara Y, Fujiyama M, Fujii Y, Takada Y, Nakai K, Izumi K, Ohashi J, Kawamura R, Yamauchi J, Takata Y, Nishida W, Hashiramoto M, Onuma H, Osawa H.
A pilot study suggests that the G/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes.
Endocr J 56: 1049-1058, 2009.

32. Osawa H, Ochi M, Kato K, Yamauchi J, Nishida W, Takata Y, Kawamura R, Onuma H, Takasuka T, Shimizu I, Fujii Y, Ohashi J, Makino H.
Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.
Biochem Biophys Res Commun 355: 342-346, 2007.