愛媛大学医学部附属病院 先端医療創生センター

業績・研究結果・年報

分子医療部門

2013年 原著論文(分子医療部門)

2014.12.20

Possible Role of Angiotensin-Converting Enzyme 2 and Activation of Angiotensin II Type 2 Receptor by Angiotensin-(1-7) in Improvement of Vascular Remodeling by Angiotensin II Type 1 Receptor Blockade. Ohshima K, Mogi M, Nakaoka H, Iwanami J, Min LJ, Kanno H, Tsukuda K, Chisaka T, Bai HY, Wang XL, Ogimoto A, Higaki J, Horiuchi M. Hypertension.Epub 2013 Dec 30.

Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline intype 2 diabetic mice. Iwanami J, Mogi M, Tsukuda K, Jing F, Ohshima K, Wang XL, Nakaoka H, Kan-No H, Chisaka T, Bai HY, Min LJ, Horiuchi M. Eur J Pharmacol. Epub 2013 Dec 18.

Serum levels of renin-angiotensin system components in acute stroke patients. Mogi M, Kawajiri M, Tsukuda K, Matsumoto S, Yamada T, Horiuchi M. Geriatr Gerontol Int.2013 Nov 26. doi: 10.1111/ggi.12167. [Epub ahead of print]

Therapeutic approach for neuronal disease by regulating renin-angiotensin system. Ohshima K, Mogi M, Horiuchi M. Curr Hypertens Rev.2013 May;9(2):99-107.

Effect of angiotensin II type 2 receptor-interacting protein on adipose tissuefunction via modulation of macrophage polarization. Jing F, Mogi M, Min LJ, Ohshima K, Nakaoka H, Tsukuda K, Wang X, Iwanami J, Horiuchi M. PLoS One.2013;8(4):e60067.

Effect of angiotensin II type 2 receptor on stroke, cognitive impairment and neurodegenerative diseases. Mogi M, Horiuchi M. Geriatr Gerontol Int.2013 Jan;13(1):13-8.

Role of renin-angiotensin-aldosterone system in adipose tissue dysfunction. Jing F, Mogi M, Horiuchi M. Mol Cell Endocrinol.2013 Sep 25;378(1-2):23-8.

Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage. Taira N, Yamaguchi T, Kimura J, Lu ZG, Fukuda S, Higashiyama S, Ono M, Yoshida K. Proc Natl Acad Sci U S A. 2013 Dec 30. [Epub ahead of print]

Efficient expansion of human keratinocyte stem/progenitor cells carrying a transgene with lentiviral vector. Nanba D, Matsushita N, Toki F, Higashiyama S. Stem Cell Res Ther. 2013; 4:127.

Second Harmonic Generation Reveals Collagen Fibril Remodeling in Fibroblast-populated Collagen Gels. Toki F, Honkura N, Shirakata Y, Imamura T, Higashiyama S, Nanba D.  Cell Struct Funct. 2013;38(2):227-36. Epub 2013 Oct 18.

Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells. Ota I, Higashiyama S, Masui T, Yane K, Hosoi H, Matsuura N. Oncol Rep. 2013 Oct;30(4):1593-600. doi: 10.3892/or.2013.2659. Epub 2013 Aug 6.

Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation. Nanba D, Toki F, Barrandon Y, Higashiyama S. J Dermatol Sci. 2013 Nov;72(2):81-6. doi: 10.1016/j.jdermsci.2013.05.009. Epub 2013 Jun 13.

Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice. Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T. Biochem Biophys Res Commun. 2013 Jul 26;437(2):185-91. doi: 10.1016/j.bbrc.2013.05.097. Epub 2013 Jun 4.

Annexin A2 regulates a disintegrin and metalloproteinase 17-mediated ectodomain shedding of pro-tumor necrosis factor-α in monocytes and colon epithelial cells. Tsukamoto H, Tanida S, Ozeki K, Ebi M, Mizoshita T, Shimura T, Mori Y, Kataoka H, Kamiya T, Fukuda S, Higashiyama S, Joh T. Inflamm Bowel Dis. 2013 Jun;19(7):1365-73. doi: 10.1097/MIB.0b013e318281f43a.

Spatiotemporal visualization of proHB-EGF ectodomain shedding in living cells. Inoue H, Sakaue T, Ozawa T, Higashiyama S. J Biochem. 2013 Jul;154(1):67-76. doi: 10.1093/jb/mvt030. Epub 2013 Apr 18.

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. Díaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge SA.  J Cell Biol. 2013 Apr 15;2013(2):279-92. doi: 10.1083/jcb.201209151.

Cisplatin influences acquisition of resistance to molecular-targeted agents through epithelial-mesenchymal transition-like changes. Kurokawa M, Ise N, Omi K, Goishi K, Higashiyama S. Cancer Sci. 2013 Jul;104(7):904-11. doi: 10.1111/cas.12171. Epub 2013 May 15.

Doxycycline-dependent inducible and reversible RNA interference mediated by a single lentivirus vector. Matsushita N, Matsushita S, Hirakawa S, Higashiyama S. Biosci Biotechnol Biochem. 2013;77(4):776-81. Epub 2013 Apr 7.

Actin filament dynamics impacts keratinocyte stem cell maintenance. Nanba D, Toki F, Matsushita N, Matsushita S, Higashiyama S, Barrandon Y. EMBO Mol Med. 2013 Apr;5(4):640-53. doi: 10.1002/emmm.201201839.

Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A. Miwa D, Sakaue T, Inoue H, Takemori N, Kurokawa M, Fukuda S, Omi K, Goishi K, Higashiyama S. Angiogenesis. 2013 Jul;16(3):675-88. doi: 10.1007/s10456-013-9345-x. Epub 2013 Mar 21.

ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells; re-evaluation of their low-affinity interaction. Wang R, Iwakura Y, Araki K, Keino-Masu K, Masu M, Wang XY, Takei N, Higashiyama S, Nawa H. Sci Rep. 2013;3:1402. doi: 10.1038/srep01402.

Telmisartan inhibits cell proliferation by blocking nuclear translocation of ProHB-EGF C-terminal fragment in colon cancer cells. Ozeki K, Tanida S, Morimoto C, Inoue Y, Mizoshita T, Tsukamoto H, Shimura T, Kataoka H, Kamiya T, Nishiwaki E, Ishiguro H, Higashiyama S, Joh T. PLoS One. 2013;8(2):e56770. doi: 10.1371/journal.pone.0056770. Epub 2013 Feb 22.

Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes. Nakayama H, Fukuda S, Matsushita N, Nishida-Fukuda H, Inoue H, Shirakata Y, Hashimoto K, Higashiyama S. J Biol Chem. 2013 Apr 12;288(15):10338-48. doi: 10.1074/jbc.M112.417527. Epub 2013 Feb 21.

部門紹介

  • バイオバンク部門
  • 再生・細胞治療部門
  • 感染症・免疫治療学部門
  • イメージング部門
  • 研究推進支援ユニット
  • 細胞プロセシングセンター