原著
1. Hosokawa, M., Kawakami, R., Imami, K., Kurosawa, R., Ishihama, Y., Imamura, T., Hagiwara, M., and Takeuchi, A. RNA-dependent SFPQ condensates coordinate multidimensional regulation of extra-long neuronal genes Cell Chemical Biology. 10.1016/j.chembiol.2026.06.004.(2026)- 🏆 Lab's Featured Paper
2. Masaki, S., Nojima, T., Oshiro-Ideue, T., Suenaga, A., Takeuchi, A., Kii, I., Suzuki, K., Tanaka, S., Hagiwara, M., and Kataoka, N. PUF60 is a Critical Regulator of PKM Splicing During Myogenesis. Mol. Cell. Biol., 1-16. 10.1080/10985549.2026.2699151.(2026)
3. Shimazaki, R., Saito, Y., Awaya, T., Minami, N., Kurosawa, R., Hosokawa, M., Ohara, H., Hayashi, S., Takeuchi, A., Hagiwara, M., Hayashi, Y.K., Noguchi, S., and Nishino, I. Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy. Orphanet J Rare Dis 20, 1. 10.1186/s13023-024-03521-2.(2025)
4. Lee, S.A., Ogawa, M., Saito, Y., Shimazaki, R., Awaya, T., Hosokawa, M., Kurosawa, R., Ohara, H., Takeuchi, A., Hayashi, S., Goto, Y.I., Hagiwara, M., Nishino, I., and Noguchi, S. Substitutions of nucleotides at the 3' ends of COL6A1/2/3 exons induce exon skipping associated with collagen VI-related muscular dystrophies and therapeutic strategies. Genet. Med., 101431. 10.1016/j.gim.2025.101431.(2025)
5. Ogi, Y., Egi, H., Ishimaru, K., Koga, S., Yoshida, M., Kikuchi, S., Akita, S., Sugishita, H., Matsumoto, H., Shimokawa, T., Takeuchi, A., and Watanabe, Y. Cadaveric and CT angiography study of vessels around the transverse colon mesentery. World J Surg Oncol 21, 36. 10.1186/s12957-023-02919-9.(2023)
6. Khan, S., Takeuchi, A., Nabeka, H., Khan, F., Shimokawa, T., Takanezawa, S., Saitou, T., Imamura, T., Tachibana, T., Nishizono, A., Hamada, F., and Matsuda, S. Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions. iScience 26, 106277. 10.1016/j.isci.2023.106277.(2023)
7. Kanemitsu, E., Zhao, X., Iwaisako, K., Inoue, A., Takeuchi, A., Yagi, S., Masumoto, H., Ohara, H., Hosokawa, M., Awaya, T., Aoki, J., Hatano, E., Uemoto, S., and Hagiwara, M. Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation. Transl Res 255, 26-36. 10.1016/j.trsl.2022.11.003.(2023)
8. Takeuchi, A., Takahashi, Y., Iida, K., Hosokawa, M., Irie, K., Ito, M., Brown, J.B., Ohno, K., Nakashima, K., and Hagiwara, M. Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Stem Cell Reports 15, 883-897. 10.1016/j.stemcr.2020.08.010.(2020)
9. Iida, K., Hagiwara, M., and Takeuchi, A. Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ. iScience 23, 101325. 10.1016/j.isci.2020.101325.(2020)
10. Kurokawa, R., Takeuchi, A., Shiina, N., Katahira, M., Yamashita, T., Matsuno, Y., Hitachi, K., Ishigaki, S., Haamad, N., Yoneda, R., Ueda, N., Iida, K., Hosokawa, M., Hagiwara, M., Iida, M., Mashima, T., Yamaoki, Y., So, M., Nagata, T., Sobue, G., Kondo, K., Watanabe, H., and Uchihashi, T. Versatility of RNA-Binding Proteins in Living Cells. Biomedical Sciences 5, 7-13. 10.11648/j.bs.20190501.12.(2019)
11. Hosokawa, M., Takeuchi, A., Tanihata, J., Iida, K., Takeda, S., and Hagiwara, M. Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. iScience 13, 229-242. 10.1016/j.isci.2019.02.023.(2019)
12. Takeuchi, A., Iida, K., Tsubota, T., Hosokawa, M., Denawa, M., Brown, J.B., Ninomiya, K., Ito, M., Kimura, H., Abe, T., Kiyonari, H., Ohno, K., and Hagiwara, M. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Cell Rep 23, 1326-1341. 10.1016/j.celrep.2018.03.141.(2018)
13. Yoshida, M., Kataoka, N., Miyauchi, K., Ohe, K., Iida, K., Yoshida, S., Nojima, T., Okuno, Y., Onogi, H., Usui, T., Takeuchi, A., Hosoya, T., Suzuki, T., and Hagiwara, M. Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proc. Natl. Acad. Sci. USA 112, 2764-2769. 10.1073/pnas.1415525112.(2015)
14. Ohnishi, T., Yanazawa, M., Sasahara, T., Kitamura, Y., Hiroaki, H., Fukazawa, Y., Kii, I., Nishiyama, T., Kakita, A., Takeda, H., Takeuchi, A., Arai, Y., Ito, A., Komura, H., Hirao, H., Satomura, K., Inoue, M., Muramatsu, S., Matsui, K., Tada, M., Sato, M., Saijo, E., Shigemitsu, Y., Sakai, S., Umetsu, Y., Goda, N., Takino, N., Takahashi, H., Hagiwara, M., Sawasaki, T., Iwasaki, G., Nakamura, Y., Nabeshima, Y., Teplow, D.B., and Hoshi, M. Na, K-ATPase alpha3 is a death target of Alzheimer patient amyloid-beta assembly. Proc. Natl. Acad. Sci. USA 112, E4465-4474. 10.1073/pnas.1421182112.(2015)
15. Sims-Lucas, S., Cusack, B., Baust, J., Eswarakumar, V.P., Masatoshi, H., Takeuchi, A., and Bates, C.M. Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Dev. Dyn. 240, 240-249. 10.1002/dvdy.22501.(2011)
16. Takeuchi, A., Hosokawa, M., Nojima, T., and Hagiwara, M. Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. PLoS One 5, e10946. 10.1371/journal.pone.0010946.(2010)
17. Takeuchi, A., Hamasaki, T., Litwack, E.D., and O'Leary, D.D. Novel IgCAM, MDGA1, expressed in unique cortical area- and layer-specific patterns and transiently by distinct forebrain populations of Cajal-Retzius neurons. Cereb. Cortex 17, 1531-1541. 10.1093/cercor/bhl064.(2007)
18. O'Leary, D.D., Chou, S.J., Hamasaki, T., Sahara, S., Takeuchi, A., Thuret, S., and Leingartner, A. Regulation of laminar and area patterning of mammalian neocortex and behavioural implications. Novartis Foundation Symposium 288, 141-159; discussion 159-164, 276-181.(2007)
19. Takeuchi, A., and O'Leary, D.D. Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1. J. Neurosci. 26, 4460-4464. 10.1523/JNEUROSCI.4935-05.2006.(2006)
20. Takeuchi, A., Mishina, Y., Miyaishi, O., Kojima, E., Hasegawa, T., and Isobe, K. Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nat. Genet. 33, 172-176. 10.1038/ng1072.(2003)
21. Kojima, E., Takeuchi, A., Haneda, M., Yagi, A., Hasegawa, T., Yamaki, K., Takeda, K., Akira, S., Shimokata, K., and Isobe, K. The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB J. 17, 1573-1575. 10.1096/fj.02-1184fje.(2003)
22. Takeuchi, A., Miyaishi, O., Kiuchi, K., and Isobe, K. Macrophage colony-stimulating factor is expressed in neuron and microglia after focal brain injury. J. Neurosci. Res. 65, 38-44. doi.org/10.1002/jnr.1125.(2001)
23. Takeuchi, A., Miyaishi, O., Kiuchi, K., and Isobe, K. Cu/Zn- and Mn-superoxide dismutases are specifically up-regulated in neurons after focal brain injury. J. Neurobiol. 45, 39-46. 10.1002/1097-4695(200010)45:1<39::AID-NEU4>3.0.CO;2-A [pii].(2000)
24. Hasegawa, T., Takeuchi, A., Miyaishi, O., Xiao, H., Mao, J., and Isobe, K. PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters. Biochem. J. 347 Pt 1, 55-59.(2000)
25. Maehara, K., Hasegawa, T., Xiao, H., Takeuchi, A., Abe, R., and Isobe, K. Cooperative interaction of NF-kappaB and C/EBP binding sites is necessary for manganese superoxide dismutase gene transcription mediated by lipopolysaccharide and interferon-gamma. FEBS Lett.449, 115-119. S0014579399004081 [pii].(1999)
26. Takeuchi, A., Isobe, K.I., Miyaishi, O., Sawada, M., Fan, Z.H., Nakashima, I., and Kiuchi, K. Microglial NO induces delayed neuronal death following acute injury in the striatum. Eur. J. Neurosci. 10, 1613-1620. doi.org/10.1046/j.1460-9568.1998.00168.x.(1998)
27. Yamada, E., Ishiguro, N., Miyaishi, O., Takeuchi, A., Nakashima, I., Iwata, H., and Isobe, K. Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA-encoding murine ATPase inhibitor. Immunology 92, 571-576. doi: 10.1046/j.1365-2567.1997.00370.x.(1997)
28. Nozaki, Y., Hasegawa, Y., Takeuchi, A., Fan, Z.H., Isobe, K.I., Nakashima, I., and Shimokata, K. Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats. American Journal of Physiology: Lung Cellular and Molecular Physiology 272, L651-658. https://doi.org/10.1152/ajplung.1997.272.4.L651.(1997)
29. Hasegawa, T., Takeuchi, A., Miyaishi, O., Isobe, K., and de Crombrugghe, B. Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. J. Biol. Chem. 272, 4915-4923. doi.org/10.1002/jnr.1125.(1997)
30. Aono, K., Isobe, K., Kiuchi, K., Fan, Z.H., Ito, M., Takeuchi, A., Miyachi, M., Nakashima, I., and Nimura, Y. In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines. J. Cell. Biochem. 65, 349-358. 10.1002/(SICI)1097-4644(19970601)65:3<349::AID-JCB5>3.0.CO;2-S [pii].(1997)
書籍
Kuroyanagi H., Takeuchi A., Nojima T. & Hagiwara M. Chapter 28: Single cell detection of splicing events with fluorescent splicing reporters. Alternative pre-mRNA Splicing: Theory and Protocols.(Stamm S., Smith C., Lührmann R. ed). Wiley-VCH. (2012)
総説
1. 武内章英. 遺伝子発現におけるRNA 結合タンパク質の多彩な機能. 実験医学増刊 セントラルドグマの新常識 (第３章 ＲＮＡの新常識), 141-148. ISBN-10 : 4758104042, ISBN-13 : 978-4758104043.(2022)
2. 武内章英. Takeuchi, A. 神経幹細胞のグリア新生への運命決定を制御するRNA結合タンパク質Qkの発見. 愛媛医学EHIME MEDICAL JOURNAL 40, 121-127.(2021)
3. 武内章英, 萩原正敏, Takeuchi, A., and M., H. 可視化スプライシング・レポーターシステムで開く哺乳類のmRNA制御の世界Visualizing Splicing Reporter System Explores the mRNA Regulation World in Mammal. 細胞工学Cell technology 31, 698-704.(2012)
4. 武内章英, 三品裕司, 磯部健一, Takeuchi, A., Y., M., and Isobe, K.-I. CURRENT TOPICS：Zfp148のハプロ不全は、マウス胎仔発生において生殖細胞の完全消失を起こすHeterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. 実験医学Experimental Medicine 21, 912-915.(2003)
5. 磯部健一, 武内章英, 長谷川忠男, 大楠晃三, Isobe, K.-I., Takeuchi, A., Hasegawa, T., and Ohkusu, K. 加齢とアポトーシスAging and Apoptosis. 臨床免疫Clinical Immunology 29, 1422-1426.(1997)
6. 宮石理, 武内章英, 磯部健一, Miyaishi, O., Takeuchi, A., and Isobe, K.-I. 分子生物学的見地からみた加齢Understanding aging from molecular cell biology. 耳鼻咽喉科・頭頚部外科Otolaryngology-Head and Neck Surgery 15, 971-975.(1997)
特許
スプライシング異常に起因するRNA病の病態解明および創薬シーズ探索のために開発したツールに関する特許：「哺乳類生物における選択的スプライシングの発現プロファイルおよび制御機構を明らかにするトランスジェニックレポーターシステム」。発明者：萩原正敏、武内章英。出願人：国立大学法人京都大学。日本国特許第5875009号（登録日：2016年1月29日）。
スプライシング異常に起因するRNA病の病態解明および創薬シーズ探索のために開発したツールに関する特許：「TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS」。発明者：Masatoshi Hagiwara、Akihide Takeuchi。出願人：Kyoto University。米国特許 US 9,273,364 B2（登録日：2016年5月11日）。
スプライシング異常に起因するRNA病の病態解明および創薬シーズ探索のために開発したツールに関する特許：「TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN RODENTS」。発明者：Masatoshi Hagiwara、Akihide Takeuchi。出願人：Kyoto University。欧州特許 EP 2576778（登録日：2017年4月7日）。