教室員の方が書いてくれた似顔絵。着任したばかりでまだ恐ろしさが伝わっていないらしい…。あと5年くらいしてこんな温厚な感じになれたらよいだろうか?。

E-mail: takeuchi.akihide.jo[@]ehime-u.ac.jp

職名主任教授
卒業名古屋大学医学部/1993年 卒業
学位医学博士/名古屋大学/1999年3月
専門分野分子神経発生、分子生物学、RNA制御、神経解剖学、肉眼解剖学
researchmaphttps://researchmap.jp/7000008943
所属学会日本解剖学会、日本分子生物学会、日本神経科学会、日本RNA学会、日本筋学会、Society for Neuroscience、RNA Society
その他岐阜県出身
剣道:教士7段(東温市または松山市で夜に稽古に参加させて貰える所を探しています)
ジョギング:フルマラソン サブ4挑戦中(大学の周辺をジョギングで散策しながら、走るのに良さそうなコースを探索中)

職歴

1993-1994岐阜大垣市民病院 研修医
1994-1995岐阜大垣市民病院 脳神経外科
1999-2003国立長寿医療研究センター リサーチレジデントおよび研究員
 2001 RINAT Neuroscience Corporation (Palo Alto, CA, U.S.A.) PostDoctoral Fellow
 2002 Stem Cells Inc. (Palo Alto, CA, U.S.A.) Scientist
2003-2006The Salk Institute for Biological Studies (La Jolla, CA, U.S.A) Research Associate (Dr. Dennis DM O'Leary)
2006-2010 東京医科歯科大学/難治疾患研究所 助手〜助教
2010-2012京都大学大学院医学研究科/形態形成機構学 助教
2012-2021京都大学大学院医学研究科/形態形成機構学 准教授
2021-愛媛大学大学院医学系研究科/生体構造医学講座(旧:解剖学・組織学講座) 教授(現在に至る)

業績

1          Takeuchi, A., Takahashi, Y., Iida, K., Hosokawa, M., Irie, K., Ito, M., Brown, J. B., Ohno, K., Nakashima, K. & Hagiwara, M. Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Stem Cell Reports 15, 883-897, doi:10.1016/j.stemcr.2020.08.010 (2020).

2          Iida, K., Hagiwara, M. & Takeuchi, A. Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ. iScience 23, 101325, doi:10.1016/j.isci.2020.101325 (2020).

3          Kurokawa, R., Takeuchi, A., Shiina, N., Katahira, M., Yamashita, T., Matsuno, Y., Hitachi, K., Ishigaki, S., Haamad, N., Yoneda, R., Ueda, N., Iida, K., Hosokawa, M., Hagiwara, M., Iida, M., Mashima, T., Yamaoki, Y., So, M., Nagata, T., Sobue, G., Kondo, K., Watanabe, H. & Uchihashi, T. Versatility of RNA-Binding Proteins in Living Cells. Biomedical Sciences 5, 7-13, doi:10.11648/j.bs.20190501.12 (2019).

4          Hosokawa, M., Takeuchi, A., Tanihata, J., Iida, K., Takeda, S. & Hagiwara, M. Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. iScience 13, 229-242, doi:10.1016/j.isci.2019.02.023 (2019).

5          Takeuchi, A., Iida, K., Tsubota, T., Hosokawa, M., Denawa, M., Brown, J. B., Ninomiya, K., Ito, M., Kimura, H., Abe, T., Kiyonari, H., Ohno, K. & Hagiwara, M. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Cell Rep 23, 1326-1341, doi:10.1016/j.celrep.2018.03.141 (2018).

6          Yoshida, M., Kataoka, N., Miyauchi, K., Ohe, K., Iida, K., Yoshida, S., Nojima, T., Okuno, Y., Onogi, H., Usui, T., Takeuchi, A., Hosoya, T., Suzuki, T. & Hagiwara, M. Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proceedings of the National Academy of Sciences, USA 112, 2764-2769, doi:10.1073/pnas.1415525112 (2015).

7          Ohnishi, T., Yanazawa, M., Sasahara, T., Kitamura, Y., Hiroaki, H., Fukazawa, Y., Kii, I., Nishiyama, T., Kakita, A., Takeda, H., Takeuchi, A., Arai, Y., Ito, A., Komura, H., Hirao, H., Satomura, K., Inoue, M., Muramatsu, S., Matsui, K., Tada, M., Sato, M., Saijo, E., Shigemitsu, Y., Sakai, S., Umetsu, Y., Goda, N., Takino, N., Takahashi, H., Hagiwara, M., Sawasaki, T., Iwasaki, G., Nakamura, Y., Nabeshima, Y., Teplow, D. B. & Hoshi, M. Na, K-ATPase alpha3 is a death target of Alzheimer patient amyloid-beta assembly. Proceedings of the National Academy of Sciences, USA 112, E4465-4474, doi:10.1073/pnas.1421182112 (2015).

8          Sims-Lucas, S., Cusack, B., Baust, J., Eswarakumar, V. P., Masatoshi, H., Takeuchi, A. & Bates, C. M. Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Developmental Dynamics 240, 240-249, doi:10.1002/dvdy.22501 (2011).

9          Takeuchi, A., Hosokawa, M., Nojima, T. & Hagiwara, M. Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. PLoS One 5, e10946, doi:10.1371/journal.pone.0010946 (2010).

10        Takeuchi, A., Hamasaki, T., Litwack, E. D. & O'Leary, D. D. Novel IgCAM, MDGA1, expressed in unique cortical area- and layer-specific patterns and transiently by distinct forebrain populations of Cajal-Retzius neurons. Cerebral Cortex 17, 1531-1541, doi:bhl064 [pii]

10.1093/cercor/bhl064 (2007).

11        O'Leary, D. D., Chou, S. J., Hamasaki, T., Sahara, S., Takeuchi, A., Thuret, S. & Leingartner, A. Regulation of laminar and area patterning of mammalian neocortex and behavioural implications. Novartis Foundation Symposium 288, 141-159; discussion 159-164, 276-181 (2007).

12        Takeuchi, A. & O'Leary, D. D. Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1. Journal of Neuroscience 26, 4460-4464, doi:26/17/4460 [pii]

10.1523/JNEUROSCI.4935-05.2006 (2006).

13        Takeuchi, A., Mishina, Y., Miyaishi, O., Kojima, E., Hasegawa, T. & Isobe, K. Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nature Genetics 33, 172-176, doi:10.1038/ng1072

ng1072 [pii] (2003).

14        Kojima, E., Takeuchi, A., Haneda, M., Yagi, A., Hasegawa, T., Yamaki, K., Takeda, K., Akira, S., Shimokata, K. & Isobe, K. The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB Journal 17, 1573-1575, doi:10.1096/fj.02-1184fje

02-1184fje [pii] (2003).

15        Takeuchi, A., Miyaishi, O., Kiuchi, K. & Isobe, K. Macrophage colony-stimulating factor is expressed in neuron and microglia after focal brain injury. Journal of Neuroscience Research 65, 38-44 (2001).

16        Takeuchi, A., Miyaishi, O., Kiuchi, K. & Isobe, K. Cu/Zn- and Mn-superoxide dismutases are specifically up-regulated in neurons after focal brain injury. Journal of Neurobiology 45, 39-46, doi:10.1002/1097-4695(200010)45:1<39::AID-NEU4>3.0.CO;2-A [pii] (2000).

17        Hasegawa, T., Takeuchi, A., Miyaishi, O., Xiao, H., Mao, J. & Isobe, K. PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters. Biochemical Journal 347 Pt 1, 55-59 (2000).

18        Maehara, K., Hasegawa, T., Xiao, H., Takeuchi, A., Abe, R. & Isobe, K. Cooperative interaction of NF-kappaB and C/EBP binding sites is necessary for manganese superoxide dismutase gene transcription mediated by lipopolysaccharide and interferon-gamma. FEBS Letters 449, 115-119, doi:S0014579399004081 [pii] (1999).

19        Takeuchi, A., Isobe, K. I., Miyaishi, O., Sawada, M., Fan, Z. H., Nakashima, I. & Kiuchi, K. Microglial NO induces delayed neuronal death following acute injury in the striatum. European Journal of Neuroscience 10, 1613-1620 (1998).

20        Yamada, E., Ishiguro, N., Miyaishi, O., Takeuchi, A., Nakashima, I., Iwata, H. & Isobe, K. Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA-encoding murine ATPase inhibitor. Immunology 92, 571-576 (1997).

21        Nozaki, Y., Hasegawa, Y., Takeuchi, A., Fan, Z. H., Isobe, K. I., Nakashima, I. & Shimokata, K. Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats. American Journal of Physiology: Lung Cellular and Molecular Physiology 272, L651-658 (1997).

22        Hasegawa, T., Takeuchi, A., Miyaishi, O., Isobe, K. & de Crombrugghe, B. Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. Journal of Biological Chemistry 272, 4915-4923 (1997).

23        Aono, K., Isobe, K., Kiuchi, K., Fan, Z. H., Ito, M., Takeuchi, A., Miyachi, M., Nakashima, I. & Nimura, Y. In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines. Journal of Cellular Biochemistry 65, 349-358, doi:10.1002/(SICI)1097-4644(19970601)65:3<349::AID-JCB5>3.0.CO;2-S [pii] (1997).

総説

1          武内章英. 遺伝子発現におけるRNA 結合タンパク質の多彩な機能. 実験医学増刊 セントラルドグマの新常識, 141-148 (2022).

2          武内章英神経幹細胞のグリア新生への運命決定を制御するRNA結合タンパク質Qkの発見. 愛媛医学 EHIME MEDICAL JOURNAL40, 121-127 (2021).