| 原著 |
Asakura M, Ueda Y, Yamaguchi O, Adachi T, Hirayama A, Hori M, Kodama K:
Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: an angioscopic study. J Am Coll Cardiol. 37, 1284-8, 2001
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Ueda Y, Asakura M, Yamaguchi O, Hirayama A, Hori M, Kodama K:
The healing process of infarct-related plaques. Insights from 18 months of serial angioscopic follow-up. J Am Coll Cardiol. 38, 1916-22, 2001
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Adachi T, Hirayama A, Asakura M, Yamaguchi O, Ueda Y, Kuzuya T, Hori M, Kodama K:
Angioscopic observation after coronary angioplasty for chronic coronary occlusion comparison with severe stenotic lesion. Diagn Ther Endosc 7,7-14, 2000
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Hirotani S, Otsu K, Nishida K, Higuchi Y, Morita T, Nakayama H, Yamaguchi O, Mano T, Matsumura Y, Ueno H, Tada M, Hori M:
Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation 105, 509-15, 2002
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Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Matsumura Y, Ueno H, Tada M, Hori M:
Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy. J Mol Cell Cardiol 34, 233-40, 2002
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Date MO, Morita T, Yamashita N, Nishida K, Yamaguchi O, Higuchi Y, Hirotani S, Matsumura Y, Hori M, Tada M, Otsu K:
The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model. J Am Coll Cardiol. 39, 907-12, 2002
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Nakayama H, Otsu K, Yamaguchi O, Nishida K, Date MO, Hongo K, Kusakari Y, Toyofuku T, Hikoso S, Kashiwase K, Takeda T, Matsumura Y, Kurihara S, Hori M, Tada M:
Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy. FASEB J. 17, 61-3, 2003
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Otsu K, Yamashita N, Nishida K, Hirotani S, Yamaguchi O, Watanabe T, Hikoso S, Higuchi Y, Matsumura Y, Maruyama M, Sudo T, Osada H, Hori M:
Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion. Biochem Biophys Res Commun. 302,56-60,2003
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Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Hikoso S, Kashiwase K, Takeda T, Watanabe T, Mano T, Matsumura Y, Ueno H, Hori M:
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B. J Biol Chem. 278, 20770-7, 2003
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Yamaguchi O, Higuchi Y, Hirotani S, Kashiwase K, Nakayama H, Hikoso S, Takeda T, Watanabe T, Asahi M, Taniike M, Matsumura Y, Tsujimoto I, Hongo K, Kusakari Y, Kurihara S, Nishida K, Ichijo H, Hori M, Otsu K:
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proc Natl Acad Sci U S A. 100, 15883-8, 2003
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Hirotani S, Higuchi Y, Nishida K, Nakayama H, Yamaguchi O, Hikoso S, Takeda T, Kashiwase K, Watanabe T, Asahi M, Taniike M, Tsujimoto I, Matsumura Y, Sasaki T, Hori M, Otsu K:
Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy. J Mol Cell Cardiol 36, 799-807, 2004
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Asahi M, Otsu K, Nakayama H, Hikoso S, Takeda T, Gramolini AO, Trivieri MG, Oudit GY, Morita T, Kusakari Y, Hirano S, Hongo K, Hirotani S, Yamaguchi O, Peterson A, Backx PH, Kurihara S, Hori M, MacLennan DH:
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A. 101, 9199-204, 2004
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Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K:
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest. 114, 937-43, 2004
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Hikoso S, Yamaguchi O, Higuchi Y, Hirotani S, Takeda T, Kashiwase K, Watanabe T, Taniike M, Tsujimoto I, Asahi M, Matsumura Y, Nishida K, Nakajima H, Akira S, Hori M, Otsu K:
Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice. Circulation. 110, 2631-7, 2004
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Nishida K, Yamaguchi O (co-1st author), Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien KR, Takeda J, Hori M, Otsu K:
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol. 24, 10611-20, 2004
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Kashiwase K, Higuchi Y, Hirotani S, Yamaguchi O, Hikoso S, Takeda T, Watanabe T, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Ueno H, Nishida K, Hori M, Otsu K:
CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy. Biochem Biophys Res Commun. 327, 136-42, 2005
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Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, Tsujimoto Y:
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature. 434, 652-8, 2005
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Tsujimoto I, Hikoso S, Yamaguchi O, Kashiwase K, Nakai A, Takeda T, Watanabe T, Taniike M, Matsumura Y, Nishida K, Hori M, Kogo M, Otsu K:
The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy. Hypertension. 45, 921-6, 2005
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Watanabe T, Otsu K, Takeda T, Yamaguchi O, Hikoso S, Kashiwase K, Higuchi Y, Taniike M, Nakai A, Matsumura Y, Nishida K, Ichijo H, Hori M:
Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death. Biochem Biophys Res Commun. 333, 562-7, 2005
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Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel DB, Bernstein A, Tomita T, Iwatsubo T, Hori M, Otsu K:
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J. 19, 2069-71, 2005
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Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S:
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 441, 101-5, 2006
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Nojiri H, Shimizu T, Funakoshi M, Yamaguchi O, Zhou H, Kawakami S, Ohta Y, Sami M, Tachibana T, Ishikawa H, Kurosawa H, Kahn RC, Otsu K, Shirasawa T:
Oxidative stress causes heart failure with impaired mitochondrial respiration. J Biol Chem. 281, 33789-801, 2006
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Nakai A, Yamaguchi O (co-1st author), Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, Otsu K:
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 13, 619-24, 2007
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Hikoso S, Ikeda Y, Yamaguchi O, Takeda T, Higuchi Y, Hirotani S, Kashiwase K, Yamada M, Asahi M, Matsumura Y, Nishida K, Matsuzaki M, Hori M, Otsu K:
Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer. J Am Coll Cardiol. 50, 453-62, 2007
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Taniike M, Yamaguchi O, Tsujimoto I, Hikoso S, Takeda T, Nakai A, Omiya S, Mizote I, Nakano Y, Higuchi Y, Matsumura Y, Nishida K, Ichijo H, Hori M, Otsu K:
Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy. Circulation. 117, 545-52, 2008
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Ueno M, Suzuki J, Zenimaru Y, Takahashi S, Koizumi T, Noriki S, Yamaguchi O, Otsu K, Shen WJ, Kraemer FB, Miyamori I:
Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice. Am J Physiol Endocrinol Metab. 294, E1109-18, 2008
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Watanabe T, Takeda T, Omiya S, Hikoso S, Yamaguchi O, Nakano Y, Higuchi Y, Nakai A, Abe Y, Aki-Jin Y, Taniike M, Mizote I, Matsumura Y, Shimizu T, Nishida K, Imai K, Hori M, Shirasawa T, Otsu K:
Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure. J Am Coll Cardiol. 52, 779-86, 2008
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Hirayama A, Saito S, Ueda Y, Takayama T, Honye J, Komatsu S, Yamaguchi O, Li Y, Yajima J, Nanto S, Takazawa K, Kodama K:
Qualitative and quantitative changes in coronary plaque associated with atorvastatin therapy. Circ J. 73, 718-25, 2009
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Omiya S, Hikoso S, Imanishi Y, Saito A, Yamaguchi O, Takeda T, Mizote I, Oka T, Taneike M, Nakano Y, Matsumura Y, Nishida K, Sawa Y, Hori M, Otsu K:
Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes. J Mol Cell Cardiol. 46, 59-66, 2009
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Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, Uno Y, Matsumura Y, Nishida K, Suzuki K, Kogo M, Hori M, Otsu K:
The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression. Circ Res. 105, 70-9, 2009
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Mizote I, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Tamai T, Oyabu J, Matsumura Y, Nishida K, Komuro I, Hori M, Otsu:
Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure. J Mol Cell Cardiol.48, 302-9, 2010
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Hirayama A, Saito S, Ueda Y, Takayama T, Honye J, Komatsu S, Yamaguchi O, Li Y, Yajima J, Nanto S, Takazawa K, Kodama K:
Plaque-stabilizing effect of atorvastatin is stronger for plaques evaluated as more unstable by angioscopy and intravenous ultrasound. Circ J. 75, 1448-54, 2011
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Taneike M, Mizote I, Morita T, Watanabe T, Hikoso S, Yamaguchi O, Takeda T, Oka T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Takeda J, Mochizuki N, Komuro I, Otsu K:
Calpain protects the heart from hemodynamic stress. J Biol Chem. 286, 32170-7, 2011
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Okada K, Ueda Y, Takayama T, Honye J, Komatsu S, Yamaguchi O, Li Y, Yajima J, Takazawa K, Nanto S, Saito S, Hirayama A, Kodama K:
Influence of achieved low-density lipoprotein cholesterol level with atorvastatin therapy on stabilization of coronary plaques: sub-analysis of the TWINS study. Circ J. 76, 1197-202, 2012
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Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu:
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature. 485, 251-5, 2012
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Takayama T, Hiro T, Ueda Y, Honye J, Komatsu S, Yamaguchi O, Li Y, Yajima J, Takazawa K, Nanto S, Saito S, Hirayama A, Kodama K:
Plaque stabilization by intensive LDL-cholesterol lowering therapy with atorvastatin is delayed in type 2 diabetic patients with coronary artery disease-Serial angioscopic and intravascular ultrasound analysis. J Cardiol. 61, 381-6, 2013
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Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa T, Nakayama H, Uno Y, Horie K, Nishida K, Sonenberg N, Shah AM, Takeda J, Komuro I, Otsu K:
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period. J Biol Chem. 288, 10176-87, 2013
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Oyabu J, Yamaguchi O, Hikoso S, Takeda T, Oka T, Murakawa T, Yasui H, Ueda H, Nakayama H, Taneike M, Omiya S, Shah AM, Nishida K, Otsu K:
Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading. Biochem Biophys Res Commun. 441, 787-92, 2013
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Mao Y, Tokudome T, Kishimoto I, Otani K, Nishimura H, Yamaguchi O, Otsu K, Miyazato M, Kangawa K:
Endogenous ghrelin attenuates pressure overload-induced cardiac hypertrophy via a cholinergic anti-inflammatory pathway. Hypertension. 2015;65(6):1238-44
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Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K:
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. Nat Commun. 6, 7527, 2015
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Masuda M, Mizuno H, Enchi Y, Minamiguchi H, Konishi S, Ohtani T, Yamaguchi O, Okuyama Y, Nanto S, Sakata Y:
Abundant epicardial adipose tissue surrounding the left atrium predicts early rather than late recurrence of atrial fibrillation after catheter ablation. J Interv Card Electrophysiol. 44, 31-7, 2015
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Masuda M, Yamada T, Mizuno H, Minamiguchi H, Konishi S, Ohtani T, Yamaguchi O, Okuyama Y, Uematsu M, Sakata Y:
Impact of atrial fibrillation ablation on cardiac sympathetic nervous system in patients with and without heart failure. Int J Cardiol. 199, 65-70, 2015
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Taniguchi T, Ohtani T, Nakatani S, Hayashi K, Yamaguchi O, Komuro I, Sakata Y:
Impact of Body Size on Inferior Vena Cava Parameters for Estimating Right Atrial Pressure: A Need for Standardization? J Am Soc Echocardiogr. 28, 1420-7, 2015
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Ichibori Y, Ohtani T, Nakatani D, Tachibana K, Yamaguchi O, Toda K, Akasaka T, Fukushima N, Sawa Y, Komuro I, Kotani J, Sakata Y:
Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization. Eur Heart J Cardiovasc Imaging. 17, 51-8, 2016
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Taneike M, Nishida K, Omiya S, Zarrinpashneh E, Misaka T, Kitazume-Taneike R, Austin R, Takaoka M, Yamaguchi O, Gambello MJ, Shah AM, Otsu K:
mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy. PLoS One. 11, e0152628, 2016
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Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis AK, Sawa Y, Sasaki H, Ozono K, Suzuki K, Yashiro K:
GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep. 16, 1026-38, 2016
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Omiya S, Omori Y, Taneike M, Protti A, Yamaguchi O, Akira S, Shah AM, Nishida K, Otsu K:
Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. Am J Physiol Heart Circ Physiol. 311(6), H1485-H1497, 2016
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Ichibori Y, Mizote I, Maeda K, Onishi T, Ohtani T, Yamaguchi O, Torikai K, Kuratani T, Sawa Y, Nakatani S, Sakata Y:
Clinical Outcomes and Bioprosthetic Valve Function After Transcatheter Aortic Valve Implantation Under Dual Antiplatelet Therapy vs. Aspirin Alone. Circ J. 81(3), 397-404, 2017
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Sakamoto Y, Kioka H, Hashimoto R, Takeda S, Momose K, Ohtani T, Yamaguchi O, Wasa M, Nakatani S, Sakata Y:
Cardiogenic shock caused by a left midventricular obstruction during refeeding in a patient with anorexia nervosa. Nutrition. 35, 148-150, 2017
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Ide S, Sumitsuji S, Yamaguchi O, Sakata Y:
Cardiac computed tomography-derived myocardial mass at risk using the Voronoi-based segmentation algorithm: A histological validation study. J Cardiovasc Comput Tomogr. 11(3), 179-182, 2017
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Taniguchi T, Ohtani T, Kioka H, Tsukamoto Y, Onishi T, Nakamoto K, Katsimichas T, Sengoku K, Chimura M, Hashimoto H, Yamaguchi O, Sawa Y, Sakata Y:
Liver Stiffness Reflecting Right-Sided Filling Pressure Can Predict Adverse Outcomes in Patients With Heart Failure. JACC Cardiovasc Imaging. pii: S1936-878X(17)31139-7, 2018.
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Misaka T, Murakawa T, Nishida K, Omori Y, Taneike M, Omiya S, Molenaar C, Uno Y, Yamaguchi O, Takeda J, Shah AM, Otsu K:
FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice. J Mol Cell Cardiol. 114: 93-104, 2018.
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| 総説 |
Nishida K, Yamaguchi O, Otsu K:
Crosstalk between autophagy and apoptosis in heart disease. Circ Res. 103, 343-51, 2008
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Nishida K, Kyoi S, Yamaguchi O, Sadoshima J, Otsu K:
The role of autophagy in the heart. Cell Death Differ. 16, 31-8, 2009
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Yamaguchi O, Otsu K:
Novel in vivo tool to evaluate autophagic activity in the heart. Circ J. 74, 49-50, 2010
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Yamaguchi O, Otsu K:
Role of autophagy in aging. J Cardiovasc Pharmacol. 60, 242-7, 2012
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Yamaguchi O, Taneike M, Otsu K:
Cooperation between proteolytic systems in cardiomyocyte recycling. Cardiovasc Res. 96, 46-52, 2012
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Hori M, Yamaguchi O:
Is tumor necrosis factor-α friend or foe for chronic heart failure? Circ Res. 113, 492-4, 2013
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Nishida K, Yamaguchi O, Otsu K:
Degradation systems in heart failure. J Mol Cell Cardiol. 84, 212-22, 2015
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Otsu K, Murakawa T, Yamaguchi O:
BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32. Autophagy. 11, 1932-3, 2015
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*Yamaguchi O, Murakawa T, Nishida K, Otsu K:
Receptor-mediated mitophagy. J Mol Cell Cardiol. 95, 50-6, 2016
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| 著書 |
Nishida K, Yamaguchi O, Otsu K:
Autophagy in the Cardiovascular System. Autophagy in Health and Disease. Roberta A. Gottlieb, Academic Press, 33-39, 2012
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| 症例報告 |
Ito S, Hagiya H, Kimura K, Nishi I, Yoshida H, Kioka H, Ohtani T, Yamaguchi O, Tanabe K, Tomono K, Sakata Y:
Capnocytophaga ochracea-related Bacterium Bacteremia in a Hypertrophic Cardiomyopathy Patient without Neutropenia. Intern Med. 55(18):2731-5, 2016
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Tsuchiya H, Kioka H, Ozu K, Ohtani T, Yamaguchi O, Yazaki Y, Yamauchi-Takihara K, Sakata Y:
Interferon Therapy Exacerbated Pulmonary Hypertension in a Patient with Hepatitis C Virus Infection: Pathogenic Interplay among Multiple Risk Factors. Internal Med. 56(9), 1061-1065, 2017
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Konishi S, Minamiguchi H, Ozu K, Mizuno H, Hikoso S, Yamaguchi O, Sakata Y:
Routine exercise testing could not predict T-wave oversensing in a patient after a subcutaneous implantable cardioverter-defibrillator implant. Clin Case Rep. 6(2): 309-313, 2017.
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Ishihara S, Kioka H, Ohtani T, Asano Y, Yamaguchi O, Hikoso S, Toda K, Saito Y, Sawa Y, Yamauchi-Takihara K, Sakata Y: Successful treatment of severe combined post- and pre-capillary pulmonary hypertension in a patient with idiopathic restrictive cardiomyopathy.
Pulm Circ. 8(3): 2045894018770131, 2018.
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