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―論文紹介その3―
 

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―論文紹介その3―

第三内科の先生方の投稿された論文を紹介させていただきます。

Author・Title・Journal・論文紹介・オーベン(corresponding authorまたは指導医)からの一言

以上の5項目を紹介させていただいております。

Authors:

Shiyi Chen, Sheikh Mohammad Fazle Akbar, Masanori Abe, Yoichi Hiasa, Morikazu Onji

Article title:

Immune suppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus

Journal:

Clinical and Experimental Immunology

論文内容紹介(論文作成に関する筆頭著者の感想も含む)

To explore functional heterogeneity of myeloid cells, myeloid-derived suppressor cells (MDSC) and their subtypes were detected in the liver, isolated to over 95% purity by flow cytometry, analyzed for T cell stimulatory capacities, and evaluated for mechanism underlying their suppressor capacities. The relative frequencies of MDSC were higher in normal mice liver than the spleen (p<0.05). Hepatic MDSC from normal mice suppressed T cell proliferation in allogenic MLR. MDSC induced T cell exhaustion and low interferon gamma production. MDSC from hepatitis B virus (HBV) transgenic mice (TM) suppressed hepatitis B surface antigen-specific T cell proliferation. Taken together, MDSC seems to be essential for maintaining homeostasis in normal mice and may be related to immune suppressive status of HBV TM. This study also inspire optimism that MDSC may be a target of immune therapy in HBV TM.

オーベンからの一言(corresponding authorまたは指導医)

Myeloid cells are regarded as mostly immunogenic that secrete several inflammatory cytokines. However, a subtype of myeloid cells, myeloid-derived suppressor cells (MDSC) are immune suppressive in cancer microenvironment. Indeed, almost nothing is known about hepatic MDSC and their role in normal and in diseases other than cancer. Dr. Shiyi checked the nature and characteristics of MDSC from normal and HBV TM in a methodological manner. Highly purified population of MDSC and their subtypes were isolated. The study yielded several new information about MDSC and their functions. Taken together, this study has prompted to check the role of MDSC in pathogenesis of liver and possibilities of MDSC-targeted immune therapy.

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愛媛大学大学院
消化器・内分泌・代謝内科学
(第三内科)
Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
〒791-0295 愛媛県東温市志津川454
愛媛大学医学部本館8F
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FAX 089-960-5310
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